Industrial Biotechnology Innovation Cluster
Lead Research Organisation:
University of Manchester
Department Name: Chem Eng and Analytical Science
Abstract
Industrial Biotechnology (IB) is a set of cross-disciplinary technologies that uses biological resources for producing and processing everyday products such as food, fuels, and medicines. The field is poised for dramatic growth and has the potential to disrupt markets worth more than £34bn in the UK alone. A confluence of consumer demand, Government carbon emission targets, feedstock production efficiencies, fundamental and technical innovation has created a perfect situation for the industry to significantly expand. This paradigm shift capitalises on the strengths of a vast range of scientific and engineering disciplines which form the foundation for leveraging the rapid, specialised, and competitive growth of the sector.
Industrial Biotechnology is an area in which the North-West (NW) of England has critical mass and is rapidly emerging as a world leading cluster. The region is home to some of the world's biggest healthcare and biomanufacturing companies, including AstraZeneca, Teva, Croda and Unilever, and the first commercial production of a biologic was in Speke with Eli Lilly's manufacture of insulin. The NW is home to several SME innovation zones, including Daresbury, Liverpool Knowledge Quarter and Alderley Park, which is the UK's largest single site life science campus. IB in the region employs 25,000 people and has a turnover of over £6Bn. The HEI sector is also thriving and recognised for its internationally leading IB research and unique facilities, purpose-built for innovation. Most recently demonstrated by the University of Manchester's Queens Anniversary Prize for higher education, which recognised the world-leading biotechnology expertise of the Manchester Institute of Biotechnology that sign-posts towards a bio industrial revolution. Translating IB to meet urgent societal needs will not happen spontaneously; an integrated strategy, cluster of translational activity and innovation ecosystem are essential.
The NW has co-location of organisations, knowledge, skills and facilities which have already demonstrated they can promote connection and collaboration - enabling those in the region to operate more flexibly and productively. Here, we will concentrate and build our regional strengths in academia, business, civic partners, accelerators, investors and creatives with civil society and establish the Industrial Biotechnology Innovation Cluster (IBIC) with the aim of accelerating commercial exploitation of our outputs and delivering economic, social and scientific impact. United by a culture of ethics, diversity, and openness, the cluster will provide businesses with access to cutting-edge R&D knowledge, capabilities and infrastructure as well as innovation finance, skills training, and specialist support and advice. IBIC will be led by The University of Manchester and headquartered in the new Innovation District in Manchester - at the heart of the north's growing economy. It has been co-created with the University of Liverpool and our wider Civic and Business Partners. It is fully aligned with Greater Manchester and Liverpool Civic Partners strategies to increase the benefit and accelerate the impact of fundamental research across the region, and more broadly the UK economy and society. IBIC will enable the UK to realise its ambition to be a global biotechnology research and innovation superpower.
The IBIC is expected to directly stimulate £2.5M cash and £4M in-kind co-investment, establish 150 collaborative projects, train 200+ students to enter careers within IB, create up to 100 green jobs, and establish 20+ new commercial ventures attracting a further £10M in investment to the North-West, generating as a minimum 3:1 economic return to public investment over the medium term. It will have a long-term legacy by helping establish IBIC as an independent and business-led cluster of excellence and by enabling society to overcome challenges in energy security, disease, and hunger mitigation.
Industrial Biotechnology is an area in which the North-West (NW) of England has critical mass and is rapidly emerging as a world leading cluster. The region is home to some of the world's biggest healthcare and biomanufacturing companies, including AstraZeneca, Teva, Croda and Unilever, and the first commercial production of a biologic was in Speke with Eli Lilly's manufacture of insulin. The NW is home to several SME innovation zones, including Daresbury, Liverpool Knowledge Quarter and Alderley Park, which is the UK's largest single site life science campus. IB in the region employs 25,000 people and has a turnover of over £6Bn. The HEI sector is also thriving and recognised for its internationally leading IB research and unique facilities, purpose-built for innovation. Most recently demonstrated by the University of Manchester's Queens Anniversary Prize for higher education, which recognised the world-leading biotechnology expertise of the Manchester Institute of Biotechnology that sign-posts towards a bio industrial revolution. Translating IB to meet urgent societal needs will not happen spontaneously; an integrated strategy, cluster of translational activity and innovation ecosystem are essential.
The NW has co-location of organisations, knowledge, skills and facilities which have already demonstrated they can promote connection and collaboration - enabling those in the region to operate more flexibly and productively. Here, we will concentrate and build our regional strengths in academia, business, civic partners, accelerators, investors and creatives with civil society and establish the Industrial Biotechnology Innovation Cluster (IBIC) with the aim of accelerating commercial exploitation of our outputs and delivering economic, social and scientific impact. United by a culture of ethics, diversity, and openness, the cluster will provide businesses with access to cutting-edge R&D knowledge, capabilities and infrastructure as well as innovation finance, skills training, and specialist support and advice. IBIC will be led by The University of Manchester and headquartered in the new Innovation District in Manchester - at the heart of the north's growing economy. It has been co-created with the University of Liverpool and our wider Civic and Business Partners. It is fully aligned with Greater Manchester and Liverpool Civic Partners strategies to increase the benefit and accelerate the impact of fundamental research across the region, and more broadly the UK economy and society. IBIC will enable the UK to realise its ambition to be a global biotechnology research and innovation superpower.
The IBIC is expected to directly stimulate £2.5M cash and £4M in-kind co-investment, establish 150 collaborative projects, train 200+ students to enter careers within IB, create up to 100 green jobs, and establish 20+ new commercial ventures attracting a further £10M in investment to the North-West, generating as a minimum 3:1 economic return to public investment over the medium term. It will have a long-term legacy by helping establish IBIC as an independent and business-led cluster of excellence and by enabling society to overcome challenges in energy security, disease, and hunger mitigation.
Organisations
- University of Manchester (Lead Research Organisation)
- Seda Pharmaceutical Development Services (Collaboration)
- Unilever (Collaboration)
- Unilever (Project Partner)
- Bionow Ltd (Project Partner)
- Holiferm Limited (Project Partner)
- Lucid Group (Project Partner)
- MANCHESTER CITY COUNCIL (Project Partner)
- Croda Europe Ltd (Project Partner)
- Britest Limited (Project Partner)
- Disyn Biotc (Project Partner)
- Deakin Bio-hybrid Materials Limited (Project Partner)
- Praetura Ventures (Project Partner)
- Imperagen (Project Partner)
- Knowledge Centre for Materials Chemistry (Project Partner)
- Bruntwood SciTech (Project Partner)
- Greater Manchester Business Board (LEP) (Project Partner)
- CPI (Project Partner)
- Science and Technology Facilities Council (Project Partner)
- ID Manchester (Project Partner)
- C3 Biotechnologies (Project Partner)
- TriRx (Project Partner)
- GREATER MANCHESTER COMBINED AUTHORITY (Project Partner)
| Description | Brewing a sustainable future: unlocking the potential of spent grains |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.manchester.ac.uk/about/news/brewing-a-sustainable-future-unlocking-the-potential-of-spen... |
| Description | Building the Bioeconomy |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://blog.policy.manchester.ac.uk/sci-tech/2024/08/building-the-bioeconomy/ |
| Description | Future Feedstocks for Sustainable Chemical Manufacturing |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.manchester.ac.uk/about/news/shaping-tomorrows-biomanufacturing-future-feedstocks/ |
| Description | Regional Policy for Biomanufacturing in the North-West Chemical Sector |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://blog.policy.manchester.ac.uk/sci-tech/2024/10/regional-policy-for-biomanufacturing-in-the-no... |
| Description | Shaping tomorrow's biomanufacturing: people, capabilities, and infrastructure |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.manchester.ac.uk/about/news/shaping-tomorrows-biomanufacturing-people-capabilities-and-i... |
| Description | Shaping tomorrow's biomanufacturing: skills, training, and diversity |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://www.manchester.ac.uk/about/news/shaping-tomorrows-biomanufacturing-skills-training-and-diver... |
| Description | Mechanic Activation of Enzymes |
| Organisation | Unilever |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Set up grant call and help connect the partners |
| Collaborator Contribution | Collaboration between The University of Liverpool and Unilever PLC |
| Impact | ongoing |
| Start Year | 2024 |
| Description | Right time, right place: optimising a drug delivery platform for endometriosis |
| Organisation | Seda Pharmaceutical Development Services |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Grant call set up and introduced collaboration partnership |
| Collaborator Contribution | Collaboration between the University of Manchester and SEDA |
| Impact | Ongoing |
| Start Year | 2024 |
| Description | Commercial Development Fund Launch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Event organised with talks and panel discussion highlighting the routes and opportunities open to commercialse research, and culminating with the launch of IBICs Commercial Development Fund. |
| Year(s) Of Engagement Activity | 2025 |
| Description | Dedicated IBIC ICURe Discovery Programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dedicated ICURe Discovery programme with 10 individuals/teams from across the NW HEI community, learning about how to commercialise their research, doing customer discovery and ending in everyone pitching their business plan to a panel of external VCs, TTO reps and entrepreneurs to win one of three Innovations Awards. One company who one 2nd place award has since incorporated and taking SEIS investment, while three others are exploring options and securing IP through their relevant TTOs. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Foresight Mapping Workshop - Shaping tomorrow's biomanufacturing: people, capabilities, and infrastructure |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Roundtable Discussion with a panel of industrialists from various sectors discussing current and future needs. Help share policy influencing ask and further activities of IBIC. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Foresight mapping workshop - Shaping tomorrow's biomanufacturing: future feedstocks |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Roundtable Discussion with a panel of industrialists from various sectors discussing current and future needs. Help share policy influencing ask and further activities of IBIC, |
| Year(s) Of Engagement Activity | 2024 |
| Description | Foresight mapping workshop - Shaping tomorrow's biomanufacturing: skills, training, and diversity |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Roundtable Discussion with a panel of industrialists from various sectors discussing current and future needs. Help share policy influencing ask and further activities of IBIC. |
| Year(s) Of Engagement Activity | 2024 |
| Description | IBIC @MMU Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | IBIC Workshop presenting our activity and open opportunities to spark ideas and engagement for knowledge exchange and commercialisation activities. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Industrial Biotechnology Launch Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Industrial Biotechnology launch Event. Stakeholders attending hear about the need to transition chemical and material manufacturing away from fossil fuel based supply chains and that biotechnology/engineering biology is an avenue able to offer these solutions. Key stakeholders included national and regional Government representatives, UKRI, industrialists (corporate and SMEs) and academics. Raised awareness of technology, challenges, opportunities and our grant programme. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Microbreweries Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | A workshop held at the University of Salford and their pilot plant brewing facility to showcase our regional academic research in turning waste feedstocks from the brewing industry into value added chemicals. Aims was to build partnerships between academics and brewing industry. To date this has led to many discussions and 3 collaborative projects starting. Impact is ongoing. |
| Year(s) Of Engagement Activity | 2024 |
| Description | NW Academic Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | NW Academic networking workshop where academics, PDRAs and PhD students from across 5 different universities met, shared recent research and talked to find overlapping areas of mutual interest and collaboration opportunities as well as shape future IBIC programme and grant calls. |
| Year(s) Of Engagement Activity | 2024 |
| Description | North West Build A Biotech Competition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Event supported and coordinated by IBIC to train PhD students in generating tangible economic impact from their research through venture creation. Ran 3 training sessions, matched the 10 teams (selected from 46 applications) to external mentors and the programme culminated in short Dragons Den style business pitching to an external expert panel, with three awards being given to individuals/teams. The team in second place has since incorporated, with the first placed team in the process of spinning out, and the third placed team generating proof of principle data to support his business plan. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Research to Impact Liverpool |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | 16 PhD students and PDRAs from The Universities of Liverpool and Liverpool John Moores engaged in a half day workshop highlighting the different potential paths of delivering tangible impact from their research. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Research to Impact Workshop in Manchester |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | 16 PhD students and PDRAs from The Universities of Manchester, Salford, Bolton and Manchester Metropolitan engaged in a half day workshop highlighting the different potential paths of delivering tangible impact from their research. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Webinar 1 - Biotechnology in Action: Bridging the Gap from the Bench to the Industry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Dr Alejandra Diaz De Rienzo and Danny Wales, University of Salford; Biotechnology in Action: Bridging the Gap from the Bench to the Industry: 78 attendees |
| Year(s) Of Engagement Activity | 2024 |
| Description | Webinar 2 - From Waste to Wealth |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Webinar from: Dr Neil Dixon and Micaela Chacon University of Manchester 'From Waste to Wealth' 74 attendees |
| Year(s) Of Engagement Activity | 2024 |
| Description | Webinar 3 - Sustainability from Salinity - The Promise of Halophile Fermentation for Biopolymer Production |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Webinar 3 Dr James Winterburn and Phavit Wongsirichot University of Manchester "Sustainability from Salinity - The Promise of Halophile Fermentation for Biopolymer Production" 64 attendees |
| Year(s) Of Engagement Activity | 2024 |
| Description | Webinar 4 - Repurposing serine integrases as tools for engineering biology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Femi Olorunniji and Alexandria Holland Liverpool John Moores University "Repurposing serine integrases as tools for engineering biology" 37 attendees |
| Year(s) Of Engagement Activity | 2024 |
| Description | Webinar 5 - Digital Enzyme Evolution |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Andrew Currin and Tim Eyes Imperagen "Digital Enzyme Evolution" 134 attendees |
| Year(s) Of Engagement Activity | 2024 |
