Suppression of T cell immunity and antibody production during virus infection and sepsis
Lead Research Organisation:
CARDIFF UNIVERSITY
Department Name: School of Medicine
Abstract
The generation of protective antibodies against infection is dependent on "help" from CD4+ T follicular helper (TFH) cells which are elicited in
response to bacteria and viruses, such as influenza and SARS CoV-2. However, these cells can decline when immune responses are over-
exaggerated (sepsis). The student will use immunological techniques and innovative gene profiling strategies to examine why low numbers of
CD4+ TFH cells correlate with poor outcome in sepsis
response to bacteria and viruses, such as influenza and SARS CoV-2. However, these cells can decline when immune responses are over-
exaggerated (sepsis). The student will use immunological techniques and innovative gene profiling strategies to examine why low numbers of
CD4+ TFH cells correlate with poor outcome in sepsis
Organisations
People |
ORCID iD |
| James Edward McLaren (Primary Supervisor) | |
| Kate Davies (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/W006308/1 | 30/09/2022 | 29/09/2028 | |||
| 2748405 | Studentship | MR/W006308/1 | 30/09/2022 | 29/09/2026 | Kate Davies |