Structure/Function Drug Interaction Studies on Voltage-Gated Sodium Channels
Lead Research Organisation:
Birkbeck, University of London
Department Name: Biological Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Cascio M.
(1994)
Red- and blue-shifting in the circular dichroism spectra of polypeptides due to dipole effects
in PROTEIN PEPT.LETT.
Hollingworth D
(2022)
Tamoxifen complexes with the voltage-gated sodium channel reveal novel drug binding sites
in Biophysical Journal
Sula A
(2021)
A tamoxifen receptor within a voltage-gated sodium channel.
in Molecular cell
| Description | as in previous report |
| Exploitation Route | development and study of channel/drug interactions |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Description | background information for industry |
| First Year Of Impact | 2020 |
| Sector | Pharmaceuticals and Medical Biotechnology |
| Title | depostion of new crystal structure entries into the protein data bank (PDB) |
| Description | The PDB is the international standard data base for the deposition of crystal structures and the many crystal structures produced during this grant have been deposited for public access |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | increased understanding of drug interactions (including off-target interations of currently marketed drugs) |
| Description | Collaboration with Simon Fraser University, Canada |
| Organisation | Simon Fraser University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | The Wallace team (Birkbeck) did all the structural and bioinformatics aspects of the partnership |
| Collaborator Contribution | Prof P. Ruben's lab did the electrophysilogy aspects of the partnership, leading to a joint publication |
| Impact | Publication (2020) in Elife which was also reported in an article written by the Diamond Light Source (and on their website). |
| Start Year | 2020 |
| Description | Collaboration with Simon Fraser University, Canada |
| Organisation | Simon Fraser University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We did strutural studies (crysallography, molecular biology, bioinformatics, mutations) |
| Collaborator Contribution | Prof. Peter Ruben's group did electophysilogy studies (and mutagenesis) |
| Impact | Publication in Elife in 2020 Article about this study in Diamond Light Source Publication |
| Start Year | 2020 |
| Description | Interview for article highlighting our work at Diamond Light Source |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview by Press Office at Diamond Light Source leading to an article online and in their newsletter about our research done using the facility which was recently published.https://www.diamond.ac.uk/Science/Research/Highlights/2021/High-resolution-structural-studies-highlight-why-CBD-helps-some-people-with-epilepsy-.html |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited presentation at International Union of Pure and Applied Biophysics (Brazil) in 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the IUPAB International Congress and the subject of a Journal article written about the symposium by Prof. Richard Garrett in Biophysical Reviews (2021): https://doi.org.10.107/s.s12551-02-00889-4 |
| Year(s) Of Engagement Activity | 2019,2020,2021 |
| Description | Talks at UK and international sites and meetings: Brazil Synchrotron Symposium, ), University of Vienna Austria (Chemistry Dept), Biochemical Society Training Course (Aston University, UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talks about Tools and Resources developed in the course of this grant at Universities and International meetings, including the headline talk at the inauguration of the Brazil Synchrotron SRCD beamline (CEDRO) held for the international community of SRCD users and potential users, The Biochemical Society training course on Membrane Proteins at Aston University, the chemistry dept at the University of Vienna. |
| Year(s) Of Engagement Activity | 2022 |
| Description | UCL-ISMB Prizewinners Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Prize Winners Symposium (i was invited as i won the RSC Khorana Prize in 2020 |
| Year(s) Of Engagement Activity | 2020 |
| Description | Wikipedia citations |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Description/reference to our work on cannabidiol in Wikipedia page (not submitted by us) |
| Year(s) Of Engagement Activity | 2020,2022 |
| URL | https://en.wikipedia.org/wiki/Cannabidiol |