Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology
Lead Research Organisation:
University of Edinburgh
Department Name: Centre for Cardiovascular Science
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Planned Impact
Who will benefit and how?
The immediate beneficiaries will be the environmental and health regulatory agencies in China, (e.g., the State Environment and Health Working Group, the Ministry of Environmental Protection, and the National Health and Family Planning Commission) and Beijing in particular (e.g., Beijing Municipal Environmental Protection Bureau), responsible for mitigation of adverse air quality in China. The citizens of China will gain immediate health and well-being benefit from mitigation actions implemented as a result of findings from this project in association with findings form the other projects within this directed research programme. Health workers and other academics will benefit from the new information we generate on adverse effects on the cardiopulmonary system caused by air pollution generally and by specific pollutants and sources.
How will they benefit?
The proposed research will provide better understanding of the role of specific pollutants and sources, their mechanisms of action, and the likely effectiveness of interventions to reduce personal exposures. Our research is geared not only towards advancement of scientific knowledge about how high levels of air pollution from sources in Beijing impact cardiopulmonary health on a mechanistic level, but also on determining the impact of interventions on health through experimental design and modelling. In particular, we focus on examining the health effects of air pollution on susceptible populations with cardiovascular and reversible airway disease and the efficacy of measures that can be taken by citizens to reduce their exposure. Additionally, through the understanding that we will gain about where people are most exposed and the source types that contribute to their total personal exposure, we will provide information that can be used to more effectively target interventions - on a regional, local, residential, and individual level.
Regulatory agencies will benefit from this information so that they can design pollution, exposure, and health reduction strategies in a more cost-effective manner, and citizens, especially those with existing cardiovascular and respiratory disease, will benefit from the recommendations of personal-level strategies that we will investigate. Our project will provide information that can be considered by Theme 4 in developing practical policy solutions to reduce air pollution exposures.
Health workers will benefit from the new information we generate through the laboratory models and population studies; new understanding of the inter-relationships between exposure biomarkers, effect biomarkers and susceptibility biomarkers in the population, under conditions of Chinese mega-cities with identification of potentially susceptible subgroups with cardiopulmonary disease; improved understanding of the mechanisms of action or cardiopulmonary toxicity; and knowledge on how a relatively simple intervention to reduce personal exposure may improve short-term health effects, from which benefits of longer-term personal exposure reduction can also be inferred.
Dissemination
We will work with the other Theme 3 project on health effects and with the atmospheric pollution themes (1 and 2) and Theme 4 (Solutions) on developing workshops and stakeholder consultations to disseminate our information to regulatory authorities, non-governmental organisations, and other relevant stakeholders. These will be led by our Chinese partners. In addition, to the standard academic channels of dissemination through journal articles and conferences, we will develop information materials that can be distributed to patients on the health impacts of air pollution and means that they can take to reduce their exposures. These materials will be made available through hospitals and doctors.
The immediate beneficiaries will be the environmental and health regulatory agencies in China, (e.g., the State Environment and Health Working Group, the Ministry of Environmental Protection, and the National Health and Family Planning Commission) and Beijing in particular (e.g., Beijing Municipal Environmental Protection Bureau), responsible for mitigation of adverse air quality in China. The citizens of China will gain immediate health and well-being benefit from mitigation actions implemented as a result of findings from this project in association with findings form the other projects within this directed research programme. Health workers and other academics will benefit from the new information we generate on adverse effects on the cardiopulmonary system caused by air pollution generally and by specific pollutants and sources.
How will they benefit?
The proposed research will provide better understanding of the role of specific pollutants and sources, their mechanisms of action, and the likely effectiveness of interventions to reduce personal exposures. Our research is geared not only towards advancement of scientific knowledge about how high levels of air pollution from sources in Beijing impact cardiopulmonary health on a mechanistic level, but also on determining the impact of interventions on health through experimental design and modelling. In particular, we focus on examining the health effects of air pollution on susceptible populations with cardiovascular and reversible airway disease and the efficacy of measures that can be taken by citizens to reduce their exposure. Additionally, through the understanding that we will gain about where people are most exposed and the source types that contribute to their total personal exposure, we will provide information that can be used to more effectively target interventions - on a regional, local, residential, and individual level.
Regulatory agencies will benefit from this information so that they can design pollution, exposure, and health reduction strategies in a more cost-effective manner, and citizens, especially those with existing cardiovascular and respiratory disease, will benefit from the recommendations of personal-level strategies that we will investigate. Our project will provide information that can be considered by Theme 4 in developing practical policy solutions to reduce air pollution exposures.
Health workers will benefit from the new information we generate through the laboratory models and population studies; new understanding of the inter-relationships between exposure biomarkers, effect biomarkers and susceptibility biomarkers in the population, under conditions of Chinese mega-cities with identification of potentially susceptible subgroups with cardiopulmonary disease; improved understanding of the mechanisms of action or cardiopulmonary toxicity; and knowledge on how a relatively simple intervention to reduce personal exposure may improve short-term health effects, from which benefits of longer-term personal exposure reduction can also be inferred.
Dissemination
We will work with the other Theme 3 project on health effects and with the atmospheric pollution themes (1 and 2) and Theme 4 (Solutions) on developing workshops and stakeholder consultations to disseminate our information to regulatory authorities, non-governmental organisations, and other relevant stakeholders. These will be led by our Chinese partners. In addition, to the standard academic channels of dissemination through journal articles and conferences, we will develop information materials that can be distributed to patients on the health impacts of air pollution and means that they can take to reduce their exposures. These materials will be made available through hospitals and doctors.
Organisations
- University of Edinburgh (Lead Research Organisation)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Capital University of Medical Sciences (Collaboration)
- Heriot-Watt University (Collaboration)
- University of York (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- Edinburgh Napier University (Collaboration)
- Peking University (Collaboration)
- Institute of Occupational Medicine (IOM) (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
Publications
Campbell SJ
(2021)
Atmospheric conditions and composition that influence PM2.5 oxidative potential in Beijing, China
in Atmospheric Chemistry and Physics
Dong W
(2019)
Different cardiorespiratory effects of indoor air pollution intervention with ionization air purifier: Findings from a randomized, double-blind crossover study among school children in Beijing.
in Environmental pollution (Barking, Essex : 1987)
Duan J
(2018)
Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos.
in Nanotoxicology
Duan J
(2017)
Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model.
in The Science of the total environment
Duan J
(2017)
Multi-organ toxicity induced by fine particulate matter PM2.5 in zebrafish (Danio rerio) model.
in Chemosphere
Feng L
(2019)
Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway.
in Particle and fibre toxicology
Hu D
(2021)
Exposure to fine particulate matter promotes platelet activation and thrombosis via obesity-related inflammation.
in Journal of hazardous materials
Hu D
(2020)
Identification of potential markers for internal exposure to ambient ozone in oral cavity of healthy adults.
in Environmental research
Huang J
(2019)
Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE).
in Environment international
Description | See Researchfish submission by UK principal investigator (Miranda Loh, IOM) which includes findings from University of Edinburgh contribution. Research within the UoEd laboratories has led to new publication of findings across multiple partners in the programme. These findings may help us to identify which are the harmful constituents in airborne particles. |
Exploitation Route | See main submission by PI |
Sectors | Environment Healthcare Transport |
Description | The health and equity impacts of climate change mitigation measures on indoor and outdoor air pollution exposure (HEICCAM) |
Amount | £507,898 (GBP) |
Funding ID | NE/V002090/1 |
Organisation | Natural Environment Research Council |
Sector | Public |
Country | United Kingdom |
Start | 08/2020 |
End | 08/2024 |
Description | APIC - EPR work with Beijing PM - collaboration expanded |
Organisation | Institute of Occupational Medicine (IOM) |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Assessing the ability of Beijing pollution particles to generate oxidative stress |
Collaborator Contribution | Exchange of filters containing air pollution particles and air pollution monitoring data |
Impact | Collaboration has been expanded to include more groups within these universities, as well as addition samples, assays and analyses. Manuscript due to be prepared |
Start Year | 2019 |
Description | APIC - EPR work with Beijing PM - collaboration expanded |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Assessing the ability of Beijing pollution particles to generate oxidative stress |
Collaborator Contribution | Exchange of filters containing air pollution particles and air pollution monitoring data |
Impact | Collaboration has been expanded to include more groups within these universities, as well as addition samples, assays and analyses. Manuscript due to be prepared |
Start Year | 2019 |
Description | APIC - EPR work with Beijing PM - collaboration expanded |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Assessing the ability of Beijing pollution particles to generate oxidative stress |
Collaborator Contribution | Exchange of filters containing air pollution particles and air pollution monitoring data |
Impact | Collaboration has been expanded to include more groups within these universities, as well as addition samples, assays and analyses. Manuscript due to be prepared |
Start Year | 2019 |
Description | APIC - EPR work with Beijing PM - collaboration expanded |
Organisation | University of Edinburgh |
Department | Centre for Cardiovascular Science |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Assessing the ability of Beijing pollution particles to generate oxidative stress |
Collaborator Contribution | Exchange of filters containing air pollution particles and air pollution monitoring data |
Impact | Collaboration has been expanded to include more groups within these universities, as well as addition samples, assays and analyses. Manuscript due to be prepared |
Start Year | 2019 |
Description | APIC - EPR work with Beijing PM - collaboration expanded |
Organisation | University of York |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Assessing the ability of Beijing pollution particles to generate oxidative stress |
Collaborator Contribution | Exchange of filters containing air pollution particles and air pollution monitoring data |
Impact | Collaboration has been expanded to include more groups within these universities, as well as addition samples, assays and analyses. Manuscript due to be prepared |
Start Year | 2019 |
Description | Deng and Guo-panel studies in Beijing |
Organisation | Peking University |
Country | China |
Sector | Academic/University |
PI Contribution | Collaboration to establish panel studies to look at the cardiorespiratory effects of air pollution in human using panel study designs. Critical input and proof reading of manuscripts |
Collaborator Contribution | Practical aspects of panel studies. Student supervision in Beijing |
Impact | I published paper and 1 further manuscript under review |
Start Year | 2016 |
Description | Mark Ross, Napier - air pollution, exercise and facemasks |
Organisation | Edinburgh Napier University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Initiated collaboration to explore the cardiorespiratory effects of air pollution and whether these can be alleviated by wearing a facemask. UoEd provides cardiovascular expertise and will perform some of the biomarker measurements |
Collaborator Contribution | Napier Uni will bring expertise in exercise physiology and host the volunteer visits for the study. Institute of Occupational Medicine bring expertise into exposure science and will perform the personal measurements of air pollution |
Impact | Ethics application in preparation ahead of seeking funding to carry out the study. See above for different disciplines |
Start Year | 2018 |
Description | Mark Ross, Napier - air pollution, exercise and facemasks |
Organisation | Institute of Occupational Medicine (IOM) |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Initiated collaboration to explore the cardiorespiratory effects of air pollution and whether these can be alleviated by wearing a facemask. UoEd provides cardiovascular expertise and will perform some of the biomarker measurements |
Collaborator Contribution | Napier Uni will bring expertise in exercise physiology and host the volunteer visits for the study. Institute of Occupational Medicine bring expertise into exposure science and will perform the personal measurements of air pollution |
Impact | Ethics application in preparation ahead of seeking funding to carry out the study. See above for different disciplines |
Start Year | 2018 |
Description | Mark Ross, Napier - air pollution, exercise and facemasks |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Initiated collaboration to explore the cardiorespiratory effects of air pollution and whether these can be alleviated by wearing a facemask. UoEd provides cardiovascular expertise and will perform some of the biomarker measurements |
Collaborator Contribution | Napier Uni will bring expertise in exercise physiology and host the volunteer visits for the study. Institute of Occupational Medicine bring expertise into exposure science and will perform the personal measurements of air pollution |
Impact | Ethics application in preparation ahead of seeking funding to carry out the study. See above for different disciplines |
Start Year | 2018 |
Description | Matt Boyles - GRACIOUS - Oxidative stress assays |
Organisation | Heriot-Watt University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developing assays for oxidative stress. Exchange of particle test materials, including air pollution particles from APIC project |
Collaborator Contribution | Developing assays for oxidative stress. Exchange of nanoparticle test materials from the European Commission H2020 programme, GRACIOUS |
Impact | to follow |
Start Year | 2019 |
Description | Matt Boyles - GRACIOUS - Oxidative stress assays |
Organisation | Institute of Occupational Medicine (IOM) |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Developing assays for oxidative stress. Exchange of particle test materials, including air pollution particles from APIC project |
Collaborator Contribution | Developing assays for oxidative stress. Exchange of nanoparticle test materials from the European Commission H2020 programme, GRACIOUS |
Impact | to follow |
Start Year | 2019 |
Description | Matt Boyles - GRACIOUS - Oxidative stress assays |
Organisation | University of Edinburgh |
Department | Centre for Cardiovascular Science |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developing assays for oxidative stress. Exchange of particle test materials, including air pollution particles from APIC project |
Collaborator Contribution | Developing assays for oxidative stress. Exchange of nanoparticle test materials from the European Commission H2020 programme, GRACIOUS |
Impact | to follow |
Start Year | 2019 |
Description | Sun-Nanoparticle toxicology and molecular interaction in preclinical models |
Organisation | Capital University of Medical Sciences |
Country | China |
Sector | Academic/University |
PI Contribution | Intellectual contribution to experimental work, design and manuscript preparation |
Collaborator Contribution | Experimental work |
Impact | Publication (Duan et al. 2017) in Science of the Total Environment, and two further manuscripts under review |
Start Year | 2016 |
Description | BHF Clinical and Policy Groups - BHF HQ London - Nov 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Supporters |
Results and Impact | Talk to interested parties at the British Heart Foundation ahead of their "Full of It" air pollution campaign. The talk included discussion of current and upcoming projects including research into extremes of air pollution in China and Delhi (NERC/MRC) and agricultural PM (NIHR). |
Year(s) Of Engagement Activity | 2019 |
Description | Interview for Environmental Protection Scotland newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Interview, published online |
Year(s) Of Engagement Activity | 2019 |
Description | Meeting with Prof Campbell Gemmell, Scotland Clean Air Strategy, Feb 19 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Policymakers/politicians |
Results and Impact | Discussions with Prof Campbell Gemmell, who will be the chairman of the Air Quality and Health in Scotland Review to be published for the Scottish Parliament later in the year. |
Year(s) Of Engagement Activity | 2019 |
Description | Presentation at Cross Party Conference, Scottish Parliament, Sept 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Policymakers/politicians |
Results and Impact | CrossParty conference on air pollution in Scotland with wide range of Stakeholders |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation for Westminster Insights on Government Clear Air Strategy, Feb 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Westminster Insights is an independent organisation that covers policies and initiatives associated with the UK government. Approx 80 people in audience from a wide range of sectors, including government departments |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.westminsterinsight.co.uk/event/3255/Reviewing_the_UKs_Clean_Air_Strategy |
Description | Visits by Members of the Scottish Parliament, Nov 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Policymakers/politicians |
Results and Impact | Separate visits from MSPs/Councillors: Rosanna Cunningham & Anna Richardson. Discussion and tour of facility. Interview videoed for website and social media |
Year(s) Of Engagement Activity | 2018 |