Identifying novel targets for treating pain in Parkinson's disease by unravelling the neuroimmune contribution.
Lead Research Organisation:
King's College London
Department Name: Wolfson Centre for Age Related Diseases
Abstract
The overall objective of this project is to investigate the cellular and molecular mechanisms underlying pain in Parkinson's disease. Specifically, we hypothesise that microglial activation in descending pathways from the brain modulates pain signalling at the spinal cord level and contributes to neuroinflammation-driven pain in Parkinson's. This collaboration between pre-clinical experts in Parkinson's (Dr Duty) and pain (Professor Malcangio) and leading clinical expert in pain in Parkinson's (Professor Chaudhuri) aims to find novel analgesic targets for better treating pain in Parkinson's patients.
Organisations
Publications
Buhidma Y
(2020)
Potential of animal models for advancing the understanding and treatment of pain in Parkinson's disease
in npj Parkinson's Disease
Clarke E
(2019)
Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia.
in Neurochemistry international
Rukavina K
(2019)
Pain in Parkinson's disease: new concepts in pathogenesis and treatment.
in Current opinion in neurology
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/N013700/1 | 30/09/2016 | 29/09/2025 | |||
1931742 | Studentship | MR/N013700/1 | 30/09/2017 | 29/06/2022 | Yazead Buhidma |