Stochastic theory of barrier-crossing processes under large thermal fluctuations
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
Formation of bonds in thermally agitated environments is ubiquitous in biological, solid state, and nuclear physics with many engineering applications. Particles or molecular associations form binary complexes when there is an energy gain upon forming a bond. Examples include nanoparticle absorption to membranes, protein-ligand bindings, and atomic force microscopy (AFM) studies of the cellular membrane. The energy gain upon forming the bond, i.e. the binding energy Q, also determines the bond's stability in an environment with thermal fluctuations. When the binding energy is small compared to thermal fluctuations that have energies of the order kBT, i.e. when Q= kBT ~ 1, the bond is unstable and can break on a short time scale. Conversely, for large binding energies, Q >> kBT, the bond is stable, and the dissociation time is very long. Current theories are successful in the latter case of large binding energy, but fail completely in the opposite limit of low energy/large thermal fluctuations. The goal of this PhD is to fill this gap in our understanding of thermally-activated dissociation processes. Stochastic methods will be employed and combined creatively with Zwanzig-Caldeira-Leggett system-bath Hamiltonian methods to properly describe the role of friction. The theory will be applied to selected important problems such as biomolecular receptor-ligand binding, biological filament dissociation, and alike.
People |
ORCID iD |
Claudio Castelnovo (Primary Supervisor) | |
Thomas Gray (Student) |
Publications
Abkenar M
(2017)
Dissociation rates from single-molecule pulling experiments under large thermal fluctuations or large applied force.
in Physical review. E
Eccles C
(2018)
Reply to 'Comment on "Temperature dependence of nuclear fission time in heavy-ion fusion-fission reactions" '
in Physical Review C
Gray TH
(2020)
Overdamped Brownian dynamics in piecewise-defined energy landscapes.
in Physical review. E
Gray TH
(2021)
An effective one-dimensional approach to calculating mean first passage time in multi-dimensional potentials.
in The Journal of chemical physics
Gray TH
(2020)
Effective diffusion in one-dimensional rough potential-energy landscapes.
in Physical review. E
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/N509620/1 | 30/09/2016 | 29/09/2022 | |||
1778174 | Studentship | EP/N509620/1 | 30/09/2016 | 29/06/2021 | Thomas Gray |
EP/R513180/1 | 30/09/2018 | 29/09/2023 | |||
1778174 | Studentship | EP/R513180/1 | 30/09/2016 | 29/06/2021 | Thomas Gray |
Description | Research into diffusion and sub-diffusion in piecewise-defined potential energy landscapes |
Organisation | Nanyang Technological University |
Country | Singapore |
Sector | Academic/University |
PI Contribution | Intellectual input - I researched the literature, developed the relevant theory, and performed the numerical simulations required in order to test it. |
Collaborator Contribution | Resources - time on the machines at the NTU High-Performance Computing Centre. Intellectual input - time spent discussing my research and theory. |
Impact | One paper has been accepted by Physical Review E and will be published in the near future. We are currently working towards a second paper. |
Start Year | 2018 |