Lysine-targeting covalent inhibitors
Lead Research Organisation:
Institute of Cancer Research
Department Name: Division of Cancer Therapeutics
Abstract
The PhD student will modify high affinity reversible ligands of mutant EGFR and mutant B-Raf with lysine-targeting electrophiles using structure based rational design. The student would then characterise their inhibitors using biochemical methods to establish kinetic parameters and compare with the wild-type proteins. The inhibitors would then be applied to cancer cells to establish kinome selectivity, off-target reactivity and wild-type/mutant cell therapeutic index.
People |
ORCID iD |
Ian Collins (Primary Supervisor) | |
James Knox (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/R01583X/1 | 01/10/2018 | 30/09/2025 | |||
2286983 | Studentship | MR/R01583X/1 | 07/10/2019 | 06/10/2023 | James Knox |