Low Containment
Lead Research Organisation:
The Pirbright Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Low containment experimental facilities support, enhance and extend the range of viruses studied at the Pirbright Institute. The primary infrastructure associated with these facilities is the BBSRC National Centre for Vaccinology, the Jenner Building, which was opened in 2016. This facility houses a wide range of groups working on strategically important endemic and exotic viral pathogens that can be handled under low containment, including Marek’s disease virus, infectious bronchitis virus and low pathogenicity animal influenzas. In addition, the Jenner building also houses groups that study the genetics and genomics of virus hosts, using state of the art technologies. This capability is nationally unique both because it supports studies of viruses not replicated elsewhere in the UK and because of its position in close proximity to High Containment Experimental Facilities in Pirbright.
Our in vivo facilities supporting avian research are housed in a temporary facility. This enables study of internationally important avian viruses within the natural host. During the term of the CCG, new facilities will be constructed on the Pirbright site, enabling expansion of this work. This includes a specified pathogen free (SPF) hatchery and rearing facility due for delivery in early 2018 and refurbishment of current high containment animal facilities to deliver a low containment Poultry Experimental Facility in late 2018.
The Low Containment National Capability has been used to address COVID-19 related challenges from 1 April 2020.
Our in vivo facilities supporting avian research are housed in a temporary facility. This enables study of internationally important avian viruses within the natural host. During the term of the CCG, new facilities will be constructed on the Pirbright site, enabling expansion of this work. This includes a specified pathogen free (SPF) hatchery and rearing facility due for delivery in early 2018 and refurbishment of current high containment animal facilities to deliver a low containment Poultry Experimental Facility in late 2018.
The Low Containment National Capability has been used to address COVID-19 related challenges from 1 April 2020.
Planned Impact
unavailable
Organisations
- The Pirbright Institute (Lead Research Organisation)
- University of Zurich (Collaboration)
- ETH Zurich (Collaboration)
- University of Surrey (Collaboration)
- Liverpool School of Tropical Medicine (Collaboration)
- Friedrich Loeffler Institute (Collaboration)
- UNIVERSITY OF READING (Collaboration)
- French Agency for Food, Environmental and Occupational Health & Safety (ANSES) (Collaboration)
- University of Minnesota (Collaboration)
- Aerogen (Collaboration)
- Royal Veterinary College (RVC) (Collaboration)
- John Innes Centre (Collaboration)
- Stanford University (Collaboration)
- Distributed Bio. (Collaboration)
- THE PIRBRIGHT INSTITUTE (Collaboration)
- Eco Animal Health Ltd (Collaboration)
- Wageningen University & Research (Collaboration)
- University of Copenhagen (Collaboration)
- Lancaster University (Collaboration)
- University of Nigeria (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- Chinese Academy of Agricultural Sciences (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- BRUNEL UNIVERSITY LONDON (Collaboration)
- University of Veterinary Medicine Hanover (Collaboration)
- Aviagen (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- Gift Of Life (Collaboration)
- Animal and Plant Health Agency (Collaboration)
- Enesi Pharma (Collaboration)
- Government of Canada (Collaboration)
- Outreach Network for Gene Drive Research (Collaboration)
- Penn State University (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Kenyan Institute for Medical Research (KEMRI) (Collaboration)
- UNIVERSITY OF ABERDEEN (Collaboration)
- UNIVERSITY OF LEEDS (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- Rosalind Franklin Institute (Collaboration)
- University of Bristol (Collaboration)
- Babraham Institute (Collaboration)
- University of Plymouth (Collaboration)
- National Institute for Biological Standards and Control (NIBSC) (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- University of California, Davis (Collaboration)
- University of Sussex (Collaboration)
- Leibniz Association (Collaboration)
- UNIVERSITY OF KENT (Collaboration)
- University of Texas Southwestern Medical Center (Collaboration)
- Zoological Society of London (Collaboration)
- International Livestock Research Institute (ILRI) (Collaboration)
- University of York (Collaboration)
- University of Utah (Collaboration)
- University of Warwick (Collaboration)
- Centre for Genomic Regulation (CRG) (Collaboration)
- UNIVERSITY OF GREENWICH (Collaboration)
- DIAMOND LIGHT SOURCE (Collaboration)
- University of Lleida (Collaboration)
- University of Tartu (Collaboration)
- DURHAM UNIVERSITY (Collaboration)
- University of Pennsylvania (Collaboration)
- University of Bath (Collaboration)
- Hebrew University of Jerusalem (Collaboration)
- St. Andrews University (Collaboration)
- UNIVERSITY OF ESSEX (Collaboration)
- University of Guelph (Collaboration)
- University of Wisconsin-Madison (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- National Institute of Genetics (Collaboration)
- QUEEN'S UNIVERSITY BELFAST (Collaboration)
- University of Melbourne (Collaboration)
- ULSTER UNIVERSITY (Collaboration)
- Bern University of Applied Sciences (Collaboration)
- Leidos (Collaboration)
- Biomathematics and Statistics Scotland (BioSS) (Collaboration)
- University of Glasgow (Collaboration)
- Polytechnic University of Valencia (Collaboration)
- University at Buffalo (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- U.S. Department of Agriculture USDA (Collaboration)
- Cardiff University (Collaboration)
- Mayo Clinic (Collaboration)
- National Health Research Institutes (NHRI) Taiwan (Collaboration)
- University of Queensland (Collaboration)
- University of Parma (Collaboration)
- National Taiwan University (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- University of Veterinary Medicine Vienna (Collaboration)
- Agricultural Research Council (ARC) (Collaboration)
- Horizon Discovery Group plc (Collaboration)
- Huvepharma (Bulgaria) (Collaboration)
- University of Malaya (Collaboration)
- Freie Universität Berlin (Collaboration)
- Technical University of Denmark (Collaboration)
- Texas A&M University-Central Texas (Collaboration)
- MSD (United Kingdom) (Collaboration)
- Fred Hutchinson Cancer Research Center (FHCRC) (Collaboration)
Publications
Abdullah N
(2018)
Structure-Guided Identification of a Nonhuman Morbillivirus with Zoonotic Potential.
in Journal of virology
Alber A
(2021)
The bird's immune response to avian pathogenic Escherichia coli.
in Avian pathology : journal of the W.V.P.A
Ali M
(2019)
Avian Influenza A(H9N2) Virus in Poultry Worker, Pakistan, 2015.
in Emerging infectious diseases
Altan E
(2019)
Molecular characterization of Peste des petits ruminants viruses in the Marmara Region of Turkey.
in Transboundary and emerging diseases
Anderson MAE
(2023)
AePUb promoter length modulates gene expression in Aedes aegypti.
in Scientific reports
Anderson MAE
(2020)
Expanding the CRISPR Toolbox in Culicine Mosquitoes: In Vitro Validation of Pol III Promoters.
in ACS synthetic biology
Anderson MAE
(2024)
A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations.
in Nature communications
Anderson MAE
(2023)
Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements.
in Nature communications
Anderson ME
(2019)
CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say.
in PloS one
Ang JX
(2022)
Considerations for homology-based DNA repair in mosquitoes: Impact of sequence heterology and donor template source.
in PLoS genetics
| Title | Additional file 2 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 2: Figure S1. Air and soil temperature data for 2016-2018 for each farm site: daily mean and maximum air temperature (°C) (top and middle rows, respectively) and daily mean soil temperature at a depth of 3.5 cm (bottom row) for ON (left-hand column) and PW (right-hand column). Line colour indicates the year: 2016 (red); 2017 (blue); or 2018 (cyan). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_2_of_Emergence_dynamics_of_adult... |
| Title | Additional file 2 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 2: Figure S1. Air and soil temperature data for 2016-2018 for each farm site: daily mean and maximum air temperature (°C) (top and middle rows, respectively) and daily mean soil temperature at a depth of 3.5 cm (bottom row) for ON (left-hand column) and PW (right-hand column). Line colour indicates the year: 2016 (red); 2017 (blue); or 2018 (cyan). |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_2_of_Emergence_dynamics_of_adult... |
| Title | Additional file 3 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 3: Figure S2. Observed and expected daily number of Culicoides biting midges caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_3_of_Emergence_dynamics_of_adult... |
| Title | Additional file 3 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 3: Figure S2. Observed and expected daily number of Culicoides biting midges caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_3_of_Emergence_dynamics_of_adult... |
| Title | Additional file 4 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 4: Figure S3. Observed and expected daily number of Culicoides obsoletus/scoticus females caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_4_of_Emergence_dynamics_of_adult... |
| Title | Additional file 4 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 4: Figure S3. Observed and expected daily number of Culicoides obsoletus/scoticus females caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_4_of_Emergence_dynamics_of_adult... |
| Title | Additional file 5 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 5: Figure S4. Observed and expected daily number of Culicoides obsoletus males caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_5_of_Emergence_dynamics_of_adult... |
| Title | Additional file 5 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 5: Figure S4. Observed and expected daily number of Culicoides obsoletus males caught in eight emergence traps at two farm sites in south-east England during 2016-2018. Each panel shows the observed daily mean (red) and the posterior median (blue dots) and 95% credible interval (shading) for the expected daily mean. The grey-shaded areas indicate when the samples were being collected from the trap |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_5_of_Emergence_dynamics_of_adult... |
| Description | The key development within low containment science at The Pirbright Institute is that of providing facilities that allow handling of non-infectious and low pathogenicity agents within laboratories and a range of desk based activities including bioinformatics and epidemiological modelling. The facilities are required to integrate with high-containment buildings on site and also provide areas for analyses of data from experiments and are expected to be safe for the user and environment and experience minimal interruptions to work through infrastructure works. These objectives have been achieved in the following ways: 1) Interruptions to science are within the boundaries set for the facilities. The BBSRC National Vaccinology Centre: The Jenner Building is part of the planned preventative maintenance schedule and is now at capacity for science, supporting low containment studies and the majority of Avian researchers. 2) The Houghton poultry facility (Specified Pathogen Free hatchery) and Pirbright remains a hub for Avian research as demonstrated by the production of publications, outreach activities and interactions with industry including dedicated vaccine commercialization funding and expertise and public interaction over the avian influenza outbreak. These are now complemented by high-containment space for avian studies in the Biggs facility. 3) Bioinformatics capabilities have been strengthened significantly with expansion and upgrade of high performance computing facilities and senior staff, the latter provisioned from the Science Services CCG component. 4) Significant progress has been made in opening up the low containment facilities for training and also in provision of outreach activities. 5) Insectary facilities, which have seen a significant rise in demand in the reporting period within the science conducted by Pirbright, have been expanded via complete refurbishment of the IS4L facility that is now a very large insectary with total redundancy of environmental conditions. We have now consolidated all insectary activities into this one dedicated facility. In total >220 peer-reviewed publications and >470 engagement activities have been enabled by this infrastructure, including a major focus on Avian research, viruses spread by arthropod vectors and host immune response genetics. |
| Exploitation Route | By acting as a hub for fundamental avian viral research, Pirbright provides disease information and expertise for a variety of high-consequence endemic viruses including Marek's disease virus. Through the use of scientific networks these areas are both extended and enhanced by external researchers, in addition to being provided to policy makers for outbreak scenario planning. In addition, a significant proportion of studies are aimed at modifying or creating vaccines that are used in the poultry sector which entails successful translation to use in industry. Bioinformatic outputs in open access databases and journals are available to workers worldwide and are a valuable resource for comparative studies of both phylogenetics and immunology. Facilities supporting insect rearing and analysis are largely focused on mosquitoes and biting midges which are supplied to both internal and external users. Studies using genetic modification of mosquitoes are part of a vanguard of research using emerging technologies that may be applicable across multiple hosts and scenarios. Hence technologies developed at Pirbright may inform global researchers in this subject area. |
| Sectors | Agriculture Food and Drink |
| Description | The findings of research on both avian and arthropod interactions with viruses have an impact on fundamental science and underpin global research in these subject areas. This includes many viruses and insect pests that have a major impact on global agriculture. Within the avian research, there is also a significant use in global policy decision making regarding viruses of Poultry with contributions to both working groups on disease control and the production of vaccines. Bioinformatic studies conducted form part of global databases that enable comparative studies of hosts and vectors carried out by researchers worldwide and can additionally information regarding the origin and spread of virus outbreaks in the case of avian studies. |
| First Year Of Impact | 2017 |
| Sector | Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal Economic Policy & public services |
| Description | BBSRC Transformative Technologies Strategic Advisory Panel - invited expert |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Criteria for the ALERT call have changed, there is an increased focus on RTPs, plus the amount available in the call has increased, and the maximum individual grant possible has increased. |
| Description | Bioimaging Steering Group |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Better management of workload and facility internally |
| Description | Chair of ALERT21/22 panel |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Enabled UKRI funded research, supporting cutting edge research across different disciplines. |
| Description | Coalition for Epidemic Preparedness Innovations Nipah Taskforce Member |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Contributed to Chief Medical Officers report- Genomics section |
| Geographic Reach | Europe |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/6310... |
| Description | Data on SARS-COV-2 antigenicity for government committees, e.g. UKHSA variant technical group, NERVtag |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Impact | This information was routinely fed into UKHSA and government decision making on managing the Covid-19 pandemic |
| Description | Grants Review Team |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Impact | More effective inclusion of microscopy technology in grants submitted from the Institute |
| Description | Human Infection Challenge Models for Vaccination |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | International Society for Neglected Tropical Diseases Dengue Advisory Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://www.isntd.org/dengue-advisory-group |
| Description | MSc research training |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The immediate outcome of this impact activity is that these Masters students went on to the following subsequent career destinations: PhD programme: 2 students Technical position in research institution: 1 student |
| Description | Member of RMS EM Section committee |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | This committee informs the RMS on which areas to invest funds in regarding training, conferences, outreach events. RMS members are international. |
| Description | Member of the Board of the Jenner Vaccine Foundation |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Helping with the strategic decisions of the Board of the Jenner Vaccine Foundation |
| Description | Member of the Virus Division for the Microbiology Society |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Microbiology Society Members Panel |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | A number of initiatives have been implemented that have made activities within the Microbiology Society more accessible to historically marginalised groups, for example the promotion of pronouns, changes to alcohol provision to make conference sessions more accessible to people who cannot be around alcohol, introduction of a knowledge-exchange forum as a new session at the Society's annual conference, improved equality, diversity and inclusion training, introduction of quiet rooms for neurodiverse scientists. |
| URL | https://microbiologysociety.org/why-microbiology-matters/council-governance/standing-panels/members-... |
| Description | Microbiology Society Policy Committee |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | PPR Global Research and Expertise Network (PPR GREN) membership (OIE/FAO) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Publication policy document for core facilities - EM-UK |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | I am a founder member of the network created for electron microscopists within UK, EM-UK. The annual meeting is highly productive, and training and managing core facilities is regularly discussed. Recognition of these facilities is essential for their continued existence so we produced a generic document hosted on the RMS website which can be adopted by any core facility in any institution, and describes the publication policy which users had to adhere to. This has already raised the profile of core facilities around the country and is a successful outcome from the EM-UK meetings. |
| Description | RCUK Engagement workshop, Cosener's House, 20-21 April 2017 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Royal Microscopical Society Training Focussed Interest Group |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | A review of the microscopy training courses available globally has been undertaken. We are in the process of collating and preparing a gap analysis. This will be used to guide RMS policy on training provided in the UK, both UK and international delegates. |
| Description | Training MSc students |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Delivered a new training session to MSc students teaching viral quantification assays. This lead to a greater understanding of laboratory techniques and academic research. |
| Description | Training of Masters students (Imperial College London) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The students gained specialist knowledge in vector-borne diseases - their transmission and emergence potential. Students came from multiple countries across the world and will take this knowledge back with them in the future. |
| Description | Training of medical students (University of Oxford) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The students on this medical degree programme were trained in tropical medicine. |
| Description | University of Copenhagen PhD course |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | We train approx 20 students per year to use the microscopes which allows them to complete their PhDs |
| Description | University of Oxford (medical students training) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | The students gained an understanding for important tropical diseases that they may encounter in patients when they begin work in the clinic. Since these diseases are not endemic to the UK they would otherwise not have gained this information. |
| URL | https://www.ox.ac.uk |
| Description | WHO R&D Blueprint Roadmaps: Consultation on Nipah virus |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Zika pandemic preparedness ten-year plan consultation (Wellcome Trust/WHO) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | 21ROMITIGATIONFUND Pirbright Institute |
| Amount | £283,000 (GBP) |
| Funding ID | BB/W510725/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 03/2022 |
| Description | 21ROMITIGATIONFUND Pirbright Institute |
| Amount | £283,000 (GBP) |
| Funding ID | BB/W510725/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 03/2022 |
| Description | 21SRF-VBD UKRI BBSRC MRC cross-council synergy in understanding vector borne and zoonotic viral disease |
| Amount | £500,000 (GBP) |
| Funding ID | BB/W01100X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 03/2022 |
| Description | A One Health Approach to Alkhumra Haemorrhagic Fever Virus Species Tropism, Pathogenesis and Epidemiology |
| Amount | £99,082 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 04/2026 |
| Description | A One Health approach to pan-valent morbillivirus vaccines |
| Amount | £773,237 (GBP) |
| Funding ID | BB/R019843/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2021 |
| Description | Active and passive Immunity induced by aerosols |
| Amount | £100,000 (GBP) |
| Funding ID | BB/R506448/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 08/2021 |
| Description | An immunogenetic approach to guide the need for booster shots and combat immune failure in SARS-CoV-2 vaccine response |
| Amount | £987,464 (GBP) |
| Funding ID | MR/W020629/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2021 |
| End | 08/2023 |
| Description | Antigenic characterisation of infectious bursal disease virus to improve vaccination strategies and vaccine design |
| Amount | £450,685 (GBP) |
| Funding ID | BB/S014594/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2023 |
| Description | Application of AI to profile the nasal and faecal microbiota of pigs following respiratory virus challenge |
| Amount | £16,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 07/2024 |
| Description | Application of field-deployable surveillance tool to enhance molecular xenomonitoring of multiple vector borne diseases |
| Amount | £4,675,662 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 09/2023 |
| Description | Application of molecular xenomonitoring in a lateral flow test format for multiplexed monitoring of vector-borne viruses and their animal reservoirs and insect vectors in low-income settings |
| Amount | £49,015 (GBP) |
| Funding ID | IAA2149 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 03/2025 |
| Description | Assessing the functionality of avian BST2 as a viral restriction factor. |
| Amount | £50,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Description | Assessment of the immunogenicity of bovine herpesvirus 4-based vectors delivering Nipah virus glycoproteins in swine |
| Amount | £41,895 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 02/2019 |
| End | 04/2019 |
| Description | Aviagen Industry Funding |
| Amount | £422,383 (GBP) |
| Organisation | Aviagen Group |
| Sector | Private |
| Country | United States |
| Start | 08/2019 |
| End | 12/2020 |
| Description | BBSRC - responsive mode |
| Amount | £187,370 (GBP) |
| Funding ID | BB/S007911/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2022 |
| Description | BBSRC IAA The Pirbright Institute |
| Amount | £300,000 (GBP) |
| Funding ID | BB/S506680/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | BBSRC IAA The Pirbright Institute |
| Amount | £300,000 (GBP) |
| Funding ID | BB/S506680/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2022 |
| Description | BBSRC Impact Accelerator Award: Evaluation of RNA-vectored delivery of PRRSV glycoproteins as a novel vaccine platform to combat emergent strains |
| Amount | £27,600 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2022 |
| End | 03/2023 |
| Description | BBSRC International Institutional Award - Evaluation of the therapeutic efficacy of a Nipah virus neutralising monoclonal antibody |
| Amount | £70,385 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 03/2023 |
| Description | BBSRC Newton Fund Swine and Poultry Research Initiative |
| Amount | £865,623 (GBP) |
| Funding ID | BB/R01275X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 06/2021 |
| Description | Blood Markers for prediction of respiratory virus infection |
| Amount | £21,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 07/2024 |
| Description | British Egg Marketing Board PhD studentship |
| Amount | £76,000 (GBP) |
| Organisation | British Egg Marketing Board |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2022 |
| Description | Broad and effective protection against influenza achieved by viral vectored vaccines |
| Amount | £1,668,741 (GBP) |
| Funding ID | MR/S037160/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 04/2023 |
| Description | Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence |
| Amount | £200,000 (GBP) |
| Funding ID | LKCS-2019- 665 |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 10/2022 |
| Description | Components of the Medea gene drive system in a mosquito Aedes aegypti |
| Amount | £758,098 (GBP) |
| Funding ID | BB/S001964/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 10/2022 |
| Description | Conserved molecular mechanisms of replication for mosquito-borne flaviviruses |
| Amount | $199,350 (USD) |
| Funding ID | 1R21AI168716-01 |
| Organisation | National Institute of Allergy and Infectious Diseases (NIAID) |
| Sector | Public |
| Country | United States |
| Start | 02/2022 |
| End | 01/2024 |
| Description | Coronavirus regulation of cellular antiviral responses and cross species transmission |
| Amount | £52,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | DARPA PREEMPT |
| Amount | $2,700,000 (USD) |
| Organisation | Defense Advanced Research Projects Agency (DARPA) |
| Sector | Public |
| Country | United States |
| Start | 09/2018 |
| End | 03/2022 |
| Description | Defining the circadian clock in chicken cells and its impact upon viral replication |
| Amount | £4,500 (GBP) |
| Organisation | The Houghton Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 11/2020 |
| Description | Dengue haemorrhage: a novel role for perivascular cells |
| Amount | £74,137 (GBP) |
| Organisation | University of Surrey |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2024 |
| Description | Development of next generation vaccine technology inducing rapid and strong immunity through targeted delivery of antigens to chicken immune cells |
| Amount | £473,080 (GBP) |
| Funding ID | BB/T013087/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2021 |
| End | 05/2024 |
| Description | Development of therapeutic monoclonal antibodies for coronaviruses |
| Amount | £120,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | Dissecting the molecular pathways of MDV oncoprotein Meq for understanding pathogenesis and aid vaccine development |
| Amount | £440,000 (GBP) |
| Funding ID | BB/R007896/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2021 |
| Description | Dysregulation and evasion of the adaptive immune system by PRRSV |
| Amount | £47,760 (GBP) |
| Funding ID | BB/W510725/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 03/2022 |
| Description | Emerging porcine influenza and coronaviruses" (EPICVIR) |
| Amount | £596,027 (GBP) |
| Funding ID | BB/X019780/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2023 |
| End | 10/2026 |
| Description | Enhancing protective efficacy of avian influenza vaccines through targeted delivery of protective antigens to chicken immune cells |
| Amount | £98,212 (GBP) |
| Funding ID | BB/R50595X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 09/2021 |
| Description | FLI- TPI joint PhD studentships Avian influenza immunology markers. |
| Amount | £100,000 (GBP) |
| Organisation | Friedrich Loeffler Institute |
| Sector | Academic/University |
| Country | Germany |
| Start | 06/2018 |
| End | 06/2022 |
| Description | Further development of infectious bronchitis virus vaccines adapted for production in cell culture |
| Amount | £262,701 (GBP) |
| Funding ID | BB/R019576/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 03/2020 |
| Description | G2P-UK; A National Virology Consortium to address phenotypic consequences of SARSCoV-2 genomic variation |
| Amount | £4,021,993 (GBP) |
| Funding ID | MR/W005611/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 07/2023 |
| Description | Genomia Project Grant |
| Amount | £174,052 (GBP) |
| Organisation | Genomia fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2020 |
| Description | Global characterisation of interlinked mosquito immune networks |
| Amount | £38,936 (GBP) |
| Funding ID | BB/W510725/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 07/2021 |
| End | 03/2022 |
| Description | How does the lung protect itself against influenza? |
| Amount | £120,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 07/2026 |
| Description | IAA - Characterising the mechanism of 2-DG inhibition of coronavirus RNA synthesis |
| Amount | £8,500 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 03/2023 |
| Description | Identification and evaluation of swine mAbs in pig influenza challenge model |
| Amount | $599,944 (USD) |
| Funding ID | OPP1201470 |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 09/2018 |
| End | 10/2019 |
| Description | Identification of innate immune genes in Aedes aegypti |
| Amount | £10,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 03/2023 |
| Description | Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2024 |
| Description | In vitro evaluation of peptide-based immune checkpoint inhibitors as potential molecular adjuvants for improved PRRS vaccines |
| Amount | £4,921 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 03/2020 |
| Description | In-year funding - Characterisation of the role of CoV accessory proteins in cross species transmission |
| Amount | £53,096 (GBP) |
| Funding ID | BB/W510725/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2021 |
| End | 03/2022 |
| Description | Internal Seed Fund- Development of an IBDV diagnostic test that can differentiate infected from vaccinated animals, for use in surveillance. |
| Amount | £10,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 02/2020 |
| Description | Investigation of Canonical and Noncanonical Transcription during Coronavirus Replication |
| Amount | £122,000 (GBP) |
| Funding ID | STUD312000 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2025 |
| Description | LVIF |
| Amount | $1,500,000 (CAD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2018 |
| End | 09/2020 |
| Description | NC3Rs Research Project Grant |
| Amount | £436,339 (GBP) |
| Funding ID | NC/R001138/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 11/2019 |
| Description | Newton Fund: UK-China-Philippines-Thailand Swine and Poultry Research Initiative |
| Amount | £841,995 (GBP) |
| Funding ID | BB/R012679/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2020 |
| Description | PRCV model to better understand immunity to SARS-CoV2 |
| Amount | £50,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 03/2022 |
| Description | Pathfinder BB/R012431/1 Grant holder: Dr Mark Fife. Grant title: chIFITM knockdown/knockout technology as a platform technology for increased vaccine yields in SPF Eggs. |
| Amount | £12,500 (GBP) |
| Funding ID | BB/R012431/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 02/2018 |
| Description | Pathogenesis, immunity, and control of coronaviruses in a large natural host animal, the pig |
| Amount | £893,800 (GBP) |
| Funding ID | BB/X014266/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2026 |
| Description | Pirbright Institute Flexible Talent Mobility Account |
| Amount | £255,000 (GBP) |
| Funding ID | BB/S507945/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 03/2022 |
| Description | Protecting poultry from avian influenza, Newcastle disease, infectious bronchitis, and Gumboro disease with a single dose of a multivalent vaccine |
| Amount | £448,937 (GBP) |
| Funding ID | BB/W003325/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2022 |
| End | 12/2024 |
| Description | Recombinant pseudorabies virus as a multivalent vectored vaccine platform for emerging and endemic porcine diseases |
| Amount | £80,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2024 |
| Description | Reducing the Economic and Zoonotic Impact of Avian Influenza (REZIAI): delivering novel vaccines and diagnostics from laboratory to the field. |
| Amount | £400,000 (GBP) |
| Funding ID | BB/S013792/1 |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2019 |
| End | 01/2021 |
| Description | SOMAmer technology to diagnose coronavirus infection: veterinary and zoonotic implications |
| Amount | £1 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Description | SOMAmer technology to diagnose coronavirus infection: veterinary and zoonotic implications. |
| Amount | £134,107 (GBP) |
| Funding ID | 2601029 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 09/2025 |
| Description | Seed Catalyst Award |
| Amount | £25,527 (GBP) |
| Funding ID | ISCF-TFPSA-Pirbright |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 02/2019 |
| Description | Society Conference Grant |
| Amount | £380 (GBP) |
| Organisation | Microbiology Society |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 04/2022 |
| Description | Society Conference Grant |
| Amount | £380 (GBP) |
| Organisation | Microbiology Society |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 04/2022 |
| Description | Society Conference Grant |
| Amount | £380 (GBP) |
| Organisation | Microbiology Society |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 04/2022 |
| Description | Taiwan Partnering Award |
| Amount | £40,700 (GBP) |
| Funding ID | BB/S020624/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | The Global Challenges Research Fund |
| Amount | £640,473 (GBP) |
| Organisation | Research Councils UK (RCUK) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2024 |
| Description | The Pirbright Livestock Antibody Hub |
| Amount | $5,500,000 (USD) |
| Organisation | Bill and Melinda Gates Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2019 |
| End | 11/2024 |
| Description | The genetic and functional analysis of variation in innate immune genes associated with restriction of influenza virus for chicken lines |
| Amount | £422,383 (GBP) |
| Organisation | Aviagen Group |
| Sector | Private |
| Country | United States |
| Start | 01/2020 |
| End | 03/2021 |
| Description | The impact of natural genetic variation on ruminant immune responses |
| Amount | £80,000 (GBP) |
| Organisation | University of Southampton |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2022 |
| Description | Towards a novel multivalent poultry vaccine: Development of a recombinant infectious bursal disease vectored vaccine encoding conserved B- and T- cell epitopes from infectious bronchitis virus |
| Amount | £5,000 (GBP) |
| Organisation | The Houghton Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 11/2020 |
| Description | UK International coronavirus network (UK-ICN) |
| Amount | £510,207 (GBP) |
| Funding ID | BB/W003287/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Description | UK-China partnership on Global Food Security: Combating avian tumor diseases for sustainable poultry proudction |
| Amount | £382,000 (GBP) |
| Funding ID | BB/R007632/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Description | Understanding the importance of the PI3K pathway in modulating influenza virus replication in chickens and ducks |
| Amount | £100,000 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 04/2025 |
| Description | Using machine learning to identify the molecular determinants of vector-borne transmission in viruses |
| Amount | £110,327 (GBP) |
| Organisation | The Pirbright Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 04/2028 |
| Description | Viral entry at the human-animal interface; dissecting the pan-tropic nature of zoonotic viruses. |
| Amount | £393,707 (GBP) |
| Funding ID | BB/W006162/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2025 |
| Description | [YY-EEID US-UK XXXX] Evaluating how immunosuppression influences influenza A virus transmission and evolution in wild and domestic birds |
| Amount | £606,360 (GBP) |
| Funding ID | BB/T008806/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 06/2023 |
| Description | iCASE studentship: Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry |
| Amount | £100,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2023 |
| Title | 8 color flow cytometry panel for cattle B cell phenotyping |
| Description | Flow cytometry panel to characterize different B cell subsets in cattle. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Following the publication of this method, we have been contacted to provide reagents and expertise for cattle B cell phenotyping in the context of diseases, and to host a researcher form a LMIC for training in flow cytometry. |
| Title | A ligation and restriction enzyme independent cloning technique: an alternative to conventional methods for cloning hard-to-clone gene segments in the influenza reverse genetics system |
| Description | we developed an easy and efficient ligation and restriction enzyme independent (LREI) cloning method for cloning influenza gene segments into pHW2000 vector. The method involves amplification of megaprimers followed by PCR amplification of megaprimers using a bait plasmid, DpnI digestion and transformation. ligation and restriction enzyme independent (LREI) cloning method represents an alternative strategy for cloning influenza gene segments that have internal restriction sites for the enzymes used in reverse genetics. Further, the problem of genetic instability in bacteria can be alleviated by growing recombinant bacterial cultures at a lower temperature. This technique can be applied to clone any influenza gene segment using universal primers, which would help in the rapid generation of influenza viruses and facilitate influenza research and vaccine development. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | The method will help in the rapid generation of reverse genetic base influenza viruses and facilitate influenza research and vaccine development. |
| URL | https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01358-2 |
| Title | A male-specific cell line from a mosquito Anopheles gambiae |
| Description | A new male-specific cell line from a mosquito Anopheles gambiae has been isolated from sexed neonate larvae. To our knowledge this is the only cell line derived exclusively from male mosquitoes. |
| Type Of Material | Cell line |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The cell line will greatly facilitate studies on components of the sex determination pathway and of dosage compensation machinery in mosquitoes. There are only several cell lines derived from Anopheles gambiae available and these are female-like. Over-expression of genes involved in male sex determination or dosage compensation is detrimental to female cells, hence use of male-derived cells is necessary for such studies. The cell line will become available upon acceptance of a manuscript describing characterization of that cell line. |
| Title | A novel optimized pre-embedding antibody-labelling correlative light electron microscopy technique |
| Description | This method provides a protocol and tips for further optimisation to allow fusing of standard immunofluorescence with electron microscopy of the same cells. This is an accessible correlative light electron microscopy protocol that does not require specialised equipment or availability of biological resources expressing fluorescent proteins. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | This method has been used by others at TPI to study bRSV inclusion bodies. |
| Title | An ex vivo IBDV infection model using a chicken primary B cell culture system |
| Description | Recently, it has become possible to culture chicken primary B cells in vitro in the presence of a soluble construct of chicken CD40L that was made at The Pirbright Institute. We have demonstrated that these chicken primary B cells can be infected with infectious bursal disease virus (IBDV). This system will be validated and expanded to other B cell tropic viruses in order to replace the use of infected chickens in research, in an NC3Rs funded grant. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Using this system, we have determined that chicken primary B cells respond to IBDV infection by inducing Type I IFN responses. However, the induction is more pronounced in cells infected with an attenuated strain compared to a very virulent strain. This is consistent with the very virulent strain down-regulating antiviral responses to a greater extent than other strains which may, in part, explain its enhanced virulence. We also observed a reduction in the expression of key genes involved in B cell proliferation and activation following IBDV infection which was only possible by using the primary B cell culture system. |
| URL | https://www.ncbi.nlm.nih.gov/pubmed/?term=broadbent+dulwich |
| Title | Assistance in establishment of NIBSC WHO International Standard for SARS-CoV-2 |
| Description | We assisted NIBSC and the WHO in developing an international serum standard (for ELISAs, VNTs etc.) for SARS-CoV-2. This is an essential tool for standardising assay results across different laboratories and the reagents have now been used by 100s of labs. The emergence of variants with altered antigencity meant that a new reagent was needed and in early 2022 we also helped with this next generation of reagents. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Development of an international standard for SARS2 is pivotal for standardising results across various labs working on the pandemic response to Covid. As such this is an essential tool for the international research community. |
| Title | CRISPR/Cas9-based gene editing of avian herpesvirus vectors to develop novel recombinant vaccines |
| Description | Development of recombinant herpesvirus vaccines are usually achieved by classical homologous recombination methods. The advent of new genome editing tools has enabled its application on avian herpesvirus vaccine strains to develop new recombinant vaccines potentially capable of expressing protective antigens from multiple pathogens |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The major impact will be in the generation of novel vaccines that can simultaneously protect against multiple avian diseases |
| URL | http://www.poultryworld.net/Health/Articles/2016/12/Is-GM-technology-the-future-of-poultry-vaccines-... |
| Title | Cattle MHC genotyping |
| Description | Using the sequence data generated through the targeted pull down of MHC, we developed a full gene and more targeted PCR approach to genotype cattle for the MHC class I region. This has been applied to many hundreds of samples to enable us to select individuals for breeding as well as survey genetic diversity in beef and diary herds. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | After publication which we anticipate in 2019, we will appy this method to targeted herds and are already attracting industry interest. |
| Title | Comprehensive analysis of genetic variants across immune loci in indigenous breeds. |
| Description | The interferon-induced transmembrane (IFITM) protein family comprises a class of restriction factors widely characterised in humans for their potent antiviral activity. Their biological activity is well documented in several animal species, but their genetic variation and biological mechanism is less well understood, particularly in avian species. Here we report the complete sequence of the domestic chicken Gallus gallus IFITM locus from a wide variety of chicken breeds to examine the detailed pattern of genetic variation of the locus on chromosome 5, including the flanking genes ATHL1 and B4GALNT4. We have generated chIFITM sequences from commercial breeds (supermarket-derived chicken breasts), ancient bone samples, indigenous chickens from Nigeria (Nsukka) and Ethiopia, European breeds and inbred chicken lines from The Pirbright Institute, totalling of 211 chickens. Through mapping of genetic variants to the latest chIFITM consensus sequence our data reveal that the chIFITM locus does not show structural variation in the locus across the populations analysed, despite spanning diverse breeds from different geographic locations. However, single nucleotide variants (SNVs) in functionally important regions of the proteins within certain groups of chickens were detected, in particular the European breeds and indigenous birds from Ethiopia and Nigeria. In addition, we also found that two out of four SNVs located in the chIFITM1 (Ser36 and Arg77) and chIFITM3 (Val103) proteins were simultaneously under positive selection. Together these data suggest that IFITM genetic variation may contribute to the capacities of different chicken populations to resist viral infection. |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | This paper is currently in press in. BMC Genomics. |
| Title | Correlative Light and Electron Microscopy (CLEM) on IBDV-infected cells |
| Description | Jenny Simpson and Pippa Hawes have developed the technique of Correlative Light and Electron Microscopy (CLEM). This technique has been used to visualise Virus Factories of IBDV. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The Virus Factories (VFs) of IBDV were thought to be paracrystalline arrays of virions in the cytoplasm. However, combining our GFP11-tagged IBDV with CLEM technology revealed that the VFs are actually proteinaceous accumulations in the cytoplasm. This has opened up a new avenue of research in terms of the ultrastructure, formation and function of the VFs. |
| Title | Detection of HA antigens of avian influenza viruses |
| Description | Assay for detection of recombinant HVT expressing HA antigens of avian influenza viruses |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This new method will help to detect recombinant HVT vaccine expressing HA antigen in infected cell. |
| Title | Developed an in vivo infection model to generate highly pathogenic bovine RSV for challenge studies. Developed an accompanying in vitro titration method to calculate yield of virus produced. |
| Description | Developed an in vivo infection model to generate highly pathogenic bovine RSV for challenge studies. Developed an accompanying in vitro titration method to calculate yield of virus produced. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Will help use and improve the calf challenge model of bovine RSV for vaccine testing. |
| Title | Developed assays for evaluation of antigen specific memory chicken T cells |
| Description | An in vitro model for generation of effector cells from memory T cells for chicken T cells were developed |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | This method will enable scientists working on poultry vaccines and immune response to pathogens to assess memory T cell responses in chickens. |
| Title | Development of CLEM techniques for RSV |
| Description | We have developed the technical expertise to perform correlative light electron microscopy on respiratory syncytial virus infected cells. This allows us to directly compare immunofluorescent images with transmission EM of the same cell. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | We have recently submitted a paper and grant building on this expertise, as well as forging new collaborations with Diamond light source. |
| Title | Development of SARS-CoV-2 pseudotypes |
| Description | Method to allow assessment of SARS-CoV-2 entry, which can be used in various experiments including VNTs to assess humoral immune response (in convalescent or vaccinated individuals) |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Application in the establishment of the SARS-CoV-2 international reference standard by NIBSC |
| Title | Development of a serological standard for Nipah virus in collaboration with NIBSC |
| Description | We have helped to test and characterise a serological standard for NIBSC. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | None to date - the reagent has yet to be released. |
| Title | Development of assay for assessing antigen-specific T cell responses in chickens |
| Description | An in vitro assay were developed to generate effector memory T cells from memory T cells (cultured ELISPOT assay for chicken T cells) |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | Enables scientists to assess memory T cell responses induced by poultry vaccines |
| Title | Development of assays for quantifying fusion inhibitory antibodies in sera (mFIT assay) |
| Description | We have developed a micro-fusion inhibition test (mFIT) assay to identify and quantify antibody responses (to vaccines etc.) which are capable of inhibiting viral induced cell-cell fusion. This test has been developed for various negative strand viruses (Nipah and RSV) as well as SARS-CoV-2 |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | This assay was used to aide development of the NIBSC WHO international standard for SARS-CoV-2 |
| Title | Development of chicken NKT cell tetramer |
| Description | Tetramer for detection and quantification of chicken NKT cells are developed and tested. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | This will lead to identification of a novel chicken lymphocytes which has major role in the control of infectious diseases and tumour in chickens. |
| Title | Development of high-throughput assay for examining viral mediated cell-cell fusion |
| Description | We have developed and optimised high-throughput assays (96 well plate format) to examine viral induced cell-cell fusion, using an adapted Bi-FC approach. We are using this to identify inhibitors of paramyxovirus, e.g. measles and RSV, fusion and attachment proteins as well as SARS-CoV-2. This has been integrated with next-generation platforms such as the Incucyte real-time imaging system available at The Pirbright Institute, and the system has been rationalised so that it is entirely inducible. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | We are using this assay to examine the innate immune restriction of paramyxovirus replication. |
| Title | Development of tetramers to study immune responses in pigs |
| Description | The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume. It is also an important vector in the birds to human infection cycle. A major drawback of the current pig model is the inability to analyze antigen-specific CD8+ T-cell responses, which are critical to respiratory immunity. We addressed this knowledge gap using an established in-bred pig model with a high degree of genetic identity between individuals, including the MHC (Swine Leukocyte Antigen (SLA)) locus. We developed a toolset that included long-term in vitro pig T-cell culture and cloning and identification of novel immunodominant influenza-derived T-cell epitopes. We also generated structures of the two SLA class I molecules found in these animals presenting the immunodominant epitopes. These structures allowed definition of the primary anchor points for epitopes in the SLA binding groove and established SLA binding motifs that were used to successfully predict other influenza-derived peptide sequences capable of stimulating T-cells. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Peptide-SLA tetramers were constructed and used to track influenza-specific T-cells ex vivo in blood, the lungs and draining lymph nodes. Aerosol immunization with attenuated single cycle influenza viruses (S-FLU) induced large numbers of CD8+ T-cells specific for conserved NP peptides in the respiratory tract. Collectively, these data substantially increase the utility of pigs as an effective model for studying protective local cellular immunity against respiratory pathogens. |
| Title | Established a method to immortalize bovine antigen presenting cells |
| Description | Established protocols to prepare lentiviruses expressing the proto-oncogenes Bmi1 and hTERT. Established protocols to transduce and generate immortal bovine antigen presenting cells derived from peripheral blood monocytes. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | This is the first successful attempt at generating bovine immortal monocytic cell lines. This method can also be applied to immortalize B cells. This will result in reducing the number of animals used in experimentation and considerably reduce costs. |
| Title | Established human T cell lines expressing bovine WC1 genes for the analysis of WC1 signal transduction pathways. |
| Description | Established human Jurkat T cells expressing bovine the bovine gammadelta WC1 co-receptor |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | This cell line will help determine the function of the WC1 co-receptor in gammadelta T cell activation and function. |
| Title | Gene expression analysis by qPCR to investigate the host immune response |
| Description | Evaluation of regulation of gene expression involved in the interferon response during viral infection is investigated by qPCR. Analysis of reference genes and experimental genes expression are compared to normalised gene expression variation and link them to events of up- and down-regulation in tissues collected during animal studies or from in vitro data of infected cells. The reference genes are first selected based on the variables occurring in the study (GeNorm and NormFinder are adopted for the selection) and the experimental genes linked to the interferon analysis are normalised to those basal expression level. The delta-deltaCt comparison is used to infer the fold change in gene expression. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | The analysis of gene expression linked to interferon response has been used for evaluating the effect of viral replication during IBV infection, testing tissues collected during an animal study. Viral loads quantified by qPCR have been correlated to gene expression levels in tissues collected from birds infected with different recombinant IBV thought to have a targeted influence on the immune response. Equally, mock infected birds have been analysed to provide the basal expression data and threshold. The data have been collected and analysed for the manuscript "Recombinant avian infectious bronchitis viruses with targeted modifications in the nsp3 Macrodomain are attenuated in vivo and display morphological distinct phenotypes in vitro" under preparation. |
| Title | Generated a MHC-defined bovine monophagocytic cell line. |
| Description | Using the method described above, successfully generated one MHC-defined bovine monophagocytic cell line (A18) which expresses and single classical MHC gene (HD6). |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | Will help reduce the number of animals used in experimentation. Will help resolve antigen presentation pathways in bovine cells and using bovine pathogens. Will help understand T cell activation pathways using MHC matched and mis-matched cells. Will help investigate bovine NK cell activation. |
| Title | Generated monophagocytic reporter cell lines to study the NF-kB signaling pathway |
| Description | Generated human monophagocytic cells expressing alkaline phosphatase reporter gene under a NF-kB promoter sequence. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | This cell line is helping determine the role of RSV genes in immune modulation of monophagocytic cells in response to RSV infection. |
| Title | Generation of cell-free virus using feather follicle stem cells |
| Description | An in vitro model for generation and purification of cell-free virus using feather follicule stem cells |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | Cell lines could be used to generate cell free vaccines against Marek's disease virus |
| Title | IBDV Reverse Genetics System |
| Description | We have developed a reverse genetics system for IBDV. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | We have used the reverse genetics system to generate recombinant IBDVs and chimeric recombinant IBDVs that contain genes from classical and very virulent strains of IBDV in the background of a cell culture adapted attenuated strain. This will enable us to study the effect of individual virus genes on pathogenicity. |
| Title | Library of Arenavirus and alphacoronavirus receptors and attachment proteins |
| Description | We have developed a wide database of attachment proteins and receptors for two different virus groups to help better understand virus host range. This was developed in collaboration with a bioinformatician to help select a representative database. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | None to date - project still ongoing. |
| Title | Luciferase assay responsive to chMX stimulation for detection of bioactive IFN |
| Description | A luciferase assay was established for detection of chicken bioactive interferon in biological samples. A plasmid was generated containing the chMX responsive element paired with the luciferase gene. Transfection of DF1 cells with the selected plasmid, paired with a renilla based construct for estimating transfection efficiency allowing data normalisation is conducted to quantify the amount of interferon (IFN) units in the tested sample. Comparison of Renilla and luciferase luminescence values (RLU) detected by a luminometer upon use of a reporter system allows for the relative comparison of IFN quantity in different samples. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | The quantification of bioactive interferon allows for the detection of an innate immune response in the context of viral infections. Specifically, reverse genetics targeting selected genes (nsp3, nsp16, spike) and allowing the generation of recombinant viruses with potential implication in the host interaction have been tested by this method to quantify the impact of the targeted modification in the ability of each rIBV to induce interferon. Notably interferon response is the first line of defence during viral infection. The assay has been tested on in vitro infections conducted in chicken kidney cells. The assay will also be used to evaluate the impact of temperature sensitivity of rIBVs in the context of the IFN immune response. |
| Title | Method to evenly load flowcells with multiple samples |
| Description | Pirbright has an Illumina NextSeq sequencing machine installed in containment. Given the large amount of sequencing reads produced by each run, multiple samples are usually multiplexed on the same flowcell. However, determining the correct concentrations needed to obtain the same amount of reads for each sample is a hard problem, and usually requires a number of expensive and material-consuming kits to be run prior to sequencing. We have developed a method that allows samples to be evenly multiplexed based only on Bioanalyzer data (we routinely run Bioanalyser on the samples anyway as a form of quality control). The method works well, and reliably across a wide range of sample concentrations and sequenced organisms. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The method greatly increased the quality of our output, and drastically simplified our workflow by eliminating the external quantification steps that were previously required. |
| Title | Methods to characterize cattle antibodies Fc-mediated functions |
| Description | A suite of assays have been developed to analyse the effector functions of cattle Ig subtypes. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | This suite of methods is now being applied to FMDV-specific antibodies, and will allow to better understand the role of non neutralizing antibodies. |
| Title | Methods to sequence cattle antibodies at different throughputs |
| Description | A suite of methods to isolate cattle B cells, amplify and sequence cattle antibody heavy and light chains, and to analyse antibody repertoires. Workflow has been adapted for low (Sanger), medium (NGS), and high (10X genomics platform) throughput. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Following the publication of these methods, we have been contacted by several research groups (University of Sao Paulo, Glasgow, ILRI institute) for collaborations on antibody repertoire analysis. |
| URL | https://doi.org/10.3390/vaccines11061099 |
| Title | Methods to sequence chicken antibodies at different throughputs |
| Description | A suite of methods to isolate chicken B cells, and to sequence antibodies at low, medium (NGS), and high (10X platform) throughputs. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | These methods have been used to sequence IBV-specific antibodies (expression ongoing), and will be used for IBDV-specific antibodies discovery (in collaboration with ANSES, France). We were contacted by a research group in Munich (Germany) to develop partnership on chicken B cell and antibody characterization (SH). |
| Title | Methods to sequence pig antibodies at different throughputs |
| Description | A suite of methods to sort pig B cells, and to amplify, sequence and characterize pig antibodies. Sequencing has been adapted for low (Sanger), and medium (NGS) throughput, and is being optimized for high throughput (10X genomics platform). |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | The primers initially used were published, and have been optimized since. They are available on demand until next publication. We have been contacted to assist in the analysis of antibody repertoire of ASFV infected warthog (AL, ILRI, Kenya), and ASFV infected pigs (AS, IVI, Switzerland). |
| Title | Optimisation of chicken kidney cell culture preparation |
| Description | We have optimised the method of extracting kidneys and preparing chicken kidney (CK) cell cultures from chickens. CK cells are used for in vitro assays to study avian viruses, in particular infectious bronchitis virus. |
| Type Of Material | Cell line |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This has increased the yield of viable cells and the quality of the cell cultures. We can now obtain the number of cells we require using fewer chicken kidneys, therefore requiring fewer chickens to be culled. This is an important development for the 3Rs. We hope to publish this method for others' information. |
| Title | Optimisation of preparation of TOCs from adult chickens |
| Description | Tracheal organ cultures (TOCs) are prepared from chicken embryos and used to assess growth of avian viruses that are not able to be propagated in cell culture. We have optimised the method of TOCs preparation from 3-week old chickens and are using these to assess viral genetic stability and phenotype in organ cultures that are a similar environment to the site of replication in whole chickens. |
| Type Of Material | Cell line |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | We hope that this technique will reduce the number of chickens required for in vivo experiments, in line with the 3Rs, and plan to publish the method in due course. |
| Title | Panel of ACE2 proteins for screening SARS-CoV-2 host range |
| Description | A biological library of ACE2 expression constructs representing receptors from 22 different human and animal species. In 2022 we extended this to over 60 proteins to widen our understanding of sarbecovirus host range. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Establishment of surveillance tools to examine the potential reverse zoonotic spillover of SARS-CoV-2 into anima species |
| Title | Recombinant antibody generation pipeline - WM |
| Description | Validated a sequencing protocol at Pirbright for mouse hybridomas, cattle heterohybridomas, and porcine B cells. Vector constructed for humans, mouse, cattle, pigs and chicken to allow ligation of commercially generated antibody gene blocks or PCR products generated by degenerate or 5' RACE PCR. These methods allow the following: • Sequencing mAbs • Making Fab fragments from mAbs • Class switching mAbs • Species switching mAbs |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The methods developed have enabled a standardised pipeline that allows cloning of PCR products or synthetic gene constructs for recombinant antibody generation from various species. This uniform approach avoids development of bespoke protocols for each species thus saving time and resources. |
| URL | http://www.immunologicaltoolbox.co.uk |
| Title | Stable chicken cell lines overexpressing chicken IFITM1,2 and 3 |
| Description | In collaboration with Mark Fife, we have produced chicken stable cell lines overexpressing chicken IFITM1,2, 3 and a mutant chicken IFITM3 lacking palmitoylation sites. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | These cell lines will be used to evaluate the effect of the IFITM proteins on the replication of different viruses, including IBDV. |
| Title | UniMMap- a pipeline for mapping RNAseq data over repetitive immune complexes. |
| Description | To exploit the abundance of available short read sequencing data we have developed a pipeline that uses mappability to accurately measure transcription over repetitive gene complexes. This methods uses known haplotypes to examine regions of uniqueness, and then the RNAseq data from the individual to train the method to be species or individual specific. This is particularly important over gene complexes that contain genes involved in the immune system, that are often highly similar in sequence but can have profoundly different functions. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | the immediate impact will be adding fine resolution data to livestock gene expression atlas projects lead by the FAANG consortium. Further impact will be arising as this method is published and we apply it to numerous existing datasets the are publically avaialable as well as generated at Pirbright and by our collaborators. |
| Title | chimeric IBDVs |
| Description | Andrew Broadbent has engineered chimeric IBDVs expressing individual genes from a very virulent strain in the backbone of an attenuated strain. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | These chimeric strains can be used to define viral determinants of virulence. |
| Title | chimeric recombinant IBDV with the hypervariable region from field strains |
| Description | Using our reverse genetics system and B cell culture system, we have engineered a chimeric IBDV with the backbone of a lab-adapted strain, but containing the hyper variable region of the capsid from a very virulent field strain (UK661). |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | This is a proof of concept that it is possible to engineer an IBDV containing the hypervariable region from another strain. We now plan to engineer chimeric viruses with the hypervariable region from strains belonging to different genogroups from different geographical regions and use them to screen the serum from vaccinated birds to deduce the breadth of antibody responses. |
| Title | in vitro model of IBDV antigenic drift in chicken B cells |
| Description | IBDV vaccines do not induce sterilising immunity, meaning vaccinated birds can become infected with field strains. As for other viruses, it is thought that vaccine-induced immune selection pressure drives the evolution of antigenic drift variants that accumulate amino acid changes in the hypervariable region of the capsid, which may lead to vaccine failures. However, antigenic drift has not been studied in any detail for IBDV, and there is therefore a paucity of information regarding how plastic the capsid is, how quickly mutations arise and become fixed in the virus population, or whether some are more dominant than others. One way of studying this is to vaccinate chickens with sub-protective doses and then challenge them with field strains of IBDV and then sequence the resulting viruses that emerge. To replace the use of birds in these experiments, we have developed an in vitro model of antigenic drift by serially passaging a field strain, F5270, in the immortalised chicken B cell line, DT40, in the presence of sub-neutralising concentrations of vaccine-induced antibodies to better characterise changes in the capsid. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | In our model, amino acid mutations arose in the hypervariable region of the IBDV capsid at the same sites previously observed in field studies, validating our model. Furthermore, we demonstrated that mutations arose early, by only 5 passages in chicken B cells, which subsequently became fixed by 10 passages. We are now doing next generation sequencing to better characterise the plasticity of the capsid. |
| Title | method for identification of lung Tissue resident memory cells in pigs |
| Description | Recent overwhelming evidence indicates the importance of local tissue-resident memory T cells (TRM) in protective immunity. Most work on TRM has been performed in mice and the TRM defined as inaccessible to intravenously administered anti-T cell antibody. However there are very few data on TRM in large animals. For the first time we have defined TRM in the pig influenza model. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The identification of TRM and their robust protective capacity in site-specific infection has provided a new paradigm by which to assess T cell-mediated responses and an important new target for vaccine design. Since swine are an economically important species, are used as a large animal model for human infection and play a key role in the emergence of novel and potentially zoonotic influenza viruses, the identification of TRM in pigs will allow us to study their role in immunity to swine influenza.and how best to induce them by immunisation. |
| Title | porcine TOCs |
| Description | We have developed the method of preparing and infecting tracheal organ cultures (TOCs) from pigs with porcine coronaviruses. |
| Type Of Material | Cell line |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | The development of the porcine TOCs will allow us to study the replication, tropism and evolution of porcine coronaviruses in biologically relevant tissues, without the requirement for an in vivo study. Porcine coronaviruses can be used as a model for SARS-CoV-2 infection of humans. |
| Title | replication competent recombinant split-GFP infectious bursal disease virus |
| Description | We have generated a replication competent recombinant split-GFP infectious bursal disease virus (IBDV) where a small GFP11 molecule is tagged to the virus polymerase (VP1) to make IBDV-VP1-GFP11. Infected cells that express the GFP1-10 molecule fluoresce green when the GFP11 tag complements the GFP1-10. The IBDV-VP1-GFP11 colocalises with VP3 and dsRNA and therefore is likely to be present at the sites of virus replication. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This tool can be used to study IBDV replication complex development in infected cells. |
| Title | scRNA seq analysis of porcine BAL |
| Description | We describe for the first time scRNA-seq analysis of porcine bronchoalveolar lavage (BAL), a cell source increasingly used to analyse respiratory immune responses, and which has been shown to be major correlate for protection against respiratory infections such as influenza, respiratory syncytial virus, and SARS-CoV-2. Our work reveals both similar and unique cell subsets and divergent transcriptome profiles of BAL immune cells compared to publicly available data from blood cells. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | The data we have generated will provide an atlas for future pig BAL scRNA-seq studies. |
| Title | tetracysteine-tagged IBDV |
| Description | Andrew Broadbent has engineered a tetracysteine (TC)-tagged IBDV that can be used in live cell imaging and co-infection studies with the split-GFP IBDV. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | This tool, combined with the split-GFP IBDV, will enable us to study co-infection, super-infection exclusion, and the intracellular requirements for viral reassortment. |
| Title | Additional file 3 of Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines |
| Description | Additional file 3. Supplementary Table S5. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Low_pathogenic_avian_influ... |
| Title | Additional file 3 of Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines |
| Description | Additional file 3. Supplementary Table S5. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Low_pathogenic_avian_influ... |
| Title | Additional file 4 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 4: Dataset 1. Full data set of collected Culicoides including site, trap location, collection date and morphological identification. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_4_of_Culicoides_species_composition_and... |
| Title | Additional file 4 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 4: Dataset 1. Full data set of collected Culicoides including site, trap location, collection date and morphological identification. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_4_of_Culicoides_species_composition_and... |
| Title | Additional file 5 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 5: Table S1. Species composition of blood-fed Culicoides caught in traps. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_5_of_Culicoides_species_composition_and... |
| Title | Additional file 5 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 5: Table S1. Species composition of blood-fed Culicoides caught in traps. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_5_of_Culicoides_species_composition_and... |
| Title | Additional file 6 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 6: Table S2. Results of blood meal analysis of Culicoides collected from ZSL London Zoo and Whipsnade Zoo. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_6_of_Culicoides_species_composition_and... |
| Title | Additional file 6 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 6: Table S2. Results of blood meal analysis of Culicoides collected from ZSL London Zoo and Whipsnade Zoo. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_6_of_Culicoides_species_composition_and... |
| Title | Additional file 7 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 7: Table S3. Comparison of different models for the number of Culicoides biting midges caught at London and Whipsnade zoos. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_7_of_Culicoides_species_composition_and... |
| Title | Additional file 7 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 7: Table S3. Comparison of different models for the number of Culicoides biting midges caught at London and Whipsnade zoos. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_7_of_Culicoides_species_composition_and... |
| Title | Additional file 7 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 7: Data S1. Full data set of collected Culicoides including site, trap location, collection date and morphological identification |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Emergence_dynamics_of_adul... |
| Title | Additional file 7 of Emergence dynamics of adult Culicoides biting midges at two farms in south-east England |
| Description | Additional file 7: Data S1. Full data set of collected Culicoides including site, trap location, collection date and morphological identification |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Emergence_dynamics_of_adul... |
| Title | Additional file 8 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 8: Table S4. Effect of seasonality, year, temperature and trap location on the number of Culicoides collected. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_8_of_Culicoides_species_composition_and... |
| Title | Additional file 8 of Culicoides species composition and molecular identification of host blood meals at two zoos in the UK |
| Description | Additional file 8: Table S4. Effect of seasonality, year, temperature and trap location on the number of Culicoides collected. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_8_of_Culicoides_species_composition_and... |
| Title | Analysis of paramyxovirus replication using Incucyte real-time imager |
| Description | We have optimised a data analysis pipeline for the Incucyte real-time imager to allow us to track viral replication in a high-throughput fashion (up to 6 x 96-well plates). This is based on simultaneous analysis of phase, as well as green and red fluorescence. |
| Type Of Material | Data analysis technique |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Only preliminary data to date. |
| Title | Babraham pig genome assembly and transcriptome atlas |
| Description | A long-read whole genome assembly of the Babraham pig (TPI_Babraham_pig_v1; GCA_031225015.1) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | None yet. |
| Title | E-MTAB-5947- Transcription profiling by array of differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV) |
| Description | Microarray data submitted to ArrayExpress from chicken primary B cells infected with a very virulent and attenuated strain of IBDV. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | This is the first ever microarray data of chicken primary B cells infected with IBDV and will be of use to other researchers in the area of B cell biology or IBDV virology |
| URL | https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-5947/ |
| Title | FDA drug screening of RSV and SARS-CoV-2 cell-cell fusion |
| Description | Using inducible cell-cell fusion assays for SARS-CoV-2 and RSV we have screened the FDA approved use drug library for inhibitors of these viral-induced processes |
| Type Of Material | Data analysis technique |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | No impact as yet, data still being validated in live virus assays |
| Title | Full length cattle MHC genes |
| Description | Using our method for full length MHC gene amplification, the largest reference set ever produced from common haplotypes has been sequenced and deposited in the publicly available data IPD-MHC with associated research tools. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | No |
| Impact | None yet, but it will allow far greater resolution when analysing MHC polymorphism and evolution in cattle populations. |
| URL | https://www.ebi.ac.uk/ipd/mhc/group/BoLA/ |
| Title | Technique for analysing interferon stimulated gene inhibition of RSV cell-cell fusion |
| Description | We have developed the techniques and performed the experiments to examine the effect of over-expressing individual interferon stimulated genes on RSV (bovine and human) replication and cell-cell fusion. This was achieved through integration of library technologies (for the ISGs) and high throughout imaging platforms. |
| Type Of Material | Data analysis technique |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | No impact yet as data has still to be published. Manuscript in preparation. |
| Title | The molecular basis of antigenic variation among A(H9N2) avian influenza viruses |
| Description | Avian influenza A(H9N2) viruses are an increasing threat to global poultry production and, through zoonotic infection, to human health where they are considered viruses with pandemic potential. Vaccination of poultry is a key element of disease control in endemic countries, but vaccine effectiveness is persistently challenged by the emergence of antigenic variants. Here we employed a combination of techniques to investigate the genetic basis of H9N2 antigenic variability and evaluate the role of different molecular mechanisms of immune escape. We systematically tested the influence of published H9N2 monoclonal antibody escape mutants on chicken antisera binding, determining that many have no significant effect. Substitutions introducing additional glycosylation sites were a notable exception, though these are relatively rare among circulating viruses. To identify substitutions responsible for antigenic variation in circulating viruses, we performed an integrated meta-analysis of all published H9 haemagglutinin sequences and antigenic data. We validated this statistical analysis experimentally and allocated several new residues to H9N2 antigenic sites, providing molecular markers that will help explain vaccine breakdown in the field and inform vaccine selection decisions. We find evidence for the importance of alternative mechanisms of immune escape, beyond simple modulation of epitope structure, with substitutions increasing glycosylation or receptor-binding avidity, exhibiting the largest impacts on chicken antisera binding. Of these, meta-analysis indicates avidity regulation to be more relevant to the evolution of circulating viruses, suggesting that a specific focus on avidity regulation is required to fully understand the molecular basis of immune escape by influenza, and potentially other viruses. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://tandf.figshare.com/articles/dataset/The_molecular_basis_of_antigenic_variation_among_A_H9N2_... |
| Title | The molecular basis of antigenic variation among A(H9N2) avian influenza viruses |
| Description | Avian influenza A(H9N2) viruses are an increasing threat to global poultry production and, through zoonotic infection, to human health where they are considered viruses with pandemic potential. Vaccination of poultry is a key element of disease control in endemic countries, but vaccine effectiveness is persistently challenged by the emergence of antigenic variants. Here we employed a combination of techniques to investigate the genetic basis of H9N2 antigenic variability and evaluate the role of different molecular mechanisms of immune escape. We systematically tested the influence of published H9N2 monoclonal antibody escape mutants on chicken antisera binding, determining that many have no significant effect. Substitutions introducing additional glycosylation sites were a notable exception, though these are relatively rare among circulating viruses. To identify substitutions responsible for antigenic variation in circulating viruses, we performed an integrated meta-analysis of all published H9 haemagglutinin sequences and antigenic data. We validated this statistical analysis experimentally and allocated several new residues to H9N2 antigenic sites, providing molecular markers that will help explain vaccine breakdown in the field and inform vaccine selection decisions. We find evidence for the importance of alternative mechanisms of immune escape, beyond simple modulation of epitope structure, with substitutions increasing glycosylation or receptor-binding avidity, exhibiting the largest impacts on chicken antisera binding. Of these, meta-analysis indicates avidity regulation to be more relevant to the evolution of circulating viruses, suggesting that a specific focus on avidity regulation is required to fully understand the molecular basis of immune escape by influenza, and potentially other viruses. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://tandf.figshare.com/articles/dataset/The_molecular_basis_of_antigenic_variation_among_A_H9N2_... |
| Description | Aerosol delivery of vaccines and therapeutics |
| Organisation | Aerogen |
| Country | Ireland |
| Sector | Private |
| PI Contribution | Developed the pig influenza model which is a natural host pathogen system |
| Collaborator Contribution | Provided expertise and equipment for aerosol delivery |
| Impact | Successfully delivered vaccines by aerosol |
| Start Year | 2015 |
| Description | Andrew Davidson - Proteome of viral replication organelles |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Projects are being initiated to study the cellular proteins associated with coronavirus replication organelle membranes and a funding application has been submitted to BBSRC. |
| Collaborator Contribution | Andrew has provided assistance with experimental planning and drafting of a grant application. He has also provided protocols to allow preliminary data to be generated. Once protocols have been established, Andrew will facilitate mass spectrometry data generation and will analyse the resulting data. |
| Impact | No outcomes to date, projects being initiated and funding applications in progress. |
| Start Year | 2018 |
| Description | Annika Posautz; University of Veterinary Medicine Vienna. Morbillivirus host-diversity analysis. |
| Organisation | University of Veterinary Medicine Vienna |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Sharing of research data regarding morbillivirus host-range and technical support to the project. |
| Collaborator Contribution | Provision of tissue samples from potential morbillivirus hosts, e.g. carnivores. |
| Impact | No outcomes as yet. |
| Start Year | 2018 |
| Description | Arbovirus reverse genetics systems (AM) |
| Organisation | University of Tartu |
| Country | Estonia |
| Sector | Academic/University |
| PI Contribution | We brought our expertise in flaviviruses, in particular emerging flaviviruses including Zika virus and Alkhumra haemorrhagic fever virus. We also brought our expertise in high containtment virology up to ACDP Hazard Group 3, SAPO3 and Schedule 5 for molecularly characterising recombinant viruses. |
| Collaborator Contribution | The partner brought their expertise in making viral reverse genetics systems for dissecting the function of viral proteins. |
| Impact | A number of reverse genetics systems for flaviviruses have been generated, which are allowing us to interrogate questions about how viruses jump between host and vector species. |
| Start Year | 2018 |
| Description | Aviagen |
| Organisation | Aviagen |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Influenza virus expertise in poultry. |
| Collaborator Contribution | Sharing of commercial poultry breed resources |
| Impact | We have a sponsored PhD studentship to commence Oct 2021 agreed. |
| Start Year | 2020 |
| Description | BBSRC - Oxford University iCASE Studentship (October 2019- September 2023). Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration between The Pirbright Institute (UK), Oxford University (UK) and industrial partners in Italy. This project will conceived and developed bu MI. The PhD student (Holly Everest) in my group is investigating the antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production. |
| Collaborator Contribution | The partners in Italy will produce and purify natural antiviral molecules effective against avian influenza and other poultry viruses. |
| Impact | This project started in January 2020. |
| Start Year | 2020 |
| Description | BBSRC LINK Project |
| Organisation | University of Plymouth |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Confirm susceptibility of porcine macrophage cell line to African swine fever virus |
| Collaborator Contribution | Provide a conditionally transformed porcine macrophage cell line for research and diagnosis of African swine fever virus |
| Impact | None yet |
| Start Year | 2019 |
| Description | BBSRC-UC Davis workshop, 16-18 October |
| Organisation | University of California, Davis |
| Department | UC Davis College of Biological Sciences |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities. |
| Collaborator Contribution | Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities. |
| Impact | Discussion of potential joint publications and grant applications; no tangible impacts yet. |
| Start Year | 2017 |
| Description | BBSRC-UC Davis workshop, 16-18 October |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities. |
| Collaborator Contribution | Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities. |
| Impact | Discussion of potential joint publications and grant applications; no tangible impacts yet. |
| Start Year | 2017 |
| Description | Belsham |
| Organisation | Technical University of Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Collaborator Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Impact | Joint PhD studentship Further funding |
| Start Year | 2016 |
| Description | Belsham |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Collaborator Contribution | Joint PhD studentship and ongoing collaboration on capsid assembly |
| Impact | Joint PhD studentship Further funding |
| Start Year | 2016 |
| Description | Bioimaging collaboration with Dr. Daniel Clare, Dr. James Gilchrist, Dr. Pippa Hawes - cryo-electron tomography Diamond Light Source |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of preliminary data on inclusion body structure to support higher resolution approaches. |
| Collaborator Contribution | Discussion of project and experimental design, technological approaches and limitations. |
| Impact | No outputs to date. Multi-disciplinary team of virologists and structural biologists |
| Start Year | 2020 |
| Description | Biophysics collaboration with Prof. Stephen McKnight, UTSW-Dallas |
| Organisation | University of Texas Southwestern Medical Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Development of preliminary data on the biophysics and biochemistry of inclusion bodies |
| Collaborator Contribution | Supportive comments on grant applications and experimental design advice. |
| Impact | No outputs to date |
| Start Year | 2020 |
| Description | Bridget Penman |
| Organisation | University of Warwick |
| Department | School of Life Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are providing genetic data and diversity measures of MHC and associated receptors to inform the modelling efforts to elucidate which selection pressures are the main drivers for the types of diversity we see in extant species. |
| Collaborator Contribution | They are experts in mathmatical modelling and will provide data to help explain genetic diversity in cattle. |
| Impact | Not yet |
| Start Year | 2017 |
| Description | CUI at King's College London |
| Organisation | King's College London |
| Department | Centre for Ultrastructural Imaging |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint PhD student based at King's |
| Collaborator Contribution | Primary supervisor is at King's |
| Impact | Student has attended Imaging meetings in Ireland and UK and has given a talk and submitted two posters. |
| Start Year | 2022 |
| Description | CVR |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Pirbright has several groups investigating various aspects of vector-borne diseases. My group provides mosquito expertise, including gene editing, genetics and transgenesis. CVR have expert arbovirologists with complementary interests. We have developed and exchanged research materials and reagents, shared expertise, and have shared grant funding. |
| Collaborator Contribution | Pirbright has several groups investigating various aspects of vector-borne diseases. My group provides mosquito expertise, including gene editing, genetics and transgenesis. CVR have expert arbovirologists with complementary interests. We have developed and exchanged research materials and reagents, shared expertise, and have shared grant funding. |
| Impact | Joint grant. Several ongoing research strands within this. |
| Start Year | 2021 |
| Description | Challenge of transgenic chickens with influenza viruses |
| Organisation | Imperial College London |
| Department | Section of Virology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have challenged transgenic chickens with recombinant avian influenza viruses to determine outcome; infectivity, transmission, pathogenicity, dissemination within host. We also processed the samples generated from these animal experiments at The Pirbright Institute. |
| Collaborator Contribution | Imperial College (Wendy Barclay and Mike Skinner) generated recombinant avian influenza viruses for challenge. |
| Impact | This collaboration has resulted in the successful award of a joint grant with imperial college aiming to carry out challenge experiments on novel transgenic chickens to facilitate control of avian influenza virus in the poultry population. BB/S007911/1 - Investigating the role of ANP32A in the replication of avian Influenza virus |
| Start Year | 2018 |
| Description | Charles Sande - KEMRI - Kenya: RSV collaboration |
| Organisation | Kenyan Institute for Medical Research (KEMRI) |
| Country | Kenya |
| Sector | Public |
| PI Contribution | Development of research proposal for PhD studentship on the innate immune response during RSV infection. This student will be hosted by my lab for 18 months from 2020 onwards. |
| Collaborator Contribution | Project design. Application for PhD funding and provision of technical support. |
| Impact | The studentship was awarded to Dr. Sande in Kenya and the student has been recruited. They will commence their studies in Spring 2019 and come to the UK in early 2020. |
| Start Year | 2018 |
| Description | Chicken Microbiome - Robert La Ragione - University of Surrey |
| Organisation | University of Surrey |
| Department | School of Veterinary Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing sequencing data of gut microbiome from chickens infected with avian influenza viruses. |
| Collaborator Contribution | Sharing expertise in the analysis of microbiome data |
| Impact | Joint manuscripts and funding opportunities are being explored |
| Start Year | 2019 |
| Description | Collaboration on SARS-CoV-2 host range with Prof. Wendy Barclay |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Assaying novel SARS-CoV-2 variant sequences for increased tropism to non-human receptors |
| Collaborator Contribution | Provision of variant Spike constructs |
| Impact | Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Zhou J, Peacock TP, Brown JC, Goldhill DH, Elrefaey AME, Penrice-Randal R, Cowton VM, De Lorenzo G, Furnon W, Harvey WT, Kugathasan R, Frise R, Baillon L, Lassaunière R, Thakur N, Gallo G, Goldswain H, Donovan-Banfield I, Dong X, Randle NP, Sweeney F, Glynn MC, Quantrill JL, McKay PF, Patel AH, Palmarini M, Hiscox JA, Bailey D, Barclay WS. Cell Rep. 2022 Feb 8;38(6):110344. https://pubmed.ncbi.nlm.nih.gov/35093235/ |
| Start Year | 2020 |
| Description | Collaboration on replication of mumps virus in cells |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input so far, training research assistant to prepare samples, imaging samples in transmission electron microscopes |
| Collaborator Contribution | Preliminary confocal microscopy to optimize sample conditions. Preparation of samples for EM. |
| Impact | No outcomes yet |
| Start Year | 2018 |
| Description | Collaboration on replication of mumps virus in cells |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input so far, training research assistant to prepare samples, imaging samples in transmission electron microscopes |
| Collaborator Contribution | Preliminary confocal microscopy to optimize sample conditions. Preparation of samples for EM. |
| Impact | No outcomes yet |
| Start Year | 2018 |
| Description | Collaboration on the development of intranasal live-attenuated vaccine against SARS-CoV-2 |
| Organisation | Lancaster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contributed reagents to tests the immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2 in preclinical animal models including mice and hamster. |
| Collaborator Contribution | The partners undertook most of the work to complete the study detailed in the publication entitled "Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2 in preclinical animal models". https://www.biorxiv.org/content/10.1101/2021.01.08.425974v1 Abstract of publication. The global deployment of an effective and safe vaccine is currently a public health priority to curtail the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a Newcastle disease virus (NDV)-based intranasal vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy in challenge studies with SARS-CoV-2. The recombinant (r)NDV-S vaccine expressing spike (S) protein of SARS-CoV-2 administrated via intranasal route in mice induced high levels of SARS-CoV-2-specific neutralizing immunoglobulin A (IgA) and IgG2a antibodies and T cell-mediated immunity. Hamsters vaccinated with two doses of vaccine showed complete protection from clinical disease including lung infection, inflammation, and pathological lesions after SARS-CoV-2 challenge. Importantly, a single or double dose of intranasal rNDV-S vaccine completely blocked SARS-CoV-2 shedding in nasal turbinate and lungs within 4 days of vaccine administration in hamsters. Taken together, intranasal administration of rNDV-S has the potential to control infection at the site of inoculation, which should prevent both the clinical disease and transmission to halt the spread of the COVID-19 pandemic. |
| Impact | The partnership resulted in a joint publication. "Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2 in preclinical animal models". https://www.biorxiv.org/content/10.1101/2021.01.08.425974v1 Abstract of publication. The global deployment of an effective and safe vaccine is currently a public health priority to curtail the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a Newcastle disease virus (NDV)-based intranasal vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy in challenge studies with SARS-CoV-2. The recombinant (r)NDV-S vaccine expressing spike (S) protein of SARS-CoV-2 administrated via intranasal route in mice induced high levels of SARS-CoV-2-specific neutralizing immunoglobulin A (IgA) and IgG2a antibodies and T cell-mediated immunity. Hamsters vaccinated with two doses of vaccine showed complete protection from clinical disease including lung infection, inflammation, and pathological lesions after the SARS-CoV-2 challenge. Importantly, a single or double dose of intranasal rNDV-S vaccine completely blocked SARS-CoV-2 shedding in nasal turbinate and lungs within 4 days of vaccine administration in hamsters. Taken together, intranasal administration of rNDV-S has the potential to control infection at the site of inoculation, which should prevent both the clinical disease and transmission to halt the spread of the COVID-19 pandemic. |
| Start Year | 2020 |
| Description | Collaboration with ANSES (France) on pig antibody repertoire analysis |
| Organisation | French Agency for Food, Environmental and Occupational Health & Safety (ANSES) |
| Country | France |
| Sector | Public |
| PI Contribution | We hosted a PhD Student (VH) to train them in porcine antibody repertoire analysis. |
| Collaborator Contribution | Expertise on Aujesky disease. |
| Impact | Transfer of knowledge, techniques, and bioinformatic tools. |
| Start Year | 2022 |
| Description | Collaboration with ARC (South Africa) on flow cytometry phenotyping of cattle B cells |
| Organisation | Agricultural Research Council (ARC) |
| Country | South Africa |
| Sector | Public |
| PI Contribution | We hosted a scientist form ARC (TN) to train them in flow cytometry of cattle B cell phenotyping. |
| Collaborator Contribution | None |
| Impact | Transfer of reagents, knowledge and expertise to a LMIC. |
| Start Year | 2023 |
| Description | Collaboration with Aberdeen on cattle B cell phenotyping |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosting an intern (HB) on the development of protocols to phenotype cattle B cells. |
| Collaborator Contribution | None |
| Impact | A set of antibodies raised in other species validated for cattle B cell phenotyping |
| Start Year | 2023 |
| Description | Collaboration with Alex Borodavka on virus phase separation |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of ideas and discussions of experimental plans to work on RNA virus phase separation |
| Collaborator Contribution | Development of ideas and discussions of experimental plans to work on RNA virus phase separation |
| Impact | Work is still ongoing |
| Start Year | 2022 |
| Description | Collaboration with Dan Horton, Surrey Uni on antigenic cartography |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data for analysis, specifically antigenic titres on SARS-CoV-2 neutralisation Provision of data for analysis, specifically data on virus receptor usage |
| Collaborator Contribution | Assessment of antigenic relatedness in neutralisation datasets by antigenic cartography Assessment of receptor usage data by cartography |
| Impact | Funding awarded by UKRI, BBSRC grant BB/W006162/1 Viral entry at the human-animal interface; dissecting the pan-tropic nature of zoonotic viruses. |
| Start Year | 2021 |
| Description | Collaboration with Dr. Joe Grove, CVR-Glasgow on viral entry |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of a HCV fusion assay and analysis of mutants |
| Collaborator Contribution | Larger scale analysis of mechanisms of HCV entry |
| Impact | This work has already been published in eLife. |
| Start Year | 2022 |
| Description | Collaboration with Dr. Lindsay Broadbent on RSV |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We worked together to write a joint application for a PhD project between Pirbright and Surrey on examining the innate immune response to RSV in ALI models of the lung. |
| Collaborator Contribution | We worked together to write a joint application for a PhD project between Pirbright and Surrey on examining the innate immune response to RSV in ALI models of the lung. |
| Impact | The PhD project was funded and a student has been recruited to start in October 2022. |
| Start Year | 2022 |
| Description | Collaboration with Dr. Michelle Linterman on Covid vaccine responses |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed virus neutralisation tests for SARS-CoV-2 against various sera from vaccinated mice, primarily looking at the response to ageing. |
| Collaborator Contribution | This work is led by the Linterman group at Babraham and we are the collaborators. They do all the mouse experiments etc. |
| Impact | There have been a number of publications already as part of this collaboration. |
| Start Year | 2022 |
| Description | Collaboration with Dr. Tom Peacock on coronavirus in wildlife including bats |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments on sarbecovirus host range and shared reagents and plasmids |
| Collaborator Contribution | Tom has performed assays looking at sarbecovirus receptor usage and collaborated with bat ecologists |
| Impact | Publication under review |
| Start Year | 2022 |
| Description | Collaboration with Dr. Tyler Starr and Prof. Jesse Bloom on sarbecoviruses |
| Organisation | Fred Hutchinson Cancer Research Center (FHCRC) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Worked together to establish this UK-US collaboration and write a small application for internal funding. Organised a research visit and developed reagents for experimentation. |
| Collaborator Contribution | Worked together to establish this UK-US collaboration and write a small application for internal funding. Agreed to share DMS technology and train and host PDRAs from Pirbright. |
| Impact | None to date, work still ongoing or planned |
| Start Year | 2022 |
| Description | Collaboration with John Innes Center (UK) on BTV VLP production |
| Organisation | John Innes Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | None yet. |
| Collaborator Contribution | Collaborators at the JIC (GL group) are producing Bluetongue virus-like particles (in-king contribution) for us to analyse the B cell response post BTV vaccination in cattle. |
| Impact | None yet. |
| Start Year | 2024 |
| Description | Collaboration with KCL (UK) on antibody competition for SARS-CoV2 epitope binding |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Capability to analyse the avidity of a set of antibodies (from KCL) for a range of SARS-CoV2 variants. |
| Collaborator Contribution | A set of human SARS-CoV2-specific antibodies covering 8 immunodominant epitopes to be tested by competition ELISA with SARS-CoV2-specific antibodies generated in pigs vaccinated with SARS-CoV2ChAdOx vaccine. |
| Impact | Known avidity of a set of SARS-CoV2-specific antibodies against a range of SARS-CoV2 variants (in-kind contribution). |
| Start Year | 2022 |
| Description | Collaboration with Katie Doores on Covid immunity |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed a series of SARS-CoV-2 Spike mutants to understand the immune response to vaccination and/or infection |
| Collaborator Contribution | The Doores lab have generated a large panel of human monoclonal antibodies from Covid-infected/vaccinated people |
| Impact | Project is still ongoing |
| Start Year | 2022 |
| Description | Collaboration with Keith Chappell on virus neutralisation |
| Organisation | University of Queensland |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Assessment of neutralisation to a range of viral immunogens by VNT using pseudotyping technology Assessment of neutralisation to a range of viral immunogens by microfusion inhibition test |
| Collaborator Contribution | Provision of sera from vaccination studies Provision of constructs for pseudotyping and cell-cell fusion |
| Impact | None yet, publications in preparation |
| Start Year | 2020 |
| Description | Collaboration with Kevin Brown at UKHSA |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Performing neutralisation assays as part of UK Covid response, in particular as part of UKHSA/PHE Consensus Study |
| Collaborator Contribution | Providing sera from Consensus study Advice on project design |
| Impact | Paper under review at Nature Microbiology |
| Start Year | 2021 |
| Description | Collaboration with Neeltje can Doremalen on Covid vaccines |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | We have performed virus neutralisation assays for SARS-CoV-2 against sera from hamsters and other animals vaccinated and/or infected with Covid vaccines. |
| Collaborator Contribution | They performed all the main experiments including the hamster infections. |
| Impact | Some of this work has been published already in Nature Communications. |
| Start Year | 2022 |
| Description | Collaboration with PSU (USA) and APHA (UK) on bTB antibody response |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Optimisation of protocols to analyse the B cell response to a range of m. bovis antigens. |
| Collaborator Contribution | Provided antigens (GJ; VK), and cells (GJ) for assays optimisation, both as in-kind contributions. |
| Impact | A new ELISpot protocol for bTB-specific memory B cell quantification. |
| Start Year | 2023 |
| Description | Collaboration with PSU (USA) and APHA (UK) on bTB antibody response |
| Organisation | Penn State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Optimisation of protocols to analyse the B cell response to a range of m. bovis antigens. |
| Collaborator Contribution | Provided antigens (GJ; VK), and cells (GJ) for assays optimisation, both as in-kind contributions. |
| Impact | A new ELISpot protocol for bTB-specific memory B cell quantification. |
| Start Year | 2023 |
| Description | Collaboration with Prof. Jane McKeating on RSV and SARS-CoV-2 virology |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Assessment of SARS-CoV-2 cell-cell fusion under various conditions, and with chemical inhibitors Provision of RSV reagents |
| Collaborator Contribution | Provision of inhibitors and other reagents Experimentation with RSV |
| Impact | None yet, paper under review |
| Start Year | 2020 |
| Description | Collaboration with Prof. Nic Locker |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of ideas and discussions of experimental plans to work on RNA virus phase separation. |
| Collaborator Contribution | Development of ideas and discussions of experimental plans to work on RNA virus phase separation. Sharing of protocols and experimental reagents. |
| Impact | Work is still ongoing. |
| Start Year | 2022 |
| Description | Collaboration with Ravi Gupta, University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the biology of this virus. We performed research towards a paper focusing on related sarbecoviruses (RaTG13) |
| Collaborator Contribution | Ravi's group led this research to understand the recurrent emergence of SARS-CoV-2 spike deletion H69/V70, leading to publication in Cell Reports. |
| Impact | Recurrent emergence of SARS-CoV- spike deletion H69/V70 and role in B.1.1.7. Meng B, Kemp SA, Papa G, Datir R, Ferriera I, Marelli S, Harvey WT, Lytras S, Mohamed A, Gallo G, Thakur N, Collier DA, Mlcochova P, The COVID-9 Genomics UK (COG-UK) Consortium, Duncan LM, Carabelli AM, Kenyon JC, Lever AM, De Marco A, Saliba C, Culap K, Cameroni E, Matheson NJ, Piccoli L, Corti D, James LC, Robertson DL, Bailey D, Gupta RK. Cell Rep. 2021 Jun 29;35(13):109292. doi: 10.1016/j.celrep.2021.109292. https://pubmed.ncbi.nlm.nih.gov/34166617/ |
| Start Year | 2021 |
| Description | Collaboration with Stephen Findlay Wilson at UKHSA |
| Organisation | Public Health England |
| Department | Public Health England Porton Down |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Collaboration on Nipah virus research helping to establish CL4 animal models for this virus. We have provided vaccines and biological assays and expertise. |
| Collaborator Contribution | Provision of expertise at CL4 with high risk pathogens |
| Impact | Establishment of assays to examine pathogenesis at CL4 |
| Start Year | 2023 |
| Description | Collaboration with Surrey University on proteomics |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sharing of ideas and reagents to work on RSV data sets and new experimental approaches. |
| Collaborator Contribution | Provision of expertise in analysing mass spec data and access to high-tech machines for downstream analysis. |
| Impact | None to date, although papers are being written up. |
| Start Year | 2022 |
| Description | Collaboration with University of Bath (UK) |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Training of an intern on cattle antibody characterization. |
| Collaborator Contribution | none. |
| Impact | Understanding of antibody functions in cattle. |
| Start Year | 2023 |
| Description | Collaboration with University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed in vitro experiments with infectious bronchitis virus, contributed to data analysis, preparation of manuscripts and discussed further funding opportunities. |
| Collaborator Contribution | Our partners have analysed viral transcription and translation, and host gene expression after infection of host cells with infectious bronchitis virus, prepared manuscripts and discussed further funding opportunities. |
| Impact | Dinan, A., Keep, S., Bickerton, E., Britton, P., Firth, A. and Brierley, I. (2019) Comparative analysis of gene expression in virulent and attenuated strains of infectious bronchitis virus at sub-codon resolution. J. Virol. 93(18) e00714-19. PhD studentship funding from The Pirbright Institute "Investigation of Canonical and Noncanonical Transcription during Coronavirus Replication" which commenced in 2021. |
| Start Year | 2012 |
| Description | Collaboration with University of Copenhagen CFIM on cell biology of virus-host interactions |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Intellectual input into virus projects which come in to the microscopy core facility at the University. Limited practical work and training given to researchers there. Includes lecturing/organisation of MSc and PhD courses at Copenhagen. PH awarded Visiting Professorship. |
| Collaborator Contribution | Research projects are presented to the core facility, I advise on the best route for achieving the data required and those researchers complete preliminary data following my advice. Collaborators are then able to produce the best possible samples for further advanced microscopy as necessary. |
| Impact | No tangible outcomes yet as we are in early stages. This is multi-disciplinary as projects can come from several University departments (medical, pathology, cell biology, veterinary, food), and other Universities in Denmark (DTU). University awarded Visiting Professorship |
| Start Year | 2018 |
| Description | Collaboration with University of Durham and The Babraham Institute on cattle B cell development and antibody repertoire generation |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosting a student (NKO) to study the development of B cells and the antibody repertoire generation and diversification in cattle. |
| Collaborator Contribution | Knowledge on B cell development and expertise on techniques to analyse antibody repertoires in human and mouse. Time of Babraham scientists was provided as in-kind contribution. |
| Impact | Optimized protocol for cattle antibody repertoire sequencing using PacBio platform. |
| Start Year | 2022 |
| Description | Collaboration with University of Durham and The Babraham Institute on cattle B cell development and antibody repertoire generation |
| Organisation | Durham University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosting a student (NKO) to study the development of B cells and the antibody repertoire generation and diversification in cattle. |
| Collaborator Contribution | Knowledge on B cell development and expertise on techniques to analyse antibody repertoires in human and mouse. Time of Babraham scientists was provided as in-kind contribution. |
| Impact | Optimized protocol for cattle antibody repertoire sequencing using PacBio platform. |
| Start Year | 2022 |
| Description | Collaboration with University of Oxford |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have written a PhD studentship and are supervising a student on this project |
| Collaborator Contribution | We have written a PhD studentship and are supervising a student on this project |
| Impact | PhD studentship funding "SOMAmer technology to diagnose coronavirus infection: veterinary and zoonotic implications" |
| Start Year | 2021 |
| Description | Collaboration with University of Oxford and Warwick |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have supplied coronavirus samples and coronavirus expertise to the collaboration. |
| Collaborator Contribution | Our partners have led the research and we have published a paper detailing the results. |
| Impact | Evaluation of imaging technologies to detect coronavirus-infected samples. Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C, Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N, Crook DW, Kapanidis AN, Robb NC. Virus Detection and Identification in Minutes Using Single-Particle Imaging and Deep Learning. ACS Nano. 2023 Jan 10;17(1):697-710. doi: 10.1021/acsnano.2c10159. Epub 2022 Dec 21. PMID: 36541630; PMCID: PMC9836350. |
| Start Year | 2020 |
| Description | Collaboration with University of Oxford and Warwick |
| Organisation | University of Warwick |
| Department | Warwick Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have supplied coronavirus samples and coronavirus expertise to the collaboration. |
| Collaborator Contribution | Our partners have led the research and we have published a paper detailing the results. |
| Impact | Evaluation of imaging technologies to detect coronavirus-infected samples. Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C, Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N, Crook DW, Kapanidis AN, Robb NC. Virus Detection and Identification in Minutes Using Single-Particle Imaging and Deep Learning. ACS Nano. 2023 Jan 10;17(1):697-710. doi: 10.1021/acsnano.2c10159. Epub 2022 Dec 21. PMID: 36541630; PMCID: PMC9836350. |
| Start Year | 2020 |
| Description | Collaboration with UoS (UK) on bovine antibody heavy and light chains pairing |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided over 42K pairs of cattle antibody heavy and light natural pairs to UoS (NG, AO). |
| Collaborator Contribution | Modeling of cattle antibody heavy and light natural pairs from bulk antibody repertoires. Overheads have been waved from computational scientist contribution. |
| Impact | None yet. |
| Start Year | 2023 |
| Description | Collaboration with Wei Huang, Uni of Oxford on SARS2 neutralisation |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Hosting of students to undertake SARS2 neutralisation experiments Training and data interpretation |
| Collaborator Contribution | Provision of synthetic antibody-bearing particles for neutralisation experiments |
| Impact | Possible grant application in the future |
| Start Year | 2021 |
| Description | Collaborative network with Ed Wright, Nigel Temperton and Giada Mattiuzzo on SARS-CoV-2 pseudotyping |
| Organisation | National Institute for Biological Standards and Control (NIBSC) |
| Country | United Kingdom |
| PI Contribution | Development and establishment of SARS-CoV-2 research tools, including pseudotypes and cell-cell fusion assays |
| Collaborator Contribution | Provision of reagents, protocols and technical guidance |
| Impact | We aided in NIBSC's development of WHO international standard for SARS-CoV-2 and have a publication in press on sarbecovirus neutralisation: bioarchived here https://www.biorxiv.org/content/10.1101/2021.08.17.456606v1 |
| Start Year | 2020 |
| Description | Collaborative network with Ed Wright, Nigel Temperton and Giada Mattiuzzo on SARS-CoV-2 pseudotyping |
| Organisation | University of Kent |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development and establishment of SARS-CoV-2 research tools, including pseudotypes and cell-cell fusion assays |
| Collaborator Contribution | Provision of reagents, protocols and technical guidance |
| Impact | We aided in NIBSC's development of WHO international standard for SARS-CoV-2 and have a publication in press on sarbecovirus neutralisation: bioarchived here https://www.biorxiv.org/content/10.1101/2021.08.17.456606v1 |
| Start Year | 2020 |
| Description | Collaborative network with Ed Wright, Nigel Temperton and Giada Mattiuzzo on SARS-CoV-2 pseudotyping |
| Organisation | University of Sussex |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development and establishment of SARS-CoV-2 research tools, including pseudotypes and cell-cell fusion assays |
| Collaborator Contribution | Provision of reagents, protocols and technical guidance |
| Impact | We aided in NIBSC's development of WHO international standard for SARS-CoV-2 and have a publication in press on sarbecovirus neutralisation: bioarchived here https://www.biorxiv.org/content/10.1101/2021.08.17.456606v1 |
| Start Year | 2020 |
| Description | Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I develop a research project proposal in which we are investigating how evolutionary changes in the H9N2 avian influenza virus modulate virus fitness and virulence in chickens. This PhD studentship project was funded by Commonwealth scholarship commission for 3 years. |
| Collaborator Contribution | The collaborating Partner Dr Nicola Lewis at Royal Veterinary College is a co-supervisor of the PhD student Thusitha Karunarathna. she provide necessary guidance to achieve prescribed objectives of this project. |
| Impact | The project is at its initial stage. |
| Start Year | 2019 |
| Description | Components of the Medea gene drive system in a mosquito Aedes aegypti |
| Organisation | National Health Research Institutes (NHRI) Taiwan |
| Department | Institute of Molecular and Genomic Medicine |
| Country | Taiwan, Province of China |
| Sector | Charity/Non Profit |
| PI Contribution | Developed joined research project and lead successful application for funding |
| Collaborator Contribution | Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress. |
| Impact | No impact yet. |
| Start Year | 2018 |
| Description | Components of the Medea gene drive system in a mosquito Aedes aegypti |
| Organisation | National Institute of Genetics |
| Department | NIG-FLY, Mishima (Drosophila RNAi resources) |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Developed joined research project and lead successful application for funding |
| Collaborator Contribution | Various lines of research, including construction of plasmids and development and characterisation of transgenic mosquito strains; and group discussions about results, conclusions and research progress. |
| Impact | No impact yet. |
| Start Year | 2018 |
| Description | Dan Clare - cryo-electron microscopy |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The project aims to characterise proteins complexes associated with coronavirus replication organelles. My team provides significant expertise in replication organelles induced by coronaviruses. Laboratory work is performed by my team. The project is funded by a joint PhD studentship working, predominantly in my laboratory. |
| Collaborator Contribution | Dan provides expertise in cryo-electron microscopy and is advising on experimental design and data analysis as well as providing training. |
| Impact | The student has generated recombinant viruses expressing fluorescently-tagged proteins to allow direct visualisation of replication organelle membranes. These have been validated and cryo-electron microscopy experiments are planned shortly. |
| Start Year | 2020 |
| Description | David Hughes - University of St. Andrews. RSV preparation. |
| Organisation | St. Andrews University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Sharing of preliminary research data on innate immune restriction of RSV. |
| Collaborator Contribution | Provision of cell-lines (Hep2-Npro) to support generation of high titre stocks of RSV. Also associated protocols. |
| Impact | No outcomes as yet, beyond preliminary data. |
| Start Year | 2018 |
| Description | David Matthews - Proteomics informed by transcriptomics |
| Organisation | University of Bristol |
| Department | Proteomics Facility |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Projects are being initiated to study the cellular proteins associated with coronavirus replication organelle membranes and a funding application has been submitted to BBSRC. |
| Collaborator Contribution | David has assisted in project design and drafting of a funding application to BBSRC. We are in the process of generating transcriptomics data, which David will process to provide an expressed protein database for peptide identification following mass spectrometry. |
| Impact | No outcomes to date, a funding application has been submitted to BBSRC. |
| Start Year | 2018 |
| Description | Derek Bickhart-USDA |
| Organisation | U.S. Department of Agriculture USDA |
| Department | Beltsville Agricultural Research Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Our group has provided the genomic framework of the cattle NK cell regions and the biological input. |
| Collaborator Contribution | The ARS group has used our data as a framework to map and predict cattle SNPs for variable immune traits using their whole genome data |
| Impact | Research application based on preliminary data to a BBSRC-NIFA call. This collaboration is multi-disciplinary combining molecular biology and computational biology |
| Start Year | 2014 |
| Description | Development of tetramers in the Babraham pig model |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Developed the aerosol delivery method of vaccine and provided material (spleen, BAL and blood) from inbred animals (Babraham pigs) following immunisation with the candidate universal vaccine, S-FLU. |
| Collaborator Contribution | Developed porcine influenza specific class I tetramers and provided the epitope map of Babrahams S-Flu responses to NP, M1, M2, PB1 and PB2 that could be presented by SLA-1 or SLA-2 Grew pig T cell clones for the first time in 30 years. |
| Impact | Multidisciplinary - immunology, virology, protein chemistry. Paper not yet published |
| Start Year | 2014 |
| Description | Distributed Bio - Gates foundation funding - universal influenza vaccine |
| Organisation | Distributed Bio. |
| Country | United States |
| Sector | Private |
| PI Contribution | Pirbright has provided expert advice to the design of adjuvant and challenge studies in appropriate animal models for human influenza vaccine trials. Pirbright is facilitating these studies in line with UK home office requirements and good scientific practice. |
| Collaborator Contribution | Distributed Bio have developed a novel vaccine that is hoped to be a candidate for a human universal influenza virus vaccine. |
| Impact | Funding from Bill and Melinda Gates foundation as part of the Grand challenges - Universal vaccine for influenza for the animal studies involving Pirbright and Distributed Bio |
| Start Year | 2019 |
| Description | Dr Alex Schock, APHA - Detemining the prevalence and sequences of IBDV in vaccinated chicken flocks in the UK |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We will determine whether samples are positive for IBDV. If they are positive, we will amplify the hypervariable region of the capsid by PCR and send for Sanger Sequencing |
| Collaborator Contribution | APHA will obtain samples from Veterinary Practices and perform histology. |
| Impact | we have been successful in obtaining funding (Pirbright Internal Seed Award, £10,000) |
| Start Year | 2019 |
| Description | Dr Carol Cardona, University of Minnesota- avian influenza virus challenge of IBDV or mock-infected chickens |
| Organisation | University of Minnesota |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We will challenge birds that have been exposed to IBDV, or mock exposed, with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens. |
| Collaborator Contribution | Dr Cardona's group will challenge birds that have been exposed to IBDV, or mock exposed, with low pathogenic avian influenza (LPAI) strains to determine how IBDV-mediated immunosuppression impacts upon LPAI infection in chickens. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/T008806/1) |
| Start Year | 2019 |
| Description | Dr Caroline Denesvere |
| Organisation | French National Institute of Agricultural Research |
| Department | INRA Loire Valley Centre |
| Country | France |
| Sector | Public |
| PI Contribution | Worked together to establish a collaboration on development of feather follicular stem cell lines as a platform for the generation of cell-free vaccine against Marek's disease virus. |
| Collaborator Contribution | Provided expertise on cell free Marek's disease and microscopic evaluation of cells generating the virus. |
| Impact | Generation of data leading to a successful BBSRC IPA grant application |
| Start Year | 2020 |
| Description | Dr David Welchman, APHA -Detemining the prevalence and sequences of IBDV in vaccinated chicken flocks in the UK |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We wiil determine whether samples are positive for IBDV. If they are positive, we will amplify the hypervariable region of the capsid by PCR and send for Sanger Sequencing |
| Collaborator Contribution | APHA will obtain samples from Veterinary Practices and perform histology. |
| Impact | we have been successful in obtaining funding (Pirbright Internal Seed Award, £10,000) |
| Start Year | 2019 |
| Description | Dr Finn Grey, The Roslin Institute- Identifying genes essential for the replicaiton of IBDV and IBV in vitro |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We will conduct a CRISPR screen and identify genes that are essential for IBDV replication |
| Collaborator Contribution | Finn Grey's group will aid in the CRISPR screen |
| Impact | we have been successful in obtaining a PhD studentship |
| Start Year | 2019 |
| Description | Dr Helena Maier, The Pirbright Institute - Identifying genes essential for the replicaiton of IBDV and IBV in vitro |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We will conduct a CRISPR screen and identify genes that are essential for IBDV replication |
| Collaborator Contribution | Helena Maier's group will aid in the CRISPR screen and identify genes that are essential for IBV replication |
| Impact | We have been successful in obtaining a PhD studentship |
| Start Year | 2019 |
| Description | Dr Holly Shelton, The Pirbright Institute- avian influenza virus challenge of IBDV or mock-infected chickens |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We will expose birds to IBDV, compared to mock controls |
| Collaborator Contribution | Holly will train my group in conducting studies with avian influenza viruses and, together, we will challenge birds with highly pathogenic avian influenza (HPAI) strains to determine how IBDV-mediated immunosuppression impacts upon HPAI infection in chickens. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/T008806/1) |
| Start Year | 2019 |
| Description | Dr Liam Morrison |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis is single cattle B cell antibody sequences |
| Collaborator Contribution | Single cattle B cell antibody sequences |
| Impact | None as yet |
| Start Year | 2019 |
| Description | Dr Michael Skinner, Imperial College London |
| Organisation | Imperial College London |
| Department | Department of Primary Care and Public Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We aim to compare the host transcriptional response of primary chicken B cells infected with different strains of IBDV of varying virulence. We have the specialist reagents and expertise in house that are required to culture primary chicken B cells, and we have access to different strains of IBDV. |
| Collaborator Contribution | Dr Michael Skinner and his team at Imperial College London have the expertise and facilities to generate and analyse RNA-Seq data in order to determine host transcriptional responses. This is required in order to complete the aim of the project. |
| Impact | Further funding: PhD studentship (£102,800) - Dr Andrew Broadbent at The Pirbright Institute and Dr Michael Skinner at Imperial College London are joint supervisors for a PhD student working on this project. Further Funding: Houghton Trust (£8,000)- Dr Andrew Broadbent was awarded a Houghton Trust Small Research Grant to contribute to this project. Further funding: NC3Rs (Grant Ref: NC/R001138/1) |
| Start Year | 2014 |
| Description | Dr Rachel Edgar, Imperial College London- defining the circadian clock in chicken cells and how this impacts upon viral replication |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | we will supply sequences of chicken clock genes and chicken cells and challenge synchronised chicken cells with IBDV and perform in vivo experiments |
| Collaborator Contribution | Dr Edagr's group will synchronise chicken cells and characterise the oscillatory expression of chicken clock genes. |
| Impact | we have been successful in obtaining funding (Houghton Trust, £4,500) |
| Start Year | 2019 |
| Description | Dr. John D. Phillips |
| Organisation | University of Utah |
| Department | School of Medicine Utah |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Additional IAA funding for long-read sequencing, assembly, and analysis of Babraham genome and transcriptome |
| Collaborator Contribution | Long- and short-read sequencing and assembly of Babraham genome. |
| Impact | Manuscript in BioRxiv. Genome assembly and reads publicly available through GenBank. |
| Start Year | 2016 |
| Description | Dr. Sabine Hammer |
| Organisation | University of Veterinary Medicine Vienna |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Characterization of pig MHC, TCR, and WC1 genes |
| Collaborator Contribution | Characterization of pig MHC, TCR, and WC1 genes |
| Impact | Two manuscripts (DOI: 10.1016/j.dci.2021.104214; 10.1111/tan.13281) in 2018 and 2021. |
| Start Year | 2016 |
| Description | Efficacy of a candidate universal influenza vaccine, S-FLU. |
| Organisation | University of Oxford |
| Department | Radcliffe Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Tested the immunogenicity and efficacy of a candidate universal influenza vaccine, S-FLU, in pigs. For the first time we demonstrated that S-FLU when administered by aerosol can reduce viral load in nasal swabs and lung in pigs after influenza virus challenge. We have shown that the most efficient way to administer this vaccine is by aerosol. |
| Collaborator Contribution | Professor Alain Townsend has developed the S-FLU vaccine. |
| Impact | The most efficient way to induce immune response in the lung is after aerosol delivery of LAIV vaccines in pigs. The most efficient way to induce cross-protective immunity is by aerosol delivery of S-FLU to the lungs of pigs |
| Start Year | 2014 |
| Description | Engineering mosquitoes for reduced vector competence for chikungunya virus |
| Organisation | University of Malaya |
| Department | Department of Medical Microbiology |
| Country | Malaysia |
| Sector | Academic/University |
| PI Contribution | Developed joint research programme, led successful application for funding, coordinate programme. |
| Collaborator Contribution | Various specific strands of research, and group discussions about results, conclusions, research progress and future activities. |
| Impact | reported under funding |
| Start Year | 2016 |
| Description | Engineering mosquitoes for reduced vector competence for chikungunya virus |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Developed joint research programme, led successful application for funding, coordinate programme. |
| Collaborator Contribution | Various specific strands of research, and group discussions about results, conclusions, research progress and future activities. |
| Impact | reported under funding |
| Start Year | 2016 |
| Description | Engineering mosquitoes for reduced vector competence for chikungunya virus |
| Organisation | University of Tartu |
| Department | Institute of Technology |
| Country | Estonia |
| Sector | Academic/University |
| PI Contribution | Developed joint research programme, led successful application for funding, coordinate programme. |
| Collaborator Contribution | Various specific strands of research, and group discussions about results, conclusions, research progress and future activities. |
| Impact | reported under funding |
| Start Year | 2016 |
| Description | Establishment of a novel poultry vaccine platform inducing rapid and strong immunity through targeted delivery of antigens to chicken immune cells |
| Organisation | MSD Animal Health |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The research focus is to develop next-generation of poultry vaccines that induce rapid and strong immune responses in chickens. The candidate vaccine constricts will be developed at the Pirbright Institute |
| Collaborator Contribution | The collaborating partner "MSD Animal Health" will evaluate the potency and efficacy for registration and feasibility for commercial production. |
| Impact | Based on the project preliminary data a new project was developed entitled Protecting poultry from avian influenza, Newcastle disease, infectious bronchitis, and Gumboro disease with a single dose of a multivalent vaccine". This project further strengthened the collaborative research work with MSD Animal Health. |
| Start Year | 2021 |
| Description | Evaluate the potential of AstraZeneca's sialic acid tag technology for treating influenza viruses with Fc molecules |
| Organisation | Liverpool School of Tropical Medicine |
| Department | Parasite Immunology Liverpool |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Established partnership to investigate the antiviral properties of novel antiviral ( fragment-crystallisable (Fc) molecules) compounds that potentially block influenza virus infection. These compounds will be used to test their antiviral activity against avian influenza and Newcastle Disease virus that are causing sever economic looses to the poultry industry. |
| Collaborator Contribution | The Partners have developed these antiviral compounds and showed that these compounds bids to specific cell surface receptors that are required by the virus to bind to and enter into the cell to cause infection. |
| Impact | Project is just started |
| Start Year | 2022 |
| Description | Evaluation of COVID-19 vaccine candidate immunogenicity in pigs |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in evaluating vaccine immunogenicity in pigs |
| Collaborator Contribution | Provided COVID-19 vaccine candidates |
| Impact | Joint publication on the evaluation of ChAdOx1 nCoV-19 (AZD1222) (https://doi.org/10.1038/s41541-020-00221-3). Data included in in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application. |
| Start Year | 2020 |
| Description | Evaluation of COVID-19 vaccine candidate immunogenicity in pigs |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in evaluating vaccine immunogenicity in pigs |
| Collaborator Contribution | Provided COVID-19 vaccine candidates |
| Impact | Joint publication on the evaluation of ChAdOx1 nCoV-19 (AZD1222) (https://doi.org/10.1038/s41541-020-00221-3). Data included in in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application. |
| Start Year | 2020 |
| Description | Evaluation of COVID-19 vaccine candidate immunogenicity in pigs |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise of using the pig as a model to evaluate vaccine immunogenicity. |
| Collaborator Contribution | Provision of COVID-19 vaccine candidates |
| Impact | The immunogenicity data of ChAdOx1 nCoV-19 in pigs was included in the pre-clinical dossier submitted to regulators (e.g., European Medicines Agency) and supported the successful Marketing Authorisation application. The immunogenicity data of RBD-SpyVLP in pigs helped support secure funding to further develop with vaccine candidate and to enter clinical trials. Published papers to date: https://www.nature.com/articles/s41541-020-00221-3 and https://www.nature.com/articles/s41467-020-20654-7 |
| Start Year | 2019 |
| Description | Evaluation of RNA vector delivery of PRRSV glycoproteins |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in PRRSV immunology and vaccine research. |
| Collaborator Contribution | Construction and formulation of an RNA vectored PRRSV vaccine candidate. |
| Impact | Work in progress. |
| Start Year | 2022 |
| Description | Evaluation of adjuvanted liposome delivery of PRRSV glycoproteins |
| Organisation | University at Buffalo |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | PRRSV immunology and vaccine research. |
| Collaborator Contribution | Provision of adjuvanted liposomes for display of PRRSV glycoprotein. |
| Impact | Ongoing. |
| Start Year | 2022 |
| Description | Evaluation of bovine herpesvirus-4 as a vaccine vector for pigs |
| Organisation | University of Parma |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Expertise in porcine vaccinology/immunology |
| Collaborator Contribution | Expertise in the generation of recombinant bovine herpesvirus-4 (BoHV-4) vectors expressing heterologous antigens |
| Impact | We demonstrated that immunisation of pigs with recombinant BoHV-4 vectors expressing Nipah virus glycoproteins are highly immunogenic in pigs. Most promising and as hypothesised, were the potent CD4 and CD8 T cell responses which were an order of greater than those induced by other viral vaccine vectors. These data have led to the external funding of projects by two companies to evaluate BoHV-4 vectors in the context of other porcine diseases. |
| Start Year | 2018 |
| Description | Evaluation of immune checkpoint inhibitors as molecular adjuvants for improved PRRSV vaccines |
| Organisation | Leidos |
| Country | United States |
| Sector | Private |
| PI Contribution | Expertise in PRRSV immunology |
| Collaborator Contribution | Patented immune checkpoint inhibitors |
| Impact | No yet |
| Start Year | 2019 |
| Description | Evaluation of mRNA vectored vaccines in pigs |
| Organisation | University of Pennsylvania |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Expertise in porcine immunology/vaccinology |
| Collaborator Contribution | Expertise in mRNA vaccines |
| Impact | We evaluated in pigs the immunogenicity an mRNA vector encoding a Nipah virus glycoprotein. This vaccine formulation induced high virus neutralising antibody titres (comparable with protein subunit in adjuvant) and T cell responses (comparable with viral vectors). We also utilised mRNA immunised pigs to isolate Nipah virus neutralising monoclonal antibodies. |
| Start Year | 2018 |
| Description | Evaluation of multivalent viral hemorrhagic fever vaccine candidates immunogenicity in pigs |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supported the pre-clinical development of multivalent viral hemorrhagic fever vaccine candidates by evaluating their immunogenicity in pigs |
| Collaborator Contribution | Conceived and produced vaccine candidates |
| Impact | Still ongoing. |
| Start Year | 2021 |
| Description | Evaluation of solid dose vaccines for livestock |
| Organisation | Enesi Pharma |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in PRRSV and vaccine evaluation |
| Collaborator Contribution | Expertise in vaccine formulation |
| Impact | Multidisciplinary collaboration between formulation scientist and viral immunologists. |
| Start Year | 2019 |
| Description | Evaluation of the therapeutic efficacy of a Nipah virus neutralising monoclonal antibody |
| Organisation | Government of Canada |
| Department | Canadian Food Inspection Agency (CFIA) |
| Country | Canada |
| Sector | Public |
| PI Contribution | Expertise in Nipah virus immunology, vaccinology and antibody discovery. |
| Collaborator Contribution | Expertise in animal models of Nipah virus infection. |
| Impact | Work ongoing. |
| Start Year | 2022 |
| Description | Exploiting mosquito immunity for generating refractory mosquitoes |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I brought my expertise in mosquito immunology and viral evasion of innate immune responses in vertebrates and invertebrates. I provided intellectual input into the project and provided training for three research assistants and one undergraduate placement student. |
| Collaborator Contribution | The partner (Luke Alphey, The Pirbright Institute) brought their expertise in mosquito transgenesis and molecular approaches to developing refractory mosquitoes that cannot transmit viruses. The partner also provided intellectual input into the project. |
| Impact | The following publications are associated with this collaboration: DOI: 10.3390/v13112116 |
| Start Year | 2020 |
| Description | FLU-Trailmap: Transmission and risk of avian influenza: learning more to advance preparedness |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | This project brought together eight leading scientific organizations in the UK to develop strategies for mitigating bird flu. Its main objective is to devise tools that bridge significant knowledge gaps concerning the virus's prevalence in wild birds and the factors leading to its emergence in poultry. We are exploring molecular determinants potentially related to changes in virus virulence, antigenicity, cross-species transmission, and the capacity to infect humans. |
| Collaborator Contribution | The partners provided field samples and sequence data of viruses isolated from disease outbreaks. This data was used to identify molecular determinants linked to virus phenotype changes. |
| Impact | At the frontline, ethnographic surveys were designed and implemented to understand farmers perceptions of farm biosecurity. Studies highlighted the need for an improved understanding of key biosecurity risk points and the implementation of effective biosecurity practices. Outputs showed that high quality facilities and management systems can be undermined by weaknesses in procedural compliance. As such, targeted farm worker education could help mitigate against future incursions which will be addressed in the follow-on research programme, FLUTRAILMAP. Recent work indicates that farm-to-farm spread is rare and that the virus is not spread long distances as an aerosol. Linked to biosecurity, virulence for poultry and the potential role of airborne spread of the virus was evaluated. Active sampling on infected premises across different hosts supported the experimental evaluation of pathogenesis and transmission (FLUMAP: Pathogenesis) by demonstrating that this virus is not spread long distances by the aerosol route (FLUMAP: Aerosol). Further, studies demonstrated that different bird species represent different risk levels for excretion of infectious material and potential transmission routes (FLUMAP: Gannets; FLUMAP: Environment; Pheasants). Ultimately, experimental, field and genetic data supported a lack of aerosol spread between premises. In support of this, genetic analysis of over 800 full bird flu virus genomes demonstrated that farm-to-farm spread was very rare with independent incursions from wild birds driving infection in poultry (FLUMAP: Genetics; Phylodynamics). Several genetic characteristics were identified that expanded our knowledge, explaining the explosive success of the current H5N1 bird flu viruses to spread fast and infect a greater range of bird species including a shift of infection dynamics to affect seabirds (FLUMAP: Infection dynamics) and via long distance and transatlantic spread (Transatlantic). These traits have contributed to the current H5N1 viruses having increased fitness across multiple species. Contemporary H5N1 viruses have enhanced fitness to infect, transmit and persist in birds, but remain of low risk to humans (FLUMAP: Characterization; Human Case). This project has defined a role for multiple virus genes which have switched and evolved over time to act together in a highly efficient manner. To better understand key species that may tolerate infection with this virus in the absence of clinical disease, sampling of hunter harvested wild birds was undertaken. Virus positive birds were detected in a small subset of Teal, Wigeon, and Pink-Footed Geese although carcasses were not available to evaluate the distribution of virus in these birds (Healthy birds). Further assessment of different avian species using this approach are planned. Gannet populations around the UK have been severely impacted by High Pathogenicity Avian Influenza (HPAI), at Bass Rock the number of occupied nest sites decreased by over 70%. Linked to the detection of the virus in apparently healthy birds, interrogating survival from infection, and in particular the role of antibodies in birds that may have been infected, but survived infection was a key interest (FLUMAP: Gannets). FLUMAP has enabled the development of a suite of laboratory tools that will enable us to dissect the immune response in birds that may have been exposed to multiple and different influenza viruses in their lifetime. Tools are now available to dissect antibody responses to each of the two different viral surface proteins (both individually and in tandem). How these two different viral coat proteins interact with each other and what optimal protein combinations mean with respect to stability of interaction has also been assessed. These tools will enable a better understanding of how different key surface proteins drive immune responses and what that means where viruses emerge containing different coat proteins. The periodic switching of the neuraminidase (NA) protein (i.e., N8 to N1) is an important factor in influencing the emergence of new strains and the tools developed in FLUMAP will enable the impact of these genetic reassortment events to be assessed. Whilst further outputs are realised from the FLUMAP project, the follow-on project, FLUTRAILMAP, will enable the application of these data to this continually emerging global situation and will enable better prevention and mitigation approaches to be defined. |
| Start Year | 2023 |
| Description | Factor H and influenza virus |
| Organisation | Brunel University London |
| Department | Brunel Arts |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Our research team are hosting a PhD student from Brunel University to facilitate the investigation of any interaction between influenza virus and complement factor H. We are providing reagents, expertise in handling influenza virus and advice on the scientific hypothesis of the research programme. |
| Collaborator Contribution | Brunel university initiated the project and provided reagents including antibodies and methods for purification human co-factor H protein. They also provide funding for this PhD studentship. |
| Impact | No outcomes as yet |
| Start Year | 2018 |
| Description | Finn Grey - CRISPR and ISG screens |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My research team is providing expertise in coronavirus biology and regulation of the host cell environment. Laboratory experiments are being performed by my team. |
| Collaborator Contribution | Finn's team have provided reagents and are advising on experimental design and data analysis. |
| Impact | Cas-9 expressing avian cells have been generated and validated. Optimisation of the CRISPR screen is underway. |
| Start Year | 2021 |
| Description | Flavivirus microvascular pathogenesis |
| Organisation | University of Surrey |
| Department | Faculty of Health and Medical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I brought my expertise in dengue and virology, and had significant intellectual input into shaping the research question and methodological approach. I also directly contributed to the training of one shared MSc student, two shared PhD students and three undergraduate students who have contributed to this project so far. |
| Collaborator Contribution | The partner (Dr. Paola Campagnolo, University of Surrey) brought their expertise in cardiovascular biology and had significant intellectual input into shaping the research question and methodological approach. They also directly contributed to the training of one shared MSc student, one shared PhD student and three undergraduate students who have contributed to this project so far. |
| Impact | The collaboration has resulted in the following publications: DOI: 10.1128/mSphere.00258-20 DOI: 10.1099/jgv.0.001634 This is an interdisciplinary collaboration. The disciplines are microbiology/virology (me) and cardiovascular biology (Dr. Paola Campagnolo, University of Surrey). |
| Start Year | 2018 |
| Description | Gene editing chickens with Roslin |
| Organisation | University of Edinburgh |
| Department | Roslin Institute Transgenic Chicken Facility |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have provided infectious pathogen challenge and infectious pathogen sample processing facilities in this collaboration. We infected the transgenic chickens with avian influenza virus and processed the samples following challenge. |
| Collaborator Contribution | Helen Sang and Mike McGrew at The Roslin Institute (University of Edinburgh) contributed by producing and providing transgenic chickens (Split GFP) for challenge. Expertise in genotype screening the transgenic birds was shared with us. |
| Impact | We have now successfully received a BBSRC responsive mode grant to carry out more transgenic bird challenges with influenza viruses. BB/S007911/1 -Investigating the role of ANP32A in the replication of avian Influenza virus. |
| Start Year | 2018 |
| Description | Generation of immortalised bovine antigen presenting cells |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Using a lentivirus vector expressing proto-oncogenic genes, we generated MHC-defined immortal bovine antigen presenting cells that can be used in antigen presentation studies or virus-host interaction studies in the future. |
| Collaborator Contribution | The University of Surrey provided several lenvirus vectors and preparation for immortalization studies. |
| Impact | A publication in progress titled "Generation of immortal bovine antigen presenting cells" and the generation of a library of MHC-defined bovine cell lines. |
| Start Year | 2017 |
| Description | Horizon Discovery Ltd Cambridge Research Park, United Kingdom |
| Organisation | Horizon Discovery Group plc |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Verify IFITM knock-out cell by qPCR and immuno-blotting. Verification of further knock-out cell lines by DNA sequencing, immuno-blotting and qPCR Cell infection with Avian Influenza Viruses Assess the viral titre of cells infected with Influenza Viruses in K/O and wildtype cells. Quantitative analysis of viral infection in IFITM K/O cells Demonstrate increased AIV viral titres at lab scale and estimation of what this may equate to with respect to vaccine dose yields. Analysis of IFITM K/O cell lines permissivity to a range of additional animal viruses (Relevant to the LVIF). Milestone 7: Demonstrate permissivity increased and viral titres for a range of LVIF relevant viruses in the edited cell lines. |
| Collaborator Contribution | Develop a CRISPR/cas9 gene editing system to specifically target the chIFITM locus in avian cell culture |
| Impact | Grant funding |
| Start Year | 2017 |
| Description | ILRI Research Collaboration (Kenya, March 2017) |
| Organisation | International Livestock Research Institute (ILRI) |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | Exchange of ideas and samples for indigenous breeds of livestock |
| Collaborator Contribution | Contributed samples for analysis. |
| Impact | Analysis of indigenous breed genomic sequences for Immune function genes. |
| Start Year | 2017 |
| Description | Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Collaborator Contribution | My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Impact | Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017. |
| Start Year | 2017 |
| Description | Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design. |
| Organisation | University of Kent |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Collaborator Contribution | My collaborators have performed experiments to generate preliminary data for a collaborative grant application, contributed to the writing of the grant proposal and responded to reviewers comments. |
| Impact | Submission of proposal entitled "Identification of conserved B-cell epitopes of highly pathogenic coronaviruses for broadspectrum immunotherapy and vaccine design" to the "One Health Approaches to Accelerate Vaccine Development" call that forms part of the UK government's commitment to Official Development Assistance (ODA) in October 2017. |
| Start Year | 2017 |
| Description | Identification of human orthologues of bovine Workshop Cluster 1 genes |
| Organisation | University of Oxford |
| Department | Nuffield Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The Workshop Cluster 1 (WC1) gene family encodes a group of proteins thought to be involved in immune recognition. These genes are exclusively expressed on T cells expressing the gamma and delta T cell receptor and are well characterized in the bovine system. We have began investigating the presence and expression of WC1 on human cells using co-immunoprecipitation and mass spectrometry analysis of putatitve human WC1 genes. |
| Collaborator Contribution | The Univ. of Oxford has developed a pipeline to identify protein fragments using mass spectrometry and bioinformatics from putative proteins from which little or no information is currently known. This pipeline has been applied to identify putative human WC1 proteins obtained from co-immunoprecipitation/mass spectrometry studies. |
| Impact | The identification of one human WC1 gene/protein. A publication in progress titled "Identification of the human orthologue of a Workshop Cluster 1 gene expressed on gammadelta T cells" |
| Start Year | 2017 |
| Description | Identification of sows with antibodies broadly neutralising PRRSV |
| Organisation | University of Lleida |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Expertise in PRRSV immunology |
| Collaborator Contribution | Access to large numbers of sows routinely vaccinated and exposed to PRRSV |
| Impact | Not yet |
| Start Year | 2019 |
| Description | Imperial |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint supervision of PhD student |
| Collaborator Contribution | Joint supervision of PhD student |
| Impact | One successful completed PhD student. Papers published or in preparation. Another PhD student in progress. |
| Start Year | 2010 |
| Description | Influenza and co-factor H protein |
| Organisation | Leibniz Association |
| Department | Leibniz Institute for Natural Product Research and Infection Biology |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We are screening influenza virus interaction with co-factor H proteins to determine the interaction interface. |
| Collaborator Contribution | Christine Skerka has provided fragment factor H peptides to facilitate our mapping studies of the interaction surface with influenza viruses. |
| Impact | No outcomes as yet |
| Start Year | 2019 |
| Description | Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses |
| Organisation | Royal Veterinary College (RVC) |
| Department | Veterinary Basic Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The overarching aims of the proposed research are to improve controls against H5 subtype of avian influenza viruses infecting poultry by investigating underlying mechanisms that define how vaccines renders effectiveness and develop novel approaches enhancing the effectiveness of H5 avian influenza vaccines. We recently generated a panel of monoclonal antibodies (mAbs) that recognise a variety of different clades of H5 viruses. Propagation of AIV in eggs or cultured cells together with mAbs drives virus to escape from mAbs neutralisation activity. These classical virus neutralization assays (VN) followed by HA gene sequence analysis allowed us to defined the role of amino acid substitutions that are associated with evasion of antibody neutralization through emergence of antigenic variants and failure of vaccine efficacy. |
| Collaborator Contribution | provided intellectual input for achieving prescribed objectives of this work. |
| Impact | Talk entitled "Molecular determinants for antigenicity and vaccine efficacy of avian influenza viruses" was presented at Newton Agham Researcher Links Workshop " Novel Vaccines and Diagnostic Technologies against Emerging and re-emerging Veterinary Pathogens" at Rizal Park Hotel, Manila, Philippines, 4-7 February 2019. |
| Start Year | 2019 |
| Description | Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses. |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We developed research programme to characterise diversity of antigenic epitopes induce protective immunity in chickens against H5 subtypes of avian influenza viruses. |
| Collaborator Contribution | Collaborating partner Dr Nicola Lewis at Royal Veterinary College provide advise to on cartography programme to visualize the antigenic similarity or difference among different strains of influenza viruses. |
| Impact | The work under this collaborative determined the antigenic differences among different clades of H5 avian influenza viruses circulating in birds. This project is multi-disciplinary. our laboratory mainly work on virology and immunology part of the project and we seek help on computer modeling part from the collaborating partner Dr Nicola Lewis. |
| Start Year | 2019 |
| Description | Investigating the role of the SH protein of RSV in the duration of immunity |
| Organisation | Imperial College London |
| Department | Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided initial data supporting the hypothesis that the small hydrophobic protein of bovine respiratory syncytial virus regulates the host's immune response by modulating the transcription factors NF-kB and STAT1 in bovine cells |
| Collaborator Contribution | Based on our results, Imperial has began investigating the role of the small hydrophobic protein of human respiratory syncytial virus on human cells. |
| Impact | Publication in progress titled "Regulation of the B cell activating factor BAFF by the small hydrophobic protein of respiratory syncytial virus". |
| Start Year | 2017 |
| Description | Invitation to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 |
| Organisation | Chinese Academy of Agricultural Sciences |
| Department | Shanghai Veterinary Research Institute |
| Country | China |
| Sector | Public |
| PI Contribution | Prof. Nair was invited to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 to present a talk on 'Novel Vaccine Development for Avian Virus Diseases'. He also participated in the round table discussions on the challenges and opportunities in the vaccines and vaccination sector |
| Collaborator Contribution | Vaccine Innovation Forum will help in expanding the future collaborations and activities of the UK-China Centre of Excellence for Research on Avian Diseases (http://www.uk-china-cerad.org/). |
| Impact | organised joint meeting in China and the UK to discuss on challenges and opportunities |
| Start Year | 2017 |
| Description | JN - Preparation of capped mesoporpus silica nanoparticles |
| Organisation | Polytechnic University of Valencia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | We were involved with testing the nanoparticles once they had been made. We also contributed purified antibody and shipped it to our collaborators for the generation of one type of nanoparticle, which we subsequently tested. We were involved with the intellectual design of experiments |
| Collaborator Contribution | Our partners generated the nanoparticles and shipped them to us for testing. Our partners were also involved with the intellectual design of experiments. |
| Impact | Experimental work performed to investigate the use of mesoporous silica nanoparticles to detect FMDV proteases in clinical samples |
| Start Year | 2016 |
| Description | JS - Production of monoclonal antibodies that recognise FMDV VP4 from mouse spleens |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | VLPs displaying the N-terminal 15 amino acids of FMDV were designed and produced at The Pirbright Institute and then mice were immunised with them. The spleens of the immunised mice were harvested and splenocytes stored. The response to the VP4 sequence was checked by ELISA and the mouse with the best response was selected to send the splenocytes for monoclonal production. |
| Collaborator Contribution | The collaborators took the splenocytes obtained from the mouse experiments and carried out the fusions. They then screened the supernatants for positive wells that detected the VP4 sequence. |
| Impact | Positive wells have been identified indicating some monoclonals that are specific for VP4 have been generated. These will be further screened for ability to recognise virus and to neutralise infection. |
| Start Year | 2017 |
| Description | Janet Daly & Stephen Dunham- PI3K pathway and influenza |
| Organisation | University of Nottingham |
| Department | School of Veterinary Medicine and Science Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Preliminary data was produced by Pirbright using reverse genetics of avian influenza viruses to secure a 50:50 funded PhD studentship that will commence in October 2020 entitled "Understanding the importance of the PI3K pathway in modulating influenza virus replication in chickens and ducks". |
| Collaborator Contribution | Preliminary data was produced by University of Nottingham using PI3K p85 subunit pulldowns to secure a 50:50 funded PhD studentship that will commence in October 2020 entitled "Understanding the importance of the PI3K pathway in modulating influenza virus replication in chickens and ducks". |
| Impact | Funding for a PhD studentship entitled "Understanding the importance of the PI3K pathway in modulating influenza virus replication in chickens and ducks". |
| Start Year | 2019 |
| Description | Lactate dehydrogenase elevating virus infection in mice as a model to study arterivirus induced immune dysregulation |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration to establish lactate dehydrogenase elevating virus infection in mice as a model to study arterivirus induced immune dysregulation. |
| Collaborator Contribution | Expertise in arterivirus immunology. |
| Impact | Ongoing work. |
| Start Year | 2022 |
| Description | Leeds FBS |
| Organisation | University of Leeds |
| Department | Faculty of Biological Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research |
| Collaborator Contribution | Research and student supervision |
| Impact | Research |
| Start Year | 2009 |
| Description | Linking sex determination and dosage compensation in a mosquito Anopheles gambiae |
| Organisation | University of Zurich |
| Department | Institute of Molecular Life Sciences |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Developed a new research program. |
| Collaborator Contribution | Provided intellectual input, contributed to drafting a joined grant proposal. |
| Impact | No output yet. |
| Start Year | 2019 |
| Description | Maria Harkiolaki - soft xray tomography |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The project aims to characterise coronavirus replication organelles in whole infected cells. My team provides significant experience in coronavirus replication organelles. The project is funded by a joint studentship and the student is, predominantly based in my laboratory. |
| Collaborator Contribution | Maria's team provide extensive expertise in soft Xray tomography and are advising on experimental design and dat aanalysis. |
| Impact | Preliminary experiments have been performed to visualise replication organelle membranes. Optimisation of experimental set up is underway. |
| Start Year | 2020 |
| Description | Martin Ludlow - University of Veterinary Medicine, Hanover. Morbillivirus collaboration. |
| Organisation | University of Veterinary Medicine Hanover |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Provision of technical information and advice about the host-range of morbilliviruses. |
| Collaborator Contribution | Provision of reagents to support our research project, e.g. plasmid clones of viral attachment proteins and receptors. |
| Impact | No outcomes as yet, only preliminary data. |
| Start Year | 2018 |
| Description | Martin Turner - The role of cellular RNA binding proteins in Coronavirus replication |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My lab has begun to establish the use of a CRISPR library targeting cellular RNA binding proteins. This includes selecting the most appropriate cells, virus and conditions for the screen and the readout method and this is based on our expertise and experience in coronavirus biology. All experimental work for the collaboration has been performed in my laboratory. |
| Collaborator Contribution | Martin Turner has provided a CRISPR knockout library targeting human and murine RNA binding proteins. He has provided advice and protocols to allow us to establish the screen using human or murine coronaviruses and will advise on analysis of data following the screen. |
| Impact | Experiments are still in initial set up stages and no results have been generated to date. |
| Start Year | 2020 |
| Description | Miguel Ángel Muñoz Alía - Mayo clinic, USA. Measles population diversity. |
| Organisation | Mayo Clinic |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Technical support and sharing of research data on the host-range of morbilliviruses. |
| Collaborator Contribution | Provision of plasmid clones representing the broad genetic diversity of measles attachment and fusion proteins. Technical support. |
| Impact | No outcomes as yet. |
| Start Year | 2018 |
| Description | Miles Carroll PHE collaboration on pseudotyping |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Provision of reagents to perform pseudotyping of Ebola G protein Hosting of visiting students to attempt sarbecovirus pseudotyping |
| Collaborator Contribution | Discussion of preliminary data Provision of sarbecovirus constructs |
| Impact | None to date, publications in preparation. |
| Start Year | 2019 |
| Description | Mosquito Interest Group |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques. |
| Collaborator Contribution | Organising and attending meetings of students, RAs, postdocs and PIs on mosquito biology and related techniques. |
| Impact | Exchange of practical techniques, for instance in tracking oviposition of individual mosquitoes. Brainstorming for projects and papers, resulting in a GCRF VBD network proposal (which passed the first review but was not funded in the second) and an informal collaboration (which was intended for submission to UK-Thai call in 2017 but Thai partner was not eligible). Exchanges of colony strains of insects planned this month. |
| Start Year | 2016 |
| Description | Mucosally Associated Invariant T cells (MAIT) in pig influenza model |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identified MAIT cells in pig Influenza model. Provide samples from infected and immunised protected animals |
| Collaborator Contribution | Provide expertise in characterising MAIT: development of tetramer; Zell scanner technology allowing high resolution studies of cell phenotype and functions |
| Impact | Joint PhD studentship with Paul Klenerman, University of Oxford |
| Start Year | 2016 |
| Description | Next-generation PRRSV vaccines |
| Organisation | Eco Animal Health Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Know how in terms of genetically manipulating PRRSV and evaluating PRRSV vaccines. |
| Collaborator Contribution | Financial contribution and know how in terms of developing a commercial vaccine. |
| Impact | Too early. |
| Start Year | 2020 |
| Description | Next-generation PRRSV vaccines |
| Organisation | Huvepharma |
| Country | Bulgaria |
| Sector | Private |
| PI Contribution | Expertise in PRRSV virology and immunology |
| Collaborator Contribution | Funding |
| Impact | Too early, project ongoing. |
| Start Year | 2019 |
| Description | Nicolas Locker - Investigation of translation regulation by infectious bronchitis virus |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My team provide experience in molecular virology and cellular interactions of coronaviruses including previous experience of accessory proteins regulating cellular translation. One PhD student has successfully completed his studies working jointly between our labs and a second is due to begin in October 2022. |
| Collaborator Contribution | Dr Locker's team provide expertise in viral regulation of cellular translation and stress granule signalling. Dr Locker is also providing protocols, advice and training for techniques including ribopuromycylation and ribosome profiling. |
| Impact | PhD student funding (studentship Oct 2017- Sept 2021) - Control of host cell translation by infectious bronchitis virus PhD student funding (studentship Oct 2022- Mar 2026) - Coronavirus regulation of cellular antiviral responses and cross species transmission |
| Start Year | 2016 |
| Description | Outreach Network for Gene Drive Research |
| Organisation | Outreach Network for Gene Drive Research |
| Sector | Charity/Non Profit |
| PI Contribution | Input to policy discussions |
| Collaborator Contribution | Network is engaged in briefing national and international entities, e.g. EU/EC, European Parliament, IUCN, Convention on Biological Diversity, on issues related to gene drive. Outreach also relates to general public (directly and via media) as well as policymakers, regulators and practitioners. The Pirbright Institute is now a member of the Network |
| Impact | Briefing and media comment regarding gene drives and gene drive research to multiple agencies e.g. EU/EC, European Parliament, IUCN, Convention on Biological Diversity, on issues related to gene drive. |
| Start Year | 2019 |
| Description | Oxford - Strubi |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Collaborator Contribution | Collaboration on virus structural biology and joint PhD studentship |
| Impact | Collaboration on virus structural biology has produced a number of novel virus structures and new understanding of virus entry and packaging |
| Start Year | 2008 |
| Description | Oxford University Collaborations |
| Organisation | University of Oxford |
| Department | Big Data Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific discussion, collaboration and manuscript preparation |
| Collaborator Contribution | Scientific discussion, collaboration and manuscript preparation |
| Impact | Manuscript in preparation |
| Start Year | 2017 |
| Description | PARTNERSHIP: Nanoparticle Vaccines Against Emerging Poultry Infections |
| Organisation | University of Wisconsin-Madison |
| Department | Department of Pathobiological Sciences |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We established a joint project with School of Veterinary Medicine, University of Wisconsin, Madison, USA. My team will contribute in the development of Novel Target antigen delivery vaccines that selectively delivers antigens to the chicken immune cells and induces faster and stronger immune responses in vaccinated chickens. |
| Collaborator Contribution | The partner developed a novel DNA nano-vaccine platform. This partnership will merge both technologies to enhance both the potency and delivery systems for poultry vaccines. |
| Impact | The partnership submitted a joint research grant proposal to USDA-NIFA-AFRI (Program A1181 Agricultural Biosecurity) entitled "Partnership: Nanoparticle Vaccines Against Emerging Poultry Infections". This grant proposal has been approved by the funders. |
| Start Year | 2022 |
| Description | Parham Lab at Stanford |
| Organisation | Stanford University |
| Department | School of Medicine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Our group designed the experiments and generated a majority of the data. We also led the analysis of the data and writing of the manuscripts |
| Collaborator Contribution | The Parham lab is the leading group worldwide in the evolutionary study of NK cell receptors and MHC class I. This group generated part of the data and helped in the analysis, interpretation and manuscript preparation |
| Impact | Definition of the Cattle Killer Cell Igndash like Receptor Gene Family: Comparison with Aurochs and Human Counterparts Nicholas D. Sanderson, Paul J. Norman, Lisbeth A. Guethlein, Shirley Ellis, Christina Williams, Matthew Breen, Steven D. E. Park, David A. Magee, Farbod Babrzadeh, Andrew Warry, Mick Watson, Daniel G. Bradley, David E. MacHugh, Peter Parham, and John A. Hammond. Journal of Immunology, Dec 15, 2014; 193 (12) This collaboration is not multi-didciplinary |
| Start Year | 2009 |
| Description | Partnering with National Taiwan University |
| Organisation | National Taiwan University |
| Country | Taiwan, Province of China |
| Sector | Academic/University |
| PI Contribution | We have prepared and submitted an application for a BBSRC-Taiwan Partnering Award to study "Assembly of Recombinant Infectious Bronchitis Virus and Determination of Antigenic Sites that Confer Hemagglutination Activity". |
| Collaborator Contribution | The partners conceived the project and got in contact about submitting an application for funding together. |
| Impact | An application has been made for a BBSRC-Taiwan Partnering Award in November 2018. |
| Start Year | 2018 |
| Description | Paul Digard & Reidun Twarock - Packaging signals |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets". |
| Collaborator Contribution | University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student. |
| Impact | Studentship commenced in October 2019 |
| Start Year | 2019 |
| Description | Paul Digard & Reidun Twarock - Packaging signals |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets". |
| Collaborator Contribution | University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student. |
| Impact | Studentship commenced in October 2019 |
| Start Year | 2019 |
| Description | Paul Digard - The Roslin Insititute |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We generated constructs that express PB1-F2 from a variety of avian influenza strains in eukaryotic expression plasmids. We generated Chimera PB1-F2 expression plasmids where the C-terminus of the PB1-F2 are switched between strains. Using these plasmids we have determined the localization and antagonist activity toward the IFN beta signaling pathway and NF-kb signaling pathway in human and chicken cells. We have therefore provided reagents and intellectual input to the collaboration. |
| Collaborator Contribution | Our collaborators have used these plasmids in there well defined stability assays to determine sequence specific effects on this characteristic. Intellectual input and expertise in a particular assay were made by these collaborators. |
| Impact | We have successfully published some of this work; "The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NF?B-dependent promoter antagonism in chicken cells." doi: 10.1099/jgv.0.001220. We have an ongoing joint PhD studentship in this area. This collaboration remains current and active. |
| Start Year | 2017 |
| Description | Paul Verkade - Electron tomography and CLEM |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Nicole Doyle has performed electron tomography to analyse the three dimensional structure of membrane rearrangements induced by the expression of IBV non-structural proteins 4 or 3 and 4 in the absence of other viral components. Sample set up was performed at Pirbright and analysis was subsequently performed at University of Bristol followed by additional analysis at Pirbright. |
| Collaborator Contribution | Paul has assisted with electron tomography data generation providing access to electron microscopes in Bristol as well as training for Nicole Doyle in performing experiments and analysing and modelling data. He is also advising Nicole while establishing correlative light electron microscopy at Pirbright. |
| Impact | doi: 10.3390/v10090477 |
| Start Year | 2018 |
| Description | Pirbright-Diamond collaboration |
| Organisation | Diamond Light Source |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | 50% of my time is now based at Diamond, I am considered in-house staff and can apply to use the instrumentation. I feed projects to eBIC for collaboration using advanced electron microscopy, centered around cell biology of host-pathogen interactions using advanced electron microscopy, plus potential use of Xray microscopy (on application). |
| Collaborator Contribution | Instrument time on cryo-FIB-SEM and screening TEM (two days per month). Diamond have loaned us a plunge freezing device. |
| Impact | No outputs yet |
| Start Year | 2019 |
| Description | Placement Studentship: Production and characterisation of nanobodies recognising avian influenza and Newcastle disease virus surface glycoproteins using phage display technology |
| Organisation | University of Bath |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Studentship allocated to Roddy Brookes producing and characterising llama nanobodies which recognise avian influenza and Newcastle disease virus surface glycoproteins, using our established methods of phage display technology. |
| Collaborator Contribution | Supervisory contributions, expertise and research guidance for undergraduate placement, attributed to the Bachelor of Science award. |
| Impact | On-going. |
| Start Year | 2023 |
| Description | Prof. Jayne Hope |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis of cattle NK cell subsets, and NK cell receptor ligands. 50% PhD studentship. |
| Collaborator Contribution | 50% PhD studentship. MHC constructs for identifying receptor-ligand interactions. |
| Impact | None as yet |
| Start Year | 2023 |
| Description | Professor Benedikt Kaufer |
| Organisation | Free University of Berlin |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Providing knowledge and methodologies. |
| Collaborator Contribution | Providing reagents and methodologies to perform experiments. |
| Impact | Two publications from this collaboration: Gurung A, Kamble N, Kaufer BB, Pathan A, Shahriar Behboudi. Association of Marek's Disease induced immunosuppression with activation of a novel regulatory T cells in chickens, PLoS Pathogens, 2017, 13 (12), e1006745. Boodhoo N, Kamble N, Kaufer BB, Shahriar Behboudi. Replication of Marek's disease virus is dependent on de novo synthesis of fatty acid and Prostaglandin E2. J Virol. 2019 Apr 10 |
| Start Year | 2019 |
| Description | Professor Helen Sang,The Roslin Institute - GFP1-10 expressing transgenic chickens |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed IBDV tagged to GFP11 |
| Collaborator Contribution | Helen Sang's group at the Roslin Institute have developed transcgenic chicken lines that constitutively express GFP1-10 in every cell. |
| Impact | we have been successful in obtaining funding (Grant Ref: BB/S014594/1) |
| Start Year | 2019 |
| Description | Professor Jim Kaufman |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided information on CD4 T cell epitopes derived from Marek's disease virus |
| Collaborator Contribution | Provided knowledge and information on assessing peptide binding to chicken MHC molecules |
| Impact | Generation of data leading to understanding correlate of protection against Marek's disease virus. |
| Start Year | 2019 |
| Description | Professor Shayan Sharif, University of Guelph, Canada |
| Organisation | University of Guelph |
| Department | Department of Pathobiology |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Collaboration between my team and Professor Sharif lead to new finding in Avian immunology, specifically in understanding the effects of nutrients on antigen presenting cells and T cells of chicken. We took the lead in studying the effects of some nutrients (Vitamin D) on the function of chicken T cells, performed most of the experiments in our laboratory. Meanwhile, we participated in studying the effects of Vitamin D on antigen presenting cells of chicken by performing some key experiments because we had access to some specific reagents (monoclonal antibodies) recognizing molecules expressed on chicken antigen presenting cells. |
| Collaborator Contribution | Professor Sharif team took the lead in studying the effects of Vitamin D on antigen presenting cells of chicken, and contributed to experimental plan for studying the effects on chicken T cells. |
| Impact | Two publications in 2015 and 2016: 1. Nitish Boodhoo, Shayan Sharif, Shahriar Behboudi. 1a,25(OH)2 Vitamin D3 Modulates Avian T Lymphocyte Functions without Inducing CTL Unresponsiveness. PLoS One. 2016 Feb 24;11(2):e0150134 2. Bahram Shojadoost, Shahriar Behboudi, Villanueva AI, Jennifer Brisbin, Ali Ashkar, Shayan Sharif. Vitamin D3 modulates the function of chicken macrophages. Res. Vet. Sci. 2015 June, 100: 45-51 |
| Start Year | 2019 |
| Description | Protecting Bees collaboration |
| Organisation | University of Liverpool |
| Department | Faculty of Health and Life Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on bee cell culture and effect of Wolbachia infection on susceptibility of cells to bee viruses |
| Collaborator Contribution | Collaboration on bee cell culture and effect of Wolbachia infection on susceptibility of cells to bee viruses |
| Impact | Collaboration on bee cell culture and effect of Wolbachia infection on susceptibility of cells to bee viruses |
| Start Year | 2022 |
| Description | Protecting Bees collaboration |
| Organisation | University of York |
| Department | Department of Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on bee cell culture and effect of Wolbachia infection on susceptibility of cells to bee viruses |
| Collaborator Contribution | Collaboration on bee cell culture and effect of Wolbachia infection on susceptibility of cells to bee viruses |
| Impact | Collaboration on bee cell culture and effect of Wolbachia infection on susceptibility of cells to bee viruses |
| Start Year | 2022 |
| Description | Protein Production UK (Formerly the Oxford Protein Production Facility) |
| Organisation | Rosalind Franklin Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We are providing the sequences of antibodies from various species to add into the vectors at Oxford to produce species specific antibodies. We are also providing and devloping assays to measure recombinant antibody confirmation and binding. |
| Collaborator Contribution | PPUK is providing access to all their facilities as well as expertise. They are also providing their vector backbone as the template for antibody production. |
| Impact | None as yet |
| Start Year | 2018 |
| Description | Pseudoparticles of influenza for interaction studies with co-factor H |
| Organisation | University of Kent |
| Department | Medway School of Pharmacy |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We have screened the interaction between influenza pseudotype particles that only contain the surface HA protein from influenza viruses for interaction with human co-factor H protein. We have screen pseudotype particles of multiple influenza subtypes. |
| Collaborator Contribution | Nigel Temperton of the viral Pseudotype Unit at the School of Pharmacy provided influenza virus pseudotype particles of multiple subtypes to allow us to screen for interaction with co-factor H protein. |
| Impact | No outcomes yet |
| Start Year | 2018 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections. |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provided reagents and day to day technical help for undertaking this project and supervising postdoctoral researcher working on this project. Reagents include influenza reverse genetic plasmids and H9N2 and H7N9-specific antibodies. |
| Collaborator Contribution | this project will aim to understand AIV genetics that facilitate the rapid acquisition of mammalian adaptation characteristics in a single host infection. The partners with our collaborations determined adaptive genetic changes in the H9N2 avian influenza virus following infection in mice (mammalian hosts). Different strains of avian influenza Viruses generated by reverse gentic techniques were inoculated into mice and lungs sampled daily. RNA recovered from lung homogenates were deep sequenced and mutations arising were characterised for adaptation. Relative viral fitness and the rapidity of the accumulation of mutations was measured and compared amongst the viral strains. |
| Impact | The results of the our experimental studies showed the avian-origin viruses rapidly acquired mutations that increase virus fitness in mammalian species. Therefore, these viruses pose zoonotic and pandemic threat to public health. |
| Start Year | 2018 |
| Description | Reannotation of the Anopheles gambiae genome |
| Organisation | Biomathematics and Statistics Scotland (BioSS) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development. |
| Collaborator Contribution | Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | Reannotation of the Anopheles gambiae genome |
| Organisation | Centre for Genomic Regulation (CRG) |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development. |
| Collaborator Contribution | Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | Reannotation of the Anopheles gambiae genome |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generated and provided RNA-seq data from the developmental transcriptome of the mosquito Anopheles gambiae Manually browsed the transcriptomic data in the genome context and provided coordinates for genome regions with not annotated genes or genes requiring annotation corrections. Generated and provided FAIRE-seq data from embryo samples of Anopheles gambiae to identify regulatory elements controlling early embryo development. |
| Collaborator Contribution | Conducting reannotation of the Anopheles gambiae genome based on RNA-seq data from the developmental transcriptome. Mapping the FAIRE-seq data to the genome and linking the mapped data the RNA-seq data. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | Research Collaboration with Nigeria (23rd - 28th January 2017) |
| Organisation | University of Nigeria |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | Analysis of rare breed indigenous chicken in Nigeria. |
| Collaborator Contribution | Helped with sampling and background information of the breed. |
| Impact | Analysis is ongoing. |
| Start Year | 2017 |
| Description | Roslin - Grey |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-investigator in BBSRC project grant Collaboration in genetic screens to understand virus host interactions |
| Collaborator Contribution | Co-investigator in BBSRC project grant Collaboration in genetic screens to understand virus host interactions |
| Impact | Co-investigator in BBSRC project grant Collaboration in genetic screens to understand virus host interactions |
| Start Year | 2019 |
| Description | Stathis Giotis - Bat immunity and differential gene expression |
| Organisation | University of Essex |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The project aims to understand the role of viral regulation of innate immune signalling in coronavirus cross-species transmission, My research team provides expertise in coronavirus biology and host cell interaction, including reverse genetics. Laboratory experiments associated with this project are conducted by my team. |
| Collaborator Contribution | Stathis has provided bat cells and bat interferon reporter plasmids, as well as advice and expertise, to perform experiments. He will also perform data analysis of planned experiments to interrogate differential gene expression of cells infected with different viruses. |
| Impact | To early in the project to say. |
| Start Year | 2020 |
| Description | Stephen Graham collaboration on structural biology with University of Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data and sharing of experimental ideas regarding viral host range and techniques for simulating virus evolution |
| Collaborator Contribution | Structural analysis of mutants to viral glycoproteins |
| Impact | Journal of Virology paper on potential PPRV emergence in human populations (Abdullah et al, 2018) Application of error-prone PCR to functionally probe the morbillivirus Haemagglutinin protein. Gallo G, Conceicao C, Tsirigoti C, Willett B, Graham S and Bailey D. Journal of General Virology. J Gen Virol 2021 Apr;102(4). doi: 10.1099/jgv.0.001580. https://pubmed.ncbi.nlm.nih.gov/33739251/ The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins. Conceicao C, Thakur N, Human S, Kelly JT, Logan L, Bialy D, Bhat S, Stevenson-Leggett P, Zagrajek AK, Hollinghurst P, Varga M, Tsirigoti C, Tully M, Chiu C, Moffat K, Silesian AP, Hammond JA, Maier HJ, Bickerton E, Shelton H, Dietrich I, Graham SC, Bailey D. PLoS Biology. 2020 Dec 21;18(12):e3001016. doi: 10.1371/journal.pbio.3001016. eCollection 2020 Dec. https://pubmed.ncbi.nlm.nih.gov/33347434/ |
| Start Year | 2018 |
| Description | Steve Goodbourn - St Georges - chicken innate molecule interactions. |
| Organisation | Ulster University |
| Department | Biomedical Sciences Research Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have collaborated by producing yeast- 2-hybrid plasmids containing the influenza PB1-F2 gene from various avian influenza strains. The PhD student on this studentship then visited Professor Goodbourn's laboratory to carry out the yeast-2-hybrid screen for interaction innate chicken molecules. |
| Collaborator Contribution | Professor Goodbourn's laboratory provided yeast-2-hybrid plasmids containing various innate chicken molecules to be screened for interaction with avian influenza virus PB1-F2 protein. They also offered help and guidance carrying out the interaction technique to understand if PB1-F2 directly associated with chicken innate components. They also provided reporter plasmids and guidance on innate reporter assays in chicken cells. |
| Impact | Successful publication of work. doi: 10.1099/jgv.0.001220. The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NF?B-dependent promoter antagonism in chicken cells. |
| Start Year | 2016 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Bern University of Applied Sciences |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | ETH Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Friedrich Loeffler Institute |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Lancaster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Queen's University Belfast |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Texas A&M University-Central Texas |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Greenwich |
| Department | Natural Resources Institute Greenwich |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Liverpool |
| Department | School of Veterinary Science Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | University of Reading |
| Department | School of Biological Sciences Reading |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Supply of Arthropods to External Partners |
| Organisation | Zoological Society of London |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Culicoides nubeculosus, C. sonorensis (biting midge) and Culex pipiens (mosquito) provided as pupae for insecticide, repellent and vector competence trials as a resource. UK supplies conducted under National Capability Grant. Approximately 30 000 insects shipped during reporting period for academic users. All insect production took place at Pirbright and training in maintenance was provided to a worker from FLI (Germany). |
| Collaborator Contribution | Daughter line of C. sonorensis was established at FLI (improving security around sustaining the lines). Training and advice on insect maintenance and handling was provided by Pirbright to LSHTM, Liverpool and Reading. Studies then carried out included investigation of bacteria in Culicoides (University of Liverpool), modeling of mosquito populations (Reading) and development of novel insecticides and repellent formulations (LSHTM). These specialist expertise were driven by the host organizations for the studies. |
| Impact | Products are still in development. |
| Start Year | 2017 |
| Description | Suresh Kuchipudi and Janet Daly |
| Organisation | Penn State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We have hosted a co-supervised PhD student twice at The Pirbright Institute. During these visits we have helped with viral infection of primary cells for analysis of PI3K pathway perturbations and generated new GM influenza viruses to help to understand if the difference in PI3K pathway activity observed between two different avian influenza viruses in avian cells was a result of difference in the NS1 protein. In addition we have provided support to the student regarding the future directions of the project and writing up and presentation of the material. Therefore we have provided reagents, practical expertise and intellectual input. |
| Collaborator Contribution | The collaborators have provided access to data generated in their laboratories and intellectual input to the project. |
| Impact | Publication: doi: 10.1038/srep17999 |
| Start Year | 2016 |
| Description | Suresh Kuchipudi and Janet Daly |
| Organisation | University of Nottingham |
| Department | School of Veterinary Medicine and Science Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have hosted a co-supervised PhD student twice at The Pirbright Institute. During these visits we have helped with viral infection of primary cells for analysis of PI3K pathway perturbations and generated new GM influenza viruses to help to understand if the difference in PI3K pathway activity observed between two different avian influenza viruses in avian cells was a result of difference in the NS1 protein. In addition we have provided support to the student regarding the future directions of the project and writing up and presentation of the material. Therefore we have provided reagents, practical expertise and intellectual input. |
| Collaborator Contribution | The collaborators have provided access to data generated in their laboratories and intellectual input to the project. |
| Impact | Publication: doi: 10.1038/srep17999 |
| Start Year | 2016 |
| Description | Surrey DTP Studentship: Pathogens and Host Defences Doctoral Training Partnership |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Studentship allocated to Oenone Bodman-Harris defining immune potentiating mechanism of vaccines targeting antigens to chicken immune cells. |
| Collaborator Contribution | Supervisory contributions, expertise and research guidance for PhD award. |
| Impact | On-going |
| Start Year | 2023 |
| Description | Swine haplotyping |
| Organisation | Gift Of Life |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Prepared and shipped samples |
| Collaborator Contribution | Sample analysis |
| Impact | Data generation. Not multi-disciplinary |
| Start Year | 2016 |
| Description | The GCRF One Health Poultry Hub |
| Organisation | Royal Veterinary College (RVC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The focus of the research is to achieve sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. We are undertaking research to investigate the diversity of avian influenza viruses prevalent in poultry and wild birds in south east Asia. |
| Collaborator Contribution | Royal Veterinary College, London is leading this GCRF One Health Poultry Hub. The project will address the need to meet rising demand for poultry meat and eggs in developing countries, while minimising risk to international public health. Population growth is driving global demand for poultry, meat and egg production; this unfortunately creates conditions in which animal diseases can spread to humans ('zoonoses'). These include bacterial food poisoning and strains with avian influenza with epidemic or pandemic potential. The GCRF One Health Poultry Hub will adopt a 'One Health' approach to the issue of combatting animal-to-human diseases by bringing together a team of laboratory, clinical, veterinary and social scientists. This team will test and evaluate novel interventions. The need for safe poultry production is most urgent in South and South East Asia, so the RVC and its partners will then use their local networks in these regions to put its positive research to immediate use. |
| Impact | Development of international interdisciplinary partnership of 55 investigators from 13 countries to address the emerging global challenges of food security and public health associated with intensification of poultry production. |
| Start Year | 2018 |
| Description | The Pirbright "Livestock Antibody Hub" funded by Bill & Melinda Gates Foundation |
| Organisation | The Pirbright Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Me and my team established collaboration in the "Livestock Antibody Hub" funded ($5.5 million) by the from Bill & Melinda Gates Foundation. Focus of our partnership is to develop techniques and capacity to analyse immune cells (B cells) of cattle, poultry and pigs that produce virus neutralizing antibodies. This research will support rational development of next generation of vaccines and to explore antibody-based passive immunization approaches for treatment and prophylaxis of infectious viral diseases affecting livestock and humans. Our initial focus is to target major animal viral pathogens that cause severe losses within Low and Middle-Income Countries (LMIC) animal production systems including avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV) and foot-and-mouth disease virus (FMDV). |
| Collaborator Contribution | This is a collaborative project and partners are providing help in provision of reagents and techniques for analysis of diversity of B cells repertoire that produce infleunza virus-specific antibodies, single cell sequencing and bioinformatic analysis. This project will further strengthen our on-going research collaborations with many research groups in academia as well as with animal health industry (Zoetis, Boehringer Ingelheim Animal Health, Merck, CEVA, Jovac, YeBio, ILRI, Galvmed, The Roslin Institute, HuMabs, AbCellera and Distributed Bio) to take the research outputs from laboratory to the field. The outputs of research will be improved vaccines and diagnostics enabling to reduce the impact of infectious diseases on farm animals, which offer substantial direct and indirect economic, public health, environmental and social benefits to the UK and rest of the world. |
| Impact | Development of passive immunization approaches against avian influenza viruses affecting poultry (project incited in January 2020). |
| Start Year | 2020 |
| Description | The Roslin Institute |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have been working with several groups using our molecular and genetic data to help understand cattle cellular immunology. We have also hosted a visiting scientist to provide training in molecular techniques and data analysis, This has continued and now includes members of the Centre for Tropical Livestock Health and Genetics where we are engaged in sample sharing and maximising the value of genetic data by linking different sources as much as possible. |
| Collaborator Contribution | Our partners have provided data and reagents as well as intellectual input to help us translate genetic diversity into functional diversity |
| Impact | This collaboration is multi-disciplinary, although largely immunology and associated genetics is also involves bioinformatics |
| Start Year | 2011 |
| Description | The effect of the microbiota on immunity to swine infleunza |
| Organisation | University of Surrey |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We wish to establish the gut and nasal microbiome in normal healthy pigs and how this is affected by influenza infection. We have collected gut samples from pigs at different stages of infection, as well as nasal swabs which we will provide to our collaborators in Surrey. |
| Collaborator Contribution | Our collaborators in Surrey will perform the sequencing and bioinformatics analysis to determine the microbial communities present in the samples. |
| Impact | No outcomes yet - we are in the process of analysing the samples. |
| Start Year | 2017 |
| Description | Thomas Bowden - STRUBI - University of Oxford - Glycoprotein structure collaboration |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of data and advice about the biological properties of viral glycoproteins, e.g. their fusion capacity with various receptors, their role in determining host-range |
| Collaborator Contribution | Advice and technical support at the structural level supporting future project development and design |
| Impact | No outcomes as yet |
| Start Year | 2018 |
| Description | TrailMap-One Health |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b is panzootic in birds. Its widespread geographical distribution, sheer numbers of infections and frequent incursions in mammals indicate it to be a virus with pandemic potential. We are working as a consortium to achieve a coordinated in-depth risk assessment of clade 2.3.4.4b viruses particularly zoonotic potential of the current clade 2.3.4.4b H5N1 viruses. |
| Collaborator Contribution | The collaborating partners are jointly providing data and samples necessary for evaluating the threat posed by H5N1 Clade 2.3.4.4b highly pathogenic avian influenza viruses (HPAIV) to human health. This effort aims to understand the risks, potential spillover routes into humans, the virus's capacity to adapt for human transmission, and the probable severity of human infections should they occur. We will meet these objectives through three interconnected work packages: (1) assessing the infection likelihood in non-human mammals that could serve as bridging species, (2) evaluating the risk of direct or adapted virus spillover infections in humans, and (3) examining the potential for Clade 2.3.4.4b H5N1 viruses to become transmissible among humans. |
| Impact | The work is currently in its initial stages, with anticipated outcomes expected by the end of this current year, 2024/2025. |
| Start Year | 2024 |
| Description | Trevor Sweeney - University of Cambridge PhD Studentship |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of PhD studentship project in collaboration with Dr. Sweeney's lab at Cambridge and application at Pirbright. |
| Collaborator Contribution | Development of PhD studentship project and application at Cambridge. |
| Impact | The PhD studentship has been funded and is currently been advertised. |
| Start Year | 2018 |
| Description | Understanding animal health threats from emerging H5 high pathogenicity avian influenza viruses |
| Organisation | Animal and Plant Health Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | This is a collaborative research project funded by the UKRI-BBSRC to understand how the high pathogenicity Avian Influenza virus (H5N1) persisting in different species of wild birds and transmits from wild birds to farmed poultry, the gaps in biosecurity that allow the virus to penetrate premises, and how this could be addressed. My team contributing by by generating research reagents (such as viruses generated using reverse genetic technique) that allows the identification of molecular markers in the virus genes responsible for virus virulence, transmission and/or antigenic change. The data generated helped the partners to utilise the viruses and reagents for testing their biological behaviors ( such as infectivity and transmission parameters) via animal infection studies. The outcome of this collaborative work will provide insights for assessing threats from new and emerging strains, enabling national and international agencies to design and execute contingencies as part of risk mitigation and disease control. This will provide vital information when considering how to invest scarce resources for surveillance design aimed at early warning of the threat. |
| Collaborator Contribution | The collaboration enhance both the capacity of my team by providing field data ( such as sequences of viruses isolated from the field) and reagents such as post-infection antiserum containing antibodies specific to the field virus. This allowed the investigation of field virus antigenic profiles that can be used for selection of candidate vaccine seeds for the production of effective vaccines. |
| Impact | The data generated provided a risk assessment of contemporary H5Nx HPAIVs that are acquiring adaptive changes to increase fitness within domestic and wild avian populations. This partnership identified viral and host factors that potentially contribute to increased transmissibility, persistence, and pathogenicity in wild birds and those that enhance their potential to disseminate and manifest disease in poultry. We identified genetic changes that drive the virological, immunological, and zoonotic infection potential of these H5N1 viruses. The data generated allowed us an establishment of current and future risks from these viruses to both animals and humans if they continue to remain prevalent in wild bird populations. |
| Start Year | 2022 |
| Description | University of Glasgow collaborations (Sam Wilson and Massimo Palmarini) |
| Organisation | University of Glasgow |
| Department | MRC - University of Glasgow Centre for Virus Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Scientific discussion and reagent sharing contributing to grant applications and active research projects |
| Collaborator Contribution | Scientific discussion and reagent sharing contributing to grant applications and active research projects |
| Impact | Successful MRC grant application |
| Start Year | 2015 |
| Description | University of Liverpool Proteomics Collaboration |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Generation of samples to analyse the membranous proteome of cells infected with paramyxoviruses. |
| Collaborator Contribution | Proteomic analysis of samples and technical support. Access to previous data-sets and expertise. |
| Impact | Preliminary data sets only to date. |
| Start Year | 2018 |
| Description | Wilhelm Gerner |
| Organisation | University of Veterinary Medicine Vienna |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Our lab hosted Dr Gerner who brought samples for RNA-seq. My lab planned and executed the sequencing and is contributing to the analysis. |
| Collaborator Contribution | Dr Gerner did all the animal work and cell sorting to produce the samples reading for RNA-seq |
| Impact | None as yet, analysis is ongoing |
| Start Year | 2019 |
| Description | Y chromosome-linked X-shredding gene drives |
| Organisation | Hebrew University of Jerusalem |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | We shared with the partner Y chromosome-linked docking lines generated in our lab. |
| Collaborator Contribution | Provided some plasmid constructs. |
| Impact | No outputs yet. |
| Start Year | 2021 |
| Title | AVIAN CELLS FOR IMPROVED VIRUS PRODUCTION |
| Description | The present Invention provides as avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM 1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3). |
| IP Reference | WO2014195692 |
| Protection | Patent granted |
| Year Protection Granted | 2014 |
| Licensed | Commercial In Confidence |
| Impact | The present invention provides an avian cell in which the expression or activity of one or more of the following genes, or a homologue thereof: Chicken IFITM1 (SEQ ID No. 1); Chicken IFITM2 (SEQ ID No. 2) and Chicken IFITM3 (SEQ ID No. 3) is reduced. The invention also provides methods for passaging viruses in avian cells, embryos and/or avian cell lines which have reduced expression of one or more IFITM genes and methods which involve investigating the sequence of one or more of the follow |
| Description | "Challenges for Poultry Industry". Organised by Fakieh Poultry at the Ritz-Carlton Hotel in Jeddah, Saudi Arabia, 2nd -3rd December 2018, |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed prevention and control of infectious diseases affecting poultry production. |
| Year(s) Of Engagement Activity | 2018 |
| Description | "Interactive session with poultry stakeholders". Title: Overview of Avian Influenza group Research at The Pirbright Institute. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The workshop discussed the economic impacts and prevention strategies against avian influenza viruses affecting poultry production and zoonotic infections. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 1st Research Coordination Meeting (RCM) of the Coordinated Research Project (CRP) on "Generic approach for the development of genetic sexing strains for SIT applications" Vienna, 7-11 October 2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FAO/IAEA Coordinated Research Project on exploring genetic and molecular methods of sex separation in insect pests; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2. Overview of Avian Influenza group Research at The Pirbright Institute. Presented at "Interactive session with poultry stakeholders" at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research Project outcomes These include presenting research data for vaccine seed strains with emergent field avian influenza variants; The zoonotic risk posed by emerging avian influenza viruses circulating in the wild birds and poultry. Impact of virus evolution on vaccine efficacy and persistence in poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.labanimaltour.org/pirbright |
| Description | 7th European Veterinary Immunology Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Selected oral presentation: Developing a 'One Health' Nipah virus vaccine to protect animal and public health |
| Year(s) Of Engagement Activity | 2021 |
| Description | A talk at a symposium entitled: Using the 3Rs to support good science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk at a Symposium held at The Pirbright Institute entitled: "Using the 3Rs to support good science". The talk was entitled: "A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry" |
| Year(s) Of Engagement Activity | 2017 |
| Description | A talk at the British Poultry Diseases Group meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | The Poultry Diseases Group meet quarterly and is comprised of representatives from private veterinary practices, vaccine and pharmaceutical industries, and the Animal and Plant Health Agency (APHA). I gave a talk at one of the meetings outlining my research to date and future directions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | AHSV talk on transmission for OIE (Thailand online) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on transmission of AHSV to interested parties following outbreak in 2020. Talk given on 9/6/20 to approx 150. |
| Year(s) Of Engagement Activity | 2020 |
| Description | AN INTERVIEW WITH PROFESSOR VENUGOPAL NAIR |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Professor Venugopal Nair is a Research Group Leader at The Pirbright Institute, a visiting Professor of Avian Virology at the Department of Zoology, and a Jenner Investigator at the Jenner Institute, University of Oxford. He is also a member of the Microbiology Society, and in this interview, he tells us more about his research into viral diseases of livestock. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/membership/meet-our-members/focus-area-viruses/an-interview-with-pro... |
| Description | Amin Asfor presented the findigs of the project at the Microbiology Society Annual meeting, 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Amin Asfor presented the findigs of the project at the Microbiology Society Annual meeting, 2019. Title: in vivo and ex vivo models of Infectious Bursal Disease Virus (IBDV) in inbred chicken lines differing in their resistance to the disease. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Amin Asfor presented the work at the NC3Rs Fellows Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Amin Asfor presented a poster at the NC3Rs Fellows Day entitled: Chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry |
| Year(s) Of Engagement Activity | 2019 |
| Description | Amy Lewis, The Scientist, 15/08/2017 re gene drive and Predator Free NZ 2050 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided information and quotes for article on potential use of gene drives as part of New Zealand effort to eradicate invasive predators |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.the-scientist.com/?articles.view/articleNo/50180/title/Driving-Down-Pests/ |
| Description | Ash Manor GCSE Mentoring 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Ash Manor school challenge week science workshops |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Discussion of research activities with school children and the school reported increased interests in the related subject. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Ash Manor school challenge week science workshops |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Provide information on research activity at The Pirbright Institute and informing on pathogens infecting farmed animals. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Avian Influenza H9N2 and H7N9 evolution, fitness in poultry and zoonotic potential presented by Munir Iqbal at UC DAVIS EDUCATION CONFERENCE ON ONE HEALTH FOR FOOD SAFETY, AGRICULTURE, AND ANIMAL HEALTH |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The research was discussed with academic and non-academic participants the risks of avian influenza viruses currently circulating in poultry and carry potential to cause zoonotic infections. Since avian influenzas viruses (AIVs) exist in many subtypes and co-infection of two or more different AIV subtypes in an individual bird can lead to the generation of novel reassortant viruses. The emergent reassortant viruses may carry differential phenotypic characteristics (virulence, host-transmission and host-range) compared to their parental viruses. Our studies revealed that experimental co-infection of chickens with two different subtypes of avian influenza viruses (H9N2 and H7N9) led to the emergence of novel reassortant H9N9 viruses which carry greater virulence for poultry and an increased zoonotic and pandemic potential. Our results also provided evidence that both H9N2 and H7N9 viruses can rapidly acquire antigenic changes in vaccinated birds causing vaccine failure and cocirculation of these viruses can also rapidly lead to rapid generation of novel reassortment viruses with increased virulence and host-range posing threat to both animals and humans. This presentation increased awareness among the audience risk posed by co-circulation of different subtypes of avian influenza viruses in poultry and wild birds and how best we can detect emerging threats and develop the disease risks and disease mitigation strategies. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.wifss.ucdavis.edu/onehealthsummer21/ |
| Description | Avian Influenza Research at Pirbright |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker to the Animal Diseases Surveillance and Control Team at The Department for Environment, Food, and Rural Affairs (DEFRA), London, UK sharing the research goals and achievements performed at the Pirbright Institute. The topics focused on (i) understanding the genetic and antigenic evolution of avian influenza viruses, (ii) drivers of zoonotic potential, (iii) improvement of poultry vaccine potency, (iv) investigating molecular markers of antigenic variants, (v) improving avian influenza detection and diagnostic approaches, e.g. lateral flow devices and (vi) development of novel vaccine candidates to improve protective efficacy including vector- and multivalent-based vaccines and targeted delivery of antigens. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Avian Influenza Vaccines Research at Pirbright |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Delivered a presentation to key research grant funders and stakeholders in the UK, including BBSRC and DEFRA, associated with animal welfare, disease control, and the research goals and achievements performed at the Pirbright Institute. The topics focused on (i) understanding the genetic and antigenic evolution of avian influenza viruses, (ii) drivers of zoonotic potential, (iii) improvement of poultry vaccine potency, (iv) investigating molecular markers of antigenic variants, (v) improving avian influenza detection and diagnostic approaches, e.g. lateral flow devices and (vi) development of novel vaccine candidates to improve protective efficacy including vector- and multivalent-based vaccines and targeted delivery of antigens. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Avian Influenza: Global Situation & Control Strategies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the International Symposium on Poultry Health Challenges in Pakistan. Organized by the World Veterinary Poultry Association (WVPA-Pakistan Branch) at Serena Hotel Faisalabad, Pakistan. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Avian flu: our food chain is in crisis. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The New paper "Telegraph" correspondent Sarah Newey (GLOBAL HEALTH SECURITY CORRESPONDENT) Interviewed Professor munir Iqbal regarding the impacts and threats of current wave if high pathogenicity avian influenza virus causing disease widespread losses to poultry production, mortality of wild birds and mammalian species (otters, foxes, minks sealions), The discussion focus on the impacts of avian influenza infections on the livelihood of farming comunities and threat of zoonotic infection to wider public. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.telegraph.co.uk/global-health/science-and-disease/what-bird-flu-pandemic-killedmillions-... |
| Description | Avian influenza virus evolution impacts on virulence and antigenicity |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk was presented at Royal Veterinary College, London, by Thusitha Karunarathna (a PhD student in the Avian Influenza group at The Pirbright Institute). The Talk described the mechanisms used by the avian influenza viruses to evade host immunity to cause disease outbreaks and persists in poultry. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Avian influenza viruses can combine two techniques to evade vaccine immunity |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A study by researchers at The Pirbright Institute reveals more clues about how avian influenza viruses can evade vaccine immunity, aiding their spread in the field. The findings are published in Emerging Microbes and Infections. Influenza viruses are able to mutate, which can enable them to evade immunity generated by natural infection or vaccination. Influenza viruses have four main ways of duping the immune system so that they can continue to infect and spread between birds. Pirbright scientists investigated two of these to further understand how the H9N2 avian influenza virus can change its genetic makeup to overcome poultry vaccines. One of the methods the virus can use is to alter one of its surface proteins, haemagglutinin (HA), which enables the virus to enter the cell and replicate. HA is also a common target for the immune system's antibodies, which block the virus from binding to cell receptors. By changing just one or two protein components, HA can latch on far more tightly to the cell, preventing antibodies from stopping the virus. However, this can come at a cost, as particularly strong binding can prevent effective replication. The other method scientists investigated is how H9N2 viruses disguise themselves by adding sugar chains to the surface of their HA proteins. This can block antibodies from binding, but also has varying fitness outcomes for the influenza virus. The researchers found that the location of the sugar chain on HA could determine how effectively the virus replicated. They also demonstrated that the two evasive techniques could either compliment or act against each other - if an influenza virus had gained mutations that enable it to bind more strongly to cells, a sugar chain in the right position could restore its ability to replicate effectively. In contrast, weakly binding influenza viruses do not benefit from HA sugar additions, which instead reduce the virus's ability to replicate. Professor Munir Iqbal, head of the Avian Influenza Group at Pirbright said, "We can use this knowledge to develop new vaccines that will help antibodies to recognise how the flu virus can change. This will provide protection to birds even as the virus evolves. We can also use this information to understand how viruses survive in poultry despite vaccination and monitor new adaptions that may appear in the field." This research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI) and the British Council with support from the Newton Fund. Article: Sealy, J. E., Peacock, T. P., Sadeyen, J. R., Chang, P., Everest, H. J., Bhat, S., Iqbal, M. (2020). Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness. Emerging Microbes & Infections, advance online publication, 12 November 2020, doi: 10.1080/22221751.2020.1850180 [SOURCE: The Pirbright Institute] |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.star-idaz.net/2020/12/avian-influenza-viruses-can-combine-two-techniques-to-evade-vaccin... |
| Description | Avian influenza viruses in Bangladesh, Vietnam, and Sri Lanka: investigating genotype to phenotype (antigenicity, virulence, host-range). Webinar on 28th March 2021. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented talk by Munir iqbal describing ongoing research outcomes. We identified genetic determined that modules avian influenza H5 and H9 antigenicity virulence and transmission fitness in different host species. The role of identified markers that change the virus binding to host cells and impact on virus-host interaction leading to mild or severe disease manifestation in chickens and mammalian species (humans). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Avian influenza: tackling large numbers of outbreaks this winter in the UK |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Nearly two years on, the COVID-19 pandemic is still dominating the news and continues to cause concern for populations across the globe. However, UK poultry and wild bird populations are currently facing their own health threat. We are not the only ones that have faced lockdowns because of spreading viruses, UK poultry and captive birds have also faced a similar situation to protect them from avian influenza. Scientists at The Pirbright Institute are working to increase understanding of how genetic changes in influenza A viruses can impact disease spread, host responses to infection and the pathology associated with the disease. What is the avian influenza virus? Avian influenza viruses are Influenza A viruses that circulate and transmit amongst birds. The disease is what we commonly know as 'bird flu'. Influenza A viruses can infect a range of hosts, including humans and two subtypes H1N1 and H3N2 circulate as seasonal flu each winter in the UK. Avian influenza viruses are different to those that can infect humans in that they cannot easily infect humans and must change and adapt to do so. Aquatic birds are a natural reservoir for avian influenza viruses, these birds typically experience fewer clinical symptoms but can spread disease to domestic birds, particularly in the migratory season, between October and March. Avian influenza viruses are categorised as either highly pathogenic (HPAI) or low pathogenic (LPAI) and this categorisation is linked to the severity of disease in chickens. HPAI has a high mortality rate which can be up to 100%, other symptoms can include swelling of the head, death of cells in the comb and wattle, red discolouration of legs and feet and diarrhoea. HPAI causes disease in more organs than just those in the respiratory or gastrointestinal tracts like LPAI, which mostly presents as respiratory symptoms such as a snick (like a sneeze), a rattle in the chest (known as rales) and discharge from the eyes and nose. What is causing bird flu outbreaks in domestic birds now? We are currently in the normal migratory season of wild birds. In the spring and summer months, these birds spend their time breeding and raising their young in North-eastern Asia where they mix with other bird species which enables virus transmission and mutation. Then, when they migrate for the autumn and winter months, they shed virus in their faeces along the way. One of the migratory paths is across Northern Europe and this includes the UK. This year, in the UK, the first avian influenza outbreak was on 15 October and was discovered in captive aquatic birds. To date (17 December 2021) there have been 50 outbreaks in England, 1 in Wales and 2 in Scotland, this has resulted in over half a million birds being destroyed to control the spread of disease. Are there more outbreaks this year compared to other years? The number of outbreaks this year has been the most extensive ever. There have been over 50 outbreaks in the UK, compared to 26 outbreaks last year. Although it is hard to pin down the reason for this high number, we know it is not linked to the COVID-19 pandemic. The UK's response to the spread of avian influenza has been rapid, and from 29 November birds were required to be housed inside with additional biosecurity measures put in place such as foot dips and disinfecting clothing. Testing and surveillance of wild birds have shown that there is a high prevalence of the virus in these birds currently, and this is contributing to the spread of disease to farm and domestic bird populations. A more detailed look at the genetic make-up of these viruses shows that they are different to those from previous years. This is predicted to be as a result of the virus infecting multiple birds across a range of species, and this provides the perfect opportunity for the virus to evolve. Analysis of these genetic changes does not raise any alarm bells for increased transmission to humans, but they are likely impacting the spread and severity of disease in birds. What should we do if we find a dead bird or are concerned about bird health? If the public finds dead waterfowl birds they are encouraged not to touch them but to report them to Defra using the appropriate phone number that can be found on the website, also any other wild birds found dead in numbers of five or greater should be reported. What is Pirbright doing to tackle this virus? Researchers at Pirbright are attempting to enhance the control and detection of avian influenza in poultry populations as well as extend our basic knowledge about the virus in avian and mammalian hosts. The research groups led by Professor Munir Iqbal and Dr Holy Shelton are investigating how avian influenza virus strains originated from wild birds can rapidly adapt to cause disease outbreaks in poultry and gain the potential to infect humans. In addition, Professor Munir Iqbal is developing improved poultry vaccines that prevent virus replication and spread. These vaccines are particularly useful in countries where avian influenza is regularly found in the domestic poultry and the control and prevention of spread isn't easy, such as in the UK. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/12/avian-influenza-tackling-large-numbers-outbreaks-winter-uk |
| Description | BBC Today programme 24/01/2019 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview on BBC Today programme regarding potential development and use of gene drives in mice |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/sounds/play/m00025bt |
| Description | BBSRC COP Climate Change Bites 21/05/2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | BBSRC-sponsored event "Climate Change Bites" - talks and panel discussion about the effects of climate change on vector-borne disease |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://bbsrc.ukri.org/news/events/2021/climate-change-events/ |
| Description | BBSRC Impact Showcase 2022 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was asked to record an interview answering questions relating to the impact of BBSRC funding on our research. This has been included as an impact case study on the BBSRC research outcomes and impact pages. |
| Year(s) Of Engagement Activity | 2022 |
| Description | BBSRC Partnering Seminar, University of Liverpool, Tamilnadu Veterinary and Animal Science University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk presented entitled " Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses". The research data shared with the colleagues working to reduce the impact of avian infectious diseases on poultry production. The discussion led to more collaboration and work together, acquiring reagents and protocols for further research and development activities. |
| Year(s) Of Engagement Activity | 2019 |
| Description | BBSRC website article: Halloween |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on BBSRC website: Halloween Creepy Crawlies |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.bbsrc.ac.uk/news/fundamental-bioscience/2017/171031-f-uk-creepiest-creepy-crawlies/ |
| Description | BIotech YES 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave a talk at the BBSRC Biotechnology Young Entrepreneurs' Scheme event at Syngenta (Jealott's Hill) |
| Year(s) Of Engagement Activity | 2019 |
| Description | BSI report on the future of veterinary immunology and vaccinology |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Organised and published a joint IVVN/BSI report to raise awareness of the UK's research status in veterinary vaccinology and immunology and the importance of maintaining this for the R&D landscape 'Securing Our Future: the value of veterinary vaccines'. This was aimed at influencing policymakers to support and commit to maintaining the UK's leading position. |
| Year(s) Of Engagement Activity | 2021 |
| Description | BSI webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I presented a webinar hosted by the British Society for Immunology entitled "BSI Coronavirus webinar: What can we learn from the animal coronaviruses?", which sparked questions and discussions afterwards. I have since been contacted to establish new collaborations with people in the audience. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Big Band Science Event- AH, ER, LVC, MdP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Big Bang Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This is a South of England Showground in which students from schools and their parents participated which lead to discussion and interest in both school children and their parents. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://nearme.thebigbangfair.co.uk/view/?eve_id=1956 |
| Description | Big Bang Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The Big Bang Near Me is a programme of regional and local Big Bang Fairs that take place all across the UK. Together with The Big Bang UK Young Scientists & Engineers Fair and The Big Bang Competition, it forms part of the wider Big Bang programme, bringing science, technology, engineering and maths (STEM) to life for young people |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://nearme.thebigbangfair.co.uk/about/ |
| Description | Big Bang Fair South East - RC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science festival/event - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Big Bang UK- Jennifer Simpson |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Big Bang UK is a science competition. JS acted as moderator for final projects submitted by students from across the UK. |
| Year(s) Of Engagement Activity | Pre-2006,2019 |
| Description | Biggs facility official opening ceremony - YC |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | YC helped host visitors during the Bigg's building opening ceremony event. This included directing visitors on site, answering questions and generally interacting. |
| Year(s) Of Engagement Activity | 2023 |
| Description | BioimagingUK meeting 2022 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | UK bioimaging community meet to discuss future directions of technology and what UK facilities are required in the future |
| Year(s) Of Engagement Activity | 2022 |
| Description | Biotech YES, Syngenta Jealott's Hill, 05 Oct 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Teams of postgraduate students from a number of universities and institutes attended talk as part of Biotech YES (Young Entrepreneurs' Scheme). Follow-up discussion influenced several aspects of their approach to entrepreneurship both within the competition and more generally |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017 |
| Description | Bird flu study from Pirbright Institute sheds light on mutations and health impacts |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Bird flu study from Pirbright Institute sheds light on mutations and health impacts. Emerging research from the Pirbright Institute shows that avian influenza mutations could increase disease threat to poultry, but make it less infectious for humans. Mutations in the H7N9 bird flu virus increase its replication rate and stability in avian cells, but reduce its preference for infecting human cells, a study from The Pirbright Institute has found. The results show that outbreaks in birds caused by strains with these mutations could pose a lower risk to human health, while remaining a significant threat to the poultry industry. H7N9 low-pathogenicity avian influenza (LPAI) virus usually infects birds, but in 2013 the first human case was recorded in China. Since then, there have been over 1,500 confirmed human infections with about 40 percent of cases resulting in fatalities. Further evolution of the H7N9 virus gave rise to a high-pathogenicity avian influenza (HPAI) strain that could cause 100 percent mortality in chickens. In 2017 the Chinese Government initiated a wide scale vaccination programme in chickens which drove down cases of both low and high pathogenicity strains. Previous Pirbright research identified three mutations in avian influenza H7N9 viruses that enabled them to overcome immunity generated by vaccines. The mutations altered a protein on the outside of the virus called haemagglutinin (HA), which binds to host cell receptors and allows the virus to enter and cause infection. In the latest study, published in the Journal of Virology, the team discovered the same mutations occurred in H7N9 viruses isolated from the field in 2019, which most likely emerged in birds that had either been immunised or naturally infected. Analysis of the viruses demonstrated that strains with these mutations have significantly increased replication rates in both chicken cell cultures and chick embryos as well as displaying greater acid and thermal stability, which could improve transmission ability. The mutations also influenced which animal cells the strain could enter - their HA proteins could still bind to the receptors of bird cells, but they lost their affinity for human cell receptors. These findings show that in evolving to escape the chicken immune system, the mutated H7N9 viruses have reduced their risk to human health whilst increasing the threat they pose to poultry, although further studies in birds are needed to confirm the impact this could have on infection and disease spread. Professor Munir Iqbal, head of the Avian Influenza Group at Pirbright, said: "Our approach has allowed us to accurately predict avian influenza mutations that appear in the field, and assess how these mutations could affect the risk they pose to both human and avian populations. This information can be used to inform surveillance efforts and provide early warnings of potentially dangerous emerging strains." |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.thepoultrysite.com/news/2020/07/bird-flu-study-from-pirbright-institute-sheds-light-on-m... |
| Description | Bird flu: What is it and what's behind the outbreak? ( BBC New) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussion with BBC News Editors (Helen Briggs & Jeremy Howell). As the The world is going through its worst-ever outbreak of bird flu which led the deaths of hundreds of thousands of wild birds and millions of domestic ones. It is also being found in mammals, so what are the threats from this virus to economy, food security, animal welfare and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bbc.co.uk/news/science-environment-63464065 |
| Description | Blenheim High School Fair - DB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Team members attended sessions at a local high school with secondary school children and those in the 6th form to talk about paths into scientific careers, sharing their experiences of working at The Pirbright Institute. Approximately 300 students attended and it stimulated increased interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Bluetongue and Wildlife (15 minute presentation on Epizootic Haemorhagic Disease Virus), (July/Pirbright, UK) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Policymakers reported greater interest in deer-associated diseases including EHDV and BTV |
| Year(s) Of Engagement Activity | 2018 |
| Description | Briefing - EU/Estonia parliamentarians and policy advisers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Briefed Estonian delegation to Brussels/EU parliament on gene drives and related issues |
| Year(s) Of Engagement Activity | 2020 |
| Description | Brownies-AH |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talking to the Brownies about science and their careers |
| Year(s) Of Engagement Activity | 2019 |
| Description | CABI_Research activity of Avian Immunology Group at The Pirbright Institute |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Release of research activity within Avian Immunology group at The Pirbright Institute |
| Year(s) Of Engagement Activity | 2018 |
| Description | CBD Open-ended online forum on synbio 06-10/2017 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | UN Convention on Biodiversity. Policy- discussion on synthetic biology: nominated participant in the Open Ended Online Forum on Synthetic biology as established in decision XII/24 of the Conference of the Parties to the Convention on Biological Diversity (COP) and extended in COP decision XIII/17 which ran from June to Oct 2017 (approx.) |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://bch.cbd.int/synbio/open-ended/discussion/ |
| Description | CBS briefing 26/05/2021 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Briefed CBS journalist in relation to story about release of transgenic mosquitoes in Florida |
| Year(s) Of Engagement Activity | 2021 |
| Description | CNN interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with CNN journalist. Journalist later followed up asking me to check and clarify some issues. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cafe Scientifique, Bradfield School, West Berkshire: "How insects spread viruses" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cafe Scientifique, Reading: "How insects spread viruses" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions. |
| Year(s) Of Engagement Activity | 2007,2017 |
| Description | Camberley Library Fun Palace 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Careers event at Bishop David Brown School, Woking - YC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | YC attended the careers event to help on the Institute stand, engaging with students, raising their aspirations. The stand introduced them to a wide variety of careers including potential STEM careers, apprenticeships, traineeships. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Caroline Seydel Genetic Literacy Project re GM mosquitoes/gene drive/Zika |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided background material and quotes for article on GM mosquitoes and control of Zika virus. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://geneticliteracyproject.org/2018/01/29/waging-war-mosquito-split-gene-drive-hinder-spread-zik... |
| Description | Centre of excellence for research on avian diseases (CERAD) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I was invited to present my work at the UK-China Centre of excellence for research on avian diseases (CERAD) meeting attended by researchers from UK, China and Thailand. There was lots of discussion about the research and future directions, including potential collaborations. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Chair and Co-Organiser for UK Vector-borne Diseases Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | UK Vector-borne Diseases meeting held bi-Annually. Half day sessions on 2nd, 9th, 16th, 23rd November 2020. Chaired session on 9th November 2020. Meeting was held online with invited and selected presentations and a poster session. Also included funders from Defra and BBSRC. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at the festival covering the Institute science in general, and transmission and gene editing to control disease, in particular. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - JP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major national science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - RC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018 - SV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Display at major science festival: changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival 2018-DP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Major national science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cheltenham Science Festival- AH, ER, JC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Present at the Pirbright stand to discuss science with the public |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenham Science festival - LB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | National science festival which Team members attended to demonstrate to the public how scientists at The Pirbright Institute can work to contain and control viral outbreaks. Over 500 people accessed the information and this stimulated increased interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cheltenhan Science Festival - Dana Perry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | DP helped to run a stand at the festival, questions from the general public stimulated increased interest in science and research and increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Co-organised relaunch event for South East Virus Network (SEVN) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Together with APHA co-organised on Pirbright's behalf a small programme of talks from Pirbright ECRs showcasing their work. The audience was made up of virologists and other microbiologists from across the SE of the UK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines. Presented at as PI of the ZELS project at ZELS grant holders and Stakeholders meeting in Hanoi, Vietnam 23th-24th January 2017. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engagement and dissemination of research outcome to representatives of research funding bodies such as Department for International Development (DFID), Medical Research Council (MRC) and the researchers working on different research projects funded by BBSRC under Zoonoses and Emerging Livestock Systems (ZELS). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Commentary on AHSV outbreak in Thailand in Science Magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | 'Thailand scrambles to contain major outbreak of horse-killing virus' - Article in Science Mag April 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.sciencemag.org/news/2020/04/thailand-scrambles-contain-major-outbreak-horse-killing-viru... |
| Description | Conference presentation at RSV 2022 meeting in Belfast |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Two group members (Dr. Jobe and Miss Emily Lacey) travelled to Belfast for RSV 2022 conference. We presented one poster on RSV inclusion bodies. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Conference presentations at Microbiology Society 2022 meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talks from our lab at the Microbiology Society general meeting in Belfast in 2022. Talks were on the immune response to Covid vaccines and SARS-CoV-2 and other viruses' host range. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Conference presentations at Negative Strand Virus meeting 2022 in Braga, Portugal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Four members of the research group (Drs Bailey, Jobe and Newman as well as Miss Thakur) travelled to Portugal to present our work on SARS-CoV-2 host range, immunity and also RSV inclusion bodies. We had 2 talks and a poster. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Conference session organiser at MMC2017 - Host Pathogen Interactions |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chair for the Imaging Host-Pathogen Interactions session run at MMC2017 (and in previous years). Session usually attracts approx. 30 delegates from national/international backgrounds, mostly academic. Talks sparked discussions and networking opportunities. |
| Year(s) Of Engagement Activity | 2012,2014,2015,2017 |
| Description | Controlling and monitoring Avian Influenza in poultry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Engagement with veterinarian and farmers involved in poultry production. The discussion focused was new strategies (vaccines and diagnostics) for reducing the the impacts of high pathogenicity of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Coronavirus lecture MSc students (Surrey) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A lecture was presented on the replication, cellular interactions and pathogenesis of coronaviruses to 15-20 MSc students from University of Surrey. The students were engaged and interested, answering and asking questions during the session. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | Could Bird Flu become a pandemic? (Aljazeera TV) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The discussion ( Inside Story) has been impacts of high pathogenicity avian influenza on poultry and whether bird flu become a pandemic?. The inside story was presented by Al Jazeera English corresponded "Mohammed Jamjoom" the discussion focus remains as the world is experiencing its largest recorded outbreak of bird flu, populations of poultry and wild birds are becoming infected. So what are threats of these viruses on food supplies, economy and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.youtube.com/watch?v=spp2Cg-jqoc |
| Description | DARPA visit April 2017 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Hosted visit by US funding agency programme manager to The Pirbright Institute |
| Year(s) Of Engagement Activity | 2017 |
| Description | DB Winston Churchill School Careers event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | School careers event for a Secondary School - 1500 children ages 11 to 16 years |
| Year(s) Of Engagement Activity | 2021 |
| Description | Deimante Lukosaityte: Microbiology Society conference 2019. Poster presentation: Chicken protection against H9N2 virus by passive immunization |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques for development of next generation of vaccines against viral diseases affecting animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Demonstrating Mathematics (Angita Shrestha) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Angita Shrestha (PhD student within Avian Influenza group) provided help in a Maths session to the new Oxford Doctoral Training Porgramme (DTP) cohort. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Determinants of antigenicity of H9 Avian Influenza Viruses. UK-China Swine and Poultry Workshop.17-18 June 2019, The Pirbright Institute, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Developing novel multivalent vaccines for poultry viral diseases |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented a talk at the Oxford University training Course on Human & Veterinary Vaccinology, UK. This talk was directed to students at the University of Oxford to teach and describe the research and challenges to overcome to enhance the efficacy of poultry-based vaccines performed at the Pirbright Institute. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Developing novel multivalent vaccines for poultry viral diseases |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk entitled "Developing novel multivalent vaccines for poultry viral diseases" was presented to post-graduate students from Univerity of Oxford. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Diamond (TT) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Diamond Light Source Open Day - explaining to general public the importance of structural biology and microscopy for understanding viruses and designing improved vaccines. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diamond Light Source Open day - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A public open day for Diamond Light Source, which Pirbright attended as a user of the facility to showcase research being performed at Pirbgith in collaboration with Diamond. There was a lot of interest in the fundamental research and sicussion about future plans and how it fit with the facility at Diamond. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diamond open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Over 300 people visited our stand at the open day, in which we described the importance of our work for food security and public health. Children from all ages were involved and learned about viruses and played with the huge virus particle that we had produced. One of the major impact was that we described to several people why we work on some viruses that we do not have them in the UK, and the importance of the work for the UK and UK economy and public health was explained. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.diamond.ac.uk/Public/VisitUs.html |
| Description | Diego Friere Pesquisa Fapesp |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with journalist leading to article regarding release of transgenic mosquitoes into the environment to control dengue and other diseases |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://revistapesquisa.fapesp.br/en/2020/02/05/jacobina-controversy/ |
| Description | Discuss gene drives with NZ Parliamentary Commissioner |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Met NZ Parliamentary Commissioner to provide background information on, and discuss, gene drive systems. New Zealand is considering genetic and other control methods for invasive pests. |
| Year(s) Of Engagement Activity | 2018 |
| Description | EFSA Hearing Expert Gene Drive Environmental Risk Assessment Working Group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Hearing Expert for EFSA Gene Drive Environmental Risk Assessment Working Group. Contributed to EFSA Scientific Opinion. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2020.6297 |
| Description | EFSA consultation July 2020 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Responded to European Food Standards Authority (EFSA) request for input regarding regulation of gene drives (public consultation) |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/sp.efsa.2020.EN-1939 |
| Description | EM-UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Co-organiser and speaker for UKRI supported network for electron microscopists in the UK. I was one (or two) of the founder members. Meeting has been running for 5 years. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | EM-UK 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM-UK is a network for electron microscopists to discuss policy, practice and science relating to the use of the microscopes. Industry representatives and funder representatives (including BBSRC) also contribute to the programme every year. |
| Year(s) Of Engagement Activity | 2022 |
| Description | EM-UK: A national network for electron microscopists |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Founder and Chair of EM-UK, a national network (with international participants) for electron microscopists. Includes a one or two day meeting with invited speakers, and email discussion list for questions, comments, advertising courses, advertising jobs. It has proved very popular with over 200 people registering for the discussion list, and 90+ delegates at each meeting. Administration is handled by the Royal Microscopical Society. |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | EMBO Workshop: Molecular and population biology of mosquitoes and other disease vectors: vector and disease control |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Sex determination pathway in Anopheles gambiae as a target for mosquito control" given during the meeting held on 22 - 26 July 2019 in Kolymbari, Greece. Following a presentation a request was made to give an informal seminar at the Department of Life Sciences, Imperial College, London. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://meetings.embo.org/event/19-mosquitoes |
| Description | EPO Inventors Revisited video |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Podcast for European Patent Office "Inventors Revisited" series |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.epo.org/news-events/events/european-inventor/inventors-revisited.html |
| Description | EPO TalkInnovation Facebook live event and podcast |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | EPO TalkInnovation Facebook live event and podcast discussing use of genetic methods to control mosquitoes and mosquito-borne disease |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.facebook.com/europeanpatentoffice/videos/a-minute-change-that-makes-a-massive-difference... |
| Description | EU parliament webinar |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited speaker for European Parliament Intergroup on Climate Change, Biodiversity and Sustainable Development webinar "Research and Innovation for biodiversity: what role for gene drive research?" |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://ebcd.org/event/online-event-research-and-innovation-for-biodiversity-what-role-for-gene-driv... |
| Description | Edinburgh Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and panel event at Edinburgh Science Festival "The Buzz about GM Insects". Sparked questions and discussions afterwards including some career questions. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Edinburgh seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave invited seminar at Edinburgh University (via Zoom) regarding development and applications of transgenic mosquitoes. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Educational article/resource - How can vaccinating pigs protect people? |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Publication of an educational article/resource - How can vaccinating pigs protect people? |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://futurumcareers.com/how-can-vaccinating-pigs-protect-people |
| Description | Elle Campbell Presented her data at the 2019 Microbiology Society Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Elle Campbell gave an oral presentation at the 2019 Microbiology Society Annual Meeting on the work we were doing with fluorescently tagged IBDVs and virus factory movement. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Emerging Threats: The Evolution and Persistence of Avian Influenza Viruses in Poultry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an Invited speaker at the 2023 International Symposium on Important Animal Diseases and Zoonoses of Yangzhou University, China. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Encouraging women into science and engineering STEM. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | MH Visited Warwick School, Redhill to talk to secondary students about careers in STEM. A very positive outcome and well received. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Engagement with poultry stakeholders (farmers and veterinarians at "Morocco Poultry Day"). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk was presented to poultry stakeholders including farmers describing the new emerging technologies that increase the efficacy of poultry vaccines, in particular vaccines against Avian influenzas and Newcastel disease virus,.The meetings was attended over 80 participates. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza. Presented by Deimante Lukosaityte at Influenza Update meeting 4th - 15th December 2020: The University of Liverpool (online meeting) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk describes a technique for the development of immunotherapy to protect poultry from Infectious diseases such as avian influenza viruses. The talk provided evidence that recombinant antibodies can provide passive immunity to protect chickens from avian influenza. Several mAbs generated from mice hybridomas targeting hemagglutinin (HA) of H9N2 virus were converted into single-chain variable fragment (scFv) antibodies. Recombinant scFvs were purified from insect cell culture supernatants and showed it could retain neutralization capacity against H9N2 virus in vitro. To test therapeutic scFv efficacy in vivo we selected two of the recombinantly produced scFv antibodies for prophylaxis and treatment of chickens infected with H9N2 UDL-01 virus. Intranasally treated birds showed reduced disease manifestation and virus shedding. These results indicate that antibody therapy could be beneficial for the provision of rapid treatment for reducing disease impacts in poultry. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.gla.ac.uk/researchinstitutes/iii/cvr/events/influenza/ |
| Description | Enhancing the Potency of Poultry Vaccines by Selectively Targeting Antigens to Chicken Antigen-Presenting Cells |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the Faculty of Veterinary Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. Our research on our newly developed targeted-delivery vaccine platform addresses these challenges by improving: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, and (6) overcome maternally derived antibodies. This platform therefore (1) enhances the efficacy, duration, and breadth of immunity, (2) reduces production losses, (3) improves cost-effectiveness, (4) improves productivity and economy, (5) improves animal welfare, and (6) reduces prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). Additionally, collaborations with industrial partners can integrate this research to adapt to new antigenic variants and/or hosts. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Enhancing the potency of poultry vaccines and overcoming maternally derived antibody interference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as keynote speaker at the GARAD-2023 conference at Harbour Hotel Guildford, UK. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. Our research on our newly developed targeted-delivery vaccine platform addresses these challenges by improving: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, and (6) overcome maternally derived antibodies. This ensures early vaccination is possible and this vaccine platform can aid control of avian influenza in early poultry populations. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Enhancing the potency of poultry vaccines by targeted delivery of antigens to chicken antigen-presenting cells |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the 12th Asian Pacific Poultry Conference (APPC2023) at Nanjing, China. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. Our research on our newly developed targeted-delivery vaccine platform addresses these challenges by improving: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, and (6) overcome maternally derived antibodies. This platform therefore (1) enhances the efficacy, duration, and breadth of immunity, (2) reduces production losses, (3) improves cost-effectiveness, (4) improves productivity and economy, (5) improves animal welfare, and (6) reduces prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). Additionally, collaborations with industrial partners can integrate this research to adapt to new antigenic variants and/or hosts. This ensures early vaccination is possible and this vaccine platform can aid control of avian influenza in early poultry populations. |
| Year(s) Of Engagement Activity | 2023 |
| Description | European Society Vector Ecology (Invited Chair for two sessions and speaker for 15min talk); (October/Palermo, Sicily) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired two sessions, one on vector-borne diseases, one on scientific networks. Latter included a discussion with early career researchers. Main outcome was coordination between active networks including The Gnatwork. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.sove.org/European%20SOVE%20folder/greecescientificprogram/palermo_Scientific_program_revi... |
| Description | Evolution of H9N2 avian influenza virus under immune pressure. Presented at 10th International Symposium on Avian Influenza, 15th - 18th April 2018, The Grand Hotel, Brighton, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of the workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. In addition, the activity hopes provide information about the emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Ewen Callaway Nature 08/01/2018 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided expert background information for article in Nature regarding engineering species barriers, described by journalist as "very helpful" in followup email. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Expert commentary on New Scientist article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I provided expert commentary on an article published in New Scientist, which summarised research performed by researchers at the University of Leeds on how mosquito bites enhance the transmission of vector-borne diseases. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://institutions.newscientist.com/article/2231141-skin-cream-applied-to-mosquito-bites-stops-vir... |
| Description | FAO/IAEA Coordinated Research Programme on methods of sex separation in mosquitoes; Research coordination meeting Bangkok 19-23 February 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FAO/IAEA Coordinated Research Programme on exploring genetic, molecular, mechanical, and behavioral methods of sex separation in mosquitoes; aimed at promoting specific areas of research, exchange of ideas and networking among the experts in the field. |
| Year(s) Of Engagement Activity | 2013,2015,2016,2018 |
| Description | FLI - presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation of current research to the FLI - Germany to build collaborations 19/20 November 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Facebook Live: Infectious Disease Portrayals in Pop Culture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Infectious diseases are a frequent topic in movies. The CDC has used zombies to talk about infectious disease and disaster preparedness, and infotainment has flamed fears of Ebola. I took part in a Facebook Live chat organised by the AAAS Public Engagement team about why infectious diseases are so often the topic of pop culture discussions; what movies, books, and other pop culture gets right and wrong about infectious disease; and how scientists can use pop culture as a jumping-off point for public engagement. The chat was broadcast live on the AAAS Facebook page. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.aaas.org/event/facebook-live-infectious-disease-portrayals-pop-culture |
| Description | Farnborough College Apprenticeship Fair- 20th March 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Careers fair attended by approx. 100 school children. Pirbright demonstrated the multiple ways that research organisations can provide jobs including scientists, engineers and computer operators. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Farnborough Sixth Form College Careers Fair - Chris Chiu |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | CC engaged at a careers day, and answered questions presented by sixth form students about working in science. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Farnborough futures careers event - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The careers event aimed to introduce the range of careers available at Pirbright. In addition I discussed my own career progression and highlighted the range of possible careers that I could have entered. Finally, I discussed some details of the research with interested students. The students had a wide range of backgrounds and career aims but were interested to hear about the Institute and the sort of work opportunities available. Several of them planned to follow up by investigating future job opportunities at Pirbright. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Food security and the control of infectious disease in livestock |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A workshop was organized by myself at St Catherine's College Oxford for the duration of three days. Representative from industry, funding agencies and media (publishers) attended this workshop. Over 20 delegates from Egypt and 20 delegates from the UK attended this meeting. The purpose of this workshop/ meeting was to promote international collaborations, provide training for undergraduate students, promote the importance of managing and controlling infectious disease in livestock and public health. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Gene Drive Resarch Sponsors and Supporter's Forum meeting Montreal Sept 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Forum met to discuss the state of the art and future considerations for gene drive research. Ongoing deliberations including specific follow-up meetings. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Global epidemic trend of avian influenza virus and its harm to public health |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk as an invited speaker at The 2023 China-ASEAN Seminar on Prevention and Control of Cross-border Animal Diseases, Guangxi Veterinary Research Institute, Nanning, Guangxi, China. The persistence of avian influenza viruses in bird populations increases zoonotic and pandemic risks. Research focuses on reducing prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). To address this, topics discussed included research focuses in: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Gnatwork Website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | New website established to act as focalpoint of project. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.gnatwork.ac.uk/ |
| Description | Gordon's schools careers Fair-AH |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Provoking interest in a range of science career paths |
| Year(s) Of Engagement Activity | 2020 |
| Description | Guest lecturer MSc Imaging course at University of Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Guest lecturer for PhD course in EM, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. Increase visibility of The Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of research outcomes to prevent and control of infectious diseases of animals and humans. - Avian influenza virus evolution and efficacy. - |
| Year(s) Of Engagement Activity | 2018 |
| Description | H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Focus of the conference was to improve control against infectious diseases affecting poultry and livestock. |
| Year(s) Of Engagement Activity | 2018 |
| Description | High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. Presented via Webinar, organized by Boehringer Ingelheim, 3rd July 2020. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled; High pathogenicity avian Influenza (HPAI) H5 in Europe -Epidemiology and Surveillance. talk was organized by Boehringer Ingelheim, 3rd July 2020 and presented via Webinar. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Holly Kernot, Veterinary Times, 13/06/2017 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussed potential of manipulating mosquito sex determination genes as tools for novel mosquito genetic control approaches. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.vettimes.co.uk/news/study-to-be-transformational-in-mosquito-control-strategies/ |
| Description | Holt School Surrey. Bee meadow & A-level outreach Talk. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I discussed the importance of pollinators for biodiversity and food security with the younger students. I also discussed careers in science with A-Level students. There was good interaction and many questions surrounding both topics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Human Infection Challenge Models Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | HIC-Vac is an international network of researchers who are developing human infection challenge (HIC) studies to accelerate the development of vaccines against pathogens of high global impact. The goal is to foster an engaged and interactive community of international researchers to promote open sharing of knowledge and expertise, generate new ideas, support and share best practice, and form new cross-discipline collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | IUCN Technical Subgroup on Synthetic Biology and Biodiversity Conservation (meeting 12-15 April and report) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Participated as member in Technical Subgroup on Synthetic Biology and Biodiversity Conservation of International Union for Conservation of Nature (IUCN). Meetings, online discussion and ultimately a report to Task Force and will ultimately go to IUCN General Assembly. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Identification of antigenic epitopes to broaden and enhance the efficacy of avian influenza vaccines. Presented at 6th Animal Vaccines and immune Adjuvant Technologies Salon & Advanced seminar, Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 18-20 October 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Imagineering Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talked to the general public about Pirbright science and Beekeeping |
| Year(s) Of Engagement Activity | 2019 |
| Description | Immuno-pathobiology of H9N2 avian influenza viruses: looking at how the viruses evolve and persist in poultry. Presented at "Techniques for Healthy Farming and Diseases Prevention & Control of Livestock and Poultry. Beijing, August 13th-15th, 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dissemination of research outputs. Improvement of vaccines and diagnostics. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Improvement in the Production Systems and Potency of Poultry Vaccines. Virtual meeting organised by Hi-Tech Poultry Breeders (Pvt) Ltd, Lahore, Pakistan. 17th January 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | A talk entitled "Improvement in the Production Systems and Potency of Poultry Vaccines" was presented by Munir Iqbal to veterinary field staff working on poultry production, particularly prevention and control of infectious diseases. The Audience was very much impressed with the new improved technology that enhance the potency of poultry vaccines. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Breadth and Duration of Immunity of Poultry Vaccines: Targeted Delivery of Antigens to Chicken Antigen Presenting Cells. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk entitled "Improving Breadth and Duration of Immunity of Poultry Vaccines: Targeted Delivery of Antigens to Chicken Antigen Presenting Cells" presented by Professor Iqbal at 2022 Yangzhou International Conference on Agriculture and Agri-Product Safety - Germplasm Innovation and Agri-Product Safety on 30th November 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Potency of Poultry Vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A talk entitled "Improving Potency of Poultry Vaccines" presented by Munir Iqbal to post graduate students at meeting "The 2022 International Animal Husbandry High-Quality Development Conference" on On 19th November 2022 hosted by Shandong Vocational Animal Science and Veterinary College. More than 300 post graduate and university staff from Shandong Vocational Animal Science and Veterinary College attended the meeting and discussed the advanced in the strategies to reduce the impacts of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Potency of Poultry Vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Research outcomes were presented by Munir iqbal at the 2022 International Animal Husbandry: High quality development of animal health and animal husbandry- Virtual Scientific Conference, on 19-Nov-2022, hosted by Shandong Vocational Animal Science and Veterinary College. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Poultry Vaccines, Virtual presentation to staff and postgraduate students at University of Veterinary and Animal Sciences, Lahore, Pakistan |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The overview was presented on the development of next-generation of poultry vaccines. The new vaccine technology selectively targets chicken immune cells and induces faster and stronger immunity against poultry viral diseases. A huge interest in the subject was perceived and everyone was interested in the new technology and eager in suggesting that this vaccine should be taken forward for commercial production and field use. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Improving Vaccines against Avian Influenza and Newcastle Disease Viruses |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the Sino-European Modern Livestock and Poultry Industry Technical Innovation seminar and the launch of the Joint Laboratory of China and European Countries. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Improving the efficacy of poultry vaccines |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the International Conference: Current Trends, Prospects & Opportunities in Vaccine Research at the Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. Our research on our newly developed targeted-delivery vaccine platform addresses these challenges by improving: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, and (6) overcome maternally derived antibodies. This platform therefore (1) enhances the efficacy, duration, and breadth of immunity, (2) reduces production losses, (3) improves cost-effectiveness, (4) improves productivity and economy, (5) improves animal welfare, and (6) reduces prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). Additionally, collaborations with industrial partners can integrate this research to adapt to new antigenic variants and/or hosts. This ensures early vaccination is possible and this vaccine platform can aid control of avian influenza in early poultry populations. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Improving vaccines and diagnostics for Avian influenza viruses affecting poultry. Presented at the International Poultry Expo "Poultry Science Conference", Lahore, Pakistan, 13-15 September 2019. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | InFocus article (Jennifer Simpson) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | InFocus review article for EM-UK meeting (2017) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Influenza antibodies reduce disease in chickens |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Research outputs were mass comminated for the general public via a news story. cientists have engineered synthetic antibody molecules that can be administered to poultry to reduce the symptoms of influenza. The molecules also decrease the amount of influenza virus shed into the environment, suggesting there is potential for their use as immunotherapy treatments to reduce the burdens of influenza in poultry. The research, conducted by a team at the Pirbright Institute, Surrey, UK, involved generating synthetic antibodies against the H9N2 strain of avian influenza, which poses significant risks to both the poultry sector and wider avian and mammalian species due to its ability to adapt to new hosts through mutation. The modified antibody segments, known as single chain variable fragment antibodies (scFvs), were shown to prevent the H9N2 virus from entering cells in laboratory tissue cultures. Further testing showed that chickens immunised intranasally with scFvs produced lower levels of virus and presented decreased weight loss compared to those that had not received treatment. The scFvs antibodies work by binding to proteins on the outside of the influenza virus, called haemagglutinin (HA), that attach to receptors on host cells. The prevents the virus from entering the cell and replicating, offering rapid protection to infected birds. To create the scFVs, the team immunised mice with an influenza vaccine, which triggered the production of mouse antibodies that could neutralise the H9N2 virus. The genetic code for 2 section of the antibodies that bind to the HA protein was then sequenced. Using genetic engineering, they linked these 2 sections together to create one new smaller antibody molecule (the scFvs). By generating these smaller molecules, the team was able to overcome issues presented by using whole antibodies, such as lower production rates and increased likelihood of immune rejection by species other than chickens. These results are encouraging and demonstrate that scFvs could provide a quick and efficient way of reducing the clinical signs of influenza and its spread in infected flocks, reducing the risk of transmission from poultry to humans." - Professor Munir Iqbal Published in Vaccines, the scFvs created in this study have additional advantages including their ability to be mass-produced in insect cells and the fact they could work against the virus in all hosts without adaption. Commenting on the results, Professor Munir Iqbal, head of the avian influenza group at Pirbright, said: "These results are encouraging and demonstrate that scFvs could provide a quick and efficient way of reducing the clinical signs of influenza and its spread in infected flocks, reducing the risk of transmission from poultry to humans. "The next step will be to establish the best method for administration, whether this is intranasal, as we have done in this study, or via aerosol or viral vector delivery systems." Prof Iqbal added that the type of immunotherapy could be used to treat other viral diseases of poultry and humans. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.poultryworld.net/health-nutrition/influenza-antibodies-reduce-disease-in-chickens/ |
| Description | Influenza update 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Approx. 70 scientists attended a Influenza update meeting at which our group presented an oral presentation and poster presentation on our work. These actions resulted in establishment of new collaborations for ongoing work and the initiation of a joint grant writing exercise. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Influenza update meeting (Pengxiang Chang) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | presented work entitled: Antigenic characterization of avian influenza H7N9 virus by in vitro immune escape mutant selection method. |
| Year(s) Of Engagement Activity | 2018 |
| Description | InnovSur : Conference in IRD Montpellier on Insect Vector Surveillance |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Working group on standardisation of techniques for surveillance of insect vectors. Included break out group brainstorming and subsequent commentaries. Total audience approximately 110 people for main lectures. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.alphavisa.com/isessah-innovsur/2018/ |
| Description | Innovate Guildford |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at Innovate Guildford science festival. Visitors to stand able to discuss issues related to animal diseases and their control (with a particular focus on influenza and on use of genetic modification technologies) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guildford (Angita Shrestha): |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | GENERAL SCIENCE |
| Year(s) Of Engagement Activity | 2019 |
| Description | Innovate Guildford - DB & KC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Public science event where team members participated on a Pirbright Institute stand which contained activities to help the public understand how scientists can help to contain and control viral outbreaks. Over 500 members of the general public attended which stimulated increased interest in science and research and led to requests for more information. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Innovate Guildford 17 March 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and exhibit at Innovate Guildford - >100 for talk, probably >500 for exhibit. Both sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Institute stand at the Innovate Guildford event, covering the work of the Institute in general and genetic modification through gene editing specifically. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.guildford.gov.uk/IG18 |
| Description | Innovate Guildford 2018 - JM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science/innovation event - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 - SB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Regional science festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford 2018 - SV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Display at regional science/innovation festival - changes in public attitudes and stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Innovate Guildford, ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented at the Pirbright Institute stand discussing science performed by the Institute with the general public. The stand focussed on an exhibit on avian influenza virus but more general virology topics were also discussed including our research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guilford |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Broadbent gave a talk at 'Innovate Guilford' Festival outlining the work we are doing with Avian Virus Vaccines, including those against IBDV. The aim was to raise public awareness on different avian viruses, and genetically modified vaccines. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Innovate Guilford-AH, AA, ER, EL |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | General science festival engaging the public in the research undertaken at Pirbright |
| Year(s) Of Engagement Activity | 2019 |
| Description | Insect Festival 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Ran a stand on blood-sucking arthropods and their role in the transmission of disease at the Royal Entomological Society's Insect Festival. Talked to public, answered questions. Lots of enquiries about ticks, midges, mosquitoes and large biting flies (particularly horseflies). |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.yorkmuseumstrust.org.uk/whats-on/events/insect-festival-2017/ |
| Description | Institute stand "Disease Detectives" at Royal Society Summer Science Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Institute stand "Disease Detectives" at Royal Society Summer Science Exhibition, 6-10 July 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://royalsociety.org/science-events-and-lectures/2022/summer-science-exhibition/ |
| Description | Institute stand at Surrey Vet School open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Interactions between receptor-binding, immune evasion and glycan shielding. Presented by Joshua Sealy at Biophysics and evolution: improving models to predict influenza vaccine effectiveness) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Influenza viruses have an error-prone polymerase complex that facilitates a mutagenic environment. Antigenic mutants swiftly arise from this environment with the capacity to persist in both humans and economically important livestock even in the face of vaccination. Furthermore, influenza viruses can adjust the antigenicity of the haemagglutinin (HA) protein, the primary influenza immunogen, using one of four molecular mechanisms. Two prominent mechanisms are: (1) enhancing binding avidity of HA toward cellular receptors to outcompete antibody binding and (2) amino acid substitutions that introduce an N-linked glycan on HA that sterically block antibody binding. In this paper, we investigate the impact that adsorptive mutation and N-linked glycosylation have on receptor-binding phenotype, virus replicative fitness and antigenicity. We show that in the context of adsorptive mutation that N-linked glycosylation can mitigate virus attenuation. We show that in the absence of adsorptive mutation, N-linked glycosylation can attenuate virus this indicating a cooperative role between adsorptive mutation and N-linked glycosylation. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.physicsoflife.org.uk/biophysics-and-evolution.html |
| Description | International Avian Respiratory Disease Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michael presented his research at the 2018 International Avian Respiratory Disease Conference in the US to an audience of avian researchers and representatives form the poultry veterinary vaccine industry. This sparked discussion and potential future collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | International Day of Women and Girls in Science |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a quote as a STEM ambassador about why I think it is important to make sure women and girls have the same opportunities in STEM. This was shared on social media to celebrate International Day of Women and Girls in Science, a UN-led initiative. |
| Year(s) Of Engagement Activity | 2019 |
| Description | International Women's Day video for social media |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Three team members were interviewed about their careers in science for International Women's Day. The videos were posted on Pirbright's website, Facebook and Twitter to celebrate what we love about working in science. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Interview on "Disease Detectives" |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview about "Disease Detectives" for BBC World Service Health Check programme, broadcast 7 July 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bbc.co.uk/sounds/play/w3ct32wl |
| Description | Interview with Anne Gulland - Telegraph article Nov 2020 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Anne Gulland of the Telegraph about HPAI outbreaks in wild birds, article published https://www.telegraph.co.uk/global-health/climate-and-people/farmers-urged-alert-highly-pathogenic-form-bird-flu/ quoted in the article. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.telegraph.co.uk/global-health/climate-and-people/farmers-urged-alert-highly-pathogenic-f... |
| Description | Interview with Associated Press |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with a journalist from Associated Press about coronavirus research at The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with BBC Radio Surrey |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with journalists from BBC Radio Surrey on the breakfast show about coronavirus research at The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with BBC World Service |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview about our paper in PLOS Biology: The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/programmes/w3cszh1l |
| Description | Interview with BBC for SARS-CoV-2 story |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with BBC about SARS-CoV-2 genome sequence |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.bbc.co.uk/news/science-environment-55565284 |
| Description | Interview with BBC journalist for article on viral emergence in new species |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interviewed by Jonathon Ball who was writing an article for the BBC on the emergence of morbilliviruses in new hosts and the importance of vaccination. I helped him to contextualise the story and put him in touch with my collaborators. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bbc.co.uk/news/science-environment-50839868 |
| Description | Interview with BuzzFeed News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with a journalist from BuzzFeed News about coronavirus research at The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interview with Dominique Patton, Beijing, Reuters article Jan 2021 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Dominique Patton (Reuters - Beijing) about outbreaks of HPAI in wild birds. Quoted in https://www.reuters.com/article/us-health-birdflu-asia/reeling-from-coronavirus-asias-poultry-farmers-battle-bird-flu-outbreak-idUSKBN29J00D?edition-redirect=uk which was picked up by multiple media outlets. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.reuters.com/article/us-health-birdflu-asia/reeling-from-coronavirus-asias-poultry-farmer... |
| Description | Interview with National Public Radio (USA) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with National Public Radio (USA) about veterinary vaccines for Covid-19 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Interview with book author |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with FT journalist for book |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interviews to discuss COVID vaccine results |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio interviews (BBC Radio Surrey and Oxford), television interview (BBC South Today) and interviews with press to discuss results from our studies evaluating COVID-19 vaccine candidates in pigs. |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | Investigating avian influenza antigenic evolution and improving potency of poultry vaccines (Internal seminar) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk presented describing how the genetic evolution of avian influenza viruses can result in vaccine failure and how we developed approaches that improve the effectiveness of poultry vaccines to reduce the economic loss in poultry. We describe our research data H5 subtype of avian influenza viruses are evolving rapidly and being classified into different clades. These viruses carry significant antigenic heterogeneity and a single candidate vaccine may not be able to protect against the virus variants infecting poultry in different countries around the globe. Our data will allow for the generation of vaccines that are better strain-matched, thus reducing the impact of AIVs in the poultry industry. We also present our work on the development of next-generation poultry vaccines termed "Targeted Antigen Delivery Vaccine (TADV)" that selectively deliver vaccine antigens to the chicken immune cells known as Antigen-presenting cells and potentiates immunogenicity of the vaccine. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invitation to give keynote talk on 'Control of avian diseases: Challenges and opportunities' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave the Keynote talk on 'Control of avian diseases: Challenges and opportunities' at this International Symposium organized with an aim to gather international virology experts from both human and veterinary fields to share research experience, update findings and contribute their expertise through presentation and interactive discussion. The topics will cover a wide range of virology research common in both human and animal aspects. In addition, technological platforms such as vaccine development, and novel assays will be emphasized and addressed. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.biotec.or.th/virus-symposium2018/index.php |
| Description | Invited Chair at European Congress of Entomology (Naples,July) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired session on vector-borne diseases at meeting and subsequent question sessions with 15 minute presentation on Culicoides biting midges. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ece2018.com/scientific-programme/day-1-monday-2-july/ |
| Description | Invited Lecture - Antivec Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation give on 'The Gnatwork'. 21/06/19. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.gla.ac.uk/research/az/antivec/ |
| Description | Invited Lecture - Public Health Interest Group (London School Hygiene and Tropical Medicine) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk presented and discussion session particiation (09/04/19) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Lecture - Wageningen University and Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title: Culicoides-borne arboviruses in Europe - Invited lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Seminar University College London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at UCL to describe my ongoing research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited lecturer for MSc Biological Electron Microscopy, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 25 internal students from University of Copenhagen visited the core imaging facility for three days during which time I delivered lectures and interacted with the students during practical workshops. This sparked questions and discussion relating to their individual projects. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited participant, Improving the Use of Evidence in Policymaking in the UK Government (Parliamentary Office of Science and Technology) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited to attend meeting to launch POST report "Improving the Use of Evidence in Policymaking in the UK Government" as a result of previous collaboration. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.sciencecampaign.org.uk/resource/casereportimprovingtheuseofevidence2017.html |
| Description | Invited presentation at the Friedrich Loeffler Institute (January; Riems) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Formal presentation on biting midges and bluetongue to professional audience with question session and collaborative meetings |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited presentation: 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited by the British Society for Immunology to give a presentation on vaccine research at the 'Beyond Jenner: The Future of Vaccines', Discovery Day, Dr Jenner House Museum and Gardens, Berkeley, UK. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited seminar at INRAE, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar to present our recent and ongoing PRRSV research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited seminar at St. Andrews University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar on ongoing RSV and SARS-CoV-2 research |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited seminar at UC Riverside 05/05/2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at University of California, Riverside |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited seminar at University College Dublin |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on ongoing RSV and SARS-CoV-2 research to academics at University College Dublin |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited seminar at the National Health Research Institutes, Taiwan. 27 Feb 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation describing research in my group on mosquito developmental biology and its potential uses for mosquito control; attended by primarily by members of the National Mosquito-Borne Diseases Control Research Center. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited seminar at the University of Nottingham seminar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited seminar entitled: "Arbovirus encephalitis: from tissue culture, to mosquitoes to mice" was delivered. Discussions for potential collaborations followed. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited seminar in Public Health England- Porton Down |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar entitled: "Innate immune responses and pathogenesis of alphavirus infections". Numerous questions were asked and requests for collaborations were made. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker - Moredun |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on Bioimaging capabilities at Pirbright to Moredun Institute. Attended by Head of Bioimaging at Roslin too, increased links between these institutes. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | Invited speaker - RMS EM School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to lecture on certain aspects of electron microscopy. I provided advice on individuals difficulties they had with sample preparation. Delegates had the opportunity to ask me any questions then had relating to any sample type. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at 9th Neuroinfections Conference, Bialowieza - Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited presentation entitled: "Using small RNAs to fight encephalitic arboviruses" was delivered. The presentation generated a lot of interest and questions. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at 9th Neuroinfections Conference, Bialowieza - Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited talk entitled: "Using small RNAs to fight encephalitic arboviruses" was delivered. Numerous questions were asked. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at APHA surveillance meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker on insect surveillance at Animal and Plant Health Agency meeting with discussion around current studies. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at Centre for Innovation Excellence in Livestock webinar on alternatives to antibiotics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Invited speaker at Centre for Innovation Excellence in Livestock webinar on alternatives to antibiotics |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://cielivestock.co.uk/events/ciel-insights-member-only-webinar-alternatives-to-antibiotics/ |
| Description | Invited speaker at Imperial College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on our recent research in swine influenza. Discussions with PIs at Imperial after the talk. Established collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker at South Wilts Virus Group (SWVG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled: "The role of small RNAs in arbovirus infections". Multiple questions were asked and potential for collaborations was identified. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at a workshop on arboviruses and their vectors in University of Malaya - Malaysia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled: " The role of small RNAs in arbovirus infections" was delivered. Multiple questions and requests for collaborations followed the presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited speaker at the British VeterinaryPoultry Association 2018 meeting at Boehringer Ingelheim |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | I was invited to present my research findings at the British Veterinary Poultry Association 2018 meeting, held at Boehringer Ingelheim. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker, . Jenner Symposium, Royal Society, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on One Health vaccines |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited speaker, Merseyside BSI Affinity group |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | I described the methods we used to identifyTissue resident memory cells in pigs, which sparked a lively discussion and interest in the technique. As a result I have established two collaborations with colleagues from Liverpool. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker, Surrey University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Under- and postgraduate students attended a talk I gave at the Department of Biological Sciences in Surrey. There was a lively discussion afterwards and as a result I have established a new collaboration. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited speaker, VIRCON (Indian Society for Virology) International Satellite Symposium. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited speaker: Developing a 'One Health' Nipah virus vaccine to protect animal and public health. VIRCON (Indian Society for Virology) International Satellite Symposium. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited speaker, Vienna Veterinary School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gave a guest lecture at the Veterinary school in Vienna. There were a lot of questions and discussion after the talk. As a result established collaboration with Gerner Wilhelm's group. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.vetmeduni.ac.at/de/graduate-school-pig-and-poultry-medicine/ |
| Description | Invited talk at Nipah Virus International Conference, Singapore |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation on our ongoing work to develop a Nipah virus vaccine for pigs. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk at Surrey-led meeting on SARS-COV-2 host range |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion group on SARS-CoV-2 infection in animals, led by University of Surrey. I presented our work on ACE2 usage by SARS-CoV-2 and its variants. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited talk at World Vaccine Congress, Washington DC, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed the potential for structural vaccinology to advance livestock vaccine development including examples of FMDV, bRSV and PRRSV |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk on 28th September 2020 on ''Challenges and opportunities for control of infectious animal diseases including zoonosis' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | International Webinar of 'Epistemological approaches to animal disease control programmes with special reference to rabies' |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited to talk at the International Conference on Building Human and Animal Health Capacities organised by the Jordan University of Science and Technology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated in the discussion and talked on 'The recent advances in vaccination-based control of poultry diseases'. The need for increased awareness of the pathogen diversity in the design of vaccines and the opportunities from advances in vaccine technologies were discussed |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.just.edu.jo/conferences/bhahc/Pages/default.aspx |
| Description | JN (DB) Ash Manor - vaccines and COVID |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Series of talks presented to pupils at Ash Manor - the talks were focused on vaccines and COVID and the subjects generated lots of discussion and interest. |
| Year(s) Of Engagement Activity | 2021 |
| Description | JN - Woking school 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Careers Fair at a local school encouraging children to consider science as a career and representing the institute in the local community. |
| Year(s) Of Engagement Activity | 2008 |
| Description | Jennifer Simpson - Big Bang Competition judge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | The Big Bang Competition recognises and rewards young people's achievements in all areas of science, technology, engineering and maths (STEM), whilst providing them with the opportunity to build their skills and confidence in project-based work. The Competition is open to all UK residents in full-time education or training. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Jennifer Simpson - Careers Fair at Woking High School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Pirbright Institute stand at the careers fair. Speak to students interested in a career in science. Sparked questions and discussions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - Girls into STEM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach activity for girls in local schools to demonstrated the variety of careers available within the STEM sector. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jennifer Simpson - InFocus article on Bioimaging in high containment |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Magazine article describing the facilities for imaging in high containment at Pirbright. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keynote speaker - 89th IUVSTA Workshop, Poland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote seminar to 'high vacuum' community, including life scientists and physical scientists, with experience in microscopy or other high end analystical techniques. increased visibility of the Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker - Danish Virology Society Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was personally invited to be keynote speaker at the annual meeting of the Danish Virology Society, to talk about high containment microscopy of cell biology of host-virus interactions. The meeting was held at the State Serum Institute in Copenhagen, followed by a social evening which enabled me to add new contacts into my network. This invitation came direct from the Danish Virology Society, independent of the work I already do with the University of Copenhagen. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keynote talk at the World Veterinary Poultry Association meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give the keynote talk on 'Avian tumour viruses: their contribution to our understanding of cancer' at the World Veterinary Poultry Association XXth Congress in Edinburgh |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.wvpac2017.com/ |
| Description | Kingdown School Warminster Wiltshire talk to 6th form students about career in science. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I presented my career path to the students to engage them on STEM careers. I had a good level of discussion and many questions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | LEAF open farm Sunday- JH, GM, WM, AH, KR, JS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The annual open farm day attended by businesses in the working in the farming industry in the Guilford area |
| Year(s) Of Engagement Activity | 2019 |
| Description | Laboratory Science Animal association (LASA) meeting in Birmingham, Invited speaker |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a presentation on the tools we have developed to study swine influenza |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.lasa.co.uk/meetings/ |
| Description | Latest Pirbright collaboration uncovers genetic markers that could guide avian influenza surveillance |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Research outputs were mass comminated for the general public via a news story. This was published online at the Pirbright Institute webpage and One Health Poultry Health webpage and distributed wildly on social media including Facebook, Twitter, In Share. Researchers at The Pirbright Institute have identified the genetic markers on avian influenza ('bird flu') viruses that could help the viruses to jump the species barrier and cause disease in people, in collaboration with other members of the One Health Poultry Hub. Co-investigators Professor Munir Iqbal and Dr Joshua Sealy worked with scientists at Imperial College London, the University of Glasgow and The Francis Crick Institute, to show how the genetic traits of avian influenza H9N2 viruses influence their preference for infecting bird or human cells. The paper detailing their findings, 'Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza viruses' is published in the Journal of Virology. The research identifies genetic traits that alter a key H9N2 viral protein, called haemagglutinin, that makes it easier for the virus to recognise and bind to different cell receptors. This is the first step of viral infection, and the general inability of avian influenza viruses to effectively bind to human receptors is a major reason why they do not, in general, jump the species barrier to people. However, given that human infections with H9N2 have been detected on an almost monthly basis since 2015, there may be a capacity for these viruses to evolve and gain the ability to efficiently target cellular receptors in people. This latest discovery reveals which haemagglutinin properties of existing H9N2 strains allow them to bind to human receptors more effectively. These included small genetic differences as well as the overall structure and charge of the haemagglutinin protein. These findings will help guide future avian influenza surveillance by providing the genetic markers that signify the emergence of viruses with the potential to transmit to people. There have been more than 60 cases recorded of people infected with H9N2 influenza viruses to date in 2020, all in countries where the virus is endemic. However, these viruses have not adapted to spread efficiently from person to person, a key element of a virus that has the potential to cause a pandemic. Professor Iqbal and his team at Pirbright have previously described H9N2 viruses which showed a preference for human-like receptors. Professor Iqbal said: "Understanding more about which traits increase the likelihood of H9N2 viruses jumping into humans help to identify viruses that could pose a future threat. Keeping an eye on viruses with these traits can help us to be prepared in the event that one of them evolves to pass between people rather than only from birds to humans." This research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) the Medical Research Council (MRC) both part of UK Research and Innovation (UKRI). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/01/latest-pirbright-collaboration-uncovers-genetic-markers-cou... |
| Description | Lecture given to University of Surrey MSc Veterinary Microbiology students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A 2-hour teaching lecture given to 10 MSc Veterinary Microbiology students at the University of Surrey on 8th December (Lara Harrup) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Lecture of dynamics of vector-borne diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Two-hour lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at University of Cambridge |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021,2022,2023,2024 |
| Description | Lecture on dynamics of infectious diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture as part of MSc in Veterinary Microbiology at University of Surrey |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017 |
| Description | Lecture on entereic coronaviruses to MSc Students (Surrey) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | A lecture was presented on the pathology, diagnosis and detection of enteric coronaviruses, including virus replication and interaction with the host. The students were engaged and asked/answered question throughout the session. We were invited to repeat the lecture for the subsequent student intakes. |
| Year(s) Of Engagement Activity | 2015,2016,2018 |
| Description | Lorin Adams (Gordon's School Careers Fair) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | MMC Learning Zone - invited speaker |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Microscience Microscopy Conference, speaker at the Learning Zone - specimen preparation for life sciences. Increase the visibility of Pirbright Institute |
| Year(s) Of Engagement Activity | 2019 |
| Description | MMC2017 Learning Zone seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented a seminar on preparation of samples for electron microscopy to 24 MMC2017 delegates. Questions followed asking for advice on specific examples, also advice on interpretation of data and how to improve results. |
| Year(s) Of Engagement Activity | 2012,2015,2017 |
| Description | MRC PhD Student DTP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | I gave a career development seminar to the MRC PhD student DTP to discuss opportunities and realities of an academic research career in universities and research institutions. |
| Year(s) Of Engagement Activity | 2021 |
| Description | MSc student visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | I hosted several MSc students from University of Surrey, discussed avian research with them and demonstrated some laboratory techniques. The students gained an understanding of academic research and laboratory work. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Malaysia workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Organised and participated in workshop on genetic control of mosquitoes, primarily focusing on refractory methods. Included a set of open lectures from international speakers at University of Malaysia and more focus workshop-style meetings. Several reported changes to research activities and also opinions, also follow-up meeting organized in Glasgow later in 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Mapping antigenic determinants of H9N2 avian influenza viruses and improving vaccines and diagnostics" presented at Foreign Talent Lecture: New strategies and new techniques for the prevention and control of major avian diseases. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. 6th August 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The focus of the meeting was to improve the control systems against poultry diseases including development of improved vaccines and diagnostics |
| Year(s) Of Engagement Activity | 2018 |
| Description | Media engagement on COVID-19 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Comments on epidemiology and modelling of COVID-19 in the early stages of the pandemic via the Science Media Centre, specifically on: - herd immunity - modelling by Oxford University on the potential seroprevalence in the UK (comments taken up and reported widely via Agence Presse France) - modelling by IMHE to predict the potential number of deaths due to COVID-19 in the UK (comments picked up by CNN and affiliates) |
| Year(s) Of Engagement Activity | 2020 |
| Description | Medical and Veterinary Virus Research Symposium (MVVR) Kenya |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at international conference on One Health research in Kenya |
| Year(s) Of Engagement Activity | 2017 |
| Description | Member of BBSRC sLoLa grants committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Member of sLoLa Committee to shortlist outline applications and review/assess application at the full stage of submission. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Member of a BBSRC expert group on the use of animal models in research |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Reviewed the key findings of the survey and identify key trends and emerging opportunities. Reviewed the proposed recommendations, discuss the challenges and barriers surrounding the use of models, and suggest how UKRI-BBSRC can help overcome these. Identified key stakeholders that UKRI-BBSRC could partner with to act on recommendations and how the report should be disseminated. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Microbiology Society 2023 meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Members of staff from my team presented at the national Microbiology Society annual meeting presenting talks on their data |
| Year(s) Of Engagement Activity | 2023 |
| Description | Microbiology Society Annual conference (UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Poster or oral presentation at Microbiology Society annual conference, a major international event. The participants included researchers from many different areas of science. This provides a platform to promote research to a wider audience as well as discuss the key findings with experts in my own field. |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014,2015,2016,2017,2018,2019 |
| Description | Microbiology Society Avian Focus Meeting (UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I gave a 15 minute oral presentation to an audience of around 80 people in 2016 and 2018. The audience consisted of researchers from many different scientific institutions from different areas of avian research. This was a great opportunity to present to experts in this field and gain novel insights into the project and the possible applications of my work. |
| Year(s) Of Engagement Activity | 2016,2018 |
| Description | Microbiology Society Online talk for Dr. Jamie Kelly |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop talk entitled, "High throughput screening to identify interferon stimulated genes whose expression is inhibitory to RSV infection. " |
| Year(s) Of Engagement Activity | 2021 |
| Description | Microbiology Today article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited article titled 'How to Image an Exotic Virus' in special Imaging issue (February 2018). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Microbiology society 2021 online meeting talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop talk entitled "SARS-CoV-2 Spike has broad tropism for mammalian ACE2 proteins, yet exhibits a distinct pattern of receptor usage when compared to other ß-coronavirus Spike proteins." |
| Year(s) Of Engagement Activity | 2021 |
| Description | Microscopy Society of Ireland annual meeting 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at annual meeting |
| Year(s) Of Engagement Activity | 2021 |
| Description | Microsoc 2018 "Structure-guided identification of a pathogen with pandemic potential" poster |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a poster on our research at the MicroSoc annual meeting |
| Year(s) Of Engagement Activity | 2018 |
| Description | Mock Interview Programme Cove School- Ai, AA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular Determinants for Antigenicity and Vaccine Efficacy of H9 and H7 Avian Influenza Viruses. Newton Agham Researcher Links Workshop: Novel vaccines and diagnostics technologies against Emerging and re-emerging veterinary Pathogens. 4-7 February 2019 at Rizal Pak Hotel, Manila, Philippines. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular determinants modulating avian influenza H7N9 virus antigenicity. Presented at The Microbiology Society Annual Conference 2019, 8-11 April ICC Belfast, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses. Presented as invited speaker at BBSRC UK-India Partnering Award seminar: University of Liverpool. 2 May 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Multiple talks at XXIInd World Veterinary Poultry Association Congress - WVPAC 2023, Verona, Italy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | three independent talks titled: (1) Selectively targeting antigens to chicken immune cells induces faster and very strong immunity in chicks with high levels of maternally derived antibodies, (2) The impact of avian influenza vaccination on zoonotic infections: lessons learned from the H7N9 avian influenza control, (3) Investigating molecular markers influences the haemagglutination activity of the H9N2 avian influenza viruses. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effective: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Munir Iqbal: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | NA PRRS Symposium & Conference of Research Workers in Animal Disease - Oral and poster presentations |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation title: Identification of host proteins that interact with non-structural proteins-1a and -1ß of PRRSV-1 |
| Year(s) Of Engagement Activity | 2019 |
| Description | NIAID PPC/TPP meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | NIAID workshop on Preferred Product Profile / Target Product Profile definitions and use for genetic vector management products |
| Year(s) Of Engagement Activity | 2020 |
| Description | Negative Strand Virus 2018 Meeting "Structure-guided identification of morbilliviruses with zoonotic potential" Poster |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented a poster on the Structure-guided identification of morbilliviruses with zoonotic potential at the international negative strand virus (NSV) meeting in Verona, Italy. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Negative Strand Virus Meeting 2018 "Creation of a high throughput RSV fusion assay for screening inhibitors" Poster |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a poster on the development of fusion assays for analysis of RSV replication and identification of inhibitors at the international negative strand virus (NSV) meeting in Verona, Italy. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Networking presentation-INRA, Paris, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation at INRA describing the role of the SH protein of BRSV in modulating immune responses in calves. This presentation resulted in a heated debate on the role of viral proteins in immune evasion and their activities in attenuated vaccines. |
| Year(s) Of Engagement Activity | 2017 |
| Description | New Scientist interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with New Scientist regarding genetic control of mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.newscientist.com/article/2210190-parasite-brings-down-mosquito-numbers-in-parts-of-guang... |
| Description | New rapid protection bird flu vaccine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Research outputs were mass comminated for the general public via a news story. This was published online on Poultry world (Poultry World edition 10 of 2021 now online) entitled. New rapid protection bird flu vaccine. Professor Munir Iqbal, head of the Avian Influenza Virus group at Pirbright Institute, speaks to Poultry World about the potential of an improved poultry influenza vaccine that triggers a rapid immune response that protects chickens against signs of disease and reduces the amount of virus that they could pass on. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://content.yudu.com/web/1r3p1/0A1zifp/PoultryWorld2021-10/html/index.html?origin=reader&page=30 |
| Description | New rapid protection bird flu vaccine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article published in the magazine "Poultry World) by Freelance journalist Natalie Berkhout describing the development of a new methods have been developed to enhance the immune response that vaccines produce and reduce the amount of virus that birds shed into the environment. One technique involves tagging flu virus proteins with a marker that makes them easier for antigen-presenting cells (APCs) to capture. These immune cells can efficiently process the tagged proteins, resulting in a robust and long-lasting antiviral response in chickens. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.poultryworld.net/health-nutrition/health/new-rapid-protection-bird-flu-vaccine/ |
| Description | Newton Agham Researcher Links Workshop on "Novel Vaccines and Diagnostic Technologies Against Emerging and Re-emerging Veterinary Pathogens, Rizal Park Hotel, Manila, Philippines 4-7 February 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The primary aim of this workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. The workshop provided information on emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn... |
| Description | Next-generation poultry vaccines, presented by Munir Iqbal to the The Pirbright Institute Trustee Board and Science Advisory Board meeting on 20th July 2021. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Data was presented to the Pirbright Institute senior management on the development and potency of a new improved vaccine to protect poultry from avian influenza viruses. The new vaccine carries the potential to triggers a rapid immune response that protects chickens against signs of disease and reduces the level of virus that they could pass on, a key element to halting the spread of bird flu through flocks. The vaccine would also be easier and less costly to produce than the traditional flu vaccines made in chicken eggs. This vaccine is now being evaluated for large scale commercial production and deployment in the field. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/07/pirbright%E2%80%99s-new-bird-flu-vaccine-provides-rapid-pro... |
| Description | Nick Rufford, Sunday Time Mag, published 27/08/2017 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Provided information and quotes for Sunday TImes Magazine article on GM mosquitoes and Zika |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.thetimes.co.uk/article/how-genetically-engineered-mosquitoes-will-save-lives-kwc8nmwh5 |
| Description | Nido2021 - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a poster at the Nidovirus symposium entitled "Identification of sites of infectious bronchitis virus RNA synthesis". She discussed our data with the audience. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I presented my work at the Nidovirus Symposium, which is held every three years and brings together researchers from industry and academia from many different countries. I had some interesting discussions with other researchers and built my network. |
| Year(s) Of Engagement Activity | 2017 |
| Description | OIE expert lecture AHSV transmission in Thailand |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Online lecture on AHSV transmission following unprecedented outbreak in Thailand - part of OIE arranged seminar series. 20th April 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://rr-asia.oie.int/en/events/oie-webinar-on-the-african-horse-sickness/ |
| Description | One Health: Zoonosis and Their Control Through the Use of Vaccines |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a talk as an invited speaker at the conference entitled "National Dialogue on Agricultural Research" at the National Agricultural Research Centre (NARC), Islamabad, Pakistan. The persistence of avian influenza viruses in bird populations increases zoonotic and pandemic risks. Research focuses on reducing prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). To address this, topics discussed included research focuses in: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Opening of The Biggs Avian Research Facility |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | We presented our research and spoke to guests attending the opening of the Biggs Avian Research Facility at Pirbright. Guests who attended included politicians and members of the public from the local area, eminent researchers from other institutions, and members of BBSRC. Guests reported that they felt much more informed about the work going on at Pirbright and were impressed by our facilities. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral and poster presentations at 13th International Veterinary Immunology Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of 3 research projects on available tools for antibody discovery in livestock species, on FMDV cross-specific epitopes discovery, and analysis of B cell transcriptomics. Each of the presentations sparked, questions and interest on protocols, methodologies, tools and reagents. These discussions have already driven knowledge and reagents transfer to LMIC, and have initiated collaborative work with international research institutes. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral presentation at European Society for Veterinary Virology conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at international scientific congress, which sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://esvv2022.ugent.be/ |
| Description | Oral presentation at Oxford-Pirbright joint B cell meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | The presentation initiated interesting discussions and potential collaborations on multi-disciplinary approaches for antibody discovery. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral presentation at Turing-Pirbright joint computational meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | I presented our work on livestock antibody repertoire analyses and the bioinformatic tools we developed to understand kinetics of antibodies during immune responses, at the Turing Institute (London). This led to engaged discussions and questions about the methodology used. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral presentation at the Microbiology Society annual meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An oral presentation on Inhibition of Semliki Forest Virus Replication Through Disruption of Lipid Homeostasis was delivered. The audience showed high interest and a good discussion and exchange of ideas followed the presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Oral presentation to Large Animal Research Network 24th May 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Talk about work understanding PB1-F2 function in avian hosts highlighting how the animal work carried out was undertaken and monitored. this was delivered to an audience of researchers, funders and industry interested in animal model systems for research and the 3Rs commitment surrounding this work. Discussions with interested parties about our chicken work at the Institute and the diverse way that the birds are entertained whilst being housed (e.g. live food, vegetables, perches, dust baths etc). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Organisation of UK-India Bioinformatics Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The meeting discussed the challenges and opportunities and have decided to come up with a strategy document on working together between UK and India on data-driven biology |
| Year(s) Of Engagement Activity | 2018 |
| Description | Organisation of joint B cell meetings between the Pirbright Institute and Oxford University |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Organisation of bi-annual meetings between The Pirbright Institute and Oxford University. In average, about 75 scientists attended each meeting. Sponsors from Industry enable funding of meetings, and enhance technical discussions. These meetings drive engaging discussions across multi-disciplinary research groups. |
| Year(s) Of Engagement Activity | 2022,2023,2024 |
| Description | Organised IVVN/BSI meting on T cell biology |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Organised virtual T cell meeting: invited 8 speakers, opened the meeting, chaired session and closed the meeting. Highly successful meeting with 170 delegates from 28 countries and excellent feedback on scientific content, engagement and organisation. Brought together immunologists from the mouse, human and veterinary filed, facilitate exchange of ideas and new collaborations. |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.immunology.org/frontiers-in-comparative-immunology-series-t-cell-biology-virtual-conferen... |
| Description | Organised the 3rd UK-China CERAD meeting in Guildford, UK in July 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The 3rd UK-China CERAD meeting helped to bring together professional from both countries to identify challenges and exploit the opportunities for improved control of poultry diseases and increasing food security. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.uk-china-cerad.org/ |
| Description | Organiser of the Animal Genetics and Diseases conference 08 - 10 May 2019 Wellcome Genome Campus, UK. Highlighting recent advances in animal genetics and genomic technologies. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I am on the organising committee for this conference. The second conference in this series will highlight recent advances in animal genetics and genomic technologies. It will bring together specialists working on the interface of genomics, genetic engineering and infectious disease with the aims of improving animal and human health and welfare. Novel genomic technologies, mathematical modelling and quantitative genetics approaches, applied to host animals, as well as their pathogens, have transformed the understanding of animal diseases, host-pathogen interactions and epidemiology and their effects on productivity of farmed animal species and food supply chains. This year's conference will not only put the spotlight on the immune response of host animals and epidemiology but also cover the genetics and genomics of pathogens and the impact of animal-human relationships. We encourage registrations from researchers, breeders and technical specialists interested in learning and disseminating the latest cutting-edge techniques and methodologies across model species, wildlife, farmed animals and companion animals. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://coursesandconferences.wellcomegenomecampus.org/our-events/animal-genetics-diseases-2019/?dm_... |
| Description | Organiser/invited speaker - PhD course in EM, University of Copenhagen |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Workshop for delegates including lectures, seminars and practical sessions. Outcomes are that delegates are able to make informed decisions regarding microscopy techniques about their future projects, and perform sample preparation and operate instruments. Delegates could ask me for advice regarding their projects which sparked questions and discussion within the group on a wide range of multi-disciplinary subjects. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Organising and giving Keynote talk at the GARAD meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Global Alliance of Poultry industry professional and academia to discuss about the advances in control strategies of diseases |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://Garad.org |
| Description | Outreach at TeenTech Events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | TeenTech runs lively initiatives with a supporting Award scheme to help young teenagers see the wide range of career possibilities in Science, Engineering and Technology. They work collaboratively with companies, Universities, business organisations and education business partnerships to build sustainable and imaginative programmes focussing on regions of greater social need in the UK and Europe. This outreach actvity involved primarily school children aged 12/13. Several hundred attended and our attendees (Laura Tugwell) spoke with about 30-40 children/teachers. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.teentech.com/ |
| Description | Oxford DTP students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | High level overview of diseases studied [at Pirbright], and the importance of our work, provided to a group of over 30 Oxford DTP students, followed by a networking lunch (29th September 2017). |
| Year(s) Of Engagement Activity | 2017 |
| Description | PDRA in my group Stacey Human attending Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | PH Filming for BBC4 programme |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview about imaging SARS2-CoV-2 in the EM |
| Year(s) Of Engagement Activity | 2021 |
| Description | PPR-Global Research and Expertise Network talk "Examining the zoonotic potential of PPRV" Vienna 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Gave a talk to the inaugural meeting of the PPR Global Research and Expertise Network (PPR GREN) at IAEA headquarters in Vienna, Austria. Participants included policy makers from the FAO and OIE. |
| Year(s) Of Engagement Activity | 2018 |
| Description | PRIDE day event TPI - HM, ND, CH, YC, MB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Stall presented describing recent research of the Coronavirus Cellular Biology group at the Pirbright Institute PRIDE event, celebrating Pirbright science and activites. |
| Year(s) Of Engagement Activity | 2023 |
| Description | PacBio Leiden |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presented data to academics and industry experts on the methods we have developed to enrich and sequence targeted areas of genomes |
| Year(s) Of Engagement Activity | 2018 |
| Description | Pandemic Live (Cheltenham Science Festival) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Approximately 250 attendees at a 1 hour discussion around a simulated virus outbreak scenario (Speakers Fry; Carpenter; Beard; Hatchett). Followed by question and answer session. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.cheltenhamfestivals.com/science/whats-on/2018/pandemic-live/ |
| Description | Participant in IDEAS arboviruses workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated in discussions and breakout groups, formed contacts. Planned future meetings on minimum reporting standards in insect infection studies (now funded and scheduled for 2018). |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://ideas.princeton.edu/workshop-for-2017/ |
| Description | Participation in a meeting regarding sex determination, Duesseldorf, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "Sex determination pathway in Anopheles gambiae as a target for mosquito control" during the Nothiger meeting on sex determination in insects, Duesseldorf, 11-13 March 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Participation in student day at the Pirbright Institute |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Student open day was participated by postgraduate students registered at several Universities, and scientists from Pirbright institute. Students were given a chance to discuss their research activities and future plans with senior scientists. Due to high interest from the students, the institute has decided to organize another open day. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Pathology Society talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at annual PathSoc meeting |
| Year(s) Of Engagement Activity | 2021 |
| Description | Pengxiang Chang: Talk presentation:The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines at Microbiology Society conference, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of vaccines to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://microbiologysociety.org/event/annual-conference/annual-conference.html |
| Description | Pengxiang Chang: UK-China Newton Fund (Poultry and swine) workshop at The Pirbright Institute.Oral presentation:Avian Influenza H7N9 Antigenic markers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pengxiang Chang:Influenza update meeting. The application of CRISPR/Cas9 in the development of vaccines against avian influenza virus |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described techniques to improve and produce new effective vaccines against viral diseases of animals and humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | PhD course in Electron Microscopy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Intensive workshop containing lectures and practicals in the use of electron microscopy in life sciences. This takes place every year at the University of Copenhagen, I am a course organizer and invited speaker. |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016,2017 |
| Description | Pig and Poultry Fair 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discussed Institute research with pig and poultry farmers, related industry and the general public. Received requests for more information related to research, business and studentships. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pigandpoultry.org.uk/ |
| Description | Pirbright Bioimaging Conference 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A small workshop on next generation imaging technologies, with collaborators from Diamond, Glasgow and other institutes. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Pirbright Dragon Fair - MZ |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Team members attended the locally held Dragon fair where the Pirbright Institute had a stand explaining the types of research that are conducted at the Institute, making our high containment science activities transparent to the local community. Approximately 60 people engaged with the stall to learn about the science happening on their doorstep. This stimulated interest in science and research. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Pirbright Institute research teams studying characteristics of influenza virus that may alter disease outcomes in poultry. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Avian influenza, commonly known as "bird flu," is a disease caused by multiple strains of influenza virus. The viruses can infect a wide range of animals, including people and pigs, but the natural reservoir lies in populations of wild aquatic birds such as ducks and gulls, according to an announcement from The Pirbright Institute in the U.K., which is conducting research to better understand avian influenza viruses to help prevent the disease in poultry. Flu virus strains are categorized by the combination of the two proteins found on the outside of the virus: hemagglutinin (H) and neuraminidase (N) -- for example, H5N6 or H9N2. The H protein binds to cell receptors in order to initiate infection, while the N protein helps release new viruses from an infected cell, the institute explained. Strains are also classified by severity. Low-pathogenic avian influenza (LPAI) viruses cause clinical signs such as mild breathing problems, decreased egg production and growth. Some birds, particularly ducks and geese, do not display any signs of LPAI infection and are still able to spread the disease, Pirbright said. When LPAI viruses circulate in high-density poultry areas, the viruses can mutate into highly pathogenic strains. Highly pathogenic avian influenza (HPAI) viruses have severe and often fatal effects on some species of birds such as chickens, Pirbright noted, but some HPAI strains cause mild or no clinical signs of disease in wild birds and domestic waterfowl. These strains are notifiable, meaning government control measures must be put in place. Avian influenza can be carried vast distances by wild migratory birds and can infect domesticated poultry through direct contact or through contaminated droppings and bodily fluids, Pirbright said. Because of this, there is a year-round risk of avian influenza, which can increase depending on the disease status in a region and the migration season of wild aquatic birds. According to Pirbright, good biosecurity is essential in preventing poultry from being exposed to the disease and can be practiced on a commercial farm, with game birds or even with just a few backyard hens. Why is influenza so difficult to prevent? The institute explained that influenza viruses are constantly changing, and when they replicate, small errors called mutations are copied into their genome. Some of these will alter the virus's proteins, allowing the virus to escape detection by the immune system. All flu viruses also have the potential to undergo a process called reassortment, where two or more strains of influenza infect the same animal, allowing them to swap parts of their genome, Pirbright said. The resulting viruses can potentially have different characteristics than the original strains, such as the ability to replicate in different species, including people, the institute added. Avian influenza viruses such as H5N1 or H7N9 have infected people, predominantly in Southeast Asia, but in these cases, the virus has been transmitted directly from infected birds to people, with no onward spread. There is some evidence that avian influenza can be passed from person to person, and while there are no records of efficient or sustained human transmission, there is a constant risk that one of the new strains may spread easily among people, which could result in a new influenza virus pandemic, Pirbright said. Changes in the virus genetics from mutation or reassortment make it very difficult to anticipate how influenza viruses will spread through a population and whether current vaccines will be suitable for the strains that are circulating, Pirbright announced. The influenza research programs at Pirbright are progressing understanding of the virus and finding better ways to prevent its spread. Pirbright Institute group leaders Dr. Holly Shelton and professor Munir Iqbal are researching how the characteristics of influenza viruses can change the outcomes of disease. Studying flu at the molecular level allows them to find out how the virus evolves to overcome avian immunity and how changes in their genome can alter disease severity and their ability to affect different species, the announcement said. Shelton's and Iqbal's teams are working on identifying genetic markers for specific disease traits that can be used in surveillance systems to provide forewarning of strains that could cause pandemics. For example, Shelton's Influenza Viruses group is looking at which characteristics allow the viruses to become resistant to antiviral drugs that are currently used to treat human infections of influenza, allowing surveillance to provide an early warning of viruses that could cross into humans and be difficult to control, Pirbright said. The team is also investigating how long it takes for avian influenza viruses to adapt to new mammalian species. According to the institute, establishing which strains can rapidly adapt and identifying the genetic changes made to enable infection of mammalian cells will help with surveillance efforts and potentially lead to the development of techniques that will help prevent these mutations occurring. Vaccination and rapid diagnosis are very important for influenza prevention and control, but it is still not currently possible to protect against all influenza strains, Pirbright said, noting that Iqbal's Avian Influenza group is exploring which sites on the virus trigger the chicken immune system to respond quickly and fight off infection. This will better inform scientists' ability to match vaccines to strains in the field and could help to develop vaccines that are more effective. Iqbal's group is also developing multivalent vaccines that protect chickens and ducks from several avian influenza subtypes at once as well as test kits for rapid diagnosis of different subtypes at the flock-side, the announcement said. Visit Pirbright's Influenza Viruses and the Avian Influenza group pages to find out more about their research. Source: The Pirbright Institute, which is solely responsible for the information provided and is wholly owned by the source. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.feedstuffs.com/nutrition-health/protecting-poultry-avian-influenza |
| Description | Pirbright Pride day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Set up a stand at the described our research, engaged with policymakers, industry and participants from other organizations and distributed leaflets. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Pirbright's new bird flu vaccine provides rapid protection, could reduce virus spread and is less costly to produce |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A news story was published online at the Pirbright Institute webpage and One Health Poultry Health webpage and distributed wildly on social media including Facebook, Twitter, In Share. Our research outputs were mass comminated for the general public. An improved poultry influenza vaccine has been developed by researchers from The Pirbright Institute. The potential vaccine triggers a rapid immune response which protects chickens against signs of disease and reduces the level of virus that they could pass on, a key element to halting the spread of bird flu through flocks. The vaccine would also be easier and less costly to produce than the traditional flu vaccines made in chicken eggs. Many poultry flu vaccines protect birds from serious illness and death, but do not prevent them from transmitting the virus. In recent years, new methods have been developed to enhance the immune responses that vaccines produce and reduce the amount of virus shed by birds into the environment. One of these techniques involves tagging flu virus proteins with a marker that makes them easier for Antigen Presenting Cells (APCs) to capture. These immune cells can efficiently process the tagged proteins resulting in robust and long-lasting antiviral responses in chickens. For the first time, researchers at Pirbright have shown that tagging the flu virus haemagglutinin (HA) protein and directing it to target a specific protein on the chicken APCs, called CD83, generates faster and stronger immune responses against the H9N2 bird flu strain compared to the current industry standard inactivated virus vaccine. The results published in npj Vaccines revealed that the vaccine was both fast-acting and effective. Birds produced antibody responses as early as six days after vaccination and they shed significantly less flu virus when challenged with a natural flu strain, indicating the birds would be less likely to spread infection. High levels of protective antibodies were produced even when birds were given a reduced dose. As well as providing enhanced protection, this vaccine will be easier and less costly to manufacture. The tagged flu virus HA protein can be produced in a laboratory culture of insect cells instead of using eggs to grow live vaccine viruses. This would enable the poultry industry to reduce its reliance on chicken eggs for vaccine production, increasing the availability of eggs for use as a food source. The use of laboratory cells instead of eggs also highlights how Pirbright scientists actively develop animal health solutions that apply the principles of the 3Rs (Reduce, Refine, Replace) in animal research. As the new vaccine does not contain live flu virus, biosafety risks are reduced and no specialist high containment facilities would be required for production. These qualities make the vaccine very attractive for large scale manufacture. The Pirbright team is currently investigating the vaccine's potential for commercial production and use in the field. Professor Munir Iqbal, Head of Pirbright's Avian Influenza Virus group, said: "By targeting HA to chicken immune cells, we have generated a powerful addition to the armoury of poultry vaccines. Our improved vaccine could help prevent the spread of flu amongst vaccinated birds, which is essential for protecting poultry welfare, increasing food production, and reducing the risk of avian influenza spreading to humans." This research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/07/pirbright%E2%80%99s-new-bird-flu-vaccine-provides-rapid-pro... |
| Description | Plenary discussion at World Vaccine Congress on Pandemic Preparedness with CEPI and WHO |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Round table discussion with representatives from WHO, CEPI and Pirbright on "how can we better collaborate with a one health approach to prepare for the next pandemic?" Organised as part of hybrid World Vaccine Congress. WHO representative was Dr. Maria Van Kerkhove who was leading the WHO's Covid response as well as Jakob Cramer from CEPI. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Plenary speaker - Electron Microscopy Cryo-techniques as Tools for Elucidating Biological Processes, University of Minas Gerais, Brazil |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was personally invited to talk about imaging the cell biology of host-virus interactions. I was available throughout the associated workshop to provide advice on delegates projects relating to microscopy. These talks sparked discussions and more questions. I was able to increase my network of connections further during this visit to Brazil. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Plenary talk at 7th European Vet workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give a plenary talk on mucosal immunity at the 7th European Vet workshop. This updated the audience on the latest developments in targeting immunization to different regions and assessing immune responses. Several colleagues contacted me to conduce join stuies and established further collaborations |
| Year(s) Of Engagement Activity | 2021 |
| Description | Population Biology of Vector-Borne Diseases Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Positive Strand Viruses Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | This was a poster presentation. There were several different poster sessions at the conference allowing a large selection of people to view each poster. The audience included world leaders in my research field and important names from groups all over the world. This gave me the opportunity to discuss my work with other scientists on a one to one basis, leading to generation of new ideas for future experiments and collaborations. |
| Year(s) Of Engagement Activity | 2010,2013,2016,2019 |
| Description | Postdoctoral research Carina Conceicao poster at Microsoc 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Carina presented data on her work about morbillivirus host range |
| Year(s) Of Engagement Activity | 2019 |
| Description | Postdoctoral researcher James Kelly - poster at Microsoc 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Jamie presented data from our MRC project on the inhibition of RSV and MeV fusion by the interferon system |
| Year(s) Of Engagement Activity | 2019 |
| Description | Postdoctoral researcher Stacey Human talk at Microsoc 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Stacey presented her data on examining the cellular processes involved in trafficking RSV components to the cell surface. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster Presentation at the 2020 British Society for Immunology Virtual meeting: "Connecting Immunology in the time of COVID-19" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Andrew Broadbent presented a digital poster at the British Society for Immunology 2020 online meeting entitled "Connecting Immunology in the time of COVID-19". |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.immunology.org/events/bsi-congress |
| Description | Poster and flash presentation at Microscience Microscopy Congress - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | 3 minute flask presentation and poster entitled "Correlative cryo-bioimaging to study coronavirus replication organelles" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presenation at Nipah @20 conference in Singapore |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attendance at a conference on Nipah virus, commemorating 20 years since its emergence in Malaysia and Singapore. The RA in my group presented a poster on our work developing new assays to screen the humoral response to this virus. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.nipah2019.com/ |
| Description | Poster presentation as ToScA conference - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | PP presented a poster entitled "Correlative cryo-imaging tools for the study of coronavirus replication organelles" at the ToScA conference. He discussed his data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster presentation at International Nidovirus Syposium 2023 - HM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster entitled "Cross virus comparison of coronavirus proteins involved in replication organelle formation" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at International Nidovirus Syposium 2023 - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation entitled "Coronavirus RNA synthesis occurs in membrane-bound sites" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at Microbiology Society annual conference - YC |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster entitled "Development of a CRISPR/Cas9 GeCKO library screen to identify pro-viral cellular genes in chicken cells that can be exploited to control avian endemic viruses" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation at Microbiology Society annual conference - YC |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | YC presented a poster entitled "Development of a CRISPR/Cas9 GeCKO library screen to identify pro-viral cellular genes in chicken cells that can be exploited to control avian endemic viruses" at the Microbiology Society annual conference in Belfast. She discussed her data with conference attendees and answered their questions. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster presentation at UK-ICN AGM - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a talk entitled "Coronavirus RNA synthesis occurs in membrane-bound sites" at the UK-International Coronavirus Network AGM. She answered questions and discussed her data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster presentation at the British Society of Immunology meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The poster presentation reached engaging scientists from human and mouse immunology field, which did not seem very aware of the importance and impact of veterinary immunology. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Poster presentation in the IMAV focused meeting on Arboviruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A poster on Inhibition of Semliki Forest Virus Replication Through Disruption of Lipid Homeostasis was presented at the IMAV meeting. The poster generated a lot of discussion and interest. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Poultry Health course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry Health Course is run as a residential and online course to transfer recent advances in avian disease research from the laboratory to the field. |
| Year(s) Of Engagement Activity | Pre-2006 |
| URL | http://www.poultryhealthcourse.com/ |
| Description | Poultry Stakeholders meeting hosted by Almarai, 15 October 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Engagement with Almarai Poultry. The focus of the meeting with Almarai Poultry disease control team was to share knowledge on improved vaccination and diagnostic techniques against avian influenza viruses affecting poultry production. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poultry Stakeholders meeting in Kuwait city 16 October 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prevention and control of avian influenza outbreaks in poultry. Described new vaccination and diagnostic technologies that provide more robust cross-protective immunity in emerging antigenic divergent strains of avian influenza viruses. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Practical training given to LSHTM MSc students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Two-hour practical teaching session given to 12 MSc students at the London School of Hygiene and Tropical Medicine (LSHTM) on 17th November 2017 (Lara Harrup). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation and sicussion with members of the CLA group visiting Pirbright Institute |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a visit to the Pirbrigtht Institute and I presented on Bluetongue virus epidemiology, transmission and risk to the UK agriculture followed by a general discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at American Society for Virology conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to give a keynote talk on "Rational vaccine design for the avian coronavirus infectious bronchitis virus" at the ASV Satellite Symposium: Viral Pathogenesis and Prevention in Animals, discussed research and future plans with other researches in the field. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at Avian Diseases Symposium - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a short talk at the Avian Diseases Symposium entitled "Identification of sites of infectious bronchitis virus RNA synthesis". She discussed our data and answered questions from the audience. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at Avian Research Symposium - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a short talk at the Avian Diseases Symposium entitled "Identification of sites of infectious bronchitis virus RNA synthesis". She discussed our data and answered questions from the audience. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Avian Research Symposium - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | PP presented a talk at the Avia Research Symposium entitled "Correlative cryo-bioimaging to study avian coronavirus replication organelles". He presented data and answered questions from the audience. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Avian viruses focussed meeting - Sept 2018 ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of data as an offered paper at the molecular biology and pathogenesis of avian viruses meeting, Oxford Sept 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Global Alliance for Research on Avian Diseases Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of my research at the Global Alliance for Research on Avian Diseases Conference in Vietnam to approximately 80 conference participants resulted in discussions about future research directions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at Imaging virus infected cells meeting - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a talk entitled "Identification of sites of infectious bronchitis virus RNA synthesis" at the Imaging Virus infected cells meeting hosted at Pirbright. She answered questions and discussed her data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Imaging virus infected cells meeting - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | PP was invited to present a talk entitled "Correlative cryo-bioimaging of coronavirus replication organelles" at the Imaging virus infected cells meeting held at Pirbright. Patrick answered questions on his presentation and discussed data with other researchers studying virus-host cell interactions using bioimaging approaches. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Inter-institute Bioimaging networking meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | An event was held to enable improved collaboration opportunities between scientists working with bioimaging techniques at the different research institutes within the UK. I presented data from the last 10 years describing our work characterising replication organelles induced by IBV, describing the different techniques and approaches we have used and the outlook for the future. The talk aimed to showcase the bioimaging facilities at Pirbright to encourage new collaborations. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at International Nidovirus Symposium 2023 - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 10 minute presentation entitled "Correlative cryo-bioimaging to study coronavirus replication organelles" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Microbiology Society Early Career Microbiologist Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | We presented a talk on "Examination of in vitro cell lines and ex vivo tracheal organ cultures for the study of porcine respiratory coronavirus" at the Early Career Microbiologist Forum organised by the Microbiology Society. This was a great opportunity for early career scientists to network with others and gain experience in presenting their research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microbiology Society Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed our work using the pig as a preclinical model to support COVID-19 vaccine development |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation at Microbiology Society annual conference - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | ND presented a talk entitled "Identification of sites of infectious bronchitis virus RNA synthesis" in a workshop session at the Microbiology Society annual conference. She answered questions and discussed her data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microbiology Society annual conference - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster presentation at the Microbiology Society annual conference entitled "Coronavirus RNA synthesis occurs in membrane-bound sites" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Microbiology Society annual conference - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | 10 minute talk entitled "Correlative cryo-bioimaging to study coronavirus replication organelles" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Microbiology Society annual conference - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | PP presented a talk entitled "Correlative cryo-bioimaging to study avian coronavirus replication organelles" in a workshop at the Microbiology Society annual conference in Belfast. He answered questions and discussed his data with conference attendees. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microbiology Society annual conference in Belfast |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of "The canonical stem loop RNA structure of the s2m genetic element is not required for avian coronavirus infectious bronchitis virus replication in vitro however deletion of the s2m sequence results in a 36-nucleotide insertion" and "Characterising the ion channel inactivating mutations in the E protein of Infectious Bronchitis Virus (IBV)" during the virology workshops to other research scientists and students. We also presented a poster on "Examination of in vitro cell lines and ex vivo tracheal organ cultures for the study of porcine respiratory coronavirus". Good feedback was received and ideas generated for further research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at Microscience Microscopy Congress - HM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster entitled "Cross virus comparison of coronavirus proteins involved in replication organelle formation" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation given on "The canonical stem loop RNA structure of the s2m genetic element in the avian coronavirus Infectious Bronchitis Virus is not required for viral replication in vitro but may play a role during in vivo infection" at the poster session of the The XVth International Nidovirus Symposium. Discussions with other researchers in the coronavirus field resulted in new ideas to take the research forwards. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at RIVR meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation of my work to other researchers at the Recently Independent Virology Researchers meeting. I discussed my data with other researchers and potential for future collaboration. |
| Year(s) Of Engagement Activity | 2016,2017,2019,2020 |
| Description | Presentation at RIVR meetings |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of my research at Recently Independent Virology Researchers (RIVR) meetings in 2016, 2017, 2018, 2019 and 2020. I discussed my work and future collaborations with other virology researchers working in the UK. |
| Year(s) Of Engagement Activity | 2016,2017,2018,2019,2020 |
| Description | Presentation at Translation UK 2019 - MJB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Poster presnetation of data to scientistis at the annual Translation UK meeting. Viewers of the poster asked lots of questions and there were some useful discussions around future plans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at UK-ICN ECR meeting - PP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 10 minute talk entitled "Structural studies of coronavirus replication organelles". |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presentation at World One Health Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed our work to develop a 'One Health' Nipah virus vaccine to protect animal and public health |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation at World Vaccine Congress Europe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed our work to develop a 'One Health' Nipah virus vaccine to protect animal and public health. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation at the 13th International Veterinary Immunology Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Selected oral presentation: Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors. 13th International Veterinary Immunology Symposium, Kruger National Park, South Africa |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ivis2023.org/ |
| Description | Presentation at the Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Cheltenham Science Festival is one of the UK's leading science festivals. Founded in 2002, the Cheltenham Science Festival has united some of the greatest scientists, writers and thinkers to explore the wonders of the natural world, the complexities of the human mind and the mysteries of science and space. It was an opportunity for inquisitive minds of all ages to find out more about the world of science. The audience included Key Stage 1-3 students on the start of their education which in turn could lead to future careers in science. The main purpose was to engage with various stakeholders from different backgrounds to inform and educate the general public on BBSRC-funded science which is carried out at the Pirbright Institute. During the talk I was able to demonstrate that basic science can have practical implications. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cheltenhamfestivals.com/science |
| Description | Presentation at the Festival of Tomorrow, Science Swindon/UKRI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation on developing livestock vaccines to prevent new/emerging diseases and the pig as a model to support COVID-19 vaccine development, which sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.scienceswindon.com |
| Description | Presentation at the Veterinary Research Club, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed our work using the pig as a preclinical model to support COVID-19 vaccine development. No known impact. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation by ND at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The post-doctoral researcher presented our data at the 14th international Nidovirus symposium. She discussed data and potential collaboration with other scientisits from the field. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation by RH at Nidovirus symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | PhD student presented our data at the 14th international Nidovirus symposium. He discussed results and potential for future collaboration with other scientists in the field. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation of data at Microbiology Society Annual conference 2019 - MJB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Oral presentation of data to scientists at the Annual Microbiology Society conferene, Belfast. After the presentation there were questions and disussion. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation of data at Microbiology Society Annual conference 2019 - ND |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of data to scientists at the annual Microbiology Society Conference, Belfast. Following the presentation there were questions and discussion with other scientists. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation to BBSRC Executive Board |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | I presented our research to the BBSRC Executive Board when they visited The Pirbright Institute in September 2018 and discussed the impacts of our work.. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation: BSI AGM: Immune regulation by the SH protein of BRSV |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the BSI's AGM to describe the data generated regarding the role of the SH protein of BRSV in regulating immune responses after natural infections. Initiated a debate about the role of the SH protein of human RSV in immune regulation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentations at Avian Research Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We have presented our research at the Avian Research Symposium organised by the National Avian Resource Facility at the Roslin Institute in 2021 (Rational vaccine design for the avian coronavirus infectious bronchitis virus) and 2023 (Disruption of the s2m RNA structure in the avian coronavirus infectious bronchitis virus results in reduced clinical disease during in vivo infection). We have engaged with other researchers to expand our network and discussed future research activities. |
| Year(s) Of Engagement Activity | 2021,2023 |
| Description | Presentations at Microbiology Society focused conference on Avian Infectious Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Microbiology Society supported a focused meeting on avian infectious disease research, bringing together scientists from all over the world to discuss their research. We gave presentations on "Characterisation of the Infectious Bronchitis Virus E Protein for Rational Vaccine Design" and "Rational vaccine design for the avian coronavirus infectious bronchitis virus", received good feedback on our work and ideas for future research. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentations at the UK International Coronavirus Network (UK-ICN) AGM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We presented research "The Genetic Stability, Replication Kinetics and Cytopathogenicity of Recombinant Avian Coronaviruses with a T16A or an A26F Mutation within the E Protein Is Cell-Type Dependent" and "A temperature sensitive recombinant of avian coronavirus infectious bronchitis virus provides complete protection against homologous challenge" and a poster on "A novel in-cell micro neutralisation assay for the human coronavirus OC-43: Allowing rapid and automated quantification of neutralising effect of antibodies and antiviral compounds" at the annual general meeting of the UK-ICN in Cambridge. We networked with other researchers working in the coronavirus field and discussed future research. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Prevalence and Control of Avian Influenza Viruses in Poultry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presented a seminar (as an invited speaker) to poultry stakeholders including farmers and veterinarians at "Morocco Poultry Day" organised by Boehringer-Ingelheim in Tangier, Morocco. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2024 |
| Description | Preventing and controlling avian influenza infections in poultry and humans |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Princess Anne opening Jenner |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Princess Anne, entourage, local politicians and dignitaries visited to open new research building. I was one of small number asked to present/demonstrate/describe our research work, which is on genetic modification of mosquitoes to provide new tools with which to help control mosquito-borne viral diseases. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Protecting poultry from avian influenza |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Avian influenza, commonly known as "bird flu," is a disease caused by multiple strains of influenza virus. The viruses can infect a wide range of animals, including people and pigs, but the natural reservoir lies in populations of wild aquatic birds such as ducks and gulls, according to an announcement from The Pirbright Institute in the U.K., which is conducting research to better understand avian influenza viruses to help prevent the disease in poultry. Flu virus strains are categorized by the combination of the two proteins found on the outside of the virus: hemagglutinin (H) and neuraminidase (N) -- for example, H5N6 or H9N2. The H protein binds to cell receptors in order to initiate infection, while the N protein helps release new viruses from an infected cell, the institute explained. Strains are also classified by severity. Low-pathogenic avian influenza (LPAI) viruses cause clinical signs such as mild breathing problems, decreased egg production and growth. Some birds, particularly ducks and geese, do not display any signs of LPAI infection and are still able to spread the disease, Pirbright said. When LPAI viruses circulate in high-density poultry areas, the viruses can mutate into highly pathogenic strains. Highly pathogenic avian influenza (HPAI) viruses have severe and often fatal effects on some species of birds such as chickens, Pirbright noted, but some HPAI strains cause mild or no clinical signs of disease in wild birds and domestic waterfowl. These strains are notifiable, meaning government control measures must be put in place. Avian influenza can be carried vast distances by wild migratory birds and can infect domesticated poultry through direct contact or through contaminated droppings and bodily fluids, Pirbright said. Because of this, there is a year-round risk of avian influenza, which can increase depending on the disease status in a region and the migration season of wild aquatic birds. According to Pirbright, good biosecurity is essential in preventing poultry from being exposed to the disease and can be practiced on a commercial farm, with game birds or even with just a few backyard hens. Why is influenza so difficult to prevent? The institute explained that influenza viruses are constantly changing, and when they replicate, small errors called mutations are copied into their genome. Some of these will alter the virus's proteins, allowing the virus to escape detection by the immune system. All flu viruses also have the potential to undergo a process called reassortment, where two or more strains of influenza infect the same animal, allowing them to swap parts of their genome, Pirbright said. The resulting viruses can potentially have different characteristics than the original strains, such as the ability to replicate in different species, including people, the institute added. Avian influenza viruses such as H5N1 or H7N9 have infected people, predominantly in Southeast Asia, but in these cases, the virus has been transmitted directly from infected birds to people, with no onward spread. There is some evidence that avian influenza can be passed from person to person, and while there are no records of efficient or sustained human transmission, there is a constant risk that one of the new strains may spread easily among people, which could result in a new influenza virus pandemic, Pirbright said. Changes in the virus genetics from mutation or reassortment make it very difficult to anticipate how influenza viruses will spread through a population and whether current vaccines will be suitable for the strains that are circulating, Pirbright announced. The influenza research programs at Pirbright are progressing understanding of the virus and finding better ways to prevent its spread. Pirbright Institute group leaders Dr. Holly Shelton and professor Munir Iqbal are researching how the characteristics of influenza viruses can change the outcomes of disease. Studying flu at the molecular level allows them to find out how the virus evolves to overcome avian immunity and how changes in their genome can alter disease severity and their ability to affect different species, the announcement said. Shelton's and Iqbal's teams are working on identifying genetic markers for specific disease traits that can be used in surveillance systems to provide forewarning of strains that could cause pandemics. For example, Shelton's Influenza Viruses group is looking at which characteristics allow the viruses to become resistant to antiviral drugs that are currently used to treat human infections of influenza, allowing surveillance to provide an early warning of viruses that could cross into humans and be difficult to control, Pirbright said. The team is also investigating how long it takes for avian influenza viruses to adapt to new mammalian species. According to the institute, establishing which strains can rapidly adapt and identifying the genetic changes made to enable infection of mammalian cells will help with surveillance efforts and potentially lead to the development of techniques that will help prevent these mutations occurring. Vaccination and rapid diagnosis are very important for influenza prevention and control, but it is still not currently possible to protect against all influenza strains, Pirbright said, noting that Iqbal's Avian Influenza group is exploring which sites on the virus trigger the chicken immune system to respond quickly and fight off infection. This will better inform scientists' ability to match vaccines to strains in the field and could help to develop vaccines that are more effective. Iqbal's group is also developing multivalent vaccines that protect chickens and ducks from several avian influenza subtypes at once as well as test kits for rapid diagnosis of different subtypes at the flock-side, the announcement said. Visit Pirbright's Influenza Viruses and the Avian Influenza group pages to find out more about their research. Source: The Pirbright Institute, which is solely responsible for the information provided and is wholly owned by the source. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.feedstuffs.com/nutrition-health/protecting-poultry-avian-influenza |
| Description | Protecting poultry from avian influenza through passive immunisation. Presented at Foreign Experts Seminar "New strategies and new tools for the prevention and control of major poultry diseases. Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 20-22 September 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public Health Entomology Group (LSHTM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture on 4th April 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Public engagement organized at Oxford |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Set up a stand at the event, a museum at Oxford, and discussed and described research activities within the Institute with public. Set up demonstrations from some biological specimens and distributed leaflets and questionnaire. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Q&A statement on coronaviruses provided to Science Media Centre - HJM |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A Q&A statement on coronaviruses was provided to the science media centre, who distributed it to media outlets. Excerpt have been used in 1420 articles incuding the Daily Mail and syndicate articles. The Q&A was also used in a Pirbright Institute media statment. |
| Year(s) Of Engagement Activity | 2020 |
| Description | RMS EM school - invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Royal Microscopical Society Electron Microscopy School, lecture in biological sample preparation for transmission electron microscopy. Lots of questions from delegates. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | RSB Genetic Tech Governance Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Workshop hosted by the Royal Society of Biology (RSB) on the use of genetic technologies and the governance and regulation of organisms developed by genetic modification, genome editing and other breeding methods |
| Year(s) Of Engagement Activity | 2019 |
| Description | Rebecca Daines: Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza. Presented at Systems Immunology Workshop: Adaptive immune repertoires and beyond. 16th-17th January 2020. University of Surrey, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk entitled "Recombinant single chain variable fragment (scFv) antibody protects chickens from avian influenza" was presented at the workshop exploring new technical advances for analysis and production of antibodies for prophylaxes and treatment of animal and humans diseases. Both academics and staff linked with animal and public health industry attended this workshop. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Recombinant vaccines against avian viral diseases affecting poultry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effective: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Reddit AMA (Ask Me Anything) on vector-borne diseases |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Took part in a Reddit Ask Me Anything (AMA) on vector-borne diseases. AMAs are a question-and-answer format activity where an individual expert or panel of experts answers questions from the public for a specified duration. We received a large number of questions and the parent post received 493 upvotes, indicating an absolute minimum of 493 participants (and very probably more), so I have given the estimated audience as 500+. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.reddit.com/r/science/comments/6he8go/aaas_ama_hi_were_maria_elena_bottazzi_marcia/ |
| Description | Research Assistant in my group Nazia Thakur attending Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Research assistant Nazia Thakur talk at Microsoc 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nazia presented her data on the development of low containment assays to monitor the humoral response to vaccines |
| Year(s) Of Engagement Activity | 2019 |
| Description | Researchers at Pirbright investigate the emergence of new bird flu viruses with the potential to infect people |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Following the news brief of our research outcomes for the general public and media was published on The Pirbright Institute and widely distributed through social media platforms including Facebook, Twitter, Linkedin. Pirbright scientists have discovered that infection with two strains of avian flu can lead to the emergence of a new virus strain with the potential to jump from birds to humans. Human cases of avian influenza are extremely rare but can occur if a person comes into very close contact with an infected or dead bird. The study shows that avian influenza virus strains H9N2 and H7N9 can share genetic information to create an H9N9 strain with the potential to cause more severe disease in poultry and pose a threat to human health. Avian influenza, also known as 'bird flu', is a type of influenza that spreads among birds. The UK faces a seasonal increase in the risk of avian influenza outbreaks which are associated with the migration patterns of wild birds. Avian influenza is found across the globe, and in countries where multiple strains circulate it is important to monitor the emergence of new strains. Low virulence H9N2 and H7N9 circulate in poultry in Asia but do not cause severe disease. However, they are known to swap genetic information which can result in the emergence of an H9N9 strain, which can cause severe disease. In collaboration with the Animal and Plant Health Agency (APHA), researchers at Pirbright discovered that the H9N9 strain was able to multiply significantly better in poultry cells, indicating the potential to cause more severe disease. They also discovered that it had a higher replication rate in human cells and could bind to these cells better than H9N2. The H9N9 strain can infect and transmit between ferrets highlighting the potential to cause disease in humans. The study, published in the Journal of Virology, shows that strains already circulating in poultry populations can exchange genetic material, leading to the creation of new strains. This increases the risk of the virus jumping from avian hosts to humans and other mammals. The study concludes that H7N9 and H9N2 viruses circulating in the same regions pose a pandemic threat, which demonstrates the need for constant monitoring for the emergence of new virus strains. Professor Munir Iqbal, Head of the Avian Influenza Group at Pirbright said: "This is the first study to show that infection with circulating H9N2 and H7N9 influenza viruses could create new virus strains such as H9N9 that cause more disease in poultry and pose a greater risk to human health. If a host is infected with two different strains, there is always a chance that they will swap genetic material to create a new strain. When this happens, it could lead to many outcomes, for example, the virus becoming more or less able to cause disease in a host, or a virus acquiring the ability to jump between hosts. This leads to viruses that primarily cause disease in animals having the ability to infect humans, which is what we have observed in this study. More research is needed to determine which avian flu viruses could combine and pose a threat to poultry and human health." This study was supported by grants funded by the UK Research and Innovation Biotechnology and Biological Sciences Research Council under Newton Fund UK-China-Philippines-Thailand Swine and Poultry Research Initiative and Zoonoses and Emerging Livestock Systems (ZELS) with grants from FCDO and Dstl. The work was also funded by the GCRF One Health Poultry Hub and Defra (UK, including the Devolved Administrations of Scotland and Wales). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.pirbright.ac.uk/news/2022/01/researchers-pirbright-investigate-emergence-new-bird-flu-vi... |
| Description | Respond to SMC enquiry re gene drives in mice |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Responded to Science Media Centre request for expert comment on a scientific paper regarding gene drives in mice. Quoted in The Independent |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.independent.co.uk/news/science/gene-editing-dna-technology-mice-pests-drives-invasive-sp... |
| Description | Respond to SMC request re Vosshall paper 08 Feb 2019 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Respond to SMC request re scientific paper describing behaviour-altering drugs in mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| Description | Respond to request for comment - MIT News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview regarding local "daisy" gene drives in mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://news.mit.edu/2019/daisy-chain-gene-drives-keeping-genetic-engineering-localized-0402 |
| Description | Returning to STEM event - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | ND attended a workshop to discuss and exchange ideas about public engagement strategies. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Reverse genetics seminar to MSc students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A seminar was presented describing reverse genetics of viruses, including infectious bronchitis virus and the application of reverse genetics in research. The students were interested and engaged, participating in activities and asking questions. We were invited to present the seminar in subsequent years for new student intakes. |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016,2018,2019 |
| Description | RobinB 25/04/22 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Responded to enquiry from journalist regarding a recent grant, and funding environment generally. Email discussion with follow-up comments and questions |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.researchprofessionalnews.com/rr-news-europe-horizon-2020-2022-4-senior-uk-researchers-co... |
| Description | Royal Institution Christmas Lectures Family Day - LA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Six Pirbright staff/students ran an all-day exhibit on gene editing and mosquitoes at the Royal Institution About 270 participants visited our stand; wide range of comments, questions, discussion and feedback |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Institution Christmas Lectures Family Day - SB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | About 270 participants visited our stand; wide range of comments, questions, discussion and feedback |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Society Summer Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Engaged the public on the uses of genetically modified mosquitoes for preventing disease transmission, and on the drivers of viral emergence events at the Royal Society Summer Exhibition (with thousands of attendees). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://royalsociety.org/science-events-and-lectures/2022/summer-science-exhibition/ |
| Description | Royal Society Summer Fair - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | HJM attended the Pirbright stand at the Royal Society Summer Fair and presented the exhibit to visiting school children and members of the general public. The exhibit called "Disease detectives" helped visitors understand processes in identifying viruses causing disease, symptoms of infection, routes and rates of infection as well as control measures currently available and in development. The event allowed discussion of work on going in HJMs projects. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Royal Society Summer Fair - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | ND attended the Pirbright stand at the Royal Society Summer Fair and presented the exhibit to visiting school children and members of the general public. The exhibit called "Disease detectives" helped visitors understand processes in identifying viruses causing disease, symptoms of infection, routes and rates of infection as well as control measures currently available and in development. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Royal Society Summer Fair - PP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | PP attended the Pirbright stand at the Royal Society Summer Fair and presented the exhibit to visiting school children and members of the general public. The exhibit called "Disease detectives" helped visitors understand processes in identifying viruses causing disease, symptoms of infection, routes and rates of infection as well as control measures currently available and in development. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Royal Society of Biology Biology week talk, Winchester, 10/10/2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk organized by Royal Society of Biology as part of Biology Week. This one in Winchester, audience was general public with strong representation of school-age. Questions and discussion during and after formal talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | SGM Meeting 2017 Presentation: Regulation of the transcription factor NF=kB by the SH protein of BRSV |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at a workshop of the Society for General Microbiology on the role of the SH protein of BRSV in regulating the transcription factor NF-kB in bovine antigen presenting cells. Many questions about protein-protein interactions were generated. Good feedback on our work. |
| Year(s) Of Engagement Activity | 2017 |
| Description | SMBE 2018 meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "Phylogenetically young genes and their function in Anopheles mosquitoes" given during the Society for Molecular Biology and Evolution 2018 meeting (8-12 July 2018) in Yokohama, Japan. Discussions held with potential collaborators on joined future research projects. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.smbe2018.jp/ |
| Description | STEAMfest - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A large open day event at hosted at University of Surrey for students from a number of schools in the region to explore different scientific questions and areas of work. |
| Year(s) Of Engagement Activity | 2019 |
| Description | STEAMfest - HS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Team members attended the event where a flu fighters stand was displayed demonstrating how scientists are working to rapidly detect and control avian influenza in the filed to protect food security, animal welfare and human health. Approximately 200 secondary school students engaged with the stall and this stimulated increased interest in science and research, |
| Year(s) Of Engagement Activity | 2019 |
| Description | STEM Day - Speed interviews and Careers Day 2018 - BA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | STEM training: Gain confidence in talking to secondary school students - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | ND attended a training event to learn effective techniques to engage with secondary school students. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Scheduled Twitter session with University of Nottingham students on professional skills for biosciences |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Hour-long Twitter chat on Friday 12th May with biotechnology students, microbiology students, animal science students interested in animal diseases and animal welfare and behaviours and agriculture students interested in livestock. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://twitter.com/search?q=%23biosciprofskills |
| Description | School Visit (Woking) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Amin Asfor engaged with Six-form students and parents at a Careers day. He showcased The Pirbright Institute and a Science career, discussed the use of animals in research and the need to do research aimed at reducing their use and replacing them with alternative methods. |
| Year(s) Of Engagement Activity | 2019 |
| Description | School careers-Big Interview MdP |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating interest in science and research to secondary school students |
| Year(s) Of Engagement Activity | 2019 |
| Description | School visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Met and discussed A level students in small groups (3 students at the time) and discussed different aspects of my work as a scientist. |
| Year(s) Of Engagement Activity | 2015 |
| Description | School visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed different aspects of scientists' work. |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit (Farnborough) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a presentation to a group of students about research performed at the Pirbright Institute and discussed various aspects of scientists' work. |
| Year(s) Of Engagement Activity | 2018 |
| Description | School visit (Tillingbourne) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a presentation to a group of students about role of insects in the environment; guided students in collection of insects and other invertebrates, and identification of collected material. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Enrichment day at Park Mead School - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | An engagment event at a local school teachin year 5 and 6 students about mosquitos and some of the work done at Pirbright. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Update to BBSRC executives |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Visit from the BBSRC to discuss science highlights |
| Year(s) Of Engagement Activity | 2019 |
| Description | Scientific Presentation: SOVE lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Society of Vector Ecology Presentation 'The Gnatwork'. 6th October 2017 over 150 attendance. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.uibcongres.org/sove2017/ |
| Description | Selectively Targeting Hemagglutinin Antigen to Chicken Antigen Presenting Cell Receptor Induces Faster and Stronger Immunity against Avian Influenza. Presented by Munir Iqbal ( IVVN Symposium) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | - Talk was presented describing the development of the next-generation Target Antigen Delivery Vaccine technology for poultry that selectively targets vaccine antigens to chicken antigen-presenting cell (APCs) and potentiates the immunogenicity of the vaccine. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Seminar at Coventry University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited seminar "One Health vaccinology to combat emerging viral zoonoses", School of Life Sciences, Coventry University, UK. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Sir John Kingman (UKRI) visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Visit to highlight Pirbright science to UKRI |
| Year(s) Of Engagement Activity | 2019 |
| Description | Site tour with Department of Trade and Industry |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Tour/site visit with Department of Trade and Industry (25 people attending) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Site tour with UK Science Partnership for Animal and Plant Health, BBSRC (Chris Jacobs, Julie Fitzpatrick) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 'Fact-finding' visit from Chris Jacobs (Head of Secretariat, UK Science Partnership for Animal and Plant Health) & Julie Fitzpatrick (Chair of the Partnership) to organisations involved in the areas of animal and plant health science capabilities, to gain a better understanding of who the key players are, what they're working on, and any particular issues the Partnership may be able to address. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Skillfluence interview |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with Skillfluence to provide real-world examples and experience to inform course materials for a programme for "Future Innovators" |
| Year(s) Of Engagement Activity | 2021 |
| Description | Speaker UK Vector-borne Disease Meeting (Liverpool - online) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation given on 23/11/20. Major outcome was discussion around climate-related impacts on Culicoides populations. |
| Year(s) Of Engagement Activity | 2020 |
| Description | St Andrew's Catholic School visit to Pirbright |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | College students visited the Institute to learn about lab designs. They were given talks about the equipment and labs and then toured around the labs at Pirbright. Students were highly interested about our facilities and the work we are conducting at The Institute. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Stacey Human - Pirbright Village Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The postdoctoral research Stacey Human in my team attended The Pirbright Village Duck Fair - a local event in our community supported by the Institute where the work of the Institute was advertised. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Stacey Human - University of Surrey Open Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The postdoctoral researcher in my team took part in the University of Surrey Open Day advertising the work of The Pirbright Institute |
| Year(s) Of Engagement Activity | 2018 |
| Description | Student Thomas Rix - poster at Microsoc 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Thomas presented his work on inhibitors of RSV fusion at the Microbiology Society Annual meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | Student in my group Ciaran Gilbride attending Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Surrey County Show |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Stall at Surrey County Show, engage with the public where they can ask any questions they have about the work we do. This sparks discussions, and an increase in knowledge of the general public. I invited the Lord Lieutenant of Surrey to our stand, with whom I have built a solid relationship. This has lead to engagement of his office with the Institute, for example the visit of HRH Princess Anne to Pirbright in 2017. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Surrey County Show |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Surrey County Show is an agricultural show in Guildford that is visited by the general public. The Pirbright Institute had a stand with various activities for visitors to take part in and explain our science to a wide audience. Giulia spent a day working on the stand and spoke with many children and adults about her work at Pirbright to change public attitudes and stimulate increased interest in research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Surrey County Show (Guildford) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Stall at Surrey County show attended by Jo Stoner (Research Technician). Gave commentary on the threat of viruses to UK livestock species. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://surreycountyshow.co.uk/ |
| Description | Surrey County Show - Dana Perry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | DP helped run the stand located at the Surrey County Show, and fielded questions regarding our science from the general public, which stimulated discussion. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Surrey Open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Described the research activity of the Pirbright Institute for students from school, graduate and postgraduate students, and provided information on research facilities in the institute. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.surrey.ac.uk/opendays/vet |
| Description | Surrey Vet School Open Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | PH helped to run a stand representing The Pirbright institute. Fielded questions from potential vet students at Surrey, and their parents/families. Increased the visibility of The Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Surrey Veterinary School Open Day- AA, WM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Stimulating interest in different science career paths |
| Year(s) Of Engagement Activity | 2019 |
| Description | Surrey vet school open day - MJB |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The event was an open day for prospective students for the University of Surrey vet school. The course includes a research placement, which can be conducted at Pirbright. Therefore there was a stand from Pirbright to describe the research we perform generally as well as a discussion of our specific research. The audience were generally interested and the information helped inform them when selecting a university course. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Sushant Bhat:Pirbright Dragon Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | TATA June 2020 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited panelist for international online panel re mosquito borne diseases, which sparked numerous questions |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=_HHvwz1gW68 |
| Description | Taiwan -UK Partnering Award: Surveillance of influenza viruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended the International Flu Virus Symposium for Celebrating IPM 47th Anniversary" in Tri-Service General Hospital in Taipei, Taiwan. Tri-Service General Hospital address: No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan (R.O.C.) Invited speaker for medical staff and research scientists. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.cdc.gov.tw/rwd/english |
| Description | Talk (Christopher Sanders): Lancaster University (Culicoides and their role as vectors) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk give to academic audience through invited lecture. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk (Christopher Sanders): Virus Transmission and Vector Competence of Culiocides (Royal Entomological Society Annual Meeting) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Annual Meeting of the ROyal Entomological Society presentation. Held at LSHTM on 21st August 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk Presented at 2nd International Congress of Veterinary Microbiology, 16th -19th October 2018. Sherwood Breezes Resort-Lara, Antalya, Turkey. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference discussed improving prevention and control of viral diseases of poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk as part of the University of Veterinary Medicine (Vienna) doctoral school "Infectious Diseases of Pig and Poultry" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Talked about the Pirbright Institute's work on African swine fever virus to researches in Veterinary Medicine (Virology and Immunology) in Vienna. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at Avian viruses focussed meeting - Sept 2018 HM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation of data as an offered paper at the Molecular biology and pathogenesis of avian viruses meeting in Oxford, September 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at Large animal research network (LARN) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a talk on the tools we have developed to target different parts of the respiratory tract and how to analyse local immune responses. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk at Microbiology Society 2021 online conference; Dr. Fatoumatta Jobe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop talk entitled: RSV modulation of the innate immune response: rerouting signalling components to block transcriptional activation |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk at Microbiology Society special symposium on SARS-CoV-2 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented our research data on the host-range of SARS-COV-2 and its potential origins to other virologists based in the UK and overseas, as part of a special symposium on the virus organised by the Microbiology Society. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Talk at Tamil Nadu Veterinary and Animal Services University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Participated in an online webinar organised by the Tamil Nadu Veterinary and Animal Services University in Chennai India as part of their Transboundary Animal Diseases - Emerging Threats to India seminar series. I talked to around 60 participants about African swine fever and African swine fever vaccine research. There were questions on vaccine development and also control of African swine fever in India. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Talk at VIV Virtual Summit -Asia Edition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Talk to just over 100 attendees to the "Genetic Futures - Productivity, Animal Health and Clean Growth" session, part of the VIV Virtual Summit -Asia Edition. The session was organised by UK Technology for Agriculture and Genetics to showcase UK scientific expertise in the livestock sector to a Asian audience. |
| Year(s) Of Engagement Activity | 2012,2021 |
| URL | https://www.vivasia.nl/viv-virtual-summit/ |
| Description | Talk at World Vaccine Congress Europe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Described research progress on ASF vaccines |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk on "Emerging Diseases" at BBSRC Cross-Institute workshop, Roslin Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Talk on Emerging Diseases in the context of a workshop on Future of Livestock in Food Production |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ed.ac.uk/roslin/news-events/latest-news/future-of-livestock-production-in-the-spotlight |
| Description | Talk to Agrifood and Biosciences Institute, Northern Ireland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Formal presentation on Culicoides-borne arboviruses with discussion of impact in Northern Ireland |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk to clinicians at Hospital for Tropical Diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to clinicians at Hospital for Tropical Diseases, London, regardingcurrent and future methods for controlling mosquito-borne disease based on mosquito genetics |
| Year(s) Of Engagement Activity | 2020 |
| Description | Targeted Antigen Delivery Vaccines: Next Generation Vaccines for Poultry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | A talk entitled "Targeted Antigen Delivery Vaccines: Next Generation Vaccines for Poultry" presented to the Executive Chair of the Biotechnology and Biological Sciences Research Council. The discussion aim was the advances approaches that can increases the strength and breath of vaccine immunity in animals and humans. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Teaching- lecturing, small group classroom teaching and laboratory practical teaching |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | I have been actively engaged with teaching activities at the University of Surrey, giving lectures, small group classes and laboratory practical classes to vet students and MSc students. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| Description | Teentech |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The annual Teentech student science event in Guildford aims to encourage teenagers to consider science subjects and science careers. Our stand had considerable interest from the schoolchildren who were very enthusiastic. The event stimulated an increased interest in science and research. |
| Year(s) Of Engagement Activity | 2016,2019 |
| Description | Teentech Guildford - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Teentech is an event held for students from a range of local school who have an interest in science to experience the range of scientific activities that could be open to them for future careers. Students in small groups rotate around stands at the event to perform activities at each station, guided by scientists. The Pirbright stand was demonstrating the principle of genetic modification of mosquitos. The children were very interested in the exhibit and asked lots of questions. |
| Year(s) Of Engagement Activity | 2013,2019 |
| Description | The Hurst careers event - HJM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The Hurst school held a careers event for GCSE students to attend throughout the day. The Pirbright stand contained a variety of engagement activities to demonstrate the research we perform and to stimulate discussion. The students seemed interested in the activities and those more interested in a science career asked a variety of questions about the research and entry into scientific research as a career. |
| Year(s) Of Engagement Activity | 2018 |
| Description | The Microbiology Society Annual Conference, Belfast - Poster presentation 08-11/04/2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster title: Identification of host proteins that interact with non-structural proteins-1a and -1ß of PRRSV-1 |
| Year(s) Of Engagement Activity | 2019 |
| Description | The Pirbright Village Duck Fair held on 16 June 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Local Village Fair, interaction with local residence to expanse research aims and activities of The Pirbright Institute and benefits to UK and around the globe to prevent and control infectious diseases of animals and humans. |
| Year(s) Of Engagement Activity | 2018 |
| Description | The co-Circulation of Low and High-path-AIV in the same country with sub-optimal bio-security: Virus evolution and impact on vaccine efficacy. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | The global Situation and pathobiology of Avian Influenza in different Avian Species. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019.. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans. |
| Year(s) Of Engagement Activity | 2019 |
| Description | The rise and fall of antigenic mutations: A path to the persistence of avian influenza viruses. The Pirbright Institute Research Update Seminar Series. 27th April 2021. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A seminar at the Pirbright Institute Research Update Seminar Series. 27th April 2021. The research outcomes were discussed detailing how the avian influenza viruses (H9 subtype) evolve under vaccine immune pressure to sustain their fitness in poultry. Described the evolutionary genetic markers that significantly change the virus antigenicity which ultimately reduce the effectiveness of poultry vaccines against avian influenza viruses affecting poultry and huamns. |
| Year(s) Of Engagement Activity | 2021 |
| Description | This Week In Virology Podcast 532: Morbillivirus had a little lamb |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Our research paper on morbillivirus host-range in Journal of Virology was highlighted for in-depth discussion on this episode of TWIV where they spent 30+ minutes talking about the work and its potential impact. This podcast is the number one podcast in virology and listened to across the globe. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.microbe.tv/twiv/twiv-532/ |
| Description | This week in Virology: 533: Recurring threads |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Following our paper being highlighted on the previous edition of TWIV I wrote a letter to further the discussion of this subject and clarify some technical points on The Pirbright Institute. This was read out as part of the podcast and discussed. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.microbe.tv/twiv/twiv-533/ |
| Description | Tillingborne Science Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Tillingbourne Bug Hunt |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Local entomology event for general public - changes in public attitudes and stimulating increased interest in insects/entomology and research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Tillingbourne School bug hunt - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Primary school students were involved in an event to identify insects in the school grounds. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Tillingbourne School science event - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Tillingbourne School held a science event for year 3 students to explore different aspects of science including smell, acid & alkali, magnetism etc. Nicole was based at the microscopy station helping children to view samples under the microscope, explain what they were looking at and answer any questions to children asked. The children were highly engaged and interested in the exhibit. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Tillingbourne Year 3 Science Day 2018 - EL |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Time for rethink on farming poultry as experts warn bird flu has slipped 'through our fingers (Sky News) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Discussion with Sky New UK corresponded Tom Clarke (Science and technology editor @aTomClarke) on continued avian influenza viruses are becoming endemic in bird populations in Europe and North America with some areas seeing a 600% increase in infection over the past few months in September -November 2022. In the UK, every day now, two or three new premises have been testing positive for bird flu. If they do, their flocks are culled and over 50 million birds culled in Europe this year and a similar number in North America. There is a need for an improved disease control strategies against these viruses. just culling of infected and at risk will not reduce viruses prevalence and spread, because virus in circulating in wild birds. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://news.sky.com/story/time-for-rethink-on-farming-poultry-as-experts-warn-bird-flu-has-slipped-... |
| Description | Toolbox workshop at IVVN Stirling 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A second workshop held as a sattelite meeting to the International Veterinary Vaccinology Conference in Stirling to decide on community priorities for future immunological tools to promote veterinary vaccine development. |
| Year(s) Of Engagement Activity | 2012,2018 |
| Description | Tour of Philip Mellor Insectary (BBSRC) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | BBSRC tour of Philip Mellor Insectary on 4th December 2017 (Jo Stoner). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Tour of Philip Mellor Insectary (Country Land and Business Association) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Tour of Philip Mellor Insectary with Country Land and Business Association (20 people) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Tour of Pirbright Research facilities for CLA group |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a tour of the Jenner building facilities at The Pirbright Institute. I led a tour of our building for the group and described the work undertaken by the avian research programme here. |
| Year(s) Of Engagement Activity | 2017 |
| Description | U3A Science Forum presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk titled 'One Health' vaccines to combat emerging zoonotic viral diseases |
| Year(s) Of Engagement Activity | 2021 |
| Description | U3A talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation on influenza virus research at The Pirbright Institute for the local University of the Third Age group, approx. 50 people aged 65 years + all with an interest in science. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://cu3asandt.wordpress.com/2018/09/23/meeting-2nd-october/ |
| Description | UAR interview 13/05/2021 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview for Understanding Animal Research regarding genetic research on mosquitoes to prevent spread of mosquito-borne diseases |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.understandinganimalresearch.org.uk/news/fighting-the-worlds-most-deadly-animal-the-mosqu... |
| Description | UEA LGBT History Month article |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | I was interviewed for a student magazine feature showcasing my work as part of LGBT History month. |
| Year(s) Of Engagement Activity | 2023 |
| Description | UK International Coronavirus Network AGM Cambridge 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Three members of the team (myself, Dr. Newman and Miss Thakur) attended the AGM of the UK-ICN - which I am a co-director of - to discuss recent data and network with other coronavirus researchers. We presented talks and DB chaired a session. |
| Year(s) Of Engagement Activity | 2022 |
| Description | UK Microbiological Society Fleming Showcase |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Described mosquito-based approaches to microbiologists and others |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/news/society-news/fleming-showcase-speaker-profile-professor-luke-al... |
| Description | UK vector meeting 2018 (Organising committee; Chair) (December; John Innes Centre, UK) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chaired and helped organise meeting on UK Vector-borne Diseases as part of committee. Included reviewing talks and inviting speakers. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.hpruezi.nihr.ac.uk/media/29013/master-draft-vbd-programme-with-titles-oct18_.pdf |
| Description | UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Emerging new approaches were discussed for prevention and control of infectious diseases affecting swines and poultry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | UKRI Festival of Tomorrow |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk and stand on viruses and engineering mosquitoes |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ukri.org/news/showcasing-incredible-discoveries-at-swindon-festival-of-tomorrow/ |
| Description | Understanding Antigenic Diversity, Zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at "UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meeting focus was to share research plans funded under "UK-China-Philippines-Thailand Swine and Poultry Research Initiative". Research projects investigate pathogens, zoonotic pathogens or "commensals" associated with food safety issues affecting poultry and swine. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bbsrc.ukri.org/funding/filter/joint-swine-poultry-initiative/ |
| Description | Understanding Evolution and Impacts of Avian Influenza Viruses |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Internal seminar presented at The Pirbright Institute, sharing the achievements and current ongoing research being performed within the Avian Influenza Virus and Newcastle Disease Virus Group to other colleagues throughout the site. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Understanding Evolution and Persistence of Avian Influenza Viruses in Poultry |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presented a talk at the LASA 60th Anniversary Conference, the Hinxton Hall Conference Centre, Wellcome Genome Campus, Cambridge, UK, sharing the research goals and achievements performed at the Pirbright Institute. Poultry production continues to face several challenges caused by avian influenza, including: (1) virus evolution & antigenic diversity, (2) emergence of new virus variants, (3) co-circulation of multiple variants of same pathogen, (4) mixed infection of different viruses (immunosuppression), (5) maternally derived antibody interference, and (6) poor quality vaccines and sub-optimal vaccination practices. From these challenges, the topic of discussion and research drives optimal vaccination strategies to improve: (1) potency: a single dose to induce faster, stronger and durable immunity against multiple pathogens, (2) effectiveness: protect from clinical disease, reduced shedding and transmission, (3) affordability: cheap to produce and easy to deliver, (4) safety: no adverse impact to host or environment, (5) stability: retain efficacy for at least 1 year at indicated temperature, (6) DIVA: to allow differentiation between infected and vaccinated animals. Implementing new emerging vaccine approaches can: (1) enhance the efficacy, duration, and breadth of immunity, (2) reduce production losses, (3) improve cost-effectiveness, (4) improve productivity and economy, (5) improve animal welfare, and (6) reduce prevalence of viruses and protect public health (reduced virus prevalence = reduced zoonosis). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at UK-China-Philippines-Thailand Swine and Poultry Research Initiative: Interim Project Workshop 13th-15th January 2020 Hilton Hotel, Bracknell, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Outcomes of the research project entitled "Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry" were presented to colleagues working on prevention and control of infectious diseases affecting animals and humans. the work led to incite further research collaborations with different groups from UK, China, Thailand and Philippine. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Understanding avian influenza virus evolution and development of next generation vaccines. Presented at 459th Scientific Meeting of The Veterinary Research Club at The Farmers Club, 3 Whitehall Court London Friday 14th February 2020. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk presented entitled"Understanding avian influenza virus evolution and development of next generation vaccines". The discussion with senior staff from DEFRA and UKRI- BBSRC, researchers and veterinary professional like with control and prevention of animal diseases in United kingdom |
| Year(s) Of Engagement Activity | 2020 |
| Description | Understanding avian influenza virus evolution, antigenic diversity and vaccine failure. Presented at the 2019 Symposium on techniques for healthy breading and disease prevention & control of livestock and poultry, Golden Harbor Hotel, Beijing, 21-23 August 2019. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk and discussion on the control of infectious animal diseases including avian influenza. |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of California Davis School of Veterinary Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | External Meeting at University of California Davis School of Veterinary Medicine, 16-18th October 2017. Talk given (Lara Harrup) on 'Tools and Resources for Arbovirus Epidemiology in the Genomic Era'. Meeting organised as part of the University of Liverpool BBSRC US Partnering Award: Vector-borne diseases in the UK & US: common threats and shared solutions (BB/N021916/1). |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of Sao Paulo Cryo-EM workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | presentation to delegates on EM of viruses |
| Year(s) Of Engagement Activity | 2021 |
| Description | University of Surrey Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I represented The Pirbright Institute at the University of Surrey Vet School open day, talking about my research and what it is like to be a research scientist. |
| Year(s) Of Engagement Activity | 2015 |
| Description | University of Surrey School of Veterinary Medicine Open Day- Dec 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | engaged with parents and 6th form students about a career as a Veterinarian and specifically a career in Veterinary Research |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of Surrey School of Veterinary Medicine Open Day- Jul 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | engaged with parents and 6th form students about a career as a Veterinarian and specifically a career in Veterinary Research |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of Surrey Vet School Open Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Institute stand at Surrey Vet School - introducing the institute to prospective vet students |
| Year(s) Of Engagement Activity | 2018 |
| Description | University of Surrey's Widening Participation and Outreach Summer Schools for Biosciences and Veterinary Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in veterinary science and research |
| Year(s) Of Engagement Activity | 2017,2019 |
| Description | Utrect-EVIC |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Sat as part of an expert panel on the future of immune reagents for veterinary research |
| Year(s) Of Engagement Activity | 2018 |
| Description | VC discussions |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Briefed venture capital groups on landscape around genetic vector management and related products |
| Year(s) Of Engagement Activity | 2020 |
| Description | Vet School Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | University of Surrey School of Veterinary Medicine Open Day - introduced The Pirbright Institute and the research we conduct to prospective students and parents. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Vet Times |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Information on research activity of Avian Immunology group at the Pirbright Institute |
| Year(s) Of Engagement Activity | 2018 |
| Description | Vet Times Interview on SARS-CoV-2 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Q&A by email for story on SARS-CoV-2 adaptation to human ACE2, later published online and print version of Vet Times |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.vettimes.co.uk/news/study-finds-how-sars-cov-2-may-have-adapted-to-humans/ |
| Description | VetVac toolbox kick off meeting, Pirbright |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Organsised a workshop part sponsored by the BBSRC Veterinary Vaccinology Network that bought key international leaders in veterinary immune reagents together to discuss lessons from the past and how we should progress in the future, reaching as wide an audience as possible. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Veterinary Research Club |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of the data generated and its importance in understanding immune responses to vaccination and natural infections. About 50 veterinarians and researchers working in veterinary sciences attended the one-day meeting, which initiated discussions about the possibility of generating new vaccines against BRSV. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Veterinary Times article on morbillivirus vaccines. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was interviewed by a journalist from The Veterinary Times about our recent Journal of Virology research paper on morbillivirus host-range. This was then written up for the next edition of this publication. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.vettimes.co.uk/news/scientists-multi-purpose-ppr-vaccine-closer-to-completion/ |
| Description | Virtual video tour of the animal facilities in Pirbright |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Contributed to public understanding of animal research by being interviewed on the virtual video tour of the animal facilities in Pirbright - one of only four such initiatives in the UK. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Visit to Cairo Poultry Company (CPC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Discussion and talk on prevention and control of poultry diseases (avian influenza and Newcastle Disease) and molecular factors affecting vaccine efficacy. The discussion and talk to present data, describing factors the directly influence protective efficacy of in use vaccines, and how they evaluate/ test vaccine failure. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Volunteered at a school open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I represented The Pirbright Institute talking at a school about my research and what it is like to be a research scientist. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Volunteering at Royal Society Summer Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Several members of the team volunteered to help at the Royal Society's Summer Science Festival, working on Pirbright's stand to talk about virology, zoonosis and Covid with the general public. |
| Year(s) Of Engagement Activity | 2022 |
| Description | WACCBIP Ghana (TT) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana. Workshops on cell biology of pathogens and career development. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | Why vaccines matter in the fight against zoonotic diseases |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A news story was published to increase the awareness of Zoonotic diseases and their impact on public health, food security, the economy and the environment. This was publicised at The Pirbright Institute webpage and One Health Poultry Health webpage and distributed wildly on social media including Facebook, Twitter, In Share. On World Zoonoses Day, Pirbright's Professor Munir Iqbal and Dr Joshua Sealy consider 600 years of developing technology to fight infectious diseases: The history of human and animal immunisation against infectious disease begins with the Chinese practice of variolation in the fifteenth century. Here, infectious material was taken from one patient and inoculated into a non-infected patient to initiate a mild but protective infection. Roughly 200 years later, Edward Jenner transformed the field of immunology by developing the world's first vaccine which involved immunising patients against smallpox using the closely related cowpox. Fast-forward another 200 years and the application of vaccines had transformed. On 6 July 1885, now celebrated as World Zoonoses Day, Louis Pasteur successfully administered the first vaccine against rabies - and within decades myriad other diseases had also been tackled effectively, including diphtheria, tetanus, anthrax, cholera, plague, typhoid, tuberculosis, measles, mumps, rubella, and polio. Many of these pathogens had been infecting humans for years, and continue to do so where vaccines are not deployed. Now, in the 21st century, vaccine research is undergoing another seismic shift. In 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the virus that causes COVID-19), emerged in humans which is believed to have originated in animals (known as zoonoses). It has since developed into the devastating COVID-19 pandemic and in doing so it triggered an urgent need to develop vaccines to control a virus that represents a growing problem at the human-animal interface. Pathogen evolution: Broadly speaking, humans have a naïve immune system to the many pathogens that exclusively circulate within animal reservoirs, including livestock. Most pathogens have evolved to infect specific animal species, which means that a significant barrier exists that prevents animal pathogens from causing disease in humans. However, a portion of these pathogens, including influenza viruses and coronaviruses, have the capacity to evolve such that they can overcome these barriers and be successful, especially as there is no prior immunity in the human population. This extraordinary ability to evolve also means that these pathogens have the potential to overcome vaccines. The application of vaccines and vaccine technology must progress to meet the challenge of zoonotic viruses. Vaccine variety: An impressive diversity of vaccine technologies is currently employed or in development to combat pathogens circulating in humans and animals. A vaccine needs to be effective at eliminating or reducing disease, but the diversity of pathogens means vaccines sometimes need to be equally diverse and must cater to specific challenges. Traditional inactivated pathogen vaccines are generated by 'killing' a pathogen so that it can be safely administered for immunisation. Subunit vaccines are vaccines that comprise only a fragment of the target pathogen which can be administered to generate an immune response exclusively to that fragment. Both technologies elicit protective antibody responses and have been successful for an exceptionally long time against a variety of pathogens. However, an antibody response does not provide sufficient protection against all pathogens that continually change their shapes to evade vaccines. Live attenuated vaccines typically use infectious pathogens that are modified to prevent them from causing disease but can still trigger an immune response similar to their naturally occurring counterparts. These vaccines are useful because as well as an antibody response, they can induce a cellular immune response, which targets conserved parts of the pathogens that remain the same across different strains. This means live attenuated vaccines are more effective at protecting against mutations that could allow the pathogen to escape vaccine immunity and they provide better protection against multiple pathogen strains. New vaccine technology: Viral vector vaccines are vaccines that comprise the 'backbone' of a virus that doesn't cause disease in the host animal, which expresses a piece of the target pathogen that induces an immune response. Most licensed viral vector vaccines are in use in animals, with only a single vectored vaccine (against the Ebola virus) being licensed for humans prior to the SARS-CoV-2 pandemic. Viral vector vaccines evoke a strong immune response that is specific to the pathogen, making it effective and long-lasting. DNA/RNA vaccines contain genetic material that codes for a piece of a pathogen, which the host cells process to elicit an immune response. Several mRNA vaccines are in use against SARS-CoV-2 and they are cost-effective, safe, and produced using chemicals synthetically and not from cell culture systems. As such, we now have the capacity to carefully select the target of our vaccines and the nature of the desired immune response. The importance of vaccines was brought into focus once again with the SARS-CoV-2 pandemic - and, going forward, the need for our growing arsenal of vaccines will only increase with the needs of humanity. Nutrition: As the human population increases so do its need for nutrition. A major source of human nutrition is animal-derived; thus, the population of farmed animals increases. Wild habitats are encroached upon to provide for the increasing population of farmed animals, and this facilitates interaction between farmed and wild animals. Consequently, we develop a tractable route for zoonotic diseases to enter the human population. Finally, the need for human nutrition is also met through the acquisition of wild animals. There is evidence to suggest that the West African Ebola virus epidemic was preceded by the capture of wild animals for human consumption. Likewise, SARS-CoV-2 is believed to have originated in wild animals. Zoonotic diseases clearly have far-reaching impacts. Humans and animals directly suffer pathogen-related sickness and death, and global economies incur significant losses. The current SARS-CoV-2 pandemic is a clear example of this - while avian influenza and several other emerging and re-emerging viruses carrying zoonotic infection potential circulating in farmed and wild birds are a constant reminder that the next pandemic could be around the corner. Written by Professor Munir Iqbal and Dr Joshua Sealy, members of the Avian Influenza Virus group at Pirbright. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.pirbright.ac.uk/news/2021/07/why-vaccines-matter-fight-against-zoonotic-diseases |
| Description | Why wet markets will never close - despite the global threat to human health (The Telegraph) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | This discussion was due to current enormous global spread of bird flu and widespread poultry outbreak has generated unprecedented opportunities for the virus to jump to humans and potentially even mutate to better spread between people. Since the Live bird markets have been identified as key factors in the spread, persistence and evolution of avian influenza viruses,. Therefore, there is an increased risk to public at the live birds markets and how these risks can be reduced to increase food safety, security and public health. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.telegraph.co.uk/global-health/science-and-disease/why-wet-markets-will-never-close-despi... |
| Description | Winston Churchill Careers Fair. Winston Churchill School, Hermitage Road, St Johns, Woking, Surrey, GU21 8TL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | AS attended and presented at this event to stimulate increased interest in science and research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Winston Churchill School Career Event - ND |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A careers event at a local school for yeat 7 to 11 students about Pirbright, what we do, the kinds of careers they can get into and routes to those careers. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Winston Churchill School Careers Fair - Jennifer Simpson |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Fielded questions from school students, stimulating increased interest in science and research. This also increased the visibility of the Pirbright Institute. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Winston Churchill School careers event - PP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Students visited a stand run by The Pirbright Institute to learn about careers in science and the work we do at Pirbright, including a microscope demonstration. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Wired interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media interview regarding use of gene drive systems in mosquitoes |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.wired.co.uk/article/genetically-modified-mosquitoes-gene-drive |
| Description | Woking School Careers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Stimulating increased interest in science and research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Workshop with MSc students in Veterinary Microbiology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Both PI and postdoctoral scientists employed on projects participated in a 1 week workshop of MSc students from the University of Surrey including training activities within the high containment facilities |
| Year(s) Of Engagement Activity | 2017,2018,2019,2020 |
| Description | World Dengue Day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was the inaugural World Dengue Day, an annual multi-day series of events to raise awareness of the global impact of dengue. The event raised awareness of dengue globally and sparked interest from a number of attendees in our research. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.adva.asia/world-dengue-day-2021/ |
| Description | World One Health Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online presentation at World One Health Congress conference on morbillivirus inter-species transmission |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://worldonehealthcongress.org/ |
| Description | World Vaccine Congress Talk on Nipah virus vaccines |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on our Innovate funded work on Nipah vaccines - which we have developed and tested in pigs. |
| Year(s) Of Engagement Activity | 2021 |
| Description | World Zoonosis Day 2018 - web story |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Contributed to an article from our institute on World Zoonosis Day highlighting the importance of research in this area. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pirbright.ac.uk/news/2018/07/pirbright-scientists-are-developing-vaccine-candidates-anim... |
| Description | a talk at the Recently Independent Virology Investigators meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talks outlining my current research and future plans. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| Description | email interview with journalist (Sukanya Charuchandra, The Wire) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Email interview for journalist for "The Wire" - an online technology-focused media outlet. Helped provide context and impact for the resulting piece. https://thewire.in/the-sciences/scientists-identify-protein-that-mosquitoes-need-to-lay-viable-eggs |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://thewire.in/the-sciences/scientists-identify-protein-that-mosquitoes-need-to-lay-viable-eggs |
| Description | international workshop on "Self-Propagation of Artificial Genetic Elements: Gene Drives, Risks & Tipping Points Bremen 19-20 June 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Workshop considering regulatory, social and technical environment for gene drive systems in insects, primarily for German and other EU regulatory and political entities. |
| Year(s) Of Engagement Activity | 2018 |
| Description | organised workshops at Microbiology Society annual conferences 2014 - 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | I co-organised virology division workshops on viral evolution and diversity and RNA viruses with colleagues from the virology division. The workshops were held at the annual Microbiology Society conferences in spring each year. Organisation involved selecting abstracts for oral or poster presentation, ordering the presentations and chairing the sessions. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018 |
| Description | talk to the U3A |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a talk to the University of the 3rd Age (U3A)- a group of the general public above the age of 65. |
| Year(s) Of Engagement Activity | 2016 |