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Industrial Biotechnology Innovation Cluster

Lead Research Organisation: University of Manchester
Department Name: Chem Eng and Analytical Science

Abstract

Industrial Biotechnology (IB) is a set of cross-disciplinary technologies that uses biological resources for producing and processing everyday products such as food, fuels, and medicines. The field is poised for dramatic growth and has the potential to disrupt markets worth more than £34bn in the UK alone. A confluence of consumer demand, Government carbon emission targets, feedstock production efficiencies, fundamental and technical innovation has created a perfect situation for the industry to significantly expand. This paradigm shift capitalises on the strengths of a vast range of scientific and engineering disciplines which form the foundation for leveraging the rapid, specialised, and competitive growth of the sector.

Industrial Biotechnology is an area in which the North-West (NW) of England has critical mass and is rapidly emerging as a world leading cluster. The region is home to some of the world's biggest healthcare and biomanufacturing companies, including AstraZeneca, Teva, Croda and Unilever, and the first commercial production of a biologic was in Speke with Eli Lilly's manufacture of insulin. The NW is home to several SME innovation zones, including Daresbury, Liverpool Knowledge Quarter and Alderley Park, which is the UK's largest single site life science campus. IB in the region employs 25,000 people and has a turnover of over £6Bn. The HEI sector is also thriving and recognised for its internationally leading IB research and unique facilities, purpose-built for innovation. Most recently demonstrated by the University of Manchester's Queens Anniversary Prize for higher education, which recognised the world-leading biotechnology expertise of the Manchester Institute of Biotechnology that sign-posts towards a bio industrial revolution. Translating IB to meet urgent societal needs will not happen spontaneously; an integrated strategy, cluster of translational activity and innovation ecosystem are essential.

The NW has co-location of organisations, knowledge, skills and facilities which have already demonstrated they can promote connection and collaboration - enabling those in the region to operate more flexibly and productively. Here, we will concentrate and build our regional strengths in academia, business, civic partners, accelerators, investors and creatives with civil society and establish the Industrial Biotechnology Innovation Cluster (IBIC) with the aim of accelerating commercial exploitation of our outputs and delivering economic, social and scientific impact. United by a culture of ethics, diversity, and openness, the cluster will provide businesses with access to cutting-edge R&D knowledge, capabilities and infrastructure as well as innovation finance, skills training, and specialist support and advice. IBIC will be led by The University of Manchester and headquartered in the new Innovation District in Manchester - at the heart of the north's growing economy. It has been co-created with the University of Liverpool and our wider Civic and Business Partners. It is fully aligned with Greater Manchester and Liverpool Civic Partners strategies to increase the benefit and accelerate the impact of fundamental research across the region, and more broadly the UK economy and society. IBIC will enable the UK to realise its ambition to be a global biotechnology research and innovation superpower.

The IBIC is expected to directly stimulate £2.5M cash and £4M in-kind co-investment, establish 150 collaborative projects, train 200+ students to enter careers within IB, create up to 100 green jobs, and establish 20+ new commercial ventures attracting a further £10M in investment to the North-West, generating as a minimum 3:1 economic return to public investment over the medium term. It will have a long-term legacy by helping establish IBIC as an independent and business-led cluster of excellence and by enabling society to overcome challenges in energy security, disease, and hunger mitigation.

Publications

10 25 50
 
Description Brewing a sustainable future: unlocking the potential of spent grains
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL https://www.manchester.ac.uk/about/news/brewing-a-sustainable-future-unlocking-the-potential-of-spen...
 
Description Building the Bioeconomy
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL https://blog.policy.manchester.ac.uk/sci-tech/2024/08/building-the-bioeconomy/
 
Description Future Feedstocks for Sustainable Chemical Manufacturing
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL https://www.manchester.ac.uk/about/news/shaping-tomorrows-biomanufacturing-future-feedstocks/
 
Description Regional Policy for Biomanufacturing in the North-West Chemical Sector
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL https://blog.policy.manchester.ac.uk/sci-tech/2024/10/regional-policy-for-biomanufacturing-in-the-no...
 
Description Shaping tomorrow's biomanufacturing: people, capabilities, and infrastructure
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL https://www.manchester.ac.uk/about/news/shaping-tomorrows-biomanufacturing-people-capabilities-and-i...
 
Description Shaping tomorrow's biomanufacturing: skills, training, and diversity
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
URL https://www.manchester.ac.uk/about/news/shaping-tomorrows-biomanufacturing-skills-training-and-diver...
 
Description Mechanic Activation of Enzymes 
Organisation Unilever
Country United Kingdom 
Sector Private 
PI Contribution Set up grant call and help connect the partners
Collaborator Contribution Collaboration between The University of Liverpool and Unilever PLC
Impact ongoing
Start Year 2024
 
Description Right time, right place: optimising a drug delivery platform for endometriosis 
Organisation Seda Pharmaceutical Development Services
Country United Kingdom 
Sector Private 
PI Contribution Grant call set up and introduced collaboration partnership
Collaborator Contribution Collaboration between the University of Manchester and SEDA
Impact Ongoing
Start Year 2024
 
Description Commercial Development Fund Launch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Event organised with talks and panel discussion highlighting the routes and opportunities open to commercialse research, and culminating with the launch of IBICs Commercial Development Fund.
Year(s) Of Engagement Activity 2025
 
Description Dedicated IBIC ICURe Discovery Programme 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dedicated ICURe Discovery programme with 10 individuals/teams from across the NW HEI community, learning about how to commercialise their research, doing customer discovery and ending in everyone pitching their business plan to a panel of external VCs, TTO reps and entrepreneurs to win one of three Innovations Awards.

One company who one 2nd place award has since incorporated and taking SEIS investment, while three others are exploring options and securing IP through their relevant TTOs.
Year(s) Of Engagement Activity 2024
 
Description Foresight Mapping Workshop - Shaping tomorrow's biomanufacturing: people, capabilities, and infrastructure 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Roundtable Discussion with a panel of industrialists from various sectors discussing current and future needs. Help share policy influencing ask and further activities of IBIC.
Year(s) Of Engagement Activity 2024
 
Description Foresight mapping workshop - Shaping tomorrow's biomanufacturing: future feedstocks 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Roundtable Discussion with a panel of industrialists from various sectors discussing current and future needs. Help share policy influencing ask and further activities of IBIC,
Year(s) Of Engagement Activity 2024
 
Description Foresight mapping workshop - Shaping tomorrow's biomanufacturing: skills, training, and diversity 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Roundtable Discussion with a panel of industrialists from various sectors discussing current and future needs. Help share policy influencing ask and further activities of IBIC.
Year(s) Of Engagement Activity 2024
 
Description IBIC @MMU Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact IBIC Workshop presenting our activity and open opportunities to spark ideas and engagement for knowledge exchange and commercialisation activities.
Year(s) Of Engagement Activity 2024
 
Description Industrial Biotechnology Launch Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Industrial Biotechnology launch Event. Stakeholders attending hear about the need to transition chemical and material manufacturing away from fossil fuel based supply chains and that biotechnology/engineering biology is an avenue able to offer these solutions. Key stakeholders included national and regional Government representatives, UKRI, industrialists (corporate and SMEs) and academics. Raised awareness of technology, challenges, opportunities and our grant programme.
Year(s) Of Engagement Activity 2024
 
Description Microbreweries Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact A workshop held at the University of Salford and their pilot plant brewing facility to showcase our regional academic research in turning waste feedstocks from the brewing industry into value added chemicals. Aims was to build partnerships between academics and brewing industry. To date this has led to many discussions and 3 collaborative projects starting. Impact is ongoing.
Year(s) Of Engagement Activity 2024
 
Description NW Academic Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact NW Academic networking workshop where academics, PDRAs and PhD students from across 5 different universities met, shared recent research and talked to find overlapping areas of mutual interest and collaboration opportunities as well as shape future IBIC programme and grant calls.
Year(s) Of Engagement Activity 2024
 
Description North West Build A Biotech Competition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Event supported and coordinated by IBIC to train PhD students in generating tangible economic impact from their research through venture creation. Ran 3 training sessions, matched the 10 teams (selected from 46 applications) to external mentors and the programme culminated in short Dragons Den style business pitching to an external expert panel, with three awards being given to individuals/teams.

The team in second place has since incorporated, with the first placed team in the process of spinning out, and the third placed team generating proof of principle data to support his business plan.
Year(s) Of Engagement Activity 2024
 
Description Research to Impact Liverpool 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact 16 PhD students and PDRAs from The Universities of Liverpool and Liverpool John Moores engaged in a half day workshop highlighting the different potential paths of delivering tangible impact from their research.
Year(s) Of Engagement Activity 2024
 
Description Research to Impact Workshop in Manchester 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact 16 PhD students and PDRAs from The Universities of Manchester, Salford, Bolton and Manchester Metropolitan engaged in a half day workshop highlighting the different potential paths of delivering tangible impact from their research.
Year(s) Of Engagement Activity 2024
 
Description Webinar 1 - Biotechnology in Action: Bridging the Gap from the Bench to the Industry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Dr Alejandra Diaz De Rienzo and Danny Wales, University of Salford; Biotechnology in Action: Bridging the Gap from the Bench to the Industry: 78 attendees
Year(s) Of Engagement Activity 2024
 
Description Webinar 2 - From Waste to Wealth 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Webinar from:
Dr Neil Dixon and Micaela Chacon
University of Manchester
'From Waste to Wealth'
74 attendees
Year(s) Of Engagement Activity 2024
 
Description Webinar 3 - Sustainability from Salinity - The Promise of Halophile Fermentation for Biopolymer Production 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Webinar 3
Dr James Winterburn and Phavit Wongsirichot
University of Manchester
"Sustainability from Salinity - The Promise of Halophile Fermentation for Biopolymer Production"
64 attendees
Year(s) Of Engagement Activity 2024
 
Description Webinar 4 - Repurposing serine integrases as tools for engineering biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Femi Olorunniji and Alexandria Holland
Liverpool John Moores University
"Repurposing serine integrases as tools for engineering biology"
37 attendees
Year(s) Of Engagement Activity 2024
 
Description Webinar 5 - Digital Enzyme Evolution 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Andrew Currin and Tim Eyes
Imperagen
"Digital Enzyme Evolution"
134 attendees
Year(s) Of Engagement Activity 2024