Diversity in blood flow control to the brain: moving from individualized modelling towards personalized treatment of the injured brain
Lead Research Organisation:
University of Oxford
Department Name: Engineering Science
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Stephen Payne (Principal Investigator) |
Publications
Alavi S
(2017)
Identifiability of Generalized Randles Circuit Models
in IEEE Transactions on Control Systems Technology
Mader G
(2015)
Modeling Cerebral Blood Flow Velocity During Orthostatic Stress.
in Annals of biomedical engineering
Mahdi A
(2017)
At what data length do cerebral autoregulation measures stabilise?
in Physiological measurement
Mahdi A
(2017)
A model for generating synthetic arterial blood pressure.
in Physiological measurement
Mahdi A
(2017)
Effects of non-physiological blood pressure artefacts on cerebral autoregulation.
in Medical engineering & physics
Mahdi A
(2017)
Increased blood pressure variability upon standing up improves reproducibility of cerebral autoregulation indices.
in Medical engineering & physics
Mahdi A
(2017)
A hybrid symbolic-numerical approach to the center-focus problem
in Journal of Symbolic Computation
Mahdi Adam
(2016)
Effects of non-physiological blood pressure artefacts on measures of cerebral autoregulation
in arXiv e-prints
| Description | - It well-known that the dynamics of autoregulation response mechanism is complex and highly nonlinear. Despite that, we discovered that the mean cerebral blood flow velocity acts like a (simple) linear viscoelastic model in response to changes in the mean blood pressure during sit-to-stand manoeuvre (Annals of Biomedical Engineering 2015). - Reproducibility is one of the key features of any medical procedure in order to move it to the bedside practice. In this context, we empirically compared the performance of a wide range of computational methods to assess cerebral autoregulation using two protocols: passive (sitting) and active (sit-to-stand). We showed that measurements taken immediately after standing up consistently and greatly improve the reproducibility of the autoregulation measures with correlation methods showing the largest difference between passive and active protocol. (Medical Engineering and Physics, in review). - Subsequently, we studied the possible lack of reproducibility due to the existence of noise and artefacts the physiological signals. We carefully examined the influence of effects most common non-physiological artefacts in on the estimates of cerebral autoregualtion. We discovered even relatively small-size artefacts in the signal can significantly bias the estimates of cerebral autoregulation. For each of the four main artefacts we identified the so-called critical size that leads to the 10% deviation in the original value (Medical Engineering and Physics, submitted). - We are in a process of developing a general framework to compare and test different autoregulation approaches. As the first step towards this we proposed a realistic synthetic model of arterial blood pressure (Physiol. Meas. 2017), which is the driving force for the cerebral autoregulation mechanism. The model allows us to create blood pressure waveforms with prescribed and desirable characteristics (e.g. heart rate, mean systolic and diastolic pressure). This permits us to test the response of different methods to varying input and create as well as use it as a filter to improve the quality of the blood pressure signal. |
| Exploitation Route | - to improve autoregulation assessment procedures - to understand the interaction between different blood pressure regulation mechanisms (barorelex and cerebral autoregulation) - to Improve the quality of physiological signals (e.g. by filtering) - to build a synthetic database of physiological signals for testing biomedical computational procedures |
| Sectors | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| URL | http://users.ox.ac.uk/~engs1301/ca.html |
| Description | EPSRC data sharing |
| Organisation | University of Leicester |
| Department | Department of Cardiovascular Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are providing analysis tools to be applied to data sets provided by the two other partners. |
| Collaborator Contribution | They are providing historical data sets that we are able to analyse. |
| Impact | Publications to follow. |
| Start Year | 2014 |
| Description | EPSRC data sharing |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are providing analysis tools to be applied to data sets provided by the two other partners. |
| Collaborator Contribution | They are providing historical data sets that we are able to analyse. |
| Impact | Publications to follow. |
| Start Year | 2014 |
| Description | Biomedical Conference 1 (Paris, France) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a conference talk "Sensitivity analysis in multiscale modeling". |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.compbiomed.net/2015/ |
| Description | Biomedical Conference 2 (Paris, France) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Gave a talk on "Modeling interaction between baroreflex and cerebral autoregulation". The presentation lead to a discussion and establishing a collaboration with researchers form UCL. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.compbiomed.net/2015/ |
| Description | Conference on Cerebral Autoregulation (Southampton) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on "Contribution of identifyability techniques to cerebral autoregulation". |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.car-net.org/media/317_CARNet_programme_7-7-2015.pdf |
| Description | Invited seminar talk (Eng, Oxford University) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | A group of approximately 40 researchers attended the talk entitled "How can identifiability and sensitivity analysis improve my model"; intended to introduce methods of model selection with application to biology and engineering. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Invited seminar talk (Math, Oxford University) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | A group of approximately 20 researchers attended. The talk "Mathematics of the blood pressure and flow regulation"; intended to introduce current mathematical techniques used in modeling blood pressure regulation. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Invited seminar talk (Roskilde University) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | A group of approximately 40 undergraduates, graduates, and well-known experts in the area of cardiovascular modeling attended the talk. The talk aimed to introduced nonstandard mathematical approaches to mathematical modeling. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Invited speaker at conference (SAMSI, NC, USA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Gave an invited talk "Computational approach to cerebral autoregulation". The some of the presented material (about identifiability of electrical models) sparked a long discussion after the end of the session and request for more information. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.samsi.info/workshop/summer-2015-uncertainties-computational-hemodynamics-june-1-3-2015 |
| Description | Invited speaker at the Tutorial Workshop on Uncertainty Quantification of Biological Models (Raleigh, NC, USA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Around 40 pupils attended the tutorial workshop in person and others joined the conference online. Practical information related to the subject have been prepared and is available online for anyone interested to use. Requests for more activities related with uncertainty quantification in physiological and biological models. |
| Year(s) Of Engagement Activity | 2014,2015 |
| URL | http://rtg.math.ncsu.edu/Workshop/ |
| Description | Organizer of the Minisymposium on Physiological/Biological Modelling (Charlotte, NC, USA) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | workshop facilitator |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | 30 researchers attended the minisymposium, which raised numerous questions and sparked discussion afterwards. This activity raised awareness a of the importance of the structural and practical identifiabilty methods in the part of biomathematical and biomedical engineering communities. Around 8 in the attendents joint the follow-up meeting "Tutorial workshop on identifiability, parameter estimation, and uncertainty quantification of biological models" organized at NC State, USA. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://meetings.siam.org/sess/dsp_programsess.cfm?SESSIONCODE=19293 |
| Description | Quantitative biology conference - QBIOX - Oxford, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Presented two posters at the QBIOX special conference. Poster 1: "Modelling baroreflex regulation of heart rate" Poster 2: "Structural identfiability of mechanical models" |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.qbiox.co.uk/ |
| Description | Stability in polynomial ODEs: complexity and computations |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk given at the special meeting organised by the complexity cluster at Keble College, Univerity of Oxford |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.keble.ox.ac.uk/about/events/complexity-cluster-research-workshop |
| Description | Workshop: Mathematics in Physiology and Medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Organizer of the international workshop on the application of mathematics in medicine. One of the main topics discussed was Autoregulation. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.ams.org/programs/research-communities/mrc-16 |