The evolutionary and mechanistic basis of virus host shifts: A Staphylococcaceae-phage system to investigate patterns of virus infectivity and evoluti
Lead Research Organisation:
UNIVERSITY OF EXETER
Department Name: Biosciences
Abstract
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Organisations
People |
ORCID iD |
| Ben Longdon (Primary Supervisor) | |
| Sarah Walsh (Student) |
Publications
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M009122/1 | 30/09/2015 | 31/03/2024 | |||
| 2237316 | Studentship | BB/M009122/1 | 30/09/2019 | 31/12/2023 | Sarah Walsh |
| BB/T008741/1 | 30/09/2020 | 29/09/2028 | |||
| 2237316 | Studentship | BB/T008741/1 | 30/09/2019 | 31/12/2023 | Sarah Walsh |
| Description | This work has allowed us to show that the genetic relationship between host species (how similar they are) is responsible for a large proportion of the difference in their susceptibility to infection (how well a virus is able to grow in them). We have shown this in a system where we have 64 Staphylococcus hosts, and the pathogen is a bacteriophage called ISP. |
| Exploitation Route | This work has so far developed a model system to investigate virus-host interactions in a multi-host system, allowing us to investigate some of the underlying factors that influence virus-host interactions such as host relatedness. This model system can be used to investigate many aspects of virus-host interactions in the future, such as the influence of local adaptation of a pathogen to a host on its ability to infect subsequent hosts, the role of generalism or specialism on susceptibility, and the underlying molecular mechanisms that contribute to these patterns of susceptibility. |
| Sectors | Other |