The role of R-loops in trinucleotide expansion diseases
Lead Research Organisation:
University of Oxford
Department Name: Sir William Dunn Sch of Pathology
Abstract
R-loops are nucleic acid structures, composed of an RNA/DNA hybrid and displaced single-stranded DNA. With an array of physiological roles, R-loops have also been implicated in human pathologies. This project aims to further uncover the molecular mechanisms that underpin R-loop-associated diseases. There will be a particular focus on Friedreich's ataxia, as a model of trinucleotide expansion diseases. Understanding the mechanisms behind R-loop function in Friedreich's ataxia will pave the way for the development of new therapeutic approaches for this group of disorders.
Organisations
People |
ORCID iD |
| Helena Harpham (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013468/1 | 30/09/2016 | 29/09/2025 | |||
| 2734299 | Studentship | MR/N013468/1 | 30/09/2022 | 29/09/2026 | Helena Harpham |
| MR/W006731/1 | 30/09/2022 | 29/09/2030 | |||
| 2734299 | Studentship | MR/W006731/1 | 30/09/2022 | 29/09/2026 | Helena Harpham |