Ambulatory microdialysis sampling system
Lead Research Organisation:
University of Bristol
Department Name: Henry Wellcome LINE
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Stafford Lightman (Principal Investigator) |
Publications
Bhake R
(2020)
Continuous Free Cortisol Profiles in Healthy Men.
in The Journal of clinical endocrinology and metabolism
Bhake RC
(2019)
Continuous Free Cortisol Profiles-Circadian Rhythms in Healthy Men.
in The Journal of clinical endocrinology and metabolism
Upton TJ
(2023)
High-resolution daily profiles of tissue adrenal steroids by portable automated collection.
in Science translational medicine
Stirrat LI
(2018)
Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity.
in Clinical endocrinology
| Description | Both patient support groups and researchers have used our data as a basis to reconsider the best way to diagnose and treat endocrine diseases |
| First Year Of Impact | 2023 |
| Sector | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | Novel diagnostic methodologies |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Improved diagnostic pathways |
| Description | EU Horizon 2020 grant - Ultradian |
| Amount | € 5,999,381 (EUR) |
| Funding ID | Programme/Call: H2020 - H2020-PHC-2014, Proposal: 633515 - ULTRADIAN |
| Organisation | European Union |
| Sector | Public |
| Country | European Union (EU) |
| Start | 08/2015 |
| End | 08/2020 |
| Description | Neonatal programming of pubertal delay: a novel neural interaction between corticotrophin-releasing hormone and kisspeptin |
| Amount | £456,779 (GBP) |
| Funding ID | BB/F007396/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2007 |
| End | 09/2010 |
| Title | Novel automated sampling system |
| Description | Miniaturized ambulatory microdialysis sampling system |
| Type Of Material | Biological samples |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Currently under international assessment |
| Description | Miniaturised ambulatory microdialysis infusion collection device |
| Organisation | Designworks |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Industrial partner |
| Collaborator Contribution | Development of device to a stage ready for commercial development |
| Impact | EU Horizon 2020 - Dynamic hormone diagnostics (ULTRADIAN) - 5,999,381 EUR - 1.9.15 - 30.8.19 |
| Start Year | 2014 |
| Title | The device is protected by a UK patent, titled Fluid Sampling Apparatus and Method, P115838GB, which was filed in September 2012 |
| Description | Automated sampling system |
| IP Reference | P115838GB UK jurisdiction |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | 24 hour sampling in the home is now possible |
| Company Name | Dynamic Therapeutics Ltd |
| Description | |
| Year Established | 2023 |
| Impact | The device has already had a marked impact on the endocrinology and chronobiology research communities as it allows 24 hour monitoring of hormones, metabolites and drugs in subjects in their own home/work environments. This will immediately improve patient involvement ( patient support groups from UK, Europe and the US are already in direct communication with us), and will improve both diagnostic procedures and therapeutic strategies . initially in endocrine disease-but in future in hypertension and Diabetes mellitus. |
| Description | Bristol Neuroscience Festival - Lecture on "The importance of rhythm for stress and the brain" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Part of the University of Bristol's outreach programme. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Public Lecture held at The Physiological Society in London and streamed world-wide on Facebook Live - The Physiology of Stress - Science of Stress. Lecture on "Mechanisms of stress" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This is the first time that The Physiological Society has streamed a public lecture for a world-wide audience. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk to Bristol Pituitary Support Group at Southmead Hospital |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | An active discussion on recent advances in treating patients with disrupted hormone secretion |
| Year(s) Of Engagement Activity | 2017 |
| Description | The importance of hormone dynamics in therapies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presentation followed by discussion about the importance of patterns of hormone replacement for best patient wellbeing. |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of Utrecht - Stress and Disorders of the Brain. Lecture on "Corticosteroid rhythms and replacement strategies" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Part of EU outreach programme |
| Year(s) Of Engagement Activity | 2016 |