REBOT: Robotic Endobronchial Optical Tomography
Lead Research Organisation:
University of Kent
Department Name: Sch of Physical Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Bondu M
(2018)
Multispectral photoacoustic microscopy and optical coherence tomography using a single supercontinuum source.
in Photoacoustics
Bradu A
(2018)
Recovering distance information in spectral domain interferometry.
in Scientific reports
Caujolle S
(2017)
Speckle variance OCT for depth resolved assessment of the viability of bovine embryos.
in Biomedical optics express
Cernat R
(2017)
Gabor fusion master slave optical coherence tomography.
in Biomedical optics express
Dasa MK
(2020)
All-fibre supercontinuum laser for in vivo multispectral photoacoustic microscopy of lipids in the extended near-infrared region.
in Photoacoustics
Economidou S
(2021)
A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery
in Additive Manufacturing
Erdelyi RA
(2021)
Optimization of X-ray Investigations in Dentistry Using Optical Coherence Tomography.
in Sensors (Basel, Switzerland)
Erdelyi RA
(2020)
Dental Diagnosis and Treatment Assessments: Between X-rays Radiography and Optical Coherence Tomography.
in Materials (Basel, Switzerland)
Hutiu G
(2018)
Assessment of Ductile, Brittle, and Fatigue Fractures of Metals Using Optical Coherence Tomography
in Metals
Jensen M
(2019)
Noise of supercontinuum sources in spectral domain optical coherence tomography
in Journal of the Optical Society of America B
| Title | Video of the Real-Time display and user interface |
| Description | Video showing the custom developed software performing the reconstruction of the OCT en-face images along with the epi-fluorescence channel.As described in Marques, Hughes et al, BOE (submitted). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://figshare.com/articles/media/Video_of_the_Real-Time_display_and_user_interface/16757164/2 |
| Title | Video of the Real-Time display and user interface |
| Description | Video showing the custom developed software performing the reconstruction of the OCT en-face images along with the epi-fluorescence channel.As described in Marques, Hughes et al, BOE (submitted). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2021 |
| URL | https://figshare.com/articles/media/Video_of_the_Real-Time_display_and_user_interface/16757164 |
| Description | In less than a year of the lifetime of this award, we have developed a distance sensor. In the following year, we have managed to assemble a rotating endoscopic probe with a thickness of 1.2 mm and a forward looking probe with a diameter of less than 3 mm, based on magnetic oscillation. Then these were installed at the Hamlyn Centre to be evaluated on human models and on ex-vivo tissue.eloped for Then a system was developed for 2 D scanning by pairing the magnetic oscillation probe with a robot arm giving the orthogonal direction. Customised the novel method of signal processing for OCT developed by the Applied Optics Group to endoscopy as well as to extended objects in depths. We have now versatile scanning devices and systems and looking for collaborators to apply them as well as the signal processing methods developed. |
| Exploitation Route | The proximity sensor can find application in a busy, highly visual surgery environment where distance is provided by sound.The other probes should help imaging inside the body. A combination of magnetic scanning with robotic scanning has been evaluated and a paper was published on the subject. We demonstrated that forward viewing OCT can be performed by combining 1D magnetic scanning with a vertical movement imprinted by robotic scanner. We have demonstrated feasibility of a combination of OCT and fluorescence channels, via a double clad fibre and also by an own assembled probe head with two closely mounted probes. We have assembled 3 side viewing probes, one being translated to the joint partner Imperial College, that was used for preliminary evaluations on exvivo tissue and on laboratory anatomical phantoms. For the OCT engines, we have proven two technologies, spectrometer based and swept source based. |
| Sectors | Electronics,Healthcare,Security and Diplomacy |
| URL | https://research.kent.ac.uk/appliedoptics/research/rebot-project/ |
| Description | The impact of this work is mainly recorded against grant ref EP/N019318/1'. We can also report nucleation of a new research direction in the Applied Optics Group, University of Kent, consisting in expertise in small size probe heads for endoscopy. This resulted in new collaborations and recent grants. |
| First Year Of Impact | 2022 |
| Sector | Healthcare |
| Description | (NETLAS) - NExt generation of Tuneable LASers for optical coherence tomography |
| Amount | € 4,199,843 (EUR) |
| Funding ID | 860807 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 02/2020 |
| End | 01/2024 |
| Description | 5-Dimensional High-Resolution non-invasive assessment of mammalian Embryos (5DHiResE) |
| Amount | £483,630 (GBP) |
| Funding ID | BB/S016643/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2022 |
| Description | Compact Forward-Viewing Endoscopic Optical Coherence Tomography |
| Amount | £475,299 (GBP) |
| Funding ID | EP/X000125/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 10/2025 |
| Title | IMAGING APPARATUS AND METHOD |
| Description | The present disclosure relates to an apparatus and method that can be used to remotely acquire high resolution depth resolved images from a sample. The apparatus employs an adapter to an imaging device, where the adapter uses a minimum of components to produce interferometry patterns on the input facet of the imaging device. The imaging device can be a bundle endoscope terminated on a camera sensor or on several camera sensors or simply a camera sensor. In conjunction with a swept source or a broadband source, at least one camera sensor may be employed to provide optical coherence tomography (OCT) images of the sample. When the imaging device uses a bundle of optical fibers, the apparatus and method can provide OCT images tolerant to bending of the bundle. |
| IP Reference | US2020037871 |
| Protection | Patent application published |
| Year Protection Granted | 2020 |
| Licensed | No |
| Impact | We hope that this novel adaptor can transform any bundle or miniature camera into a depth resolved imaging instrument. |
| Description | AOG at the Hamlyn Christmas Showcase 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | At this year's annual Hamlyn Centre Christmas showcase, the AOG was represented by two members of the REBOT research team, Dr Michael Hughes and Dr Manuel Marques. This event aims to demonstrate the latest innovations from the Hamlyn Centre to the wider community within Imperial College London. The AOG participated with a live, in-phantom demo of an OCT system for endoscopy, incorporating a forward-viewing, 1-D raster scanning probe from Dr Gelikonov's group at the Institute of Applied Sciences, Russia. It was deployed via the robotic catheter developed by REBOT team members at the Hamlyn Centre, Dr Anzhu Gao and Mr Ning Liu. This was a fantastic event, as not only were we able to showcase part of our research from our on-going collaboration through the REBOT project, but we were also able to see first-hand some of the interesting and cutting-edge work carried out at the Hamlyn Centre. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://research.kent.ac.uk/applied-optics/2019/01/18/aog-at-the-hamlyn-christmas-showcase-2018/ |
| Description | Chelsea and Westminster Hospital Research, Innovation and Quality Improvement event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | This event was attended by both teams from Imperial College and University of Kent. This has allowed the two teams to present their technology and engage with possible users and potential collaborators. Dr Khushi Vyas from Hamlyn Centre, Imperial College London presented a short talk titled "Robotic EndoBronchial Optical Tomography (REBOT) - towards minimally-invasive diagnosis and intervention in lung surgery". Authors: Khushi Vyas, Manuel J. Marques, Michael Hughes, Ning Liu, Mali Shen, Haojie Zhang, Anzhu Gao, Adrian Bradu, Adrian Podoleanu, Pallav Shah and Guang-Zhong Yang |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://research.kent.ac.uk/applied-optics/2019/11/28/aog-at-the-chelsea-and-westminster-hospital-re... |
| Description | Community Outreach on Light at Ramsgate Market |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | On Saturday 5th October, members of the Applied Optics Group (AOG) teamed up with the SPS Outreach team and Discovery Planet to run a day-long event in Ramsgate. The team ran two marquee stalls in Ramsgate Market: 'Light Loops' and 'Light Botic', full of activities to demonstrate some of the properties and applications of light. The key message of the event was to illustrate via simple experiments many different aspects of light technologies and their value to society. The science was explained through a series of games (some participants playing them twice!), while there was more detailed information available for those who wanted to find out more. The first two experiments in the 'Light Loops' tent demonstrated how light travels through tubes of perspex and water by total internal reflection. While it's universally accepted that 'light travels in straight lines', these demonstrations showed how light can be 'bent' using optical fibres, getting it to where we need it. These fibres now play a key role in our society, from the fibre broadband in our homes to medical devices in our hospitals. Next, a maze of 'security' light rays challenged participants to reach a crystal placed in the middle of the maze. Finally in this tent, an ultraviolet torch was used to find four hidden letters written using fluorescent materials, introducing the idea of using fluorescence in medical imaging and document security (as taught to our forensic science students). Finding the remaining three letters to complete an anagram then took participants over to the 'Light Botic' tent. Here, the participant had to try their skills as a medic, hunting for the remaining letters inside a 'patient' using a flexible endoscope, and giving them an insight into how difficult medical diagnostics can be. This tent also showcased some of our latest work in miniaturised medical imaging devices for the lung. We had lots of interest, from both adults and children, and we even had a surprise visit from the University Vice-Chancellor Prof Karen Cox who happened to be passing by! Market Traders and shoppers also told us they enjoyed the extra buzz and energy in the market. Notes: The event was funded by the EPSRC REBOT (Robotic Endobronchial Optical Tomography project), a collaboration between the AOG and Imperial College London on combining optical coherence tomography with medical robotics for imaging the lung. SPS staff and students taking part were: Adrian Podoleanu, Manuel Marques, Mike Hughes, Vicky Mason, Hannah Tonry, Andy Thrapp, Adrian Uceda, Gianni Nteroli, and Julien Camard. We were also joined by two students currently visiting the Applied Optics Group from Germany (Melanie Wacker) and Mexico (Victor Rico Botero), as well as volunteers from Discovery Planet. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://research.kent.ac.uk/applied-optics/2019/10/10/community-outreach-at-ramsgate-market/ |