Nanoparticulate chemotherapeutic drug transporters for delivery across the blood-brain barrier
Lead Research Organisation:
University of Portsmouth
Department Name: Sch of Pharmacy & Biomedical Sciences
Abstract
This project is aimed towards the preparation and evaluation of polymer-based nanoparticulate vehicles that have an increased lifetime in the circulatory system and facilitate drug delivery (through the blood-brain barrier) to the brain, via specific transport mechanisms. The study will be centred on biodegradable nanoparticles that possess moderate-hydrophilic surfaces and that can be loaded with chemotherapeutic agents known to be active in a range of the central nervous system (CNS) diseases, but normally limited by the blood-brain barrier in reaching their site of action. This work will generate a range of well-characterised nano-formulations whose performance and toxicity will be evaluated both in vitro and in vivo. The results generated by this study are expected to bring a significant contribution to the process of developing effective drug targeting technologies.
Technical Summary
This project is aimed towards the formulation and evaluation of new polymeric nano-carriers that can overcome the reticulo-endothelial system (RES) phagocytosis and facilitate drug delivery through the blood-brain barrier (BBB) via nanoparticle-mediated transport. The study will be centred on biodegradable nano-sized structures that possess moderate-hydrophilic surfaces and can be loaded with chemotherapeutic agents known to be active in a range of central nervous system (CNS) diseases, but are normally limited by the BBB in reaching the site of action. This work will generate a range of well-characterised nano-formulations whose performance and toxicity will be evaluated both in vitro and in vivo. The results generated by this study are expected to bring a significant contribution to the process of developing effective BBB drug targeting technologies.
Publications
Lien CF
(2012)
In vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles as permeating vectors for the blood-brain barrier.
in Biomacromolecules
Molnar, E.
(2011)
Nanoparticulate carriers for drug delivery to the brain
Molnár É
(2010)
Alkylglyceryl chitosan nanoparticles for drug delivery across the blood-brain barrier
in Drug Discovery Today
Barbu E
(2009)
The potential for nanoparticle-based drug delivery to the brain: overcoming the blood-brain barrier.
in Expert opinion on drug delivery
Description | This project was aimed towards the preparation and evaluation of polymer-based nanoparticulate vehicles that can permeate through the blood-brain barrier and facilitate drug delivery to the brain. The study was centred on biocompatible nanoparticles that can be loaded with fluorescent markers and chemotherapeutic agents known to be active in a range of diseases of the central nervous system, but their transport is prevented by the blood-brain barrier. This work generated a range of well-characterised nanomaterials that show high potential for delivering drugs into the brain. |
Exploitation Route | The results generated by this study are expected to contribute towards the development of effective technologies for the delivery of therapeutic compounds to the brain. |
Sectors | Chemicals,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | 3D-all-human blood-brain barrier model in evaluating nanoparticle-facilitated drug delivery systems |
Amount | £151,877 (GBP) |
Organisation | Dr Hadwen Trust (DHT) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2012 |
End | 07/2015 |
Description | Peptide Research Network of Excellence |
Amount | £423,227 (GBP) |
Organisation | European Commission |
Department | Interreg : European Territorial Co-operation |
Sector | Public |
Country | European Union (EU) |
Start | 02/2012 |
End | 03/2015 |
Title | SACCHARIDE DERIVATIVES |
Description | The invention relates to a saccharide or polysaccharide substituted at one or more -OH functionalities with an alkyl glycerol; wherein the polysaccharide is selected from chitosan, chitin, polyglucosamine and derivatives and combinations thereof, and wherein the saccharide is selected from glucosamine and derivatives thereof. Particles formed from these saccharides or polysaccharides, and methods of preparation of the particles are also disclosed. |
IP Reference | WO2011104134 |
Protection | Patent application published |
Year Protection Granted | 2011 |
Licensed | No |
Impact | - |
Description | 24th European Conference on Biomaterials, Dublin, Ireland |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | . |
Year(s) Of Engagement Activity | 2011 |
Description | Biomaterials for aging populations 1st UK-China Summer School. Sichuan University, Chengdu, Sichuan Province, China |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Participants in your research and patient groups |
Results and Impact | discussions with potential collaborators - |
Year(s) Of Engagement Activity | 2010 |
Description | Emerging Pharmaceutical Scientists, AstraZeneca, Loughborough, UK |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | . |
Year(s) Of Engagement Activity | 2008 |
Description | Focus on Health - Brain |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | discussions increase public awareness |
Year(s) Of Engagement Activity | 2014 |
Description | UKICRS Symposium, Kings College London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | - |
Year(s) Of Engagement Activity | 2009 |