fusing MEDICAL IMAGES and CFD for precision VASCULAR INTERVENTIONS (MEDICARE)
Lead Research Organisation:
UNIVERSITY COLLEGE LONDON
Department Name: Mechanical Engineering
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Stokes C
(2023)
Aneurysmal growth in type-B aortic dissection: assessing the impact of patient-specific inlet conditions on key haemodynamic indices.
in Journal of the Royal Society, Interface
Franzetti G
(2022)
Experimental evaluation of the patient-specific haemodynamics of an aortic dissection model using particle image velocimetry.
in Journal of biomechanics
Girardin L
(2024)
Patient-specific compliant simulation framework informed by 4DMRI-extracted pulse wave Velocity: Application post-TEVAR.
in Journal of biomechanics
Girardin L
(2024)
Patient-Specific Haemodynamic Analysis of Virtual Grafting Strategies in Type-B Aortic Dissection: Impact of Compliance Mismatch
in Cardiovascular Engineering and Technology
Stokes C
(2023)
The Influence of Minor Aortic Branches in Patient-Specific Flow Simulations of Type-B Aortic Dissection.
in Annals of biomedical engineering
| Description | We found out what are the best surgical strategies to treat TBAD |
| Exploitation Route | Next phase would be a clinical trial |
| Sectors | Healthcare |
| Description | Research Excellence (round 4) - University College London |
| Amount | £3,000,000 (GBP) |
| Funding ID | RE/24/130013 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2024 |
| End | 09/2029 |
| Description | BBSRC Institutional Award - PHYSICS- INFORMED, DATA DRIVEN TOOLS FOR FAST HEMODYNAMIC PROTOTYPING |
| Organisation | University of Bern |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | We seek to consolidate a world-class collaboration with Swiss partners, enabled by previous BBSRC international partnership funds, to further develop an image driven, computational framework for vascular pathologies. We aim to capitalise on the success of our previous knowledge exchange and achievements to develop fast physics-informed, data driven computational tools to extract hemodynamic information from clinical images in real time, to accelerate diagnosis and personalised intervention planning through the tailoring of medical devices. The world-class expertise of our Swiss partner on clinical imaging, rich patient datasets on complex pathologies, such as aortic dissection and peripheral arteriovenous malformations (AVMs), and access to imaging facilities therein provide an ideal springboard for our vision towards personalised vascular interventions. |
| Collaborator Contribution | The Swiss team is led by Prof. Hendrik von Tengg-Kobligk, Professor of Radiology and Vice Chair of Diagnostic, Interventional and Pediatric Radiology Inselpital, Bern University Hospital. He is an expert in cardiovascular imaging, particularly hemodynamic analysis using 4D MR flow, disease prediction and risk. The University Hospital Bern hosts a Swiss AVM Malformation Centre and a Centre for Endovascular Aortic Repair; they are high volume centres for both conditions and have world-class clinical expertise, rich sets of clinical data, and patient groups that our group benefitted from. The UCL-Bern partnership funded by the one year BBSRC International partnership programme (MEDICARE, BB/X005062/1) stimulated significant knowledge exchange, access to unprecedent patient datasets and access to clinical imaging facilities. It allowed us to fuse 4DMR clinical data with computational models, develop novel computational approaches and explore the link between hemodynamic indices to aneurysmal growth in aortic dissection, leading to two publications in prestigious journals (Stokes et al 2023a, b) and one about to be submitted. Research exchanges between Bern and UCL and two workshops, one patient led at UCL and one held in Bern, stimulated further discussions with patients, clinicians, other academics and SMEs across Europe. |
| Impact | Journal papers and Conference papers as described in the relevant section, multidisciplinary The relevant publications have University Hospital Bern as a partner |
| Start Year | 2022 |
| Description | Collaboration with Inselspital Bern for future applications, including EU grants |
| Organisation | University Hospital of Bern |
| Country | Switzerland |
| Sector | Hospitals |
| PI Contribution | We provided mathematical models and expertise to analyse patient cases using 4DMRI data to validate our models. |
| Collaborator Contribution | Rich, high-quality, longitudinal datasets of Aortic Dissection cases. Quality unavailable in the UK. |
| Impact | A number of papers (see Publications section) Grants submitted (1 to EU) Collaboration is multidisciplinary, involving engineering, modelling and simulation, clinical medicine, radiology |
| Start Year | 2022 |
| Description | Presentation at BVS Berlin 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We participated in the Basic Vascular Science Workshop and Meeting at the Langenbeck-Virchow-House in Berlin from February 23rd to 24th, 2024. Over 50 participants, including doctors, surgeons, nurses, and researchers, attended in person. The event covered a range of topics, focusing on clinical challenges, advanced imaging and engineering, vascular biology, and preclinical models. This diversity enriched our understanding of vascular diseases from various perspectives. The BVS meeting is an annual event fostering the exchange of ideas among clinicians and researchers across Europe. It provides a platform to share novel research and cultivate collaborations, enhancing our collective understanding of vascular diseases. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.bvssm.com/event-details/bvs-berlin-2024 |
| Description | Presentation at ESBiomech2023 in Maastricht |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | We showcased our research on Arteriovenous Malformation at the 28th Congress of the European Society of Biomechanics in Maastricht from July 9th to 12th, 2023. Our session was dedicated on Cardiovascular patient-specific modelling and drew nearly 50 participants, fostering insightful discussions within the scientific community. The well-received presentation allowed for meaningful engagement with fellow researchers focusing on similar topics. The conference, hosting over 800 participants, featured 3 plenary talks, more than 480 oral presentations, and over 300 posters creating a vibrant setting that provided the ideal platform for exchanging ideas and discuss new avenues for our research initiatives. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://esbiomech.org/conference/esb2023/ |
| Description | Presentation at European Society of Biomechanics 2024: NOVEL PATIENT-SPECIFIC, COMPLIANT SIMULATION FRAMEWORK TUNED WITH 4DMRI-EXTRACTED PULSE WAVE VELOCITY |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation on novel methods to compute patient-specific Aortic Dissection dynamics |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.conftool.com/esb2024/index.php?page=browseSessions&cols=0&mode=table&presentations=show |
| Description | Presentation at the European Society of Biomechanics Conference 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of our unique analysis of blood flow using our patient-specific experimental setup in an Aortic Dissection case |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.conftool.com/esb2024/index.php?page=browseSessions&cols=0&mode=table&presentations=show |
| Description | Science of Surgery 2024 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The Science of Surgery his an Annual Event hosted by the Hawkes Institute at UCL (formerly WEISS) where we open the Centre to the public and explain the work/research that we do to a wide audience, which includes a substantial number of children. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.ucl.ac.uk/interventional-surgical-sciences/events/2024/apr/science-surgery-friday-12th-a... |
| Description | The Festival of Engineering (at UCL) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Programme of free interactive events for the whole family will showcase how UCL engineers are creating the future, in fields such as artificial intelligence, space exploration, robotics and medicine. We had a stand where we explained how we perform research in Aortic Dissections and arteriovenous malformations. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.ucl.ac.uk/news/2024/jul/festival-celebrates-engineers-helping-solve-some-worlds-greatest... |
| Description | Yale-UCL-Bern Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | We hosted a Workshop to discuss research on Aortic Dissections, AVMs and Aortic Pathologies. We had strong participation from international collaborators (from Yale University and University of Bern) in London, who discussed clinical cases and current clinical practice. We also had patient representatives to share patients' views and experiences. |
| Year(s) Of Engagement Activity | 2024 |