UoCardiff Confidence in Concept 2013
Lead Research Organisation:
CARDIFF UNIVERSITY
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
- CARDIFF UNIVERSITY (Lead Research Organisation)
- UNIVERSITY OF EDINBURGH (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Aber Instruments (Collaboration)
- KEELE UNIVERSITY (Collaboration)
- GE Healthcare Limited (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- Nagoya University (Collaboration)
People |
ORCID iD |
| Bryan Paul Morgan (Principal Investigator) |
Publications
Aufricht C
(2017)
Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network.
in Kidney international
Carpanini SM
(2019)
Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System.
in Frontiers in immunology
Chavez R
(2016)
Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment
in Journal of Histology and Histopathology
Cuff S
(2018)
An improved cell-permeable fluorogenic substrate as the basis for a highly sensitive test for NAD(P)H quinone oxidoreductase 1 (NQO1) in living cells.
in Free radical biology & medicine
Eberl M
(2014)
Pathogen-Specific Immune Fingerprints during Acute Infection: The Diagnostic Potential of Human ?d T-Cells.
in Frontiers in immunology
Howard J
(2017)
The Antigen-Presenting Potential of V?9Vd2 T Cells During Plasmodium falciparum Blood-Stage Infection
in The Journal of Infectious Diseases
Jiang L
(2020)
Liposomes loaded with transforming growth factor ß1 promote odontogenic differentiation of dental pulp stem cells.
in Journal of dentistry
Jordan RP
(2016)
An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens.
in Journal of dentistry
Khalid U
(2015)
A Localized Ischemic Preconditioning Regimen Increases Tumor Necrosis Factor a Expression in a Rat Model of Kidney Ischemia-Reperfusion Injury.
in Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
Khalid U
(2014)
Acute kidney injury: a paradigm for miRNA regulation of the cell cycle.
in Biochemical Society transactions
| Description | 747278 ILTIS - Innate-Like T-Cells In Sepsis (ILTIS): Implications for Early Diagnosis and Rescue of Immune Suppression. |
| Amount | € 97,727 (EUR) |
| Funding ID | 747278 ILTIS |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2017 |
| End | 08/2018 |
| Description | ACCELERATE |
| Amount | £468,913 (GBP) |
| Organisation | Government of Wales |
| Department | Welsh European Funding Office |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 03/2021 |
| Description | Elucidation of the downstream signalling mechanisms by which epoxy-tiglianes promote preferential dermal wound healing responses |
| Amount | £166,000 (GBP) |
| Organisation | QBiotics |
| Sector | Private |
| Country | Australia |
| Start | 09/2019 |
| End | 12/2020 |
| Description | Health Technology Challenge Fund |
| Amount | £25,000 (GBP) |
| Organisation | South East Wales Academic Health Sciences Partnerships |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 05/2017 |
| Description | Identifying a microRNA signature of Chronic Kidney Disease (CKD) progression in blood and urine |
| Amount | £255,000 (GBP) |
| Organisation | UCB Pharma |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Description | Immune fingerprints in haemodialysis patients with acute infection |
| Amount | £49,995 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2018 |
| End | 02/2019 |
| Description | Innate-like T-cells in sepsis (ILTIS): Implications for early diagnosis and rescue of immune suppression |
| Amount | £80,000 (GBP) |
| Funding ID | 747278-ILTIS-H2020-MSCA-IF-2016 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 06/2017 |
| End | 06/2018 |
| Description | Life Science Bridging Fund |
| Amount | £75,000 (GBP) |
| Organisation | Government of Wales |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 02/2017 |
| Description | Life Sciences Bridging Fund |
| Amount | £75,000 (GBP) |
| Organisation | Government of Wales |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 07/2017 |
| Description | MRC |
| Amount | £534,009 (GBP) |
| Funding ID | MR/N023145/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2016 |
| End | 11/2019 |
| Description | Machine-learning guided immune fingerprinting for rapid detection of life-threatening infection in liver cirrhosis |
| Amount | £60,000 (GBP) |
| Funding ID | 2122971 |
| Organisation | Cardiff University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2021 |
| Description | Sepsis and the newborn's immune system - Linking microbiome metabolites to protective immunity |
| Amount | £60,000 (GBP) |
| Organisation | Cardiff University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2021 |
| Description | Systemic immune fingerprints in patients with acute severe sepsis |
| Amount | £60,000 (GBP) |
| Organisation | Cardiff University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2021 |
| Description | Tenovus PhD Studentship |
| Amount | £90,000 (GBP) |
| Organisation | Tenovus Cancer Care |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Title | Assays for complement biomarkers |
| Description | Immunoassays for complement-mediated pathologies |
| Type Of Material | Antibody |
| Provided To Others? | No |
| Impact | New assays available |
| Title | Cell therapy |
| Description | Cellular immunotherapy reagent |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | Intervention in pathologies reliant on gamma delta T cells |
| Title | miR detection in wound fluid |
| Description | Collection of wound fluid and demonstration of presence of miR biomarkers |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Stratification of non-healing wounds |
| Title | urine miRs |
| Description | Method for detecting microRNAs in urine to measurement in organ perfusate |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | Development of methods for early detection of nephropathy |
| Description | Aber Instruments Collan |
| Organisation | Aber Instruments |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Industry scoping |
| Collaborator Contribution | Strategic input and technical expertise |
| Impact | molecular diagnostics and engineering for detection |
| Start Year | 2017 |
| Description | Fraser/Ploeg |
| Organisation | University of Oxford |
| Department | Quality in Organ Donation |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Exchange of knowledge and data |
| Collaborator Contribution | Exchange of knowledge and data. Biobank samples. |
| Impact | Availability of samples |
| Start Year | 2014 |
| Description | Morgan/Lambie |
| Organisation | Keele University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Exchange of knowledge and data |
| Collaborator Contribution | Exchange of knowledge and data |
| Impact | Data analysis |
| Start Year | 2014 |
| Description | Morgan/Mizuno |
| Organisation | Nagoya University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Exchange of knowledge and data |
| Collaborator Contribution | Exchange of knowledge and data |
| Impact | Replication sets |
| Start Year | 2014 |
| Description | Moser/Steven |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Exchange of knowledge and data |
| Collaborator Contribution | Exchange of knowledge and data |
| Impact | Manufacture of clinical grade cells |
| Start Year | 2014 |
| Description | Stevens/Hughes |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Inflammation Research |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Exchange of knowledge and data |
| Collaborator Contribution | Exchange of knowledge and data |
| Impact | N/A |
| Start Year | 2014 |
| Description | Weeks/GE |
| Organisation | GE Healthcare Limited |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Exchange of knowledge and data |
| Collaborator Contribution | Exchange of knowledge and data. Availability of sampling materials. |
| Impact | Sampling methods |
| Start Year | 2014 |
| Title | CHRONIC KIDNEY DISEASE DIAGNOSTIC |
| Description | The invention relates to a diagnostic method for determining at least one of, or a combination of, the following: has-miR-155-5p, hsa-miR-126-3p and has-miR-29b-3p in a urine sample for determining the existence of, or progression of, chronic kidney disease in a subject; and a kit of parts for undertaking said method. |
| IP Reference | WO2017129977 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | n/a |
| Title | Kidney Disease Diagnostic |
| Description | Detection of micro RNA biomarkers in urine as an early marker of nephropathy |
| IP Reference | |
| Protection | Patent application published |
| Year Protection Granted | |
| Licensed | Commercial In Confidence |
| Impact | None yet |
| Title | Non-invasive test for bladder cancer |
| Description | Urine test for the detection and monitoring of bladder cancer. Used to test >100 urine samples with clinical correlation. Recently funded by external investment presently negotiating renewal of funding |
| Type | Diagnostic Tool - Non-Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2014 |
| Development Status | Actively seeking support |
| Impact | Potential for use in other diagnostic tests |
| Description | Public lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Public Lecture for the Welsh Livery Guild |
| Year(s) Of Engagement Activity | 2016 |
| Description | Public lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lecture for Welsh Livery Guild |
| Year(s) Of Engagement Activity | 2015 |