Proximity to Discovery 2014 – University of Nottingham
Lead Research Organisation:
University of Nottingham
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The MRC Proximity to Discovery scheme awards universities funds to help develop new collaborations, and ways of exchanging knowledge and skills. The awards can be used to support activities that promote the value of academic-industry partnership, and enhance academic and industry researchers’ understanding of each other’s needs and capabilities. This may be through people exchanges, creation of technology demonstrators, showcase events, commercialisation workshops and ‘entrepreneurs in residence’ schemes. Such exchanges of knowledge and skills will boost the most fruitful collaborations between UK universities and life science companies.
Organisations
- University of Nottingham (Lead Research Organisation)
- Oxtex Ltd (Collaboration)
- Astex Pharmaceuticals (Collaboration)
- Jaguar Land Rover Automotive PLC (Collaboration)
- Eisai Ltd (Collaboration)
- Brain in Hand Ltd (Collaboration)
- University of Rochester (Collaboration)
- SiMPore Inc (Collaboration)
- Crown Bioscience Inc. (Collaboration)
- ParAid Ltd (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Alliance Boots (Collaboration)
- Sygnature Discovery Ltd (Collaboration)
Publications
Kettlewell J
(2019)
A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries.
in Clinical rehabilitation
Kettlewell J
(2018)
Informing evaluation of a smartphone application for people with acquired brain injury: a stakeholder engagement study.
in BMC medical informatics and decision making
Macdonald SJ
(2016)
Passing on the medicinal chemistry baton: training undergraduates to be industry-ready through research projects between the University of Nottingham and GlaxoSmithKline.
in Drug discovery today
Madejski G
(2018)
TEM Tomography of Pores with Application to Computational Nanoscale Flows in Nanoporous Silicon Nitride (NPN).
in Membranes
McInally T
(2017)
Unusual Undergraduate Training in Medicinal Chemistry in Collaboration between Academia and Industry.
in Journal of medicinal chemistry
Othman O
(2023)
Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice.
in International immunopharmacology
Starr NJ
(2016)
Age-Related Changes to Human Stratum Corneum Lipids Detected Using Time-of-Flight Secondary Ion Mass Spectrometry Following in Vivo Sampling.
in Analytical chemistry
Starr NJ
(2019)
Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling.
in International journal of pharmaceutics
| Description | David Scurr - Innovate UK KTP with Alliance Boots |
| Amount | £150,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Dr David Scurr - University of Nottingham Hermes |
| Amount | £5,000 (GBP) |
| Organisation | University of Nottingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Dr Kevin Webb - EPSRC/UoN IAA |
| Amount | £19,236 (GBP) |
| Organisation | University of Nottingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 03/2017 |
| Description | Dr Kevin Webb - University of Nottingham Hermes |
| Amount | £27,000 (GBP) |
| Organisation | University of Nottingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Improving neonatal outcomes with an evidence-based, multi-disciplinary developed transport system |
| Amount | £864,745 (GBP) |
| Funding ID | II-LA-0715-20003 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 11/2022 |
| Description | Jade Kettlewell SPCR Post Doc Fellowship 2022 |
| Amount | £145,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2024 |
| Description | UoN Hermes award to PI McInally: In Vivo testing of avb1 Integrin Inhibitors for Fibrotic Diseases |
| Amount | £5,600 (GBP) |
| Organisation | University of Nottingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 10/2016 |
| Description | UoN MRC CiC Round 9: Needle free delivery of macromolecular therapeutics |
| Amount | £156,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 12/2020 |
| Description | Dr David Scurr: Active Compound Delivery into the Skin - Industrial Partners Engagement |
| Organisation | Alliance Boots |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Research activities within the School of Pharmacy have led to the development of spectrometry based methodologies which can be used to probe the extent of active pharmaceutical and / or cosmetic agents into skin tissue. |
| Collaborator Contribution | Alliance Boots PLC have provided knowledge and skills in topical delivery. |
| Impact | 27010630 |
| Start Year | 2015 |
| Description | Dr Don Sharkey: Neonatal Inter-Hospital Transport System |
| Organisation | Jaguar Land Rover Automotive PLC |
| Department | Jaguar Land Rover |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Design of a novel neonatal transport system, to reduce noise and vibration in addition to more secure transport. |
| Collaborator Contribution | Computer design, further developmental design input and regulatory affairs. |
| Impact | No outcomes yet; anticipated registering of design rights, plus patent filings and publications. |
| Start Year | 2015 |
| Description | Dr Don Sharkey: Neonatal Inter-Hospital Transport System |
| Organisation | ParAid Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Design of a novel neonatal transport system, to reduce noise and vibration in addition to more secure transport. |
| Collaborator Contribution | Computer design, further developmental design input and regulatory affairs. |
| Impact | No outcomes yet; anticipated registering of design rights, plus patent filings and publications. |
| Start Year | 2015 |
| Description | Dr Ian Todd: Reuse and refinement of anti-microbials as anti-inflammatories for therapy of orphan autoinflammatory diseases. |
| Organisation | Sygnature Discovery Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Performance of a multiplexed signalling molecule detection methodology as a platform for drug repurposing and refinement, which has led to identification of a number of lead compounds. |
| Collaborator Contribution | Identification of additional chemical structures of interest for screening by University of Nottingham, built models of potency for each compound cluster, Bayesian modelling and 3-D predictions |
| Impact | No outputs to date. |
| Start Year | 2015 |
| Description | Dr Kate Radford: Evaluation of the Brain in Hand software for use with people with acquired brain injuries (ABI) |
| Organisation | Brain in Hand Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | • Undertake some early stakeholder engagement activity in partnership with Brain in Hand to inform the necessary technological developments for bid development and evaluation as part of the existing project. • Explore the potential for widening the market for Brain in Hand's application in other conditions such as children with ABI and adults with MS and dementia; • Identify and engage with relevant networks and showcase our research at UoN, thereby acting as a catalyst for further networking and collaboration. • Provide an opportunity for an experienced post-doctoral researcher to assist in bid writing, while developing their potential to become an independent researcher. |
| Collaborator Contribution | • Facilitation of User and Professional technical workshops (these will be held at least 3 times during the study programme to ensure that user and professional views about BiH software development are factored in to the overall design). Glenn Atter (Technical Director) and Heather Cook (Client Director) along with other members of the BiH team will facilitate these workshops • Development and implementation of marketing and PR campaign, promoting the collaboration between University of Nottingham and Brain in Hand to foster the development of BiH into the ABI rehabilitation pathway. |
| Impact | None |
| Start Year | 2015 |
| Description | Dr Kevin Webb: Commercialisation of next-generation erasable flow-through biosensors |
| Organisation | SimPore Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | Demonstration of utility of SERS for applications for intrinsic evaluation of Raman spectra of: o Proteins o Small molecules o Lipids o Nucleic Acids o Nano-particles o Exemplification in different bio-matrices (Blood, saliva, urine etc) |
| Collaborator Contribution | Benchmark known SERS performance against leading prior art - cost and performance |
| Impact | None |
| Start Year | 2015 |
| Description | Dr Kevin Webb: Commercialisation of next-generation erasable flow-through biosensors |
| Organisation | University of Rochester |
| Department | University of Rochester Medical Centre |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Demonstration of utility of SERS for applications for intrinsic evaluation of Raman spectra of: o Proteins o Small molecules o Lipids o Nucleic Acids o Nano-particles o Exemplification in different bio-matrices (Blood, saliva, urine etc) |
| Collaborator Contribution | Benchmark known SERS performance against leading prior art - cost and performance |
| Impact | None |
| Start Year | 2015 |
| Description | Dr Marie-Christine Pardon: Thymosin beta 4: a potential candidate drug for Alzheimer's disease and vascular dementia |
| Organisation | Astex Pharmaceuticals |
| Department | Astex Therapeutics Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Identification of a novel potential disease mechanism for Alzheimer's disease - Improved understanding of the role of TB4 in immune cell function - Increased confidence in the suitability of TB4 as therapeutic target for Alzheimer's disease |
| Collaborator Contribution | Knowledge related to therapeutic peptide development |
| Impact | None |
| Start Year | 2016 |
| Description | Dr Marie-Christine Pardon: Thymosin beta 4: a potential candidate drug for Alzheimer's disease and vascular dementia |
| Organisation | Eisai Ltd |
| Country | Japan |
| Sector | Private |
| PI Contribution | Identification of a novel potential disease mechanism for Alzheimer's disease - Improved understanding of the role of TB4 in immune cell function - Increased confidence in the suitability of TB4 as therapeutic target for Alzheimer's disease |
| Collaborator Contribution | Knowledge related to therapeutic peptide development |
| Impact | None |
| Start Year | 2016 |
| Description | Dr Tom McNally: Inhibitors for Fibrotic Diseases - People Exchange Programme to Progress Early Leads and Enable Applications for More Substantial Funding |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Identification of a small molecule inhibitor for the treatment of idiopathic pulmonary fibrosis. |
| Collaborator Contribution | Assays, computer modelling and medicinal chemistry. |
| Impact | No outputs yet, a patent filing by the University of Nottingham is anticipated. |
| Start Year | 2015 |
| Description | GSK - University of Nottingham |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Dr Tom McInally's collaboration with GSK to explore new inhalation therapeutics. |
| Collaborator Contribution | Provision of pharmaceutical industry expertise. |
| Impact | No outputs to date |
| Start Year | 2017 |
| Description | Prof David Gardner: Minimally Invasive Cloacal Repair Operation (MICRO) |
| Organisation | Oxtex Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Investigation of a unique treatment options for cloaca; the defect is one of the most formidable technical challenges in pediatric surgery. A pilot study using available cadaveric material will establish the surgical techniques and efficacy of implantation of tissue expanders into the ano-genital sinus of a pig. |
| Collaborator Contribution | The tissue engineering and development of anisotrophic tissue expanders was conducted by Oxtex Ltd, Witney, UK |
| Impact | None |
| Start Year | 2016 |
| Description | Prof Lindy Durrant: Crown Bioscience Exchange: pre-clinical models |
| Organisation | Crown Bioscience Inc. |
| Country | United States |
| Sector | Private |
| PI Contribution | Generation of a panel of therapeutic monoclonal antibodies. |
| Collaborator Contribution | Expertise with screening and testing of functionality and likely immunogenicity. |
| Impact | None |
| Start Year | 2016 |
| Description | Faculty of Medicine and Health Sciences Showcase |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | In July 2016 we hosted a Transformative Technologies Research Showcase, attended by academic colleagues, industrial collaborators, prospective industrial partners, charities, policy makers and funders and where we showcased the Clinical Translational Research undertaken at Nottingham. Intended to kick-start new industrial relationships and to provide a space for academic colleagues to come together and prompt new cross faculty, multi-disciplinary collaborations, the event was hosted by Professor Jonathan Ball, Director of Research, Faculty of Medicine & Health Sciences and was an opportunity for delegates to find out about some of the world leading technologies developed out of Nottingham. They also had the opportunity to see some of them in our pop-up Faculty of Medicine and Health Sciences Technology Demonstrator. A programme of speakers covered a range of topics from both industry and academic perspective. The event was held in the University of Nottingham Medical School, and was attended by around 100 delegates - 36 industry guests and 62 internal, cross-faculty guests. |
| Year(s) Of Engagement Activity | 2016 |