Determining important novel mechanisms that regulate T-cell-mediated immune responses.
Lead Research Organisation:
The University of Manchester
Department Name: School of Biological Sciences
Abstract
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People |
ORCID iD |
| Mark Travis (Primary Supervisor) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011208/1 | 30/09/2015 | 31/03/2024 | |||
| 1908755 | Studentship | BB/M011208/1 | 30/09/2017 | 29/09/2021 |
| Title | Splenic dendritic cells from wild type mice |
| Description | Integrin avb8 is an important activator of TGF beta, which is released in a latent form that is bound to the latency associated peptide (LAP). Splenic dendritic cells (DCs) were incubated with LAP for 2 or 6 hours versus a control condition. Extracted RNA was sequenced at the Genomic Technologies Core Facilities at the University of Manchester. The aim is to define novel pathways triggered by avb8 activation. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | We found a regulation of three different biological pathways that are likely to be involved in this process. |