Nanoparticles for the Targeted Delivery of Therapeutic Agents to the Brain for the Treatment of Dementias.
Lead Research Organisation:
King's College London
Department Name: Pharmaceutical Sciences
Abstract
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Organisations
People |
ORCID iD |
| Margaret Lawrence (Principal Investigator) |
Publications
Campbell F
(2011)
Non-viral, coated nanoparticles as vectors for gene therapy
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Campbell F
Polymer coated, targeted lipopolyplexes - a versatile non-viral gene vector
in To be decided
Dabkowska AP
Interaction of lipoplexes with early and late stage endosomal model membranes
in Molecular Pharmaceutics
Kudsiova L
(2016)
Delivery of siRNA using ternary complexes containing branched cationic peptides: the role of peptide sequence, branching and targeting.
in Molecular bioSystems
Kudsiova L
(2011)
Effect of the helper lipid DOPE on endosomal membrane integrity
in HUMAN GENE THERAPY
Kudsiova L
Comparing the delivery of anionic and cationic lipopolyplexes to the brain by convection enhanced delivery
in International Journal of Pharmaceutics
Welser K
(2013)
Tailoring Nanocomplexes for the Delivery of Plasmid DNA or siRNA: The Role of Cationic Peptide Sequence and Branching
in Biopolymers
Welser K
(2013)
Gene delivery using ternary lipopolyplexes incorporating branched cationic peptides: the role of Peptide sequence and branching.
in Molecular pharmaceutics
| Description | We have discovered for the first time, that the use of trichain cationic lipids, as opposed to their more usual dichain equivalents, produces delivery vehicles using our novel preparation process that exhibits a much enhanced level of DNA transfection in the target cells. In addition we have found that the use of salt to prepare the gene delivery vehicles can improve DNA deliver. The information from the research is being used by researchers including ourselves in academia and the pharmaceutical industry to guide their formulation of nucleic acids. |
| Exploitation Route | The information we have found can be used to prepare significantly improved gene delivery vehicles - the novel lipids have significant implications for the preparation of improved delivery vehicles. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | In addition to the data obtained being published in the form of scientific papers and presented in the form of talks and posters at major national and international conferences it has been used to inform a variety of work around public engagement (Cheltenham Festival of Science) and public information (web-sites including bloging sites). The information obtained from the study has been invaluable in preparing improved vehicles to delivery siRNA and DNA for the ultimate benefit of the patient. The information from the research is being used by researchers including ourselves in academia and the pharmaceutical industry to guide their formulation of nucleic acids. |
| First Year Of Impact | 2009 |
| Sector | Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Cultural Societal Policy & public services |
| Description | Kings College London |
| Amount | £76,000 (GBP) |
| Funding ID | King's China Overseas Research Student Awards |
| Organisation | King's College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2011 |
| End | 12/2014 |
| Description | Neutron beam time |
| Amount | £60,000 (GBP) |
| Funding ID | RB1120431; RB1120399; RB1210318 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Department | ISIS Neutron and Muon Source |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2011 |
| End | 12/2011 |
| Description | Neutron beam time |
| Amount | £30,000 (GBP) |
| Funding ID | RB1220386; RB1220379 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Department | ISIS Neutron and Muon Source |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 03/2012 |
| Description | Neutron beam time |
| Amount | £70,000 (GBP) |
| Funding ID | ILL 8-02-577; ILL 8-02-579; RB1110429; RB1110440 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Department | ISIS Neutron and Muon Source |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 12/2010 |
| Description | Neutron beam time |
| Amount | £20,000 (GBP) |
| Funding ID | RB920412 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Department | ISIS Neutron and Muon Source |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2009 |
| End | 10/2010 |
| Description | 2015 British Science Festival Panel Debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Debate panel member at the 2015 British Science Festival, Bradford. Debate entitled 'Developing effective medicines in the modern age'. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cheltenham Science Festival, invited panelist in public debate about genetic medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Our presentations as part of the debate sparked lots of questions and discussion Invited to further debates |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deuteration Laboratory, Science Technology Facilities Council |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 'Modelling the Cellular Fate of Gene Delivery Vehicles' (2015) ISIS Deuteration Facility Meeting, Oxford Spires Four Pillars, Oxford. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Drugs, genes and ethics - invited lecture (KIng's College London) to 14-16 year olds |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Students commented that they enjoyed the presentation as it gave them a new insight into gene delivery As yet unknown |
| Year(s) Of Engagement Activity | 2014 |
| Description | Formulation and Drug Delivery Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 'Rational Design of Complexes for Gene Delivery: A Case Study' (2015) Formulation and Drug Delivery Congress, London. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Invited presentation at International Review of ISIS, Rutherford Appleton Laboratories, Didcot. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation (entitled molecules, membranes and medicines) was for the purposes of the international review of ISIS and was well received by the panel as an example of international research performed at ISIS. The presentation contributed to the excellent report the neutron facility at ISIS received from the review |
| Year(s) Of Engagement Activity | 2013 |
| Description | Invited presentation at PharmSci Fair, Prague, Czech Republic: Nanoparticles: their Potential in Delivering Therapeutic Molecules |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Presentation stimulated discussion and initiated a collaboration between ourselves and another speaker Good feedback from the conference organisers regarding presentation |
| Year(s) Of Engagement Activity | 2011 |
| Description | Invited presentation of Work at Interpharm - Joint Academic Industrial Meeting of Senior People in the Pharmaceutical Field |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk sparked interest from several industries and which resulted in joint research being undertaken An opportunity to promote the research to a wide range of people in the pharmaceutical industry |
| Year(s) Of Engagement Activity | 2012 |
| Description | Invited presentation to Nanocolloid meeting, Amsterdam, Holland 'Rationale Design of Ternary Nanocomplexes for Gene Delivery' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Presentation stimulated considerable discussion afterwards and sparked at least two collaborations Collaboration initiated between our group and that of Prof. Dganit Danino (Technicon, Isreal) around cryoelectron microscopy |
| Year(s) Of Engagement Activity | 2012 |
| Description | Molecules, Membranes and Medicines |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented talk entitled 'Molecules, Membranes and Medicines: Where Are We Now?' (2015) to Science Technology Facilities Council Science Board, Swindon. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Schools visit (Bishop Wand School, Sunbury, Middlesex) RE lesson taken |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Presentation greatly stimulated debate about gene therapy amongst the students (aged 14-16) School reported back that the students has been challenged to think about things in a completely different way by the presentation |
| Year(s) Of Engagement Activity | 2012 |
| Description | Swedish Chemical Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 'Gene Delivery and the Interaction of DNA with Biomembranes: Neutron and X-Ray Scattering' (2014) Realizing Reformulation - A Symposium on Surface and Materials Chemistry, Swedish Chemical Society, Lund, Sweden. |
| Year(s) Of Engagement Activity | 2014 |