BBSRC DTG Studentship:Cell biological behaviour of GIMAP GTPases

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Mature T and B lymphocytes are the essential mediators of specific immunity and immunological memory in vertebrates. Characteristic features of these cells are their long life (months to years) and their relative quiescence, which is maintained unless and until they encounter a ‘cognate’ substance (an antigen) that can activate them to respond and to initiate a protective immune response. The maintenance of the long lifespan and quiescence of lymphocytes is now recognised to require the active engagement of several signalling pathways. It is also appreciated that a healthy and diverse lymphocyte repertoire can contribute significantly to healthy ageing. Our work is focussed on one family of proteins, the GIMAP GTPases, some of which are required for lymphocyte survival. By studying the behaviour of these proteins inside cells we aim to understand more about the mechanisms underlying lymphocyte survival in general and to uncover new ways whereby lymphocytes may be manipulated to enhance or to suppress immune responsiveness, where desirable.

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