The relationship between TSE infectivity in sheep blood and lymphiod tissues, PrP genotype, and disease pathogenesis
Lead Research Organisation:
Roslin Institute
Abstract
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Technical Summary
The project objectives are to develop more sensitive assays for PrPsc and infectivity in sheep blood, to determine the distribution of infectivity and / or PrPsc among subsets of sheep leukocytes, to determine the degree of correlation between TSE infectivity in lymphoid tissues and blood and to determine whether PrP genotype influences the levels of PrP protein expressed in sheep tissues.
Planned Impact
unavailable
Organisations
People |
ORCID iD |
| Eleanor Fiona Houston (Principal Investigator) |
Publications
Appleford NE
(2008)
alpha-Hemoglobin stabilizing protein is not a suitable marker for a screening test for variant Creutzfeldt-Jakob disease.
in Transfusion
McCutcheon S
(2014)
Prion protein-specific antibodies that detect multiple TSE agents with high sensitivity.
in PloS one
Sisó S
(2010)
Pathological phenotype of sheep scrapie after blood transfusion.
in Journal of comparative pathology
Tan BC
(2012)
Significant differences in incubation times in sheep infected with bovine spongiform encephalopathy result from variation at codon 141 in the PRNP gene.
in The Journal of general virology