Identifying DNA methylation signatures in Alzheimer's disease blood
Lead Research Organisation:
UNIVERSITY OF EXETER
Department Name: University of Exeter Medical School
Abstract
The identification of novel biological markers (biomarkers) for Alzheimers Disease (AD) will allow earlier and more successful treatment. This project will integrate genome-wide genetic, epigenetic and gene expression measures in blood from AD patients with detailed clinical, epidemiological and neuroimaging data with the aim to identify unique biomarkers for AD
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013794/1 | 01/10/2016 | 30/09/2025 | |||
| 1790286 | Studentship | MR/N013794/1 | 01/10/2016 | 31/12/2020 | Janou Roubroeks |
| Description | A multi-omic approach to elucidate novel disease mechanisms and biomarkers for psychosis in Alzheimer's disease |
| Amount | $1,626,428 (USD) |
| Funding ID | R01 AG067015 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 12/2019 |
| End | 11/2023 |
| Description | ARUK pump priming grant |
| Amount | £3,399 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2018 |
| End | 08/2018 |
| Title | Blood DNA methylation data from the AddNeuroMed cohort |
| Description | A subset of whole blood samples from the AddNeuroMed cohort were used to generate genome-wide DNA methylation data using Illumina HumanMethylation 450K arrays. Participants in this study include controls, Alzheimer's disease patients, and individuals with mild cognitive impairment. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | This dataset will be published on GEO following the publication of the associated research paper, enabling other researchers to make use of this data. |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE144858 |
| Description | Collaboration between Maastricht University and the University of Exeter |
| Organisation | Maastricht University (UM) |
| Department | Maastricht School for Mental Health and Neuroscience (MHeNS) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Prof Katie Lunnon now has an honorary position at the University of Maastricht whilst similarly Dr Ehsan Pishva now has an honorary position at the University of Exeter. We are in the process of establishing a double PhD for next academic year |
| Collaborator Contribution | As a result of the EPI-AD JPND funding we are now seeking to establish a double PhD between the two universities |
| Impact | Numerous publications (see outputs) |
| Start Year | 2020 |
| Description | 2019 University of Pisa, Italy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited seminar at the University of Pisa, Italy to discuss findings from the grant |
| Year(s) Of Engagement Activity | 2019 |
| Description | ARUK Conference and Early Careers Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of work related to the project 'Identifying novel blood biomarkers in Alzheimer's disease' at the Alzheimer Research UK conference. |
| Year(s) Of Engagement Activity | 2018,2019,2020 |
| Description | Alzheimer's Research UK Annual Conference 2019, Harrogate, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Talk delivered at ARUK conference on results of grant funding |
| Year(s) Of Engagement Activity | 2019 |
| Description | Alzheimer's Research UK Annual Conference 2020, Online |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation on the project at the ARUK 2020 (online) conference |
| Year(s) Of Engagement Activity | 2020 |
| Description | British Neuropathological Society bi-annual meeting 2019, London, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the Bristish Neuropathology Society meeting for Cavanagh award |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cardiff Dementia Research Institute (DRI) 2020, Cardiff, Wales |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited seminar at the Cardiff DRI on findigns from this grant |
| Year(s) Of Engagement Activity | 2020 |
| Description | Dutch Neuroscience Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of work related to the project 'Identifying novel blood biomarkers in Alzheimer's disease' at the Annual Dutch Neuroscience meeting. |
| Year(s) Of Engagement Activity | 2016,2019 |
| Description | Society for Neuroscience Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of work related to the project 'Identifying novel blood biomarkers in Alzheimer's disease' at the Society for Neuroscience conference in Chicago (19-23 October 2020). |
| Year(s) Of Engagement Activity | 2020 |
| Description | University of Exeter Annual Research Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of work related to the project 'Identifying novel blood biomarkers in Alzheimer's disease' at the Annual Research Event of the University of Exeter. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |