sensitising-solid-cancers-to-car-t-cell-therapy-using-matrix-remodelling-bacteria
Lead Research Organisation:
Queen Mary University of London
Department Name: Barts Cancer Institute
Abstract
The overall aims of the project are to:
Explore how CAR T-cells move within the tumour matrix and identify components which inhibit their movement.
Engineer therapeutic bacteria that are capable of modifying specific components of the tumour matrisome in situ.
Explore how modifying the tumour matrix in-situ may improve CAR T-cell therapy, using a unique tumour targeted and matrix modifying bacterial system.
Explore how CAR T-cells move within the tumour matrix and identify components which inhibit their movement.
Engineer therapeutic bacteria that are capable of modifying specific components of the tumour matrisome in situ.
Explore how modifying the tumour matrix in-situ may improve CAR T-cell therapy, using a unique tumour targeted and matrix modifying bacterial system.
People |
ORCID iD |
| Oliver Pearce (Primary Supervisor) | |
| Marcos Burger Ramos (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/R015686/1 | 30/09/2018 | 29/09/2025 | |||
| 2620712 | Studentship | MR/R015686/1 | 30/09/2021 | 29/09/2025 | Marcos Burger Ramos |