Water exchange in the vasculature of the brain (WEX-BRAIN)
Lead Research Organisation:
University of Leeds
Department Name: School of Medicine
Abstract
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Organisations
People |
ORCID iD |
| David Buckley (Principal Investigator) |
| Description | Diffusion MRI methods can be used to measure water exchange across the blood-brain barrier in the healthy brain. - Contrast-enhanced arterial spin labelling provides a potential alternative strategy for assessing subtle blow-brain barrier permeability to water. - Water exchange methods are sensitive to blood-brain barrier disruption caused by lung infection. |
| Exploitation Route | Application in a range of neurological diseases to probe subtle blood brain barrier involvement, potentially as an early marker of disease. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | We have been involved in a number of public engagement activities that have helped inform members of the public of the role that MRI plays in diagnosing neurological diseases. |
| First Year Of Impact | 2021 |
| Sector | Education |
| Impact Types | Societal |
| Description | The impact of water exchange on measures of myocardial blood flow and extracellular volume by contrast-enhanced MRI |
| Amount | £203,700 (GBP) |
| Funding ID | PG/20/10008 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2024 |