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Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.

Lead Research Organisation: University of Warwick
Department Name: Chemistry

Abstract

This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.

This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.

People

ORCID iD
Tomos Morgan (Student)

Publications

10 25 50
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Lam YPY (2018) Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation? in Chemical communications (Cambridge, England)

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Van Agthoven M (2018) Can Two-Dimensional IR-ECD Mass Spectrometry Improve Peptide de Novo Sequencing? in Analytical Chemistry

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Wootton CA (2018) Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes. in Chemical science

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Morgan T (2018) Coupling Electron Capture Dissociation and the Modified Kendrick Mass Defect for Sequencing of a Poly(2-ethyl-2-oxazoline) Polymer in Analytical Chemistry

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Banerjee S (2018) New activation mechanism for half-sandwich organometallic anticancer complexes. in Chemical science

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Floris F (2018) Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin. in Journal of the American Society for Mass Spectrometry

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Lermyte F (2019) MIND: A Double-Linear Model To Accurately Determine Monoisotopic Precursor Mass in High-Resolution Top-Down Proteomics. in Analytical chemistry

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Van Agthoven MA (2019) Phase relationships in two-dimensional mass spectrometry. in Journal of the American Society for Mass Spectrometry

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Wootton CA (2019) Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation. in The Analyst

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Van Agthoven MA (2019) Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry. in European biophysics journal : EBJ

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/P510695/1 30/09/2016 31/12/2021
1837376 Studentship EP/P510695/1 30/09/2016 29/03/2020 Tomos Morgan