Understanding the impact of the microvasculature on quantification of fibre orientation in the heart using Diffusion Spectrum MRI and computer models

Lead Research Organisation: University of Oxford
Department Name: RDM Cardiovascular Medicine

Abstract

The heart is a highly efficient and effective electro-mechanical pump for supplying the continue flow of blood that is essential for life. The critical importance of its function is represented by the very high number of deaths associated with heart disease both in the UK and the western world. The pump function crucially depends on the complex architecture of the heart: individual muscle cells are arranged in chains often referred to as muscle fibres. These muscle fibres are ordered in complex three-dimensional (3D) arrangements, joined together by non-muscle 'connective' tissue. In addition, an extended network of blood vessels is embedded within the heart muscle to provide vital blood supply to the individual cells. It is this micro-structural architecture that fundamentally defines both the electrical conductivity and mechanical stiffness of the muscle wall, and thus determines the function of the heart.
This central role of cardiac micro-structure in both, health and disease has motivated the development of non-invasive techniques to image cardiac structure. Particularly, Magnetic Resonance Imaging (MRI), which allows for increasingly detailed insight into the structure and function of tissues and organs. The value of MRI data means this type of imaging has gained rapid acceptance within both the pre-clinical and clinical domains. Even though these recordings are not yet sufficiently detailed to reliably identify fibre orientation in hearts of individual patients, major research efforts are underway to achieve this goal.
Underpinning these efforts is that a precise understanding of detailed cardiac tissue architecture will be of great importance for an accurate diagnosis of cardiac diseases, prediction of their progression, and identification of useful treatment approaches. The key role of the heart's structure also means that MRI data are increasingly being used to validate computer models, which describe the electrical conductivity and mechanical function of the heart. These computer models of the heart are not only essential in basic science research, but will also play a fundamental role in personalized medicine where doctors can use these models to assess treatment options, and predict treatment outcomes for a specific individual before the patient even enters the operating theatre.
However, there is a fundamental question that has to be answered before this technique can be considered as a reliable tool for structural assessment in the heart: is the reading of MRI indeed reflecting the orientation of the muscle-fibres, or is it dominated by the many (small) blood vessels supplying the heart muscle with nutrients? The answer to this question is of particular relevance for the diseased heart, where the highly regular micro-structure (fibres and blood vessels) of the muscle is distorted.
This proposed project exactly aims to answer this open question by combining the expertise of leading teams in cardiac MRI (Cardiovascular Medicine at the John Radcliffe Hospital Oxford), and image analysis and computational modelling (Department of Bioengineering, Kings College London). The teams will jointly develop techniques and validate them in small rodents models, with the vision that all algorithms can in future be adapted to the investigation of human hearts.

Planned Impact

Several areas/groups of beneficiaries of the proposed project can be identified:
Firstly, the project will facilitate and benefit pre-clinical research. Given the multi-disciplinary nature of the project, the two PIs and their Departments represent large sections of this group, including basic bio-research, image analysis/modelling of biological systems, cardiovascular medicine, and magnetic resonance imaging. Furthermore, the PIs have strong network collaborations at national and international levels (as partially reflected in this proposal). Because the outcome of this proposal is of direct relevance for the research of our teams and their collaborators in areas such as structure-function studies, structural-vascular interactions research, (for an illustration, see lists of publications of the PIs) we anticipate the impact of our work to be rapidly disseminated across this network.
Secondly, in the longer run, the project will serve the medical community by paving the way for development of new tools and models to aid the diagnoses, patient selection, planning and optimisation of interventions, and tailoring of treatments. This work will ultimately improve prognosis for patients with heart disease, whether congenital or acquired.
Thirdly, the project embraces the concept of the 3Rs (Reduction, Refinement, and (partial) Replacement of animal-based research). Advancing MR techniques to be applicable, non-invasively, to high-fidelity structure-function studies enables a reduction in the number of animals required for research. This finds reflection in our study design, where each heart serves as its own control (using multiple imaging modalities; going from in vivo to ex vivo). Stringent intra-individual control and validation provides more powerful statistical analyses in an otherwise highly inhomogeneous biological model. The development and cross-validation of computer models further helps to reduce the use of animals for research, development, and teaching.
Fourth, it is clear that there is significant potential for commercial benefit. This includes manufacturers of preclinical magnetic resonance systems, who will be able to assess the benefit of newly developed MRI techniques; providers of biomedical image analysis and visualisation software who will have access to new image alignment and structure extraction tools; and - in the longer run - pharmaceutical companies who will eventually benefit from the availability of new technologies to test the efficacy and side effects of drugs using either the newly developed imaging techniques or the computational models that will arise.
Last but not least, considering the burden heart disease places on individuals, their families, the economy, and the social and health systems in the developed world, the techniques and tools provided by this proposal will be of general societal benefit, as the outcome of this work will fundamentally contribute to the understanding of normal and patho-physiological structural-mechano-interaction in the heart.

Publications

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Bueno-Orovio A (2016) Anomalous Diffusion in Cardiac Tissue as an Index of Myocardial Microstructure. in IEEE transactions on medical imaging

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Bueno-Orovio A (2016) Anomalous Diffusion in Cardiac Tissue as an Index of Myocardial Microstructure. in IEEE transactions on medical imaging

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Burton RA (2014) Three-dimensional histology: tools and application to quantitative assessment of cell-type distribution in rabbit heart. in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

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Goyal A (2013) Model-based vasculature extraction from optical fluorescence cryomicrotome images. in IEEE transactions on medical imaging

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Homoky WB (2016) Quantifying trace element and isotope fluxes at the ocean-sediment boundary: a review. in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

 
Description - We have developed an optimised diffusion MRI technique to characterise cardiac micro-architecture at a hitherto unprecedented level of detail.
- We have developed (and disseminated) calibration techniques that are essential to obtain these high-quality data.
- We have developed novel algorithms to denoise (µ)CT and MRI data.
- We have developed algorithms to automatically extract the vasculature from cardiac MRI data.
Exploitation Route We have developed techniques to calibrate imaging gradients on any MR system. The ease of our technique makes it attractive, particularly for other preclinical MR labs to adapt this approach.
Cardiac diffusion MRI has recently gained significant interest, primarily due to technical advance in hardware and software on clinical MR systems. We have developed a phantom that can be used to establish "ground truth" of cardiac diffusion processes and ensure multi-site compatibility.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Member of Finnish Academy funding committee
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
Impact Advice on research funding
 
Title Denoising methods for image reconstruction 
Description Development of algorithms for denoising micro-CT and potentially other data [Davidoiu V, Vernet A, Thornton V, Teh I and Schneider JE] 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Publications (in preparation) 
 
Title Tools for vascular segmentation 
Description Wavelets/curvelets techniques using FISTA (fast iterative shrinkage-thresholding algorithm) [Davidoiu V, McClymont D] 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact Publications (in preparation) 
 
Title High resolution interspecies cardiac images 
Description A database containing multimodality (microCT, MRI and 3d histology) images of various mammalian species (mice, rat, rabbit, goat, human) 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact No actual Impacts realised to date 
 
Description Development of anomalous diffusion models for characterising the myocardium 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Development and optimisation of diffusion MRI methods; acquisition of preclinical cardiac diffusion MRI data.
Collaborator Contribution Development of anomalous diffusion models; application to preclinical cardiac diffusion MRI data.
Impact Bueno-Orovio A, Teh I, Schneider J, Rodriguez B, Burrage K, Grau V, Anisotropic anomalous diffusion spectrum imaging in cardiac tissue, British Heart Foundation CRE Annual Symposium, 16 Sep 2014
Start Year 2013
 
Description Development of cardiac diffusion phantom 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Assembly of cardiac diffusion phantom; MRI acquisition and analysis.
Collaborator Contribution Fabrication of co-electrospun fibre strips; SEM characterisation of fibre strips.
Impact One conference proceeding at ISMRM (2015) and one publication in JMRI (2015) including front cover of JMRI. The project is multidisciplinary involving expertise in polymer fabrication and characterisation, and diffusion MRI for structural characterisation.
Start Year 2013
 
Description Development of double diffusion encoding MRI for cardiac tissue characterisation 
Organisation Hvidovre Hospital
Country Denmark 
Sector Hospitals 
PI Contribution Project initiation, expertise in cardiac MRI, preparation of hearts, MRI data acquisition and analysis, paper writing
Collaborator Contribution Expertise in double diffusion encoding methods, software for MRI data acquisition and analysis, simulations, paper writing
Impact One abstract accepted for oral presentation at ISMRM 2016. The collaboration brings together expertise in diffusion MRI in the brain and heart.
Start Year 2015
 
Description Investigation of placental spiral artery development in the mouse model 
Organisation University of Oxford
Department Department of Experimental Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution The vascular casting and imaging technique developed in the previous grant is being used to investigate the development of the spiral arteries during pregnancy in the mouse model. Abnormal development of the spiral arteries is implicated in pre-eclampsia, however there is a lack of quantitative data regarding the stages of vascular development. The Oxford/Leeds team are providing the micro-CT imaging, and the King's team are providing the image processing capabilities.
Collaborator Contribution The contribution of the original hypothesis and the specimen collection are driven by the new partners in Oxford, who are leading the animal work in the collaboration.
Impact At present, we are still developing the protocols and no outputs have been produced yet. This collaboration is inter-disciplinary, combining physiological research, imaging, and engineering/computer science.
Start Year 2016
 
Description MIT_2017 
Organisation Massachusetts Institute of Technology
Department Institute for Medical Engineering and Science (IMES)
Country United States 
Sector Academic/University 
PI Contribution Provided high-resolution cardiac diffusion MRI data
Collaborator Contribution Used these data for novel computational simulations of the heart
Impact Conference abstract and manuscript submitted
Start Year 2017
 
Description Structure tensor synchrotron imaging of the heart 
Organisation Diamond Light Source
Department Diamond
Country United Kingdom 
Sector Academic/University 
PI Contribution Project initiation, preparation of hearts, MRI acquisition and image reconstruction, development of structure tensor methods, data analysis, paper writing
Collaborator Contribution Synchrotron imaging, image reconstruction of SI data, paper writing
Impact One abstract accepted for presentation at ISMRM 2016. The collaboration is multi-disciplinary and involves MRI and synchrotron imaging of the heart.
Start Year 2015
 
Title Gerardus 
Description Open source computational biology and biomedical image analysis scripts and programs. It contains all software developed in our research group at the Institute of Biomedical Engineering, part of it from BHF funding (in particular, the code for reconstructing three-dimensional structures from histological slices). 
Type Of Technology Software 
Year Produced 2014 
Open Source License? Yes  
Impact The code is under continuous development but will be used in subsequent publications related to the grant. 
URL https://code.google.com/p/gerardus/
 
Title VasEx 
Description A distributed GPU-accelerated environment for processing angiographic images from a variety of modalities (microCT, CT, MRI, cryomicrotome, confocal microscopy etc) 
Type Of Technology Software 
Year Produced 2015 
Impact The software has enabled joint publications with international collaborators (Amsterdam, New Zealand) and provided the basis for a new collaboration (Beijing) as well as supporting 3 projects in the EPSRC imaging Centre for Doctral Training at King's College London 
 
Description Aberdeen_JES_14 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Pushing the boundaries of preclinical cardiac MR - Invited Lecture at CV Progamme, University of Aberdeen, December 9th 2014
Year(s) Of Engagement Activity 2014
 
Description BC_ISMRM_2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited keynote lecture on preclinical cardiac MRI; sparked interest and discussions
Year(s) Of Engagement Activity 2017
 
Description BHF_NS_2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented talk on Multi-scale clinically relevant models of Heart Failure, London September 10th 2014


Dissemination of knowledge, stimulation of discussion, raising profile of research and funding sources.
Year(s) Of Engagement Activity 2014
 
Description Bruker microCT industry conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Over 90 participants of microCT users attended from a variety of research fields, and had presentations and discussions which led to recommendations that fed back to the manufacturer's development plans
Year(s) Of Engagement Activity 2014
 
Description Computational modelling of the heart 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact African Congress of Computational Mechanics, . Livingston 2nd August, overview talk on the integration of imaging data within clinical models to create clinically applicable whole heart models of electrical excitation, perfusion and contraction.

request for papers
Year(s) Of Engagement Activity 2013
 
Description IBME Away Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Darryl McClymont attended the Institute of Biomedical Engineering's Away Day on 21 Nov 2014, and presented a 15 minute entitled Diffusion Spectrum Imaging Super Resolution. This sparked general discussion about the use of adaptive dictionaries (or competing methods) for super resolution in MRI, which has become the topic of a DPhil project in IBME.
Year(s) Of Engagement Activity 2014
 
Description InAug_Lect_2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Inaugural lecture as Chair in Biomedical Imaging
Year(s) Of Engagement Activity 2017
 
Description Invited internal Seminar in Computer Sciences 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Talk sparked questions and discussion, which improved understanding across disciplines

No notable impact as yet.
Year(s) Of Engagement Activity 2014
 
Description Invited talk at Oxford Centre for Doctoral Training in Biomedical Imaging 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited talk
Year(s) Of Engagement Activity 2015,2016
 
Description LICAMM_Seminar_2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This was an invited seminar at the Leeds Institute for Cardiovascular and Metabolic Medicine, which was attended by local scientists. This sparked an increased interest in preclinical (cardiac) MR.
Year(s) Of Engagement Activity 2016
 
Description LICAMM_Seminar_2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Seminar on preclinical cardiac MR & MRS; sparked interest and discussion in this subject
Year(s) Of Engagement Activity 2017
 
Description Latest Advances in Cardiac Modelling, Image-based Modelling of Integrated Cardiac Perfusion 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation paper presentation
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited paper presentation at the workshop Advances in Cardiac Modelling in Munich 10th July 2003, Talk on the modelling of coronary blood flow using cyromicrotome data from whole heart preparations including the integration of myocardial mechanics and perfusion imaging.

The presentation introduced the audience to a new computational modelling methodology, and led to requests for information from those applying alternative research strategies. It has also indirectly led to a potential PhD project inquiry.
Year(s) Of Engagement Activity 2013
 
Description Leeds_CBiol_Seminar_2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Invited Seminar on preclinical cardiac MR; sparked interest and discussion in this modality.
Year(s) Of Engagement Activity 2017
 
Description MedIm_Oslo_15_JES 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited Lecture at MedIm Conference for PhD Students, Oslo, November 16&17, 2015
Year(s) Of Engagement Activity 2015
 
Description Medical Image Analysis (MedIAN) cardiovascular workshop, speaker and organiser 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Organised a day-long workshop and gave a talk.
Year(s) Of Engagement Activity 2015
 
Description Medical conference (Oxford) - RDM_2015_McClymont 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Poster presentation at the Radcliffe Department of Medicine Annual Symposium on 2 Feb 2015 at Said Business School, Oxford. The poster was entitled Prospective acceleration of diffusion tensor MRI with compressed sensing and was authored by Darryl McClymont, Irvin Teh, H. Whittington, D. McAndrew, L. Diffley, C. A. Lygate, J. E. Schneider.
Year(s) Of Engagement Activity 2015
 
Description Medical conference (Oxford) - RDM_2015_Teh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Poster presentation at the Radcliffe Department of Medicine Annual Symposium on 2 Feb 2015 at Said Business School, Oxford. The poster was entitled Pushing the Boundaries of High Resolution Cardiac Diffusion Tensor Imaging and was authored by I. Teh, D. McClymont, H. Whittington, D. McAndrew, L. Diffley, C. A. Lygate, and J. E. Schneider.
Year(s) Of Engagement Activity 2015
 
Description Medical conference (Oxford) - RDM_2016_McClymont 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Poster presentation at the Radcliffe Department of Medicine Annual Symposium on 2 Feb 2015 at Said Business School, Oxford. The poster was entitled Assessing non-Gaussian Diffusion in Cardiac Tissue and was authored by Darryl McClymont, Irvin Teh, Hannah Whittington, Vicente Grau, and Jürgen E. Schneider
Year(s) Of Engagement Activity 2016
 
Description Medical conference (Oxford) - RDM_2016_Teh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Poster presentation at the Radcliffe Department of Medicine Annual Symposium on 2 Feb 2015 at Said Business School, Oxford.
Year(s) Of Engagement Activity 2016
 
Description Modelling of microcirculatory flows 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk at IUPS Birmingham 24th July 2013, Talk on the modelling of coronary blood flow though both large vessels and microcirculatory flows using confocal and cyromicrotome data from whole heart preparations.

requests for papers
Year(s) Of Engagement Activity 2013
 
Description Multi-scale Coronary Modelling 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk at special IUPS satellite Amsterdam 19th July 2013, Talk on the modelling of coronary blood flow using cyromicrotome data from whole heart preparations including the integration of myocardial mechanics and perfusion imaging.

request for papers and collaboration
Year(s) Of Engagement Activity 2013
 
Description Newcastle_JES_14 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Advanced MRI Measures of Heart Function in Small Animals - Invited Lecture at the CIVI Research Imaging Day, University of Newcastle, December 1st 2014
Year(s) Of Engagement Activity 2014
 
Description OCMR Study Day 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Darryl McClymont gave a presentation at the Oxford Centre for Magnetic Resonance's study day on 26 September 2014 entitled Assessing the microarchitecture of the heart using Diffusion MRI techniques.
Year(s) Of Engagement Activity 2014
 
Description OCMR study day 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Irvin Teh gave a presentation at the Oxford Centre for Magnetic Resonance's study day on 20 March 2015, entitled High resolution cardiac diffusion MRI ex vivo.
Year(s) Of Engagement Activity 2015
 
Description OIBN_ML_2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Attended Oxford Interdisciplinary Bioscience Networking Event

no impact yet
Year(s) Of Engagement Activity 2014
 
Description Preclinical Seminar (DM 25/9/2014) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Darryl McClymont gave a talk in the Oxford pre-clinical seminar series, entitled Acceleration of Diffusion MRI using Compressed Sensing with Adaptive Dictionaries.
Year(s) Of Engagement Activity 2014
 
Description Preclinical seminar (DM 25/2/2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Darryl McClymont gave a presentation in the Oxford pre-clinical MRI seminar series entitled Non-Gaussian modeling of cardiac diffusion MRI.
Year(s) Of Engagement Activity 2016
 
Description RDM_IT_2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation poster presentation
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Presented poster on Accelerated fast spin echo diffusion spectrum imaging in the mouse heart ex-vivo based on FSE, RDM Annual Symposium, 25 Mar 2013


Dissemination of knowledge, stimulation of discussion, raising profile of research and funding sources.
Year(s) Of Engagement Activity 2013
 
Description SCMR_16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lecture on 'Myocardial Microstructure: What Is There To See'
Year(s) Of Engagement Activity 2016
 
Description SCMR_2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk on diffusion MRI at the Annual Meeting of the SCMR to an audience consisting of Clinicians & Basic Scientists. This technique becomes increasingly more relevant in both clinical and basic science research.
Year(s) Of Engagement Activity 2016
 
Description SCMR_WorkingGroup_2017 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Participation in the SCMR Cardiac Diffusion Working Group
Year(s) Of Engagement Activity 2017
 
Description SCMR_WorkingGroup_2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Participation and formal presentation at the SCMR Cardiac DTI Working Group; I will take a leading role in in the Working Group and coordinate the development of a phantom to standardise clinical cardiac DTI.
Year(s) Of Engagement Activity 2018
 
Description Stavanger_0317 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited lecture on cardiac MRS at the NORHEART course 'Cardiac Imaging in Research'; NORHEART is a Norwegian PhD School for heart research
Year(s) Of Engagement Activity 2017
 
Description Talk at University of Xian, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Talk to University audience
Year(s) Of Engagement Activity 2017
 
Description Translating multi-scale modelling to the heart of the clinic 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chia Laguna, Sardinia, Italy, 11 June, overview talk on the integration of imaging data within clinical models to create clinically applicable whole heart models of electrical excitation, perfusion and contraction.

Invitation to contribute a book chapter
Year(s) Of Engagement Activity 2013
 
Description VPH_NS_2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented talk at Trondheim Norway, September 8th 2014

Dissemination of knowledge, stimulation of discussion, raising profile of research and funding sources.
Year(s) Of Engagement Activity 2014
 
Description WCB_NS_2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented talk on Biomechanics of Coronary Circulation, Boston July 8th 2014

Dissemination of knowledge, stimulation of discussion, raising profile of research and funding sources.
Year(s) Of Engagement Activity 2014
 
Description Wuerzburg_2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited Seminar at the University of Wuerzburg, Department of Experimental Radiology, which sparked discussion and interest
Year(s) Of Engagement Activity 2018