Small molecule tools to target glucose metabolism in non-alcoholic fatty liver disease
Lead Research Organisation:
Newcastle University
Department Name: Sch of Natural & Environmental Sciences
Abstract
This project aims to modulate glucokinase using small molecule tools to determine whether a reduction in hepatic glucokinase activity has the desired effect of halting the progression of non-alcoholic fatty liver disease. More specifically this project involves the design and synthesis of small molecule inhibitors that target glucokinase, from 3 chemical series validated by a high-throughput screening.
People |
ORCID iD |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/T517914/1 | 30/09/2020 | 29/09/2025 | |||
| 2744284 | Studentship | EP/T517914/1 | 30/09/2022 | 29/09/2026 |