Privileged Metallocene Catalysts for Asymmetric Synthesis
Lead Research Organisation:
University of East Anglia
Department Name: Chemistry
Abstract
Bulky cobalt metallocenes have recently found application in a number of asymmetric transformations characterised by high enantioselectivity. The further development of this area is hampered by the absence of a general methodology for the synthesis of planar chiral derivatives. A general solution to this problem is proposed involving asymmetric desymmetrisation by either metal catalysed cross-coupling and/or enantioselective halogen-metal exchange. The resulting non-racemic products will be used for the synthesis of representative P, PN and PP ligands, and also for the generation of palladium based and 'organocatalytic' rearrangement catalysts for application in asymmetric synthesis.
Organisations
People |
ORCID iD |
| Chris Richards (Principal Investigator) |
Publications
Amin J
(2012)
Diastereoselective synthesis of half-sandwich chiral-at-metal cobaltacycles by oxidative cyclisation.
in Chemical communications (Cambridge, England)
Bergin E
(2010)
Application of the Suzuki reaction to the asymmetric desymmetrisation of 1,2- and 1,3-disubstituted bulky cobalt metallocenes
in Tetrahedron: Asymmetry
Cassar DJ
(2013)
Enantioselective synthesis and application to the allylic imidate rearrangement of amine-coordinated palladacycle catalysts of cobalt sandwich complexes.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Günay M
(2010)
Models for the basis of enantioselection in palladium mediated C-H activation reactions
in Tetrahedron: Asymmetry
| Description | Bulky cobalt metallocenes have recently found application in a number of asymmetric transformations characterised by high enantioselectivity. The further development of this area is hampered by the absence of a general methodology for the synthesis of planar chiral derivatives. A general solution to this problem is proposed involving asymmetric desymmetrisation by either metal catalysed cross-coupling and/or enantioselective halogen-metal exchange. The resulting non-racemic products will be used for the synthesis of representative P, PN and PP ligands. In addition, enantioselective palladation will be developed for the rapid assembly of new rearrangement catalysts for application in asymmetric synthesis. |
| Exploitation Route | Catalysts developed have the potential to be used in several areas of organic chemistry for the discovery and manufacture of bioactive compounds. |
| Sectors | Chemicals,Pharmaceuticals and Medical Biotechnology |
| Description | New methodology was established for the synthesis of chiral organometallic structures that were in turn used for the synthesis of novel catalysts. These enable the highly selective synthesis of organic building blocks for the generation of bioactive compounds. |
| First Year Of Impact | 2009 |
| Sector | Chemicals,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural,Societal,Economic |