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Genomic of vector borne diseases: from pathogens to mosquitoes

Lead Research Organisation: London School of Hygiene and Tropical Medicine
Department Name: Infectious and Tropical Diseases

Abstract

Mosquito-borne diseases are a major challenge for public health. Malaria, caused by parasites transmitted by Anopheles mosquitoes, was responsible for 435 000 deaths in 2017. Arboviruses, such as Dengue, Zika and Chikungunya transmitted by Aedes mosquitos, are causing major outbreaks around the world. Insecticide resistance, with its genetic underpinning, has increased rapidly in prevalence and threatens vector control. Similarly, mutations in pathogens can lead to drug-resistance and adaptation to new vectors, affecting disease control. Genomics can be used to investigate changes in the genetic diversity of both mosquitos and pathogens and increase knowledge of their biology and evolution.

People

ORCID iD

Publications

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Collins E (2022) A next generation targeted amplicon sequencing method to screen for insecticide resistance mutations in Aedes aegypti populations reveals a rdl mutation in mosquitoes from Cabo Verde in PLOS Neglected Tropical Diseases

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Acford-Palmer H (2023) Application of a targeted amplicon sequencing panel to screen for insecticide resistance mutations in Anopheles darlingi populations from Brazil

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Acford-Palmer H (2023) Detection of insecticide resistance markers in Anopheles funestus from the Democratic Republic of the Congo using a targeted amplicon sequencing panel. in Scientific reports

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Moss S (2024) Genomic surveillance of Anopheles mosquitoes on the Bijagós Archipelago using custom targeted amplicon sequencing identifies mutations associated with insecticide resistance. in Parasites & vectors

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Acford-Palmer H (2023) Identification of two insecticide resistance markers in Ethiopian Anopheles stephensi mosquitoes using a multiplex amplicon sequencing assay targeting vgsc, rdl, gste2 and ace1 loci

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Acford-Palmer H (2023) Identification of two insecticide resistance markers in Ethiopian Anopheles stephensi mosquitoes using a multiplex amplicon sequencing assay. in Scientific reports

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Collins E (2024) Profiling insecticide resistance phenotypes and genotypes in Aedes aegypti populations across four regions in Puerto Rico

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Kristan M (2023) Towards environmental detection, quantification, and molecular characterization of Anopheles stephensi and Aedes aegypti from experimental larval breeding sites. in Scientific reports

Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M009513/1 30/09/2015 31/03/2024
2241712 Studentship BB/M009513/1 30/09/2019 29/09/2023