Towards broad-spectrum antimicrobial vaccines: uniting automated and enzymatic glycan assembly for the synthesis and bioconjugation of bacterial exopo
Lead Research Organisation:
University of York
Department Name: Chemistry
Abstract
In this project we propose to unite two novel strategies for synthesis of complex carbohydrates, automated and enzymatic glycan assembly, in the construction of antigenic bacterial polysaccharides for the development of an enabling technology for vaccine construction. There is a pressing need for antibodies and vaccines of improved efficacy, and improved methods for their production. This project is aimed at creating a new enabling technology for controlled synthesis of a carbohydrate-protein vaccine conjugate in pursuit of a broad-spectrum antimicrobial vaccine
Organisations
People |
ORCID iD |
Martin Fascione (Primary Supervisor) | |
Joshua Fair (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/T518025/1 | 01/10/2020 | 30/09/2025 | |||
2595945 | Studentship | EP/T518025/1 | 01/10/2021 | 31/03/2025 | Joshua Fair |