Organoid transplantation to reverse intestinal failure
Lead Research Organisation:
University College London
Department Name: Great Ormond St. Instit of Child Health
Abstract
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Technical Summary
This application is a UK-Canada exchange project relating to regenerative medicine. Regenerative medicine is defined as the branch of medicine that develops methods to regrow, repair or replace damaged or diseased cells, organs or tissues. The purpose of the project is to provide new skills to researchers, including ECRs, technicians and newly independent investigators, and to build links between UK and Canada based scientists for continued or future collaboration. The exchange will support the work being undertaken on the project "Organoid transplantation to reverse intestinal failure".
People |
ORCID iD |
| Paolo De Coppi (Principal Investigator) |
| Description | Building mini-organs for disease modelling |
| Amount | £92,791 (GBP) |
| Organisation | Great Ormond Street Hospital (GOSH) |
| Department | NIHR Great Ormond Street Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2024 |
| End | 12/2026 |
| Description | TRANSLATE: Tissue-engineeRed grAft for the treatmeNt of OeSophageaL ATrEsia - optimisation of GMP-compatible conditions |
| Amount | £402,034 (GBP) |
| Organisation | Great Ormond Street Hospital Children's Charity (GOSHCC) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2024 |
| End | 06/2027 |
| Description | Toronto Sick Kids - UCL GOS ICH/GOSH collaboration on intestinal engineering |
| Organisation | The Hospital for Sick Children (SickKids) |
| Department | MICe Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | JS visited Toronto labs (Prof Pierro) between Oct'23-Dec'23 to learn and co-develop an intestinal failure (Necrotising Entercolitis/NEC) in vivo murine model in order to translate it into a rat model. In addition, JS learnt to develop a human-dervied in vitro organoid NEC model. |
| Collaborator Contribution | BL visited the UCL labs with Prof De Coppi between March 2023-June 2023 to learn organoid derivation from intestinal tissue using state of the art facilities at the Zayed Research Centre. |
| Impact | We have not published papers yet, but recently had a manuscript submitted entitled "Impairment of the stromal-epithelium regenerative crosstalk in Hirschsprung's disease priming for the progression of Hirschsprung-associated enterocolitis" |
| Start Year | 2023 |