Diminshing DNA Replication: Consequences for genome stability - WCUB, ENWW
Lead Research Organisation:
University of Oxford
Department Name: Interdisciplinary Bioscience DTP
Abstract
Eukaryotic cells co-regulate DNA replication and the cell cycle, ensuring a single round of replication occurs during each cell cycle. Re-initiation of replication origins (re-replication) has been associated with tumorigenesis; however the opposite phenomenon (under-replication) has been less well studied. Potential outcomes include single-stranded DNA protection, alternative replication mechanisms, chromosome breaks, 'fragile sites' and/or cell death. This project aims to create a system in which a large genomic region is selectively vitiated from replication during S-phase, and characterise the resulting effects on genome stability.
This project falls primarily within the BBSRC 'World-Class Bioscience' priority research area, as it addresses a fundamental biological process. It is also fulfils the 'Data-Driven Biology' remit, generating sequence data for large genomic replicons.
This project falls primarily within the BBSRC 'World-Class Bioscience' priority research area, as it addresses a fundamental biological process. It is also fulfils the 'Data-Driven Biology' remit, generating sequence data for large genomic replicons.
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011224/1 | 01/10/2015 | 31/03/2024 | |||
| 1810162 | Studentship | BB/M011224/1 | 01/10/2015 | 30/09/2019 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I designed a series of DNA themed resources which taught DNA structure and replication to students aged 5 - 18 years. A group of our lab delivered these at cheltenham science festival. We got excellent feedback from parents and children on the day. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Junior School Science Weeks |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A day of multiple DNA workshops, developed and delivered during my PhD, were delivered in three different Oxfordshire primary schools. |
| Year(s) Of Engagement Activity | 2017,2019 |