A Global Network for Neglected Tropical Diseases
Lead Research Organisation:
Durham University
Department Name: Chemistry
Abstract
It is estimated that ~1 in 6 of the world's population suffer from a Neglected Tropical Disease (NTD) representing a significant challenge to global human health and well-being and this has been recognised by the United Nations (UN). One of the primary aims of the UN's Sustainable Development Goal on "Health and Well-Being" is to "ensure health and well-being for all" and with 1.7 billion people in 185 countries requiring treatment for at least one NTD in 2014, advances in the development of new medicines for NTDs is critical. Indeed, the target set by the UN is "By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases." Supporting the delivery of this goal are many world-wide ventures directed towards the treatment of AIDs (e.g. The Global Fund), tuberculosis (e.g. The Global Fund) and malaria (e.g. Medicines for Malaria Venture) but there is currently no corresponding world-wide sustained effort for NTDs. It is this gap that our global NTD network will fill and, in doing so, will contribute to the delivery of the UN's goal on "Health and Well-Being".
Within the spectrum of NTD pathogens, insect-borne parasites represent a major threat to human health across the developing world. In particular, leishmaniasis and Chagas disease represent a significant challenge for developing nations with lower levels of research investment and infrastructure exacerbated by a lack of suitably trained personnel capable of developing much needed solutions. With over 350 million people world-wide considered at risk, more than 1.7M new cases each year, 12 million people currently infected and an economic cost that can be estimated in terms of 2.4 million Disability Adjusted Life Years (DALYs), the health challenge of leishmaniasis is undeniable. A similar situation exists for Chagas disease where there are currently 10M people infected and, in Latin America alone, Chagas disease leads to approx.700,000 (DALYs), nearly six times the socioeconomic toll of malaria in the region. Globally, the total annual economic effect of Chagas disease is estimated at over $7 billion. The challenge presented by these disease states is heightened by the fact that the few efficacious drugs currently available often exhibit serious, potentially fatal, side-effects, and have difficult and prolonged modes of administration leading to poor patient compliance within developing nations. Moreover, reports of resistance to even the most modern drugs are beginning to emerge.
We will establish a "Global Network For Neglected Tropical Diseases" which will bring together over 50 academics and more that 500 researchers at 14 institutes around the world all working towards the common goals of delivering scientific advances that will help to combat Leishmaniasis and Chagas disease
Within the spectrum of NTD pathogens, insect-borne parasites represent a major threat to human health across the developing world. In particular, leishmaniasis and Chagas disease represent a significant challenge for developing nations with lower levels of research investment and infrastructure exacerbated by a lack of suitably trained personnel capable of developing much needed solutions. With over 350 million people world-wide considered at risk, more than 1.7M new cases each year, 12 million people currently infected and an economic cost that can be estimated in terms of 2.4 million Disability Adjusted Life Years (DALYs), the health challenge of leishmaniasis is undeniable. A similar situation exists for Chagas disease where there are currently 10M people infected and, in Latin America alone, Chagas disease leads to approx.700,000 (DALYs), nearly six times the socioeconomic toll of malaria in the region. Globally, the total annual economic effect of Chagas disease is estimated at over $7 billion. The challenge presented by these disease states is heightened by the fact that the few efficacious drugs currently available often exhibit serious, potentially fatal, side-effects, and have difficult and prolonged modes of administration leading to poor patient compliance within developing nations. Moreover, reports of resistance to even the most modern drugs are beginning to emerge.
We will establish a "Global Network For Neglected Tropical Diseases" which will bring together over 50 academics and more that 500 researchers at 14 institutes around the world all working towards the common goals of delivering scientific advances that will help to combat Leishmaniasis and Chagas disease
Technical Summary
It is estimated that ~1 in 6 of the world's population suffer from a Neglected Tropical Disease (NTD) representing a significant challenge to global human health and well-being and this has been recognised by the United Nations (UN). One of the primary aims of the UN's Sustainable Development Goal on "Health and Well-Being" is to "ensure health and well-being for all" and with 1.7 billion people in 185 countries requiring treatment for at least one NTD in 2014, advances in the development of new medicines for NTDs is critical. Indeed, the target set by the UN is "By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases." Supporting the delivery of this goal are many world-wide ventures directed towards the treatment of AIDs (e.g. The Global Fund), tuberculosis (e.g. The Global Fund) and malaria (e.g. Medicines for Malaria Venture) but there is currently no corresponding world-wide sustained effort for NTDs. It is this gap that our global NTD network will fill and, in doing so, will contribute to the delivery of the UN's goal on "Health and Well-Being".
Within the spectrum of NTD pathogens, insect-borne parasites represent a major threat to human health across the developing world. In particular, leishmaniasis and Chagas disease represent a significant challenge for developing nations with lower levels of research investment and infrastructure exacerbated by a lack of suitably trained personnel capable of developing much needed solutions. With over 350 million people world-wide considered at risk, more than 1.7M new cases each year, 12 million people currently infected and an economic cost that can be estimated in terms of 2.4 million Disability Adjusted Life Years (DALYs), the health challenge of leishmaniasis is undeniable. A similar situation exists for Chagas disease where there are currently 10M people infected and, in Latin America alone, Chagas disease leads to approx.700,000 (DALYs), nearly six times the socioeconomic toll of malaria in the region. Globally, the total annual economic effect of Chagas disease is estimated at over $7 billion. The challenge presented by these disease states is heightened by the fact that the few efficacious drugs currently available often exhibit serious, potentially fatal, side-effects, and have difficult and prolonged modes of administration leading to poor patient compliance within developing nations. Moreover, reports of resistance to even the most modern drugs are beginning to emerge.
We will establish a "Global Network For Neglected Tropical Diseases" which will bring together over 50 academics and more that 500 researchers at 14 institutes around the world all working towards the common goals of delivering scientific advances that will help to combat Leishmaniasis and Chagas disease
Within the spectrum of NTD pathogens, insect-borne parasites represent a major threat to human health across the developing world. In particular, leishmaniasis and Chagas disease represent a significant challenge for developing nations with lower levels of research investment and infrastructure exacerbated by a lack of suitably trained personnel capable of developing much needed solutions. With over 350 million people world-wide considered at risk, more than 1.7M new cases each year, 12 million people currently infected and an economic cost that can be estimated in terms of 2.4 million Disability Adjusted Life Years (DALYs), the health challenge of leishmaniasis is undeniable. A similar situation exists for Chagas disease where there are currently 10M people infected and, in Latin America alone, Chagas disease leads to approx.700,000 (DALYs), nearly six times the socioeconomic toll of malaria in the region. Globally, the total annual economic effect of Chagas disease is estimated at over $7 billion. The challenge presented by these disease states is heightened by the fact that the few efficacious drugs currently available often exhibit serious, potentially fatal, side-effects, and have difficult and prolonged modes of administration leading to poor patient compliance within developing nations. Moreover, reports of resistance to even the most modern drugs are beginning to emerge.
We will establish a "Global Network For Neglected Tropical Diseases" which will bring together over 50 academics and more that 500 researchers at 14 institutes around the world all working towards the common goals of delivering scientific advances that will help to combat Leishmaniasis and Chagas disease
Planned Impact
The significant social, developmental and economic impacts of Neglected Tropical Diseases (NTDs) on the World's poor are now recognised and efforts such as the World Health Organization 2020 Roadmap on NTDs and the London Declaration (2012) have raised the global profile within academic and industrial communities. The capacity to deliver new, effective therapies is often challenged by a lack of robust target validation tools and/or a lack of trained personnel with appropriate experience and expertise in both the UK and endemic ODA countries. We will address these twin capacity/capability deficiencies by establishing an active and sustainable global network of researchers, working collaboratively to develop and share new chemical and genetic technologies for drug target validation for the NTDs, leishmaniasis and Chagas disease. The network's 'open science' approach to knowledge transfer will facilitate the development of capacity and key capabilities in cell technology, chemical biology and assay development. These skills are vital to kick start interactions with both academic and industrial partners, providing robustly validated targets for downstream drug discovery initiatives. The network will deliver training, career development and collaborative opportunities to researchers at all career stages, from PhD-level to established academics. Training will be delivered via multiple pathways including research secondments and travel bursaries, training workshops in key skills and science 'sandpit' events. This will deliver >500 researchers ready to provide the skills and expertise, chemical and genetic, to address drug target validation challenges both in NTDs and other disease states. By providing new targets and assays our scientists and outputs will directly enhance academic communities interested in delivering new therapies to tackle diseases of poverty across the globe. In addition, the skills, focus and research outputs of our researchers will enable successful collaborations, grant applications and career independence. In addition to network and wider academic impact, potential impacts of the network's research on many non-academic stakeholder groups are described below:
Beneficiary 1: The pharmaceutical sector with a commitment to developing new therapies for the control of NTDs, particularly leishmaniasis and Chagas disease. Our research outcomes will benefit the pharma sector by [a] validating and characterizing novel drug targets in Leishmania spp and T. cruzi; [b] developing enzyme assay platforms for the screening of compound libraries; [c] developing a pool of dedicated, highly trained scientists focused on NTD target validation.
Beneficiary 2: The international knowledge economy through skills, training and development. All network participants will develop expertise in interdisciplinary research skills in chemical and/or genetic target validation and assay development. This skills profile is of great value to international industry in the knowledge economy, contributing to boosting the profile of NTDs in the pharmaceutical and other sectors.
Beneficiary 3: International development. Our international ODA partners are resident in endemic countries in which leishmaniasis and Chagas disease are a major cause of economic loss through their effects on human health and development.
Beneficiary 4: The wider, international general public. Public understanding of sciences is a vital function of active research and is especially important for the NTDs, both in the UK and in endemic nations. Utilizing existing structures and creating new social media initiatives the research network will ensure that the wider public are engaged via, for example: [a] a network webpage; [b] researcher blogs; [c] the construction of thematic Wikipedia pages; and [d] engagement with local outreach programmes
Also see Pathways to Impact for details on the mechanism that will be used to reach the beneficiaries.
Beneficiary 1: The pharmaceutical sector with a commitment to developing new therapies for the control of NTDs, particularly leishmaniasis and Chagas disease. Our research outcomes will benefit the pharma sector by [a] validating and characterizing novel drug targets in Leishmania spp and T. cruzi; [b] developing enzyme assay platforms for the screening of compound libraries; [c] developing a pool of dedicated, highly trained scientists focused on NTD target validation.
Beneficiary 2: The international knowledge economy through skills, training and development. All network participants will develop expertise in interdisciplinary research skills in chemical and/or genetic target validation and assay development. This skills profile is of great value to international industry in the knowledge economy, contributing to boosting the profile of NTDs in the pharmaceutical and other sectors.
Beneficiary 3: International development. Our international ODA partners are resident in endemic countries in which leishmaniasis and Chagas disease are a major cause of economic loss through their effects on human health and development.
Beneficiary 4: The wider, international general public. Public understanding of sciences is a vital function of active research and is especially important for the NTDs, both in the UK and in endemic nations. Utilizing existing structures and creating new social media initiatives the research network will ensure that the wider public are engaged via, for example: [a] a network webpage; [b] researcher blogs; [c] the construction of thematic Wikipedia pages; and [d] engagement with local outreach programmes
Also see Pathways to Impact for details on the mechanism that will be used to reach the beneficiaries.
Organisations
- Durham University (Lead Research Organisation)
- University of Glasgow (Collaboration)
- Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society (Collaboration)
- University of York (Collaboration)
- Novartis Institutes for BioMedical Research (NIBR) (Collaboration)
- CSIR - Institute of Microbial Technology (Collaboration)
- Federal University of Rio de Janeiro (Collaboration)
- DURHAM UNIVERSITY (Collaboration)
- Council of Scientific and Industrial Research (Collaboration)
- Federal University of Minas Gerais (Collaboration)
- Pasteur Institute of Montevideo (Collaboration)
- Instituto de Química del Noroeste Argentino (Collaboration)
- Huazhong Agricultural University (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Federal University of Rio Grande do Sul (Collaboration)
- State University of Campinas (Collaboration)
- University of Karachi (Collaboration)
- Universidade de São Paulo (Collaboration)
- Federal Rural University of Rio de Janeiro (Collaboration)
- Birla Institute of Technology and Science, Pilani (Collaboration)
- University of Buenos Aires (Collaboration)
- The University of Texas at San Antonio (Collaboration)
- National University of Rosario (Collaboration)
- University of California, San Diego (UCSD) (Collaboration)
- Drugs for Neglected Diseases initiative (DNDi) (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- Federal University of Sao Carlos (Collaboration)
Publications
Akhtar M
(2020)
Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells
in PLOS Pathogens
Aldfer MM
(2022)
The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues.
in Molecules (Basel, Switzerland)
Alencar MB
(2020)
Measurement of Energy States of the Trypanosomatid Mitochondrion.
in Methods in molecular biology (Clifton, N.J.)
Ali I
(2024)
P -toluenesulfonychloride-based niosomes for Amphotericin- B against Leishmaniasis
in Journal of Surfactants and Detergents
Alonso VL
(2021)
Alpha-Tubulin Acetylation in Trypanosoma cruzi: A Dynamic Instability of Microtubules Is Required for Replication and Cell Cycle Progression.
in Frontiers in cellular and infection microbiology
Alonso VL
(2022)
Ultrastructure Expansion Microscopy (U-ExM) in Trypanosoma cruzi: localization of tubulin isoforms and isotypes.
in Parasitology research
Alpizar-Sosa E
(2022)
Genome deletions to overcome the directed loss of gene function in Leishmania
in Frontiers in Cellular and Infection Microbiology
Alpizar-Sosa EA
(2022)
Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response.
in PLoS neglected tropical diseases
| Description | Multiple drug targets have been validated (or de-validated) in Leishmania species and Trypanosoma cruzi using genetic and chemical approaches. some of these are progressing into drug discovery programmes. Training of >100 early career researchers in the technologies associated with this. |
| Exploitation Route | Drug discovery for leishmaniasis and Chagas disease - this is happening although the results will not be known in full for some time. This work involves industrial partners. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Description | The Global Network for NTDs brought together more that 500 researchers at 13 institutes from India, Pakistan, South America and the UK to work towards our shared goals of delivering scientific advances that will help to combat leishmaniasis and Chagas disease. The commitment of all parties (represented by the nomination Team) to our values of equitable practice and collaboration has allowed us to realise our aims to provide training, opportunity, experience and insight - all with a view to advancing science and impact on disease. Without such large-scale funding, this undertaking would have been impossible and the impact and legacy of the Network unrealised - and the world would lack hundreds of newly upskilled researchers who will push forward research to find much needed solutions for NTDs. |
| First Year Of Impact | 2017 |
| Sector | Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural |
| Description | Change of academic collaborator policy at GSK Openlab (Tres Cantos, Spain) from 'single collaborator' to 'multiple collaborators from international acedemic consortium' |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Middle East Biology of Parasitism |
| Geographic Reach | Asia |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Students train in modern approaches. |
| Description | New Anti-leishmanial Leads from Natural Sources Concepts and Approaches |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Students train in modern approaches. |
| Description | Amino acid metabolism in Trypanosoma cruzi: a "toolbox" to survive in "hostile environments |
| Amount | $1,000,000 (USD) |
| Organisation | São Paulo Research Foundation (FAPESP) |
| Sector | Public |
| Country | Brazil |
| Start | 03/2023 |
| End | 03/2028 |
| Description | Building the pathway for translational drug development of orally active new chemical entities for cutaneous leishmaniasis |
| Amount | £230,000 (GBP) |
| Organisation | Dioraphte Foundation |
| Sector | Charity/Non Profit |
| Country | Netherlands |
| Start | 01/2021 |
| End | 01/2024 |
| Description | CNPq Universal |
| Amount | R$ 136,500 (BRL) |
| Funding ID | 405235/2021-6 |
| Organisation | National Council for Scientific and Technological Development (CNPq) |
| Sector | Public |
| Country | Brazil |
| Start | 01/2021 |
| End | 01/2026 |
| Description | Centre for Doctoral Training in Molecular Sciences for Medicine |
| Amount | £6,916,264 (GBP) |
| Funding ID | EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 10/2027 |
| Description | Deconvoluting the mode-of-action of novel anti-Chagas and anti-leishmanial compounds |
| Amount | £284,068 (GBP) |
| Funding ID | TC279 |
| Organisation | Tres Cantos Open Lab Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2023 |
| Description | Development of Medicinal Plants Based Topical Formulation to Treat Cutaneous Leishmaniasis, A Neglected Tropical Disease and Cause of Major Economic Burden of Pakistan |
| Amount | £53,169,100 (PKR) |
| Organisation | Higher Education Commission |
| Sector | Public |
| Country | Pakistan |
| Start | 09/2022 |
| End | 10/2023 |
| Description | Development of platforms to study transmembrane proteins - towards medical, agricultural and biotechnological benefits |
| Amount | £40,000 (GBP) |
| Organisation | São Paulo Research Foundation (FAPESP) |
| Sector | Public |
| Country | Brazil |
| Start | 12/2018 |
| End | 11/2021 |
| Description | FINEP |
| Amount | R$ 3,000,000 (BRL) |
| Organisation | Funding Authority for Studies and Projects |
| Sector | Public |
| Country | Brazil |
| Start | 01/2023 |
| End | 01/2028 |
| Description | Identificação e validação funcional de genes de Leishmania spp. associados à suscetibilidade e resistência a fármacos |
| Amount | R$ 136,500 (BRL) |
| Funding ID | 405235/2021-6 |
| Organisation | National Council for Scientific and Technological Development (CNPq) |
| Sector | Public |
| Country | Brazil |
| Start | 01/2022 |
| End | 02/2025 |
| Description | Identification of drugs for Chagas disease that target the amino acid and polyamine transporters of Trypanosoma cruzi |
| Amount | $ 1,000,000 (ARS) |
| Organisation | National Agency for Scientific and Technological Promotion |
| Sector | Public |
| Country | Argentina |
| Start | 05/2020 |
| End | 05/2023 |
| Description | Leishmania donovani and TIM |
| Amount | ₹6,144,000 (INR) |
| Organisation | Department of Science & Technology |
| Sector | Public |
| Country | India |
| Start | 06/2023 |
| End | 06/2026 |
| Description | Making sense of how Leishmania detect changes in pH and temperature |
| Amount | £2,263,414 (GBP) |
| Funding ID | 226513/Z/22/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 05/2031 |
| Description | Mining the Reframe library for leishmaniasis |
| Amount | £69,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 01/2022 |
| Description | Pakistan: National Research Program for Universities |
| Amount | £8,160,000 (PKR) |
| Funding ID | 20-17599/NRPU/R&D/HEC/2021 |
| Organisation | Higher Education Commission |
| Sector | Public |
| Country | Pakistan |
| Start | 05/2023 |
| End | 05/2025 |
| Description | Paromomycin for the treatment of tegumentary leishmaniasis: investigation in vitro, in vivo and in the identification of molecular markers associated with susceptibility and resistance |
| Amount | R$ 72,999,627 (BRL) |
| Funding ID | 2016/21171-6 |
| Organisation | São Paulo Research Foundation (FAPESP) |
| Sector | Public |
| Country | Brazil |
| Start | 09/2020 |
| End | 09/2023 |
| Description | Patient-centric supramolecular formulations of new anti-leishmanial drugs for Indian Communities |
| Amount | £906,253 (GBP) |
| Funding ID | EP/T020490/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2022 |
| Description | Pharmacokinetic and dynamic evaluation of lead molecules for CL |
| Amount | £53,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 01/2023 |
| Description | Primera caracterización de genes de respuesta a hemo en Trypanosoma cruzi |
| Amount | $150,000 (USD) |
| Funding ID | PICT 2021 - I-A 00274 |
| Organisation | National Agency for Scientific and Technological Promotion |
| Sector | Public |
| Country | Argentina |
| Start | 04/2023 |
| End | 05/2027 |
| Description | RNA as a new vaccine strategy to control Chagas disease, leishmaniasis and malaria |
| Amount | $35,000 (USD) |
| Organisation | National Council for Scientific and Technological Development (CNPq) |
| Sector | Public |
| Country | Brazil |
| Start | 01/2022 |
| End | 01/2023 |
| Description | Reposicionamento de medicamentos baseados em inibidores de quinases como terapias antiparasitárias para o tratamento de leishmaniose tegumentar |
| Amount | R$ 299,999,998 (BRL) |
| Funding ID | grant number 0479/22 |
| Organisation | Funding Authority for Studies and Projects |
| Sector | Public |
| Country | Brazil |
| Start | 09/2021 |
| End | 10/2025 |
| Description | Sir J. C. Bose Fellowship |
| Amount | ₹4,739,783 (INR) |
| Organisation | Department of Science & Technology |
| Sector | Public |
| Country | India |
| Start | 01/2022 |
| End | 01/2023 |
| Description | UK:Brazil Joint Centre Partnership in leishmaniasis |
| Amount | £1,416,241 (GBP) |
| Funding ID | MR/S019472/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2022 |
| Description | Validação funcional de genes associados à suscetibilidade e resistência a drogas em Leishmania |
| Amount | R$ 7,200 (BRL) |
| Funding ID | 2068/23 |
| Organisation | State University of Campinas |
| Sector | Academic/University |
| Country | Brazil |
| Start | 01/2023 |
| End | 01/2024 |
| Title | Custom peptide microarray to profile histone:bromodomain interactions |
| Description | Our use of a custom peptide microarray to profile histone:bromodomain interactions was selected by PepperPrint as a "featured publication" as it highlighted a novel use of their technology. This was disseminated on their social media and website https://www.linkedin.com/posts/pepperprint-gmbh_bromodomain-factor-5-as-a-target-for-antileishmanial-activity-7130513375108694016-e82F/ https://www.pepperprint.com/downloads-resources/publications/cited-publications |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Pending |
| URL | https://www.pepperprint.com/downloads-resources/publications/cited-publications |
| Title | Microdialysis to improve treatment of leishmaniasis |
| Description | Optimising and developing the use of microdialysis to help determine better and effective treatment regimens for cutaneous leishmaniasis |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Pending |
| Title | Purification of immune-active macrophage super enhancers by chemical cross-linked chromatin immune precipitation |
| Description | STAR Protocol. 2023 Jan 11;4(1):102004. doi: 10.1016/j.xpro.2022.102004. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Pending |
| Title | Vectors to improve the toolbox for deletions by using CRISPR/Cas9 technology |
| Description | These vectors have been designed for making 'addback' controls for deletions. The manuscript is in preparation and they will be available for the community under request. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | They have a very flexible PLS and several genes for resistance to many antibiotics, so they can be easily combined with selection markers used for making the CRISPR/Cas9 knock outs. |
| Title | XL-BioID for Leishmania |
| Description | Contribution to development of XL-BioID (pmid: 36437406 ) for proximal protein ID and guidelines on how best to apply it (pmid: 35601102). |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Pending |
| Title | ChIP Seq |
| Description | LmxBDF5 ChIP Seq integrated into TriTrypDB : https://tritrypdb.org/tritrypdb/app Raw BDF5 ChIP seq data and associated RNAseq of BDF5 deficient mutant: (European Nucleotide Archive under the accession code PRJEB46800) BDF5 Proximal proteome dataset Raw Data : (MassIVE (MSV000087750) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Pending |
| Title | Chromosomes of Trypanosoma cruzi |
| Description | A web page was generated with the datasets and graphic representation of the chromosomes of Trypanosoma cruzi |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Pending |
| URL | http://bioinformatica.fcien.edu.uy/cruzi/ |
| Title | Dual RNA seq for gene expression of Leishmania donovani and Leishmania infatum in infected mice (spleen and liver) |
| Description | RNAseq |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Pending |
| Title | Structure of BDF5 bromodomain |
| Description | Protein Data Bank ID 8BPT |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Pending |
| Title | The genomic information and the genome annotation from T. cruzi |
| Description | https://tritrypdb.org/tritrypdb/app/workspace/strategies/327621753/432597513 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | The strain used is now a reference strain of Trypanosoma cruzi. |
| Description | CONICET-CSIR |
| Organisation | Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society |
| Country | Argentina |
| Sector | Public |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific lead |
| Impact | Pending |
| Start Year | 2017 |
| Description | CONICET-CSIR |
| Organisation | Council of Scientific and Industrial Research |
| Department | Indian Institute of Chemical Biology |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific lead |
| Impact | Pending |
| Start Year | 2017 |
| Description | CONICET-Cassará Foundation |
| Organisation | Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society |
| Country | Argentina |
| Sector | Public |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific leadership, in-kind contribution |
| Impact | Pending |
| Start Year | 2020 |
| Description | CONICET-USP |
| Organisation | Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society |
| Country | Argentina |
| Sector | Public |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific lead |
| Impact | Claudio A. Pereira, Melisa Sayé, Chantal Reigada, Ariel M. Silber, Guillermo R. Labadie, Mariana R. Miranda, and Edward Valera-Vera. Computational approaches for drug discovery against trypanosomatid caused diseases (2020). Parasitology, 147(6):611-633. (ISSN: 0031-1820, PMID: 32046803 DOI: 10.1017/S0031182020000207) |
| Start Year | 2017 |
| Description | CONICET-USP |
| Organisation | Universidade de São Paulo |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific lead |
| Impact | Claudio A. Pereira, Melisa Sayé, Chantal Reigada, Ariel M. Silber, Guillermo R. Labadie, Mariana R. Miranda, and Edward Valera-Vera. Computational approaches for drug discovery against trypanosomatid caused diseases (2020). Parasitology, 147(6):611-633. (ISSN: 0031-1820, PMID: 32046803 DOI: 10.1017/S0031182020000207) |
| Start Year | 2017 |
| Description | CONICET-University of Rosario |
| Organisation | Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society |
| Country | Argentina |
| Sector | Public |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific lead |
| Impact | Noelia S. Medran, Melisa Sayé, Claudio A. Pereira, Babu L. Tekwani, Agustina La-Venia, and Guillermo R. Labadie. Expanding the scope of synthetic 1,2,4-trioxanes towards Trypanosoma cruzi and Leishmania donovani (2020). Bioorganic & Medicinal Chemistry Letters, 30(20):127491 (ISSN: 0960-894X, PMID: 32795626 DOI: 10.1016/j.bmcl.2020.127491) Claudio A. Pereira, Melisa Sayé, Chantal Reigada, Ariel M. Silber, Guillermo R. Labadie, Mariana R. Miranda, and Edward Valera-Vera. Computational approaches for drug discovery against trypanosomatid caused diseases (2020). Parasitology, 147(6):611-633. (ISSN: 0031-1820, PMID: 32046803 DOI: 10.1017/S0031182020000207) |
| Start Year | 2017 |
| Description | CSIR-Central Drug Research Institute (CDRI)(Lucknow, India) Molecular and Structural Biology Division |
| Organisation | Council of Scientific and Industrial Research |
| Department | Central Drug Research Institute |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: Dr. A. A. Sahasrabuddhe [joint IC](Gene cloning, protein expression and purification, Leishmania cell biology, Vaccine and diagnostics development, Biotherapeutics); Dr. A. Arora [joint IC](protein NMR spectroscopy, protein solution and crystal structure, molecular cloning, thermodynamics, immunology). Microbiology: Dr. K. K. Srivastava (molecular cloning, infection biology, protein kinases, gene knock-out and knock-in, immunology). Medicinal Chemistry: Dr. A. K. Sinha (chemical synthesis, natural products, antimicrobials, antileishmanials). Endocrinology: Dr. N. Chattopadhyay (bone biology, osteogenesis, MicroCT, receptor biology, osteogenic compounds). |
| Impact | none yet |
| Start Year | 2017 |
| Description | CSIR-Commercial |
| Organisation | Council of Scientific and Industrial Research |
| Department | Indian Institute of Chemical Biology |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific Leadership i) GLP/ GMP standard liposomal Amphotericin B formulation ii) GLP/GMP liposomal vaccine |
| Impact | Pending |
| Start Year | 2020 |
| Description | CSIR-Indian Institute of Chemical Biology (IICB)(Kolkata, India) Infectious Diseases & Immunology Division |
| Organisation | Council of Scientific and Industrial Research |
| Department | Indian Institute of Chemical Biology |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise in the following: Professor N. Ali [HUB leader][IC](Immunology, Biochemistry, Parasitology, Diagnostics, Drug delivery, Vaccinology) and Structural Biology and Bioinformatics: Dr. S. Adak (enzymology, cell biology and molecular biology). |
| Impact | None yet |
| Start Year | 2017 |
| Description | CSIR-Indian Institute of Microbial Technology (IMTECH) (Chandigarh, India) |
| Organisation | CSIR - Institute of Microbial Technology |
| Country | India |
| Sector | Public |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | CSIR-Indian Institute of Microbial Technology (IMTECH) (Chandigarh, India) Division of Cell Biology and Immunology: Dr P. Sen [IC](Immunology, Cell Biology, Immunoregulation by Leishmania donovani, transcriptional regulation and cell signalling) |
| Impact | None yet |
| Start Year | 2017 |
| Description | CSIR-UFRJ |
| Organisation | Council of Scientific and Industrial Research |
| Department | Indian Institute of Chemical Biology |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific Leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | CSIR-UFRJ |
| Organisation | Federal Rural University of Rio de Janeiro |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific Leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | CSIR-York |
| Organisation | Council of Scientific and Industrial Research |
| Department | Indian Institute of Chemical Biology |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | CSIR-York |
| Organisation | University of York |
| Department | Department of Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | Drug target deconvolution |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Tres Cantos Medicines Development Campus |
| Country | Spain |
| Sector | Private |
| PI Contribution | Drug target deconvolution project focused on selected compounds from the GSK Leish and Chagas Boxes: genomics, target validation, metabolomics, lipidomics and proteomics. Led by Durham but involves multiple Network and other partners. |
| Collaborator Contribution | Provision of compounds, access to funding (Tres Cantos Open Lab Foundation) and consultancy. |
| Impact | Tres Cantos Open Lab Foundation funding to continue project to 2024. Genomics, target validation, metabolomics, lipidomics and proteomics. |
| Start Year | 2020 |
| Description | Federal University of Minas Gerais (UFMG) (Brazil) Department of Biochemistry and Immunology |
| Organisation | Federal University of Minas Gerais |
| Department | Dept of Biochemistry and Immunology |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: Department of Biochemistry and Immunology: Prof. S.M. Teixeira [IC](immunology, parasite gene regulation, molecular biology of T.cruzi), Department of Parasitology: Prof. D.C. Bartholomeu (Genomics, surface antigens of T.cruzi, diagnostics) and Prof. R.T. Fujiwara (immunology, Leishmania and T.cruzi diagnostics) |
| Impact | None yet |
| Start Year | 2017 |
| Description | Federal University of Rio Grande do Sul (UFRGS)(Brazil) Department of Organic Chemistry |
| Organisation | Federal University of Rio Grande do Sul |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: ) Department of Organic Chemistry: Prof. A. Pohlmann [IC](organic chemistry, polymeric delivery systems, transdermal delivery), College of Pharmacy: Prof. S. Stanisçuaski Guterres (pharmacy, polymeric delivery systems). |
| Impact | none yet |
| Start Year | 2017 |
| Description | Federal University of Rio de Janeiro (UFRJ)(Brazil) Institute of Biophysics |
| Organisation | Federal University of Rio de Janeiro |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: Prof. B. Rossi-Bergmann [IC] (Molecular parasitology, pharmaceutics); Prof. L. Mendes (pharmacy, nanocrystals); Prof. R. Coutinho (Immunology, purinergic receptors) and Dr A. P. Lima (Immunology, animal models, parasitology) Federal |
| Impact | none yet |
| Start Year | 2017 |
| Description | ICCBS-Durham |
| Organisation | Durham University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific oversight |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2022 |
| Description | ICCBS-Durham |
| Organisation | University of Karachi |
| Country | Pakistan |
| Sector | Academic/University |
| PI Contribution | Scientific oversight |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2022 |
| Description | IMTECH:UNICAMP |
| Organisation | State University of Campinas |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research |
| Impact | Not yet |
| Start Year | 2019 |
| Description | IPM:Glasgow |
| Organisation | University of Glasgow |
| Department | Institute of Biodiversity, Animal Health and Comparative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Genome plasticity in Trypanosoma cruzi Genome analysis |
| Impact | Pending |
| Start Year | 2023 |
| Description | India-Brazil partnership |
| Organisation | CSIR - Institute of Microbial Technology |
| Country | India |
| Sector | Public |
| PI Contribution | Facilitation |
| Collaborator Contribution | Facilitation |
| Impact | Pending |
| Start Year | 2017 |
| Description | India-Brazil partnership |
| Organisation | State University of Campinas |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Facilitation |
| Impact | Pending |
| Start Year | 2017 |
| Description | India-China collaboration |
| Organisation | Birla Institute of Technology and Science, Pilani |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Planning for future grant funding applications when suitable calls come. |
| Collaborator Contribution | Planning for future grant funding applications when suitable calls come. |
| Impact | None as yet |
| Start Year | 2021 |
| Description | India-China collaboration |
| Organisation | Huazhong Agricultural University |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Planning for future grant calls |
| Collaborator Contribution | Planning for future grant calls |
| Impact | None as yet |
| Start Year | 2021 |
| Description | India-UK collaboration |
| Organisation | Council of Scientific and Industrial Research |
| Department | Central Drug Research Institute |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Facilitation |
| Impact | Zohib M, Maheshwari D, Pal RK, Freitag-Pohl S, Biswal BK, Pohl E, Arora A. Crystal structure of the GDP-bound GTPase domain of Rab5a from Leishmania donovani. Acta Crystallogr F Struct Biol Commun. 2020 Nov 1;76(Pt 11):544-556. doi: 10.1107/S2053230X20013722. Epub 2020 Oct 29. PMID: 33135673; PMCID: PMC7605105. |
| Start Year | 2017 |
| Description | India-UK collaboration |
| Organisation | Durham University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Facilitation |
| Impact | Zohib M, Maheshwari D, Pal RK, Freitag-Pohl S, Biswal BK, Pohl E, Arora A. Crystal structure of the GDP-bound GTPase domain of Rab5a from Leishmania donovani. Acta Crystallogr F Struct Biol Commun. 2020 Nov 1;76(Pt 11):544-556. doi: 10.1107/S2053230X20013722. Epub 2020 Oct 29. PMID: 33135673; PMCID: PMC7605105. |
| Start Year | 2017 |
| Description | Institut Pasteur de Montevideo (IPM) (Uruguay) Unit of Molecular Biology |
| Organisation | Pasteur Institute of Montevideo |
| Country | Uruguay |
| Sector | Charity/Non Profit |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows - Prof. C. A. R. Porto [IC]( virulence factors in trypanosomatids, parasite models T. cruzi, T. brucei, transcriptomics profiling of hostpathogen interactions) |
| Impact | None yet |
| Start Year | 2017 |
| Description | Instituto de Química-CSIR |
| Organisation | Council of Scientific and Industrial Research |
| Department | Central Drug Research Institute |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Research Leadership |
| Impact | Pending |
| Start Year | 2018 |
| Description | Instituto de Química-CSIR |
| Organisation | Instituto de Química del Noroeste Argentino |
| Country | Argentina |
| Sector | Public |
| PI Contribution | Facilitation |
| Collaborator Contribution | Research Leadership |
| Impact | Pending |
| Start Year | 2018 |
| Description | Instituto de Química-Durham |
| Organisation | Durham University |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitative |
| Collaborator Contribution | Research leadership |
| Impact | Pending |
| Start Year | 2019 |
| Description | Instituto de Química-Durham |
| Organisation | Instituto de Química del Noroeste Argentino |
| Country | Argentina |
| Sector | Public |
| PI Contribution | Facilitative |
| Collaborator Contribution | Research leadership |
| Impact | Pending |
| Start Year | 2019 |
| Description | National University of Rosario (NUR) (Argentina) School of Pharmacy and Biochemistry |
| Organisation | National University of Rosario |
| Country | Argentina |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: School of Pharmacy and Biochemistry: Prof. G. R. Labadie [IC](organic synthesis, medicinal chemistry, chemical-biology); Dr. E.O.J. Porta (chemical biology, molecular modelling), Dr. C. Delpiccolo (catalysis, medicinal chemistry), Dr. A. La Venia (solid phase synthesis, peptides and peptidomimetics), Prof. J. A. Cricco (parasitology, microscopy, biophysics) |
| Impact | None yet |
| Start Year | 2017 |
| Description | State University of Campinas (UNICAMP) (Brazil) Department of Animal Biology |
| Organisation | State University of Campinas |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: Department of Animal Biology: Dr. A.C. Coelho [IC](drug resistance, molecular diagnosis, chemotherapy of leishmaniasis); and Dr. D.C. Miguel (drug screening, chemotherapy of leishmaniasis). |
| Impact | None yet |
| Start Year | 2017 |
| Description | UFRJ-Lima |
| Organisation | Drugs for Neglected Diseases initiative (DNDi) |
| Country | Switzerland |
| Sector | Charity/Non Profit |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research and engagement |
| Impact | Pending |
| Start Year | 2020 |
| Description | UFRJ-Lima |
| Organisation | Durham University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research and engagement |
| Impact | Pending |
| Start Year | 2020 |
| Description | UFRJ-Lima |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research and engagement |
| Impact | Pending |
| Start Year | 2020 |
| Description | UFRJ-Lima |
| Organisation | Novartis Institutes for BioMedical Research (NIBR) |
| Department | Novartis Vaccines Institute for Global Health (NVGH) |
| Country | United States |
| Sector | Private |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research and engagement |
| Impact | Pending |
| Start Year | 2020 |
| Description | UFRJ-Lima |
| Organisation | University of California, San Diego (UCSD) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research and engagement |
| Impact | Pending |
| Start Year | 2020 |
| Description | UFRJ-Lima |
| Organisation | University of Texas |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research and engagement |
| Impact | Pending |
| Start Year | 2020 |
| Description | UFRJ-Lima |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research and engagement |
| Impact | Pending |
| Start Year | 2020 |
| Description | UINCAMP:DU:IPM:USP:UFSC |
| Organisation | Durham University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research alliance |
| Impact | Pending |
| Start Year | 2019 |
| Description | UINCAMP:DU:IPM:USP:UFSC |
| Organisation | Federal University of Sao Carlos |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research alliance |
| Impact | Pending |
| Start Year | 2019 |
| Description | UINCAMP:DU:IPM:USP:UFSC |
| Organisation | Pasteur Institute of Montevideo |
| Country | Uruguay |
| Sector | Charity/Non Profit |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research alliance |
| Impact | Pending |
| Start Year | 2019 |
| Description | UINCAMP:DU:IPM:USP:UFSC |
| Organisation | State University of Campinas |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research alliance |
| Impact | Pending |
| Start Year | 2019 |
| Description | UINCAMP:DU:IPM:USP:UFSC |
| Organisation | Universidade de São Paulo |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation and funding |
| Collaborator Contribution | Research alliance |
| Impact | Pending |
| Start Year | 2019 |
| Description | UNICAMP-Durham |
| Organisation | Durham University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | UNICAMP-Durham |
| Organisation | State University of Campinas |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | UNICAMP-IPM |
| Organisation | Pasteur Institute of Montevideo |
| Country | Uruguay |
| Sector | Charity/Non Profit |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | UNICAMP-IPM |
| Organisation | State University of Campinas |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | UNICAMP-Rosario |
| Organisation | National University of Rosario |
| Country | Argentina |
| Sector | Academic/University |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | UNICAMP-Rosario |
| Organisation | State University of Campinas |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitative |
| Collaborator Contribution | Scientific leadership |
| Impact | Pending |
| Start Year | 2017 |
| Description | USP-York |
| Organisation | Universidade de São Paulo |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific leadership |
| Impact | https://www.frontiersin.org/articles/10.3389/fmolb.2021.692668/full |
| Start Year | 2017 |
| Description | USP-York |
| Organisation | University of York |
| Department | Department of Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitation |
| Collaborator Contribution | Scientific leadership |
| Impact | https://www.frontiersin.org/articles/10.3389/fmolb.2021.692668/full |
| Start Year | 2017 |
| Description | University of Buenos Aires (UBA) (Argentina) Medical Research Institute |
| Organisation | University of Buenos Aires |
| Country | Argentina |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: laboratory of Molecular Parasitology: Dr. C. A. Pereira [IC] (target validation in Trypanosoma cruzi, drug discovery, virtual screening, medicinal chemistry) |
| Impact | None yet |
| Start Year | 2017 |
| Description | University of Karachi (UoK)(Pakistan) - International Centre for Chemical and Biological Sciences |
| Organisation | University of Karachi |
| Country | Pakistan |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: Prof. I. Choudhary [HUB Leader][IC](Medicinal chemist); Prof. K.M. Khan (Medicinal chemist), Dr. A. Wahab (Structural Biologist), Dr. S. Yousuf (Natural Product chemist), Dr. S. Ahmed (Microbiologist), and Dr. S. Farooq (Microbiologist). |
| Impact | None yet |
| Start Year | 2017 |
| Description | University of São Paulo (USP)(Brazil) Institute of Biomedical Sciences |
| Organisation | Universidade de São Paulo |
| Department | Institute of Biomedical Sciences |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise in the following: Prof. A. Silber biochemistry, genetics, molecular biology of T. cruzi; Department of Parasitology: Dr. SR. Uliana [IC](chemotherapy of leishmaniasis, drug assay development); Dr. JMP. Alves (Genomics, Bioinformatics, Parasitology); Institute of Tropical Medicine of São Paulo: Dr. PC. Cotrim (molecular diagnosis, drug resistance) and Dr. JAL. Lindoso (chemotherapy of leishmaniasis, diagnosis of infectious diseases, HIVLeishmania co-infection). Ribeirão Preto campus. Prof. A.Cruz (Genetics, Parasitology) and Dr L.Tosi (Leishmania, DNA replication biology) |
| Impact | None yet |
| Start Year | 2017 |
| Description | University of York (UoY)(UK) Centre for Immunology and Infection |
| Organisation | University of York |
| Department | Centre for Immunology and Infection |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Durham University has taken the lead of the Global network for neglected tropical diseases, it contributes the following expertise: Department of Chemistry: Prof. G. Sandford, PI (organic synthesis, organofluorine chemistry); Prof. P. Steel (organic synthesis, chemical probes, chemical-biology); Dr S. Cobb [IC](peptide chemistry, medicinal-chemistry, chemical-biology); Dr R. Pal (diagnostics, cell based imaging, microscopy) and Dr R. Kataky (biomarkers, diagnostics, drug delivery). School of Biological Sciences: Dr P. Denny [HUB leader](parasitology, assay development, target validation); Dr E. Pohl (drug design, biophysical sciences, protein crystallography); Prof. C. Jahoda (skin biology, 3D skin cell models) and Dr C. Ambler (immunology, skin wound healing). |
| Collaborator Contribution | Expertise as follows: Centre for Immunology and Infection: Prof. J. Mottram [IC](molecular parasitology, target validation, animal models of infection); Prof. P. Kaye (immunology, parasitology, vaccine development, computational modelling); Dr P. Walrad (molecular parasitology, RNA biology); Department of Chemistry: Prof. T. Wilkinson (protein crystallography, structure-based drug design). Department of Electronics: Prof. J. Timmis (Computational immunology, Fault-tolerant swarm robotic systems) SimOmics (SME spin out; Evidence based simulation tools for drug discovery). Organisation of the 2nd advanced course in genetic manipulation of parasitic protozoa to be held in July 2018. |
| Impact | None yet |
| Start Year | 2017 |
| Description | York-Durham |
| Organisation | Durham University |
| Department | School of Biological and Biomedical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Attempted expression of Phytase in Leaf Expression System. |
| Collaborator Contribution | Target gene was cloned into pEAQ-HT (York) and shared with LES (Norwich). |
| Impact | Pending |
| Start Year | 2019 |
| Description | York-Durham |
| Organisation | University of York |
| Department | Department of Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Attempted expression of Phytase in Leaf Expression System. |
| Collaborator Contribution | Target gene was cloned into pEAQ-HT (York) and shared with LES (Norwich). |
| Impact | Pending |
| Start Year | 2019 |
| Description | York-IPM |
| Organisation | University of York |
| Department | Department of Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Grant application development. |
| Collaborator Contribution | Shared RPB1 ChIPseq Data to initiate preliminary work for proposed project on regulation of gene expression in Leishmania. |
| Impact | Pending |
| Start Year | 2018 |
| Title | Microbial Infection, Treatment of Leishmaniasis |
| Description | Novel antileishmanial compounds |
| IP Reference | PCT/GB2022/052392 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | Pending |
| Title | Kinetic data to non-linear mechanistic functions |
| Description | Developed a software to package improve the adjustment of kinetic data to non-linear mechanistic functions. The manuscript is in preparation. |
| Type Of Technology | Software |
| Year Produced | 2023 |
| Impact | Pending |
| Description | A Global Network for Negelcted Tropical diseases (NTD Network) programme website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Independent website for this collaborative research programme "A Global Network for Neglected Tropical Diseases" (known as the NTD network). This website has acted as a source of information for people involved with the programme, and a range of audiences beyond the Nt=etwork's membership and their teams. The site introduces our programme, and provides updated information on Network-internal and external partner events, our staff, and our publications arising from the project. The website's blog has been used throughout the programme to provide updates and reporting on our Network-wide activities, including workshops and symposia, prizes awarded to our members, meetings and gatherings, as well as features on some of our publications. This blog archive has documented evidence of our meetngs and gatherings, and other events, with photos of Network members engaged in activites across the programme. The site also offers the opportunity to sign up for email updates on job vacancies, relevant scientific events and symposia, and opportunities to apply for small Network funding allocations, e.g. for travel bursaries administered under our programme. This list of subscribers offers us one route to expanding the reach of the Network programme, and sign-ups have now reached around 500 contacts, across Europe, Asia, the Middle EAst, Africa, Australia, the US and South America. A secure (password protected) page has been used to deposit supporting documentaiton mentioned in the annual reports and 'additinal funder questions' on Researchfish. |
| Year(s) Of Engagement Activity | 2018,2019,2020,2021,2022 |
| URL | https://ntd-network.org/ |
| Description | Article A very unpleasant kiss, Microbiologist |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Article for the Microbiologist, the magazine of the Society for General Microbiology: A very unpleasant 'kiss'. Microbiologist 18(4): 20-21. ISSN/ISBN: 1479-2699 |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://issuu.com/societyforappliedmicrobiology/docs/web_version_microbio_dec_2017 |
| Description | Article for Durham University alumni magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article written for Dunelm Magazine (the Durham Alumni publication) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Contribution to MediaPlanet NTD campaign |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The Neglected Tropical Diseases (NTDs) campaign was created off the back of the WHO's new 2020-2030 NTD Elimination Roadmap, which delves into how we can eliminate all NTDs by the year 2030, through a united, collaborative effort. The campaign aimed to raise awareness around the work being done in the field, why it's crucial for NTDs to remain in the spotlight amidst the COVID-19 pandemic, and how these diseases can be beaten through the incorporation of innovation, collaboration and a One Health approach. Potential reach of >33M people. Print within Guardian newspaper coupled with online presence and social media promotion. |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.globalcause.co.uk/campaign/neglected-tropical-diseases/ |
| Description | Durham University website news feature (opinion piece) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | News and opinion feature at home institution website. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.durham.ac.uk/research/current/thought-leadership/durham-led-research-network-rises-to-th... |
| Description | INDEPTH |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Summer school in Gdansk, Poland |
| Year(s) Of Engagement Activity | 2023 |
| Description | MRC 'Insights' Blog |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | MRC 'Insights' blog article, 3rd May 2019 "The gene-editing workshops tackling invisible diseases" - guest author article describing a CRISPR-Cas9 training workshop hosted by this project in Kolkata, India, in March 2019, which provided skills training in this technology for students from India, the Middle East, and the UK. (although the blog piece is no longer live on the MRC website, a pdf version of this feature blog is available via our supplementary documents page. (see https://ntd-network.org/annual-report-2022/ Password: AP2022!v0.1 |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://mrc.ukri.org/news/blog/the-gene-editing-workshops-tackling-invisible-diseases/ |
| Description | Northern Echo feature (16 February 2022) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | News feature article in The Northern Echo (Northeast England regional newspaper) |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.thenorthernecho.co.uk/news/health/features/19918434.durham-university-networks-work-negl... |
| Description | Pint of Science Symposium on the Life Sciences |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Outreach event in local public house, focused on general public. Part of wider Pint of Science outreach event in the North East of England. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Youtube animation: 'Cutaneous leishmaniasis: the patient experience" |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | NTD Network Youtube animation: 'Cutaneous leishmaniasis: the patient experience" launched 202, with scope for use by colleagues around the world as an easy introduction to the challenge of this disease for patients - research amongst colleagues n endemic areas identified this type of communication as an unmet need area. Discussions are underway about producing a version of this video with Urdu voiceover. The animation addresses the misconceptions and stigma around this disease which is common in disease-endemic countries. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/channel/UCLMKAvmTQ3urKaY6jT0Do6w |