Functionalised Microfluidic Sensors for Biomedical Applications

Lead Research Organisation: University of Cambridge
Department Name: Materials Science & Metallurgy

Abstract

Conformal and biocompatible force sensors have many potential applications, such as in tactile and haptic sensing, sensor-assisted surgery and bio-telemetry. The aim of the project is to develop a novel microfluidic-based technology that could potentially offer sensitive, flexible and biocompatible sensors with the ability to sense a range of biologically relevant forces, and incorporate additional features such as wireless data transmission into the device structure. This project aims to characterise and test the use of different materials for the production of "functionalised" microfluidic sensors by incorporating additive manufacturing methods. The sensors will be calibrated using bespoke experimental setups and in conjunction with clinical partners, and their design and implementation will be further optimised using finite element modelling.
 
Description A device that can measure an applied force has been developed using a low-cost, scalable process that takes advantage of additive manufacturing techniques such as aerosol-jet printing and 3d printing. This force sensor could be used to aid orthopaedic surgeons during joint replacement surgeries, to improve the quality of life of patients.
Exploitation Route More potential applications could be found for this sensor technology, both within healthcare and in other sectors.
Sectors Healthcare

Manufacturing

including Industrial Biotechology
URL https://www.researchgate.net/publication/354016713_Conformable_and_robust_force_sensors_to_enable_precision_joint_replacement_surgery
 
Description A spinout company has been founded. The sensors could potentially be used to improve orthopaedic surgery and increase quality of life for patients.
First Year Of Impact 2019
Sector Healthcare
 
Title A MICROFLUIDIC SENSOR 
Description A microfluidic sensor comprising: a first substrate; a second substrate; a cavity formed between the first substrate and the second substrate, the cavity comprising a reservoir portion and a channel portion extending from the reservoir portion; a capacitive element disposed between the first substrate and the second substrate, the capacitive element being at least partially disposed in the channel portion of the cavity; and a dielectric sensing liquid provided in the reservoir portion. Upon application of a force to the first substrate adjacent the reservoir portion, the reservoir portion is configured to deform and displace the sensing liquid along the channel portion, so as to change the capacitance of the capacitive element within the channel portion. 
IP Reference WO2022043709 
Protection Patent application published
Year Protection Granted 2022
Licensed No
Impact Patent application has just been published 10/03/2022.
 
Company Name Artiosense Limited 
Description ArtioSense is a spin-out from the University of Cambridge that seeks to commercialise a novel, conformable force sensing technology for applications in orthopaedic surgery, sports medicine and beyond. They have invented a microfluidic force sensor that measures large forces passing through weight-bearing joints with state-of-the-art additive manufacturing techniques. 
Year Established 2021 
Impact Collaborations with clinical partners, patent application.
Website http://artiosense.co.uk/