Growing a community for health research translation at York
Lead Research Organisation:
University of York
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Publications
Antony J
(2019)
Sleep Spindles and Memory Reprocessing
in Trends in Neurosciences
Ashton JE
(2019)
Sleep Preserves Physiological Arousal in Emotional Memory.
in Scientific reports
Baker SC
(2020)
Procarcinogen Activation and Mutational Signatures Model the Initiation of Carcinogenesis in Human Urothelial Tissues In Vitro.
in European urology
Baker SC
(2021)
Does a Novel Mutagenic Process Target KMT2D Mutation in the Most Common First Event on the Path to Bladder Cancer?
in European urology
Cairney SA
(2018)
Memory Consolidation Is Linked to Spindle-Mediated Information Processing during Sleep.
in Current biology : CB
Capatina AL
(2022)
Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges.
in Reviews of physiology, biochemistry and pharmacology
Gaskell MG
(2019)
Contextual priming of word meanings is stabilized over sleep.
in Cognition
Harrington MO
(2021)
Losing Control: Sleep Deprivation Impairs the Suppression of Unwanted Thoughts.
in Clinical psychological science : a journal of the Association for Psychological Science
Harrington MO
(2021)
No benefit of auditory closed-loop stimulation on memory for semantically-incongruent associations.
in Neurobiology of learning and memory
Harrington MO
(2021)
Phase-locked auditory stimulation of theta oscillations during rapid eye movement sleep.
in Sleep
| Description | Call 2 - UKRI CoA Extension to R18884 - Challenging Dogma: an alternative non-hierarchical, epigenetically regulated model of the urothelium |
| Amount | £82,574 (GBP) |
| Funding ID | EP/V520561/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2021 |
| End | 09/2021 |
| Description | Challenging dogma: an alternative non-hierarchical, epigenetically regulated model of the urothelium. |
| Amount | £453,910 (GBP) |
| Funding ID | BB/R006172/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 04/2022 |
| Description | Combating depression with non-invasive modification of REM-sleep brain activity |
| Amount | £30,000 (GBP) |
| Organisation | Grow MedTech |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2020 |
| Description | Development of a novel human biomaterial HABM (Human Acellular Bladder Matrix) for surgical applications |
| Amount | £20,006 (GBP) |
| Organisation | Grow MedTech |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 03/2022 |
| Description | Effect of cancer-associated CIZ1 fragments on CIZ1 function in maintenance of epigenetic landscape |
| Amount | £54,136 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2020 |
| Description | HABM: a natural regenerative biomaterial for surgical use |
| Amount | £34,977 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 03/2022 |
| Description | High-fidelity epigenetic maintenance in somatic cells: CIZ1 assemblies as molecular shield |
| Amount | £492,427 (GBP) |
| Funding ID | MR/V029088/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 08/2025 |
| Description | Partnership Award with Barts Cancer Institute |
| Amount | £11,522 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 08/2019 |
| Description | Role of CIZ1 in maintenance of epigenetic landscape in primary differentiated cells |
| Amount | £407,860 (GBP) |
| Funding ID | MR/R008981/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 06/2022 |
| Description | Transplantation urology: scoping new sources and applications for a natural acellular bladder biomaterial |
| Amount | £27,990 (GBP) |
| Organisation | Grow MedTech |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 01/2020 |
| Description | Understanding how unwanted memories persist: The role of sleep spindles in emotional memory consolidation |
| Amount | £40,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 09/2019 |
| Description | White Rose BBSRC DTP studentship 2019 - 2022 - Alina Capatina |
| Amount | £97,344 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2023 |
| Description | Sleep and emotional regulation in forensic mental health settings: Partnership with NHS Mental Health Foundation Trust |
| Organisation | Tees, Esk and Wear Valleys NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | An event took place on 23rd January 2019 involving talks on sleep from academics, including Dr. Scott Cairney, and specialists working in forensic and clinical settings (including secure units). |
| Collaborator Contribution | The event included talks on sleep from clinical/forensic leads within the Tees, Esk and Wear Valleys (TEWV) NHS Foundation Trust. |
| Impact | Collaboration has been ongoing since the event with exploration of the potential to use NIHR Research Capability Funding (RCF) to develop sleep research capacity in secure units. The collaborators are currently writing up a scoping review. |
| Start Year | 2019 |
| Description | University of York & Ono Pharmaceuticals |
| Organisation | Ono Pharmaceutical |
| Country | Japan |
| Sector | Private |
| PI Contribution | Three people in the lab carried out defined experiments using our specialist expertise |
| Collaborator Contribution | Financial contribution |
| Impact | Answered the company's questions |
| Start Year | 2017 |
| Company Name | CIZZLE BIOTECHNOLOGY HOLDINGS PLC |
| Description | Enabling faster treatment with early lung cancer detection to save lives Cizzle Biotech was initially funded by Yorkshire Cancer Research, White Rose Technology Seed Corn Fund, Finance Yorkshire Seedcorn LLP and Viking Members, who with management, invested in the project to support the development of a prototype blood test. |
| Year Established | 2007 |
| Impact | Cizzle Biotech has gained patent protection for its core technology and has developed a laboratory Cizzle have been listed on the London Stock Exchange |
| Website | https://cizzlebiotechnology.com |
| Description | Presentation at "Incontinence: The Engineering Challenge XI" at the Institution of Mechanical Engineers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | We attended the conference as a key note speaker and presented our research project to an audience of academics and industry contacts. We were able to liaise with pharmaceutical companies at the conference. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://events.imeche.org/ViewEvent?code=CON6475 |