Using field pathogenomics to study wheat yellow rust dispersal and population dynamics at a national and international scale
Lead Research Organisation:
John Innes Centre
Department Name: Crop Genetics
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Planned Impact
PI Saunders will lead the impact plan that will be an agenda item at monthly project meetings with Co-I's. All Co-I's have excellent track records in communicating the outcomes of their research to a broad audience and sharing tools, resources and code in a free and open manner. The PI and Co-I's also are regularly invited to speak about their research at national/international meetings and at various other venues.
Beneficiaries include:
Those involved in wheat yellow rust surveillance such as the UK cereal pathogen virulence survey (funded by Fera and the HGCA). They will benefit from development of high-resolution genotyping methods that will be incorporated into the UKCPVS. During the project, information will also be relayed to the UKCPVS as soon as relevant and reported in the NIAB-TAG's quarterly journal (Landmark) to reach the > 3000 NIAB-TAG members including agronomists, breeders and farmers.
Researchers working with wheat yellow rust disease. All data will be made freely available where practical, at the earliest opportunity. The data will initially be hosted via a modified version of the TGAC http://opendata.tgac.ac.uk website to ensure rapid release under a creative commons license. Once submitted for publication all data will be deposited in public repositories and linked to via the project-specific website.
Farmers, breeders, agronomists and wheat variety testing authorities will benefit from the rapid means of confirming whether previously resistant wheat varieties have been broken by virulent races of the pathogen. Our research will also confirm outbreaks on particular wheat varieties and look for associations between pathogen genotypes and host pedigrees. Participation of four major UK wheat breeders (KWS, Limagrain, Syngenta, RAGT) as partners reflects the urgency of the problem. Understanding the underlying variation and how this affects resistance breeding is essential for the strategic planning required to produce high-yielding wheat varieties that will be resistant when deployed in 10 years (considering time between initial crossing and variety release). This may also lead directly to management decisions on how to effectively manage the threat of PST to UK wheat production. This audience will be reached through publications in the farming press. For instance, results from our preliminary study have already been reported in EDP24, the HGCA newsletter, NIAB-TAG bulletin, world-grain.com, Farmers Guardian, Agrii company newsletter, EADT24 and the Crop Production Magazine.
Population geneticists. Where possible new tools and data analysis pipelines generated herein will be integrated into the interactive Galaxy user interface to ensure they are accessible to the widest demographic, that includes bench biologists. All tools and pipelines once verified will be publically released without delay.
The general public will benefit from interactions with the PI and Co-I's, who have given talks to public audiences on a variety of issues such as plant biosecurity. They will specifically focus on further educating the public on genome science and pathogen dispersal in relation to plant pathogens and the crops they infect. They will give at least one talk to a public audience relating to this project, at least once per year.
The PDRA's, programmer and RA recruited for this project will benefit from improved skills, knowledge and experience gained from the research and wider training. This will contribute to their future economic activity in the public and/or private sectors. The innovative nature of the project ensures these individuals will likely develop unique skills that should prove highly attractive in the marketplace. This proposal also brings together an array of disciplines that will provide an exciting training ground for a cadre of excellent young scientists. This will contribute to the next generation of skilled crop scientists, with benefits beyond the immediate outcomes of this project
Beneficiaries include:
Those involved in wheat yellow rust surveillance such as the UK cereal pathogen virulence survey (funded by Fera and the HGCA). They will benefit from development of high-resolution genotyping methods that will be incorporated into the UKCPVS. During the project, information will also be relayed to the UKCPVS as soon as relevant and reported in the NIAB-TAG's quarterly journal (Landmark) to reach the > 3000 NIAB-TAG members including agronomists, breeders and farmers.
Researchers working with wheat yellow rust disease. All data will be made freely available where practical, at the earliest opportunity. The data will initially be hosted via a modified version of the TGAC http://opendata.tgac.ac.uk website to ensure rapid release under a creative commons license. Once submitted for publication all data will be deposited in public repositories and linked to via the project-specific website.
Farmers, breeders, agronomists and wheat variety testing authorities will benefit from the rapid means of confirming whether previously resistant wheat varieties have been broken by virulent races of the pathogen. Our research will also confirm outbreaks on particular wheat varieties and look for associations between pathogen genotypes and host pedigrees. Participation of four major UK wheat breeders (KWS, Limagrain, Syngenta, RAGT) as partners reflects the urgency of the problem. Understanding the underlying variation and how this affects resistance breeding is essential for the strategic planning required to produce high-yielding wheat varieties that will be resistant when deployed in 10 years (considering time between initial crossing and variety release). This may also lead directly to management decisions on how to effectively manage the threat of PST to UK wheat production. This audience will be reached through publications in the farming press. For instance, results from our preliminary study have already been reported in EDP24, the HGCA newsletter, NIAB-TAG bulletin, world-grain.com, Farmers Guardian, Agrii company newsletter, EADT24 and the Crop Production Magazine.
Population geneticists. Where possible new tools and data analysis pipelines generated herein will be integrated into the interactive Galaxy user interface to ensure they are accessible to the widest demographic, that includes bench biologists. All tools and pipelines once verified will be publically released without delay.
The general public will benefit from interactions with the PI and Co-I's, who have given talks to public audiences on a variety of issues such as plant biosecurity. They will specifically focus on further educating the public on genome science and pathogen dispersal in relation to plant pathogens and the crops they infect. They will give at least one talk to a public audience relating to this project, at least once per year.
The PDRA's, programmer and RA recruited for this project will benefit from improved skills, knowledge and experience gained from the research and wider training. This will contribute to their future economic activity in the public and/or private sectors. The innovative nature of the project ensures these individuals will likely develop unique skills that should prove highly attractive in the marketplace. This proposal also brings together an array of disciplines that will provide an exciting training ground for a cadre of excellent young scientists. This will contribute to the next generation of skilled crop scientists, with benefits beyond the immediate outcomes of this project
Organisations
- John Innes Centre (Lead Research Organisation)
- Bayer (Collaboration)
- RAGT Seeds (Collaboration)
- KWS UK (Collaboration)
- Punjab Aricultural University (Collaboration)
- International Centre for Maize and Wheat Improvement (CIMMYT) (Collaboration)
- International Center for Agricultural Research in the Dry Areas (Collaboration)
People |
ORCID iD |
Cristobal Uauy (Principal Investigator) |
Publications
Alemu SK
(2021)
Genome-wide association mapping identifies yellow rust resistance loci in Ethiopian durum wheat germplasm.
in PloS one
Bansal M
(2020)
Aegilops umbellulata introgression carrying leaf rust and stripe rust resistance genes Lr76 and Yr70 located to 9.47-Mb region on 5DS telomeric end through a combination of chromosome sorting and sequencing.
in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Bansal M
(2021)
A robust KASP marker for selection of four pairs of linked leaf rust and stripe rust resistance genes introgressed on chromosome arm 5DS from different wheat genomes.
in Molecular biology reports
Benbow HR
(2020)
Insights into the resistance of a synthetically-derived wheat to Septoria tritici blotch disease: less is more.
in BMC plant biology
Bentley AR
(2022)
Near- to long-term measures to stabilize global wheat supplies and food security.
in Nature food
Corredor-Moreno P
(2022)
Temporally coordinated expression of nuclear genes encoding chloroplast proteins in wheat promotes Puccinia striiformis f. sp. tritici infection.
in Communications biology
Dobon A
(2016)
The host-pathogen interaction between wheat and yellow rust induces temporally coordinated waves of gene expression.
in BMC genomics
Getie B
(2016)
Identification and mapping of resistance to stem rust in the European winter wheat cultivars Spark and Rialto
in Molecular Breeding
Goddard R
(2020)
Dissecting the genetic basis of wheat blast resistance in the Brazilian wheat cultivar BR 18-Terena.
in BMC plant biology
Description | Field pathogenomic approaches have been developed to identify pathogen races in the field and through an early detection method. The approach was winner of the BBSRC Innovator of the Year award (Dr. Diane Saunders) and has garnered much international attention as well. The method is now routinely applied in UK surveillance. |
Exploitation Route | New methods emerged, such as MARPLE, and this is now being used by UKCPVS. |
Sectors | Agriculture Food and Drink Chemicals |
URL | https://acaciaafrica.org/marple-diagnostics-a-pioneering-step-in-ethiopian-wheat-rust-management/ |
Description | New approaches such as MARPLE and also implementation as part of the UK Cereal Pathogen Virulence Survey. |
First Year Of Impact | 2015 |
Sector | Agriculture, Food and Drink,Environment |
Impact Types | Societal Policy & public services |
Description | Leveraging genetic innovations for accelerated breeding of climate resilient and nutritious crops |
Amount | £1,300,000 (GBP) |
Organisation | Foreign Commonwealth and Development Office (FCDO) |
Sector | Public |
Country | United Kingdom |
Start | 01/2024 |
End | 12/2026 |
Description | A meeting between CIMMYT and DFW funded by BMGF to discuss collaboration projects |
Organisation | International Centre for Maize and Wheat Improvement (CIMMYT) |
Country | Mexico |
Sector | Charity/Non Profit |
PI Contribution | I organised a meeting funded by Bill and Melinda Gates Foundation brought together members of the BBSRC's coordinated wheat programme (Designing Future Wheat) with members of CIMMYT (who breed wheat for the resource poor in the developing world), discuss potential opportunities for interaction. These opportunities are taken forward by writing proposals for Newton , GCRF or IWYP funding calls |
Collaborator Contribution | See above |
Impact | This interaction is still ongoing between members of BBSRC's coordinated wheat programme (Designing Future Wheat) and researchers within CIMMYT with proposals being written for IWYP and Newton calls |
Start Year | 2018 |
Description | Bayer |
Organisation | Bayer |
Department | Bayer CropScience Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Wheat genetics and genomics |
Collaborator Contribution | Wheat breeding and molecular knowledge |
Impact | joint projects |
Start Year | 2012 |
Description | Bayer |
Organisation | Bayer |
Department | Bayer CropScience Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Wheat genetics and genomics |
Collaborator Contribution | Wheat breeding and molecular knowledge |
Impact | joint projects |
Start Year | 2012 |
Description | CGIAR |
Organisation | International Center for Agricultural Research in the Dry Areas |
Country | Syrian Arab Republic |
Sector | Charity/Non Profit |
PI Contribution | Provide molecular markers for yellow rust and blast resistance genes; provide germplasm with improved traits. |
Collaborator Contribution | provide field phenotyping and delivery into wheat cultivars |
Impact | n/a |
Start Year | 2013 |
Description | CGIAR |
Organisation | International Centre for Maize and Wheat Improvement (CIMMYT) |
Country | Mexico |
Sector | Charity/Non Profit |
PI Contribution | Provide molecular markers for yellow rust and blast resistance genes; provide germplasm with improved traits. |
Collaborator Contribution | provide field phenotyping and delivery into wheat cultivars |
Impact | n/a |
Start Year | 2013 |
Description | KWS |
Organisation | KWS UK |
Country | United Kingdom |
Sector | Private |
PI Contribution | Genetics and genomics |
Collaborator Contribution | Breeder know how and germplasm |
Impact | joint projects |
Start Year | 2009 |
Description | Punjab Agricultural University |
Organisation | Punjab Aricultural University |
Country | India |
Sector | Academic/University |
PI Contribution | Know how on wheat genomics and genetics, training. |
Collaborator Contribution | Gernplasm, local knowledge |
Impact | Have helped partners implement marker technology. |
Start Year | 2011 |
Description | RAGT |
Organisation | RAGT Seeds |
Country | United Kingdom |
Sector | Private |
PI Contribution | Genetics and genomics |
Collaborator Contribution | Wheat germplasm and know how |
Impact | Shared projects |
Start Year | 2009 |
Title | GENES ASSOCIATED WITH RESISTANCE TO WHEAT YELLOW RUST |
Description | The invention relates to genes associated with disease resistance in plants. According to an aspect of the invention is provided an isolated nucleic acid encoding a nucleotide-binding and leucine-rich repeat (NLR) polypeptide comprising a zinc-finger BED domain, wherein expression of the NLR polypeptide in a plant confers or enhances resistance of the plant to a fungus, for example wheat yellow (stripe) rust fungus Puccinia striiformisi f. sp. tritici. |
IP Reference | WO2019197408 |
Protection | Patent application published |
Year Protection Granted | 2019 |
Licensed | No |
Impact | Wheat yellow rust resistance genes. |
Description | Agricultural Industries Confederation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | Agribusiness Meeting: A step change in plant breeding to achieve a UK competitive advantage |
Year(s) Of Engagement Activity | 2016 |
Description | Australian, UK scientists solve 30-year wheat rust genetics puzzle |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Australian, UK scientists solve 30-year wheat rust genetics puzzle |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.eurekalert.org/pub_releases/2018-08/uos-aus082418.php |
Description | Discussion Norman Lamb, MP |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Discussion Norman Lamb, MP |
Year(s) Of Engagement Activity | 2017 |
Description | Discussion with Gov Office Science |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Discussion with Gov Office Science |
Year(s) Of Engagement Activity | 2017 |
Description | JIC Open day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | JIC Open Day |
Year(s) Of Engagement Activity | 2018 |
Description | Penny Mordaunt, Secretary of State for International Development. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Policymakers/politicians |
Results and Impact | Penny Mordaunt, Secretary of State for International Development. |
Year(s) Of Engagement Activity | 2018 |
Description | Rachel Lambert, Senior Livelihoods Adviser, Agriculture Research DFID |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Policymakers/politicians |
Results and Impact | Rachel Lambert, Senior Livelihoods Adviser, Agriculture Research DFID |
Year(s) Of Engagement Activity | 2018 |