Modelling NAFLD using human IPSCs
Lead Research Organisation:
King's College London
Department Name: Genetics and Molecular Medicine
Abstract
1. Can white adipocytes be generated from hiPSCs using a directed differentiation approach based on manipulating key signalling pathways?
2. How does mechanical sheer force presented via microfluidic system impact upon the biology of hiPSC-derived hepatocytes and white adipocytes?
3. How does in-parallel communication between hiPSC derived hepatocytes and adipocytes in a microfluidic system further instruct call biology and can this 'multi organ on a chip' srt up be used to model NAFLD?
2. How does mechanical sheer force presented via microfluidic system impact upon the biology of hiPSC-derived hepatocytes and white adipocytes?
3. How does in-parallel communication between hiPSC derived hepatocytes and adipocytes in a microfluidic system further instruct call biology and can this 'multi organ on a chip' srt up be used to model NAFLD?
Organisations
People |
ORCID iD |
| Gavin Bewick (Primary Supervisor) | |
| Deniz Kent (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013700/1 | 01/10/2016 | 30/09/2025 | |||
| 1847416 | Studentship | MR/N013700/1 | 26/09/2016 | 30/09/2020 | Deniz Kent |