Mathematical models of experimental microbial evolution
Lead Research Organisation:
University of Bath
Department Name: Mathematical Sciences
Abstract
My research lies at the interface of ecology and evolution and is focused around two key questions in evolutionary ecology: 'What determines species diversity?' and 'How did cooperative behaviour evolve?' These questions are among 25 unsolved problems facing the scientific community over the coming decade highlighted in the 125th anniversary issue of Science. The Science issue also stressed that the advancement of our understanding of the issues relating to the above questions requires a 'major interdisciplinary' effort and this is precisely what my fellowship will address. The fellowship is a collaboration between myself as a mathematical modeller and a group of experimental microbial population biologists namely Dr A Buckling, University of Oxford; Dr T Ferenci, University of Sydney; Professor P Rainey, University of Auckland; and Dr C MacLean, Imperial College London. I will be based at the University of Bath where I will work on the development of mathematical models for a range of projects designed to explore ecological mechanisms involved in the evolution of diversity and cooperation. The studies will be conducted by bringing to bare modern techniques of mathematical analysis and computation on the microbial evolutionary experiments of my collaborators.
Organisations
People |
ORCID iD |
Ivana Gudelj (Principal Investigator) |
Publications
Beardmore RE
(2011)
Metabolic trade-offs and the maintenance of the fittest and the flattest.
in Nature
Estrela S
(2010)
Evolution of cooperative cross-feeding could be less challenging than originally thought.
in PloS one
Gudelj I
(2016)
Stability of Cross-Feeding Polymorphisms in Microbial Communities.
in PLoS computational biology
Gudelj I
(2007)
Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments.
in Journal of evolutionary biology
Gudelj I
(2010)
An integrative approach to understanding microbial diversity: from intracellular mechanisms to community structure.
in Ecology letters
Levert M
(2010)
Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections.
in PLoS pathogens
Lindsay RJ
(2016)
Harbouring public good mutants within a pathogen population can increase both fitness and virulence.
in eLife
MaClean RC
(2010)
A mixture of "cheats" and "co-operators" can enable maximal group benefit.
in PLoS biology
Maharjan R
(2013)
The form of a trade-off determines the response to competition.
in Ecology letters
Meyer JR
(2015)
Biophysical mechanisms that maintain biodiversity through trade-offs.
in Nature communications