Staphylococcus aureus Infections - Development of A Novel, Effective Vaccine
Lead Participant:
ABSYNTH BIOLOGICS LIMITED
Abstract
S. aureus is a bacterium that colonises the nasal lining and skin of >30% of people. Accidents, surgery or device implantation that breach natural barriers, allow invasion, which may result in life-threatening infections such as pneumonia and blood-borne infections particularly by the antibiotic resistant form (MRSA). Despite several attempts S. aureus no vaccine is yet available. All vaccine clinical trials have failed despite promising pre-clinical animal model data. The partners and subcontractors in this project led by Absynth Biologics Limited and the University of Sheffield are bringing together capabilities to address this problem namely: novel vaccine targets and technologies to more effectively stimulate the human immune system. This coupled with a greater understanding of the development of infection (physiological and immunological) will be used used innovatively to select the best candidate vaccine for clinical development.
Lead Participant | Project Cost | Grant Offer |
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ABSYNTH BIOLOGICS LIMITED | £2,588,292 | £ 1,552,975 |
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Participant |
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UNIVERSITY OF SHEFFIELD | £460,731 | £ 460,731 |
INNOVATE UK |
People |
ORCID iD |
Fiona Marston (Project Manager) |