Portuguese Government Studentship: PI3K signaling in neutrophils related to the regulation of superoxide formation by ras and PI3K
Lead Research Organisation:
Babraham Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Integrins are molecules on the surface of cells that enable them to stick to other cells and to surfaces and migrate. We have evidence that the distribution of integrins on white blood cells is controlled by hormones and this mechanism enables these abilities of white blood cells to be switched on and off as needed. In this project we are investigating the molecular mechanism by which the distribution of integrins on the surface of white blood cells is controlled.
Planned Impact
unavailable
Organisations
People |
ORCID iD |
| Len Stephens (Principal Investigator) |
Publications
Gambardella L
(2011)
The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.
in Blood
| Description | We generated a method to study the distribution of adhesion receptors on neutrophils that are critical for neutrophil movement. This allowed us to test the idea that PI3K signalling directly controlled the distribution of adhesion receptors to control cell movement. We found evidence that part of the effect of PI3K signalling on neutrophil migration was indeed through this mechanism. |
| Exploitation Route | The method developed is a poweful strategy for further research and has been used in other labs since. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Description | Invited lecturer to international meetings (average 2-3 per year) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | promoted discussions, collaborations scientific collaborations, joint grants and publications |
| Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019 |