Asymmetric Assembly of Cobalt Metallocenes - Accessible Building Blocks for Novel Catalysts
Lead Research Organisation:
University of East Anglia
Department Name: Chemistry
Abstract
Molecules that exist in 'handed' form are of growing importance to many research areas, not least the pharmaceutical industry where sales of such compounds now exceed $100 billion per annum. 'Handed' molecules exist in two non-superimposable mirror image forms of which only one usually displays the desired property such as an ability to mediate biological activity. One of the most efficient and cost effective means to generate such molecules is to employ a small quantity of a metal/ligand catalyst that selectively generates one 'handed' form over the alternative. Central to this strategy is the ligand which contains the information required to successfully control the reaction taking place at the metal, to which it is attached. Thus many different ligand types have been synthesised and tested, yet it is striking how certain groups, or privileged structures as they have been coined, are successful for a wide range of applications. One of these groups is the metallocenes, normally derivatives of iron-based compounds called ferrocenes. In this proposal a new strategy is outlined for the synthesis of cobalt based metallocenes that is significantly simpler than the existing ferrocene methodology. Furthermore, it has much greater variability and flexibility that will enable rapid access to, and optimisation of, a ligand for a given metal catalysed 'handed' synthesis.
Organisations
People |
ORCID iD |
Chris Richards (Principal Investigator) |
Publications
Amin J
(2012)
Diastereoselective synthesis of half-sandwich chiral-at-metal cobaltacycles by oxidative cyclisation.
in Chemical communications (Cambridge, England)
Amin J
(2015)
Application of the Nicholas reaction to the synthesis of dicobalt hexacarbonyl complexed diyne ethers
in Journal of Organometallic Chemistry
Nguyen H
(2008)
Synthesis and 1H NMR spectroscopic properties of substituted (?4-tetraarylcyclobutadiene)(?5-cyclopentadienyl)cobalt metallocenes
in Journal of Organometallic Chemistry
Panchal K
(2015)
Synthesis of racemic palladacycles from 2-ferrocenylphenylphosphines
in Journal of Organometallic Chemistry
Description | Molecules that exist in 'handed' form are of growing importance to many research areas, not least the pharmaceutical industry where sales of such compounds now exceed $100 billion per annum. 'Handed' molecules exist in two non-superimposable mirror image forms of which only one usually displays the desired property such as an ability to mediate biological activity. One of the most efficient and cost effective means to generate such molecules is to employ a small quantity of a metal/ligand catalyst that selectively generates one 'handed' form over the alternative. Central to this strategy is the ligand which contains the information required to successfully control the reaction taking place at the metal, to which it is attached. Thus many different ligand types have been synthesised and tested, yet it is striking how certain groups, or privileged structures as they have been coined, are successful for a wide range of applications. One of these groups is the metallocenes, normally derivatives of iron-based compounds called ferrocenes. In this work a new strategy is outlined for the synthesis of cobalt based metallocenes that is significantly simpler than much of the existing ferrocene methodology. Furthermore, it has much greater variability and flexibility that will enable rapid access to, and optimisation of, a ligand for a given metal catalysed 'handed' synthesis. In addition the methodology has been extended to the asymmetric synthesis of other chiral building blocks, specifically chiral-at-metal complexes which also display propeller chirality as a result of a configurationally stable coordinated phosphine. |
Exploitation Route | The synthesis of new catalysts for use in synthesis. |
Sectors | Chemicals,Pharmaceuticals and Medical Biotechnology |
Description | Results obtained are used in ongoing work in the area of catalyst synthesis and application. |
First Year Of Impact | 2008 |
Sector | Chemicals,Pharmaceuticals and Medical Biotechnology |
Impact Types | Cultural,Societal,Economic |