The virtual seed (vSEED)

Lead Research Organisation: University of Nottingham
Department Name: Sch of Biosciences

Abstract

The aim of the vSEED project is to provide a dynamic mathematical description of seed dormancy, after-ripening and germination focussing on the key seed compartments the radicle and endosperm. This interdisciplinary project will analyse the comparative biology of the closely related Brassicaceae species Arabidopsis thaliana and Lepidium sativum, using engineering, imaging, modelling and post-genomics approaches to develop a virtual germinating seed. We propose that germination is an ideal exemplary subject for the integration of new technologies and for developing molecular plant biomechanics in conjunction with dynamic mathematical modelling.

Technical Summary

The aim of the vSEED project is to provide a dynamic mathematical description of seed dormancy, after-ripening and germination focussing on the key seed compartments the radicle and endosperm. This interdisciplinary project will analyse the comparative biology of the closely related Brassicaceae species Arabidopsis thaliana and Lepidium sativum, using engineering, imaging, modelling and post-genomics approaches to develop a virtual germinating seed. We propose that germination is an ideal exemplary subject for the integration of new technologies and for developing molecular plant biomechanics in conjunction with dynamic mathematical modelling. The research programme will be achieved through five inter-related work packages: WP1: Identification and mathematical modelling of key transcriptome networks associated with radicle and endosperm function. WP2: Analysis of cell wall biology during embryo growth and endosperm weakening. WP3: Provision of tissue/seed scale biomechanical modelling through the use of novel engineering and imaging approaches. WP4: Multi-scale modelling, integrating cross-species analysis, from transcriptomic networks though tissue biomechanical models to physiological seed behaviour (including abiotic stresses). WP5: Resource development and model validation through use of unique, and development of novel, genetic resources.

Publications

10 25 50

publication icon
Bassel GW (2014) Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Bassel GW (2011) Genome-wide network model capturing seed germination reveals coordinated regulation of plant cellular phase transitions. in Proceedings of the National Academy of Sciences of the United States of America

publication icon
Bassel GW (2011) Seed bioinformatics. in Methods in molecular biology (Clifton, N.J.)

publication icon
Middleton AM (2012) Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling. in Proceedings of the National Academy of Sciences of the United States of America

 
Description Detailed information about the molecular biology and mechanics of seed germination
Exploitation Route Further scientific research
Sectors Agriculture

Food and Drink

Education