Equine gut health: identifying behavioural, physiological and microbiome biomarkers associated with ulcers and inflammation in horse populations
Lead Research Organisation:
University of Manchester
Department Name: Earth Atmospheric and Env Sciences
Abstract
In managed horses (and other equids), disorders associated with inflammation in the equine gastrointestinal (GI) tract, including gastric ulcers, high parasite burdens and enteritis/colitis are widespread health and welfare issues. We currently do not know how prevalent these issues are in free-ranging populations. This project will use a combination of stress and inflammatory markers, parasite and microbiome analyses to compare gastrointestinal health in both intensively managed and free-ranging horse populations. This information can be used to guide management of horse GI systems and to understand how unmanaged horse guts respond to environmental and seasonal challenges.
Objectives: This project will use an integrated evaluation of risk factors and gut biomarkers to: 1) validate and further develop the application of gut inflammation markers and microbiome community changes with clinically confirmed pathologies, and 2) apply the biomarkers validated in (1) to characterise variation in gastrointestinal inflammation in managed and free-ranging horses in response to parasites, stress, microbiome and diet.
Study design: The study is divided into two parts: A) The student will validate inflammatory and microbial biomarkers in horses with diagnosed acute GI inflammation (severe gastric ulceration, high parasite burdens and colitis). Horses will be monitored for changes in inflammation markers and microbiome from initial diagnosis through treatment and post recovery. B) The student will then monitor changes in inflammatory gut biomarkers across three populations: 1) intensively managed sport horses, 2) semi-intensively managed leisure horses, and 3) a population of free-ranging semi-feral ponies. For the free-ranging population, the student will conduct observational data and collect samples from the Carneddau mountain ponies in Snowdonia National Park. These ponies have been studied for over ten-years, and our previous has shown that: 1) that parasite loads are highly variable, 2) that cortisol and faecal oxidative stress respond to stressors, and 3) that microbiome community structure varies over time and space across the population
Objectives: This project will use an integrated evaluation of risk factors and gut biomarkers to: 1) validate and further develop the application of gut inflammation markers and microbiome community changes with clinically confirmed pathologies, and 2) apply the biomarkers validated in (1) to characterise variation in gastrointestinal inflammation in managed and free-ranging horses in response to parasites, stress, microbiome and diet.
Study design: The study is divided into two parts: A) The student will validate inflammatory and microbial biomarkers in horses with diagnosed acute GI inflammation (severe gastric ulceration, high parasite burdens and colitis). Horses will be monitored for changes in inflammation markers and microbiome from initial diagnosis through treatment and post recovery. B) The student will then monitor changes in inflammatory gut biomarkers across three populations: 1) intensively managed sport horses, 2) semi-intensively managed leisure horses, and 3) a population of free-ranging semi-feral ponies. For the free-ranging population, the student will conduct observational data and collect samples from the Carneddau mountain ponies in Snowdonia National Park. These ponies have been studied for over ten-years, and our previous has shown that: 1) that parasite loads are highly variable, 2) that cortisol and faecal oxidative stress respond to stressors, and 3) that microbiome community structure varies over time and space across the population
Organisations
People |
ORCID iD |
| Susanne Shultz (Primary Supervisor) | |
| Jessica Irving (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/T008725/1 | 30/09/2020 | 29/09/2028 | |||
| 2625299 | Studentship | BB/T008725/1 | 30/09/2021 | 29/09/2025 | Jessica Irving |