Biobank Re-imaging Study co-funded by Medical Research Council (MRC), Chan Zuckerberg Initiative (CZI) and Calico Life Sciences LLC (Calico)
Lead Research Organisation:
UK Biobank
Department Name: UNLISTED
Abstract
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Technical Summary
Re-imaging Study co-funded by Medical Research Council (MRC), Chan Zuckerberg Initiative (CZI) and Calico Life Sciences LLC (Calico)
The MRC Contribution to the study is £10m out of a total investment between the funders of £30m. The investment is to support:-
UK Biobank is a large, prospective cohort study that enrolled 500,000 men and women aged 40 to 69 from across the UK during 2006-10. At recruitment, they answered a large number of questions about their lifestyle, environment and other exposures, had a series of physical measurements (including eye imaging in a subset of about 100,000) and provided samples of blood and urine (and saliva in a subset of about 100,000) for both immediate haematological assays and frozen archiving for subsequent assays (including genotyping and genetic sequencing of the whole cohort). UK Biobank has become the pre-eminent biomedical research platform for studying the aetiology of common diseases of middle and later life (Sudlow et al. 2015), with over 20,000 registered researchers conducting over 2,000 approved research projects, leading to over 2,500 publications by mid-2021.
The MRC Contribution to the study is £10m out of a total investment between the funders of £30m. The investment is to support:-
UK Biobank is a large, prospective cohort study that enrolled 500,000 men and women aged 40 to 69 from across the UK during 2006-10. At recruitment, they answered a large number of questions about their lifestyle, environment and other exposures, had a series of physical measurements (including eye imaging in a subset of about 100,000) and provided samples of blood and urine (and saliva in a subset of about 100,000) for both immediate haematological assays and frozen archiving for subsequent assays (including genotyping and genetic sequencing of the whole cohort). UK Biobank has become the pre-eminent biomedical research platform for studying the aetiology of common diseases of middle and later life (Sudlow et al. 2015), with over 20,000 registered researchers conducting over 2,000 approved research projects, leading to over 2,500 publications by mid-2021.
Organisations
People |
ORCID iD |
| Rory Collins (Principal Investigator) |
Publications
Foster PJ
(2023)
Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia.
in BMJ open
He D
(2023)
A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank
in Osteoporosis International
Leonardsen EH
(2023)
Genetic architecture of brain age and its causal relations with brain and mental disorders.
in Molecular psychiatry
Luettich A
(2023)
Functional connectivity between interoceptive brain regions is associated with distinct health-related domains: A population-based neuroimaging study.
in Human brain mapping
Rutter CE
(2023)
Exploring regression dilution bias using repeat measurements of 2858 variables in =49 000 UK Biobank participants.
in International journal of epidemiology
Topiwala A
(2023)
Telomere length and brain imaging phenotypes in UK Biobank.
in PloS one