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Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.

Lead Research Organisation: University of Warwick
Department Name: Chemistry

Abstract

This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.

This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.

People

ORCID iD
Tomos Morgan (Student)

Publications

10 25 50
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Marzullo B (2020) Advantages of Two-Dimensional Electron-Induced Dissociation and Infrared Multiphoton Dissociation Mass Spectrometry for the Analysis of Agrochemicals in Analytical Chemistry

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Floris F (2018) Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin. in Journal of the American Society for Mass Spectrometry

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Van Agthoven M (2018) Can Two-Dimensional IR-ECD Mass Spectrometry Improve Peptide de Novo Sequencing? in Analytical Chemistry

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Marzullo B (2020) Comparison of Fragmentation Techniques for the Structural Characterization of Singly Charged Agrochemicals in Analytical Chemistry

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Morgan T (2018) Coupling Electron Capture Dissociation and the Modified Kendrick Mass Defect for Sequencing of a Poly(2-ethyl-2-oxazoline) Polymer in Analytical Chemistry

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Lam YPY (2020) Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry. in Journal of the American Society for Mass Spectrometry

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Lam YPY (2020) Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation? in Chemical communications (Cambridge, England)

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Lam YPY (2018) Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation? in Chemical communications (Cambridge, England)

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Morgan TE (2020) Electron Capture Dissociation of Trithiocarbonate-Terminated Acrylamide Homo- and Copolymers: A Terminus-Directed Mechanism? in Analytical chemistry

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Lermyte F (2019) Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. in Cells

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/P510695/1 30/09/2016 31/12/2021
1837376 Studentship EP/P510695/1 30/09/2016 29/03/2020 Tomos Morgan