Employing multi-omic approaches to the investigation of the causation of cardio-metabolic disease.
Lead Research Organisation:
University of Cambridge
Department Name: MRC Epidemiology Unit
Abstract
Type 2 diabetes and other metabolic comorbidities of obesity are (important / major burden)
To complement lifestyle approaches to their prevention and management, better understanding of their underlying mechanisms will inform future drug targets and identification of high-risk groups.
Recent advances in technology have allowed large-scale quantification of genomics, epigenomics, proteomics and metabolomics - current challenges lie in the integration of such data to produce disease focussed insights. This PhD will take a genetic epidemiological approach using principles of meta analysis and causal modelling to identify and validate potential drug targets in Type 2 diabetes and other metabolic comorbidities of obesity.
To complement lifestyle approaches to their prevention and management, better understanding of their underlying mechanisms will inform future drug targets and identification of high-risk groups.
Recent advances in technology have allowed large-scale quantification of genomics, epigenomics, proteomics and metabolomics - current challenges lie in the integration of such data to produce disease focussed insights. This PhD will take a genetic epidemiological approach using principles of meta analysis and causal modelling to identify and validate potential drug targets in Type 2 diabetes and other metabolic comorbidities of obesity.
Organisations
People |
ORCID iD |
| Nicholas Wareham (Primary Supervisor) | |
| Nicholas Bowker (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/R502303/1 | 01/10/2017 | 30/04/2022 | |||
| 1950385 | Studentship | MR/R502303/1 | 01/10/2017 | 31/12/2020 | Nicholas Bowker |
| Description | Danish Diabetes Association PhD Summer School Poster Presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Nicholas Bowker presented a poster as part of the Danish Diabetes Association PhD Summer School, which is an academic conference on diabetes aetiology to highlight the work of PhD students in their second and final years.. |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC Press Release - LPL-enhancing drugs |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | MRC Press Release "New drugs could reduce risk of heart disease and diabetes when added to statins, according to genetic study simulating clinical trial" on JAMA Cardiology publication "Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes". Reported by Daily Mail (Print and online) https://www.dailymail.co.uk/health/article-6185367/Give-millions-patients-statins-new-type-drug.html, Inews https://inews.co.uk/news/health/new-drug-statins-reduce-diabetes-heart-disease/, Breitbart https://www.breitbart.com/news/study-drug-combo-could-reduce-heart-attack-risk/ and at least 6 other online news outlets and tweeted by more than forty accounts. LL did interview with MedicalResearch.com https://medicalresearch.com/diabetes/lowering-triglycerides-and-cholesterol-could-reduce-heart-disease-and-diabetes-risk/44600/ |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.mrc-epid.cam.ac.uk/blog/drugs-reduce-risk-heart-disease-diabetes/ |