Use of Dynamic Nuclear Polarisation Nuclear Magnetic Resonance (DNP NMR) for Advanced Solid-State Structural Characterisation of Active Pharmaceutical

Lead Research Organisation: University of Nottingham
Department Name: Sch of Chemistry

Abstract

molecular structure and dynamics of a broad range of systems from heterogeneous materials to biological materials. In some situations the solid-state NMR can suffer from low sensitivity, because of the small nuclear spin polarizations involved, so that long acquisition times or large samples volumes are required. However, weak NMR signals can be dramatically enhanced by dynamic nuclear polarization (DNP), which involves transfer of electron spin polarization from radicals implanted in the sample to nearby nuclei. The substantial enhancements (up to 300-fold) obtained with DNP make NMR studies of dilute species feasible for the first time and have already prompted exciting new NMR applications to interfaces, porous materials and microcrystalline substances.

The University of Nottingham has recently established a DNP-enhanced solid-state NMR Facility funded by a grant of £2.5m from EPSRC. In this collaboration with GSK DNP-enhanced solid-state NMR will be used to study pharmaceutical formulations and drug delivery systems. These are challenging systems to study by solid-state NMR because of the low concentration of the active pharmaceutical ingredient (API). However, the substantial signal enhancements obtained with DNP will allow natural abundance investigations of changes to polymorphs or hydration states of APIs and excipients which include fillers, binders, lubricants and preservatives, as well as drug delivery vehicles.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/R512059/1 30/09/2017 30/03/2023
1934928 Studentship EP/R512059/1 30/09/2017 30/08/2018 Sarah Brooks