Microscale devices for detection of key pollutants in the built environment

Lead Research Organisation: University of York
Department Name: Chemistry

Abstract

Polar volatile organic compounds (pVOC) have a profound impact on the functioning of the atmosphere and many are also toxic airborne pollutants. They are however very difficult to measure, being sticky, reactive and in some cases thermally unstable. These same species are also very significant in the built environment, negatively influencing indoor air quality, malodours, human health and contributing to costly effects such as sick building syndrome. Through previous NERC support we developed a unique microfluidic approach to measuring trace levels of pVOCs in the atmosphere. We achieved this using a novel lab-on-a-chip technology that allows for a highly efficient chemical derivatization of pVOCs in the gas phase, which in simple terms converts the target molecules into more stable forms that are much easier to detect. Once derivatised, pVOCs can then be measured using common analytical techniques such as gas chromatography and mass spectrometry, instruments that are found in most modern chemical laboratories.

The key to our new technology is a micro-reactor that integrates together three laboratory functions: (1) a gas and liquid mixer and reactor, where derivatization takes place, (2) controlled reagent heating to speed up the analysis, and (3) sample pre-concentration to enable lower detection limits. The output from the micro-reactor is a microlitre effluent stream of processed sample that has stripped the pVOCs from the gas phase into a stable and highly concentrated liquid form, and that is ready for direct introduction to Gas Chromatography-Mass Spectrometry (GC-MS) or other technique. The micro-reactor can be completely automated and provides a highly effective solution to an otherwise multi-step, manual analytical procedure by providing a fast and highly efficient derivatization reaction at elevated temperatures, and using very low chemical volumes

The assessment of pVOCs in the gas phase in the built environment is a widespread problem with significant economic impacts, and for which here are few effective technical solutions. These chemicals are emitted from furniture, carpets, paints and building construction materials in general and there have been significant new regulatory requirements introduced in the EU, USA and China in recent years that have created a major but as yet unmet demand for simple and efficient measurement methods. Any product sold for the built environment in the EU must comply with the very recent 2013 Construction Productn Regulation Directives before it can be put on sale and a supplier must demonstrate this either by testing their products in-house, or outsourcing the analysis to third-party laboratories.

Our proposed innovation for follow-on funding is therefore to take a technology developed for a niche area of atmospheric chemistry and translate this into a urgently required turn-key sample preparative product for the analytical industries associated with gaseous emissions materials testing and the built environment. We plan to complete the technical implementation of a fully functional prototype device and work with commercial partners to develop demonstration activities for particular industriesWe identify that the global market for such specialised analytical devices is relatively modest (measured in hundreds to low thousands of units), but that the improved lower-cost testing leads to improved product competitiveness, with much wider economic impacts . The societal and economic impact of the innovation should therefore be viewed more widely than simply the commercial revenue that might be obtained from device sales alone.

Planned Impact

An improved ability to detect pVOCs ultimately has benefits for public health, since their control and regulation is for reasons of health and well-being. The recent introduction of new regulations reflects both the growing body of evidence about health impacts (such as respiratory disease and long term cancer risk) and is a response to the increasing risk of accumulation of chemicals within buildings as they become more airtight as a consequence of energy efficiency measures. Improved testing of a wider range of chemicals is therefore likely to lead to more general reductions in VOC exposure within homes and workplaces.

Instrumental methods to detect difficult-to-measure chemicals are essential to the functioning of a wide range of laboratory and field applications, and there is potential for our innovative analytical device to operate in many different markets that require the measurement of polar compounds in gas phase matrices. These markets include flavour and fragrances, fuels and lubricants, security and defence and personalised healthcare, all of which have some critical dependencies on knowing volatile organic compound composition in gas phase mixtures. We are specifically prioritising however small carbonyl compounds, since these are commonly emitted (and accumulate) within the built environment, and are subject to recent legislative changes that demand improved measurements from suppliers of materials for use indoors due to their impact on the health and wellbeing of individuals. We see this as a uniquely timely opportunity to introduce new ideas and concepts developed for atmospheric chemistry research into a new discipline area, and we have a technical solution to a difficult measurement problem that is more automated, more sensitive and has lower operating costs than competing approaches. We prioritise the development of a micro-fluidic derivatising tool as an turn-key peripheral device, since this matches well with existing supply pathways and allows us to retrofit onto existing standard laboratory GC-MS as well as support integrated new equipment bundles.

For the in-house and contract laboratories who adopt our technology, this will improve the ability to detect trace levels of key chemicals, increase sample throughput and, by extension, reduce the cost per analysis. The availability of an automated and lower-cost methodology will lower barriers to market for the supply chain associated with the built environment. Since all materials to be sold for use in the EU now require testing, the measurement requirement and its associated costs become a barrier to new product introductions, particularly for smaller companies without in-house testing capabilities. For such companies, an improved analytical methodology, which can be used in-house or procured from contract laboratories, will help overcome the regulatory hurdles for VOC emissions and so bring products to market at lower cost.

Publications

10 25 50
 
Description A new method for the simple detection of airborne and liquid phase aldehydes of interest for environment science and also for indoor air quality. A new analytical method has beed developed for commercialisation allowing for a wider range of these pollutant types to be measured on industry standard GC-MS equipment. In addition new methods for the calibration of OVOCs have been developed and this also commercialised.
Exploitation Route Likely to be used in multiple sectors beyond environmental science, since aldehydes are of interest in many other science areas. Current interest from consumer products companies in using the method to help quantify malodour.
Sectors Chemicals

Environment

 
Description Methods developed in this project have been adopted and commercialised by Anatune Ltd and supplied to a range of customers in the UK analytical sciences industry.
First Year Of Impact 2017
Sector Chemicals,Energy,Environment
Impact Types Economic

 
Description Emerging sensor technologies for developing countries
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Development work on low cost sensors has been influential in setting the national and international agenda and NCAS has provided guidelines for the use of sensors for air pollution measurement in developing countries. Publications on the performance of sensors have been used by the World Meteorological Organisation in an advice note to governments on the application of sensors. Evidence has been provided to Defra and to Go-Science in the UK on the applicability and use of low cost NO2 sensors for regulatory measurements.
 
Description WMO Guidance document on the use of low cost sensors system for air pollution.
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a guidance/advisory committee
Impact Research in the project led to new insight into the performance of lower cost sensing systems for air pollution measurement. This turn was used within a WMO guidelines document issued to the public and national agencies on the best use of sensors for pollution detection.
URL https://www.wmo.int/pages/prog/arep/gaw/documents/Low_cost_sensors_post_review_final.pdf
 
Description Hazards airborne tracer detection
Amount £120,000 (GBP)
Organisation Defence Science & Technology Laboratory (DSTL) 
Sector Public
Country United Kingdom
Start 03/2018 
End 08/2018
 
Description Industrial funding, online mass spectrometry
Amount £250,000 (GBP)
Organisation Anatune 
Sector Private
Country United Kingdom
Start 06/2017 
End 12/2020
 
Description Study of VOCs in indoor air
Amount £92,000 (GBP)
Organisation Givaudan 
Sector Private
Country Switzerland
Start 02/2018 
End 02/2020
 
Description Indoor air pollution assessment 
Organisation Givaudan
Country Switzerland 
Sector Private 
PI Contribution Development and application of methods to assess air pollution in UK homes.
Collaborator Contribution Provision of product devices and access to panel cohort to allow for testing in 60 homes in UK.
Impact Papers on indoor air pollution and emissions: DOI https://doi.org/10.1039/D2EM00444E DOI https://doi.org/10.1039/D0EM00504E
Start Year 2017
 
Title Designs for the calibration of OVOCs in humid matrices 
Description A design and software for an analytical device that allows the generation of low concentrations of polar OVOC compounds in ambient air has been developed. This has been licensed to an instrument manufacturer and is now offered for sale worldwide. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2019
Licensed Yes
Impact Licensing income of £60,000 has been received, plus an unkind donation of a new £200,000 mass spectrometry instrument
 
Description Hay Festival 2018, lecture and short animation. Collaboration between Ally Lewis and Aardman Animations 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Hay Festival 2018, lecture and short animation. Collaboration between Ally Lewis and Aardman Animations
Year(s) Of Engagement Activity 2018
URL https://www.hayfestival.com/p-13836-aardmans-dan-binns-and-ally-lewis-talk-to-andy-fryers.aspx
 
Description Lectures/talks/debates 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Three public lecture given on 'atmospheric pollution, from kerbside to global', part of the John Jeyes Award lecture series.
RSC Public lecture series on air pollution.
Year(s) Of Engagement Activity 2013,2015
URL https://www.youtube.com/watch?v=WXspBhHcx2U
 
Description Online webinar 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Profession web seminar on the use of sift online MS technologies for trace detection of VOCs
Year(s) Of Engagement Activity 2018
 
Description Public Lectures on atmospheric science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presentation at Manchester Science Festival for the Penny University on air quality.
Presentation at Royal Society of Chemistry on air pollution
Presentation at York Festival of Science
Presentation at Cheltenham Science Festival
Presentation at Haye Festival
Year(s) Of Engagement Activity 2013,2014,2015