Immune homeostasis and the immune response
Lead Research Organisation:
Babraham Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
In older humans and in experimental mouse models the generation of immunological memory after vaccination is defective, leading to impaired immunity. This research objective will focus on characterising the molecular and cellular mechanisms that maintain lymphocyte repertoires and on age-dependent changes in memory cell formation and function. To meet this objective we will study mechanisms of lymphocyte selection and survival and importantly expand our current portfolio to consider the role of non-lymphoid cells in memory cell formation. Here the recent recruitment of Alice Denton, who is a BBSRC Future Leader Fellow studying stromal cells, offers a unique contribution. The mechanisms by which stromal cells promote or inhibit germinal centre responses will be studied and we will address potential mechanisms of trans-differentiation into follicular dendritic cells (FDCs) as well as the senescence-associated secretory phenotype (SASP) of older stromal cells. This work will be further strengthened by collaboration with Dr Simon Cook in the Signalling ISP who is engaged in elucidating the molecular mechanisms of the SASP using model cell lines and gene editing technologies. We will study human and mouse immune responses. The study of mouse models will enable us to dissect cellular responses that are driven by intrinsic versus extrinsic factors - an essential requirement for a mechanistic understanding of the cellular interactions that sustain the repertoire and drive the GC response to produce humoral and cellular memory. Based on published evidence, we suggest that an excess of interferon ã (IFNã) may contribute to defective immune responses at the extremes of age and that a better understanding of the molecular processes limiting IFNã production may enable productive immune responses and avoidance of autoantibody production. The project will also look at interaction between lymphocytes and epithelial or stromal cells as it is fundamental for both immunity and the maintenance of tissue integrity during stress. Epithelial cells form the first cellular barrier between host and environment. In the lung they mediate mucociliary clearance and also important coordinators of immune responses as they produce a variety of cytokines, surfactants and antimicrobial peptides that are able to modulate pathogens and commensals directly, and also recruit leucocytes to tissues to facilitate local immune responses. Stromal cells respond to infection by remodelling the lung tissue to facilitate local immune responses, such as in the formation of germinal centres35. In this objective we seek a deeper understanding of the interactions between epithelial cells, stromal cells and lymphocytes using the lung as a relevant model of immune responses to viruses and bacteria in a complex non-lymphoid tissue. This is important because respiratory infections are poorly tolerated and a better understanding of the cellular and molecular mechanisms of immunity and resilience to infection has the strong potential to bring benefits36. We describe here plans, which build on our investment in these models, to elucidate the role of the PI3K pathway in the molecular regulation of lung epithelial and stromal cell immune function. Our focus on PI3K builds on significant previous work performed by us and others, and our proposed studies will discover new contexts in which this pathway, which links growth factor and nutrient sensing mechanisms to cellular responses, functions. We want to understand more about the immune cell-stromal cell interactions that underpin effective immune responses outside of the specialised environment of lymphoid tissue as this is relevant to the mechanisms of vaccine efficacy. Moreover, this is particularly important to health-span because normal ageing is associated with increased susceptibility to infections of the lung such as Influenza A Virus (IAV) and streptococcal pneumonia (Strep). These pathogens often act in concert, such that infection with flu increases the susceptibility to and severity of a subsequent Strep infection37. The use of co-infection models will strengthen our understanding of physiologically relevant immune responses, as the immune responses elicited in the young by these co-challenges remain incompletely characterised making it very difficult to identify the nature of the defects that occur upon ageing. The reason why resistance to these pathogens drops precipitously upon ageing is poorly understood, but is likely to involve a reduced capacity to produce high affinity antibodies and the defective function of innate immune cell such as neutrophils. Importantly, neutrophils engage in a dialogue with lymphocytes in inflamed tissues and, through the elaboration of cytokines, can influence lymphocyte function and immune memory and support the development of tertiary lymphoid structures in the lung.
Planned Impact
unavailable
Organisations
- Babraham Institute (Lead Research Organisation)
- Cancer Research Technology (CRT) (Collaboration)
- Swiss Tropical & Public Health Institute (Collaboration)
- Barcelona Institute for Global Health (Collaboration)
- University College London (Collaboration)
- AstraZeneca (Collaboration)
- Artios Pharma Limited (Collaboration)
- Flemish Interuniversity Council (Collaboration)
- Erasmus MC (Collaboration)
- UNIVERSITY OF EXETER (Collaboration)
- University of Oxford (Collaboration)
- Sanquin (Collaboration)
- F-star Therapeutics (Collaboration)
- The Walter and Eliza Hall Institute of Medical Research (WEHI) (Collaboration)
- Ifakara Health Institute (Collaboration)
- Ducentis BioTherapeutics (Collaboration)
- Cell Guidance Systems Ltd (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
Publications
Kishore M
(2017)
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
in Immunity
Igarashi K
(2017)
BACH transcription factors in innate and adaptive immunity.
in Nature reviews. Immunology
Brucklacher-Waldert V
(2017)
Cellular Stress in the Context of an Inflammatory Environment Supports TGF-ß-Independent T Helper-17 Differentiation.
in Cell reports
Matheson L
(2017)
Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination
in Frontiers in Immunology
Levin-Klein R
(2017)
Clonally stable V? allelic choice instructs Ig? repertoire.
in Nature communications
Webb LMC
(2017)
Signals that drive T follicular helper cell formation.
in Immunology
Denton A
(2017)
Stromal networking: cellular connections in the germinal centre
in Current Opinion in Immunology
| Title | Additional file 1: of The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis |
| Description | Confirmation of ablation of ZFP36L1 and ZFP36L2 in satellite cells of Zfp36L1/L2-P mice. Western blot determining the expression of ZFP36L1 and ZFP36L2 in isolated satellite cells from Zfp36L1/L2-P and control mice. (TIF 76 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/Additional_file_1_of_The_RNA-binding_proteins_Zfp36l1_a... |
| Title | Additional file 1: of The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis |
| Description | Confirmation of ablation of ZFP36L1 and ZFP36L2 in satellite cells of Zfp36L1/L2-P mice. Western blot determining the expression of ZFP36L1 and ZFP36L2 in isolated satellite cells from Zfp36L1/L2-P and control mice. (TIF 76 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/Additional_file_1_of_The_RNA-binding_proteins_Zfp36l1_a... |
| Title | Additional file 2: of The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis |
| Description | Characterisation of mice lacking either Zfp36l1 or Zfp36l2 (referred to as Zfp36L1-P or Zfp36L2-P mice). A. Weights of male and female mice measured from 10 to 45 days. Error bars represent SEM, two-way ANOVA with Tukey's multiple comparison test, n = 10. B. TA and gastrocnemius muscle weights from 7-week-old male and female mice. Significance was measured by unpaired two-tailed Mann Whitney test; n = 6 for Zfp36L1-P and its respective control, and n = 8 for Zfp36L2-P and its control. Red data points indicate female mice and blue data points indicate male mice for the Zfp36L2-P graph. C. Average number of satellite cells in cross-sections of TAs from 7-week-old control, Zfp36L1-P and Zfp36L2-P mice. Error bars represent SEM, significance was measured by unpaired two-tailed Student's t test; n = 5 for Zfp36L1-P and its respective control, and n = 4 for Zfp36L2-P and its control. Controls represent Cre-negative littermates. Calculations based on 10 fields of view per experiment. (TIF 201 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/Additional_file_2_of_The_RNA-binding_proteins_Zfp36l1_a... |
| Title | Additional file 2: of The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis |
| Description | Characterisation of mice lacking either Zfp36l1 or Zfp36l2 (referred to as Zfp36L1-P or Zfp36L2-P mice). A. Weights of male and female mice measured from 10 to 45 days. Error bars represent SEM, two-way ANOVA with Tukey's multiple comparison test, n = 10. B. TA and gastrocnemius muscle weights from 7-week-old male and female mice. Significance was measured by unpaired two-tailed Mann Whitney test; n = 6 for Zfp36L1-P and its respective control, and n = 8 for Zfp36L2-P and its control. Red data points indicate female mice and blue data points indicate male mice for the Zfp36L2-P graph. C. Average number of satellite cells in cross-sections of TAs from 7-week-old control, Zfp36L1-P and Zfp36L2-P mice. Error bars represent SEM, significance was measured by unpaired two-tailed Student's t test; n = 5 for Zfp36L1-P and its respective control, and n = 4 for Zfp36L2-P and its control. Controls represent Cre-negative littermates. Calculations based on 10 fields of view per experiment. (TIF 201 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/Additional_file_2_of_The_RNA-binding_proteins_Zfp36l1_a... |
| Title | Additional file 3: of The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis |
| Description | Transverse cross sections of the TA muscles from mice lacking either Zfp36l1 or Zfp36l2 (referred to as Zfp36L1-P or Zfp36L2-P mice), and their respective controls, recovered at 1, 5, 10 and 25 days following injection with either CTX or PBS, stained with haematoxylin (H; myofibre; pink) and eosin (E; nuclei; purple) to assess the skeletal muscle architecture. Open arrows identify centrally located nuclei, an indication of muscle regeneration. Controls represent Cre-negative littermates. Scale bars: 100 µm. Representative of n = 3. (TIF 843 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/Additional_file_3_of_The_RNA-binding_proteins_Zfp36l1_a... |
| Title | Additional file 3: of The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis |
| Description | Transverse cross sections of the TA muscles from mice lacking either Zfp36l1 or Zfp36l2 (referred to as Zfp36L1-P or Zfp36L2-P mice), and their respective controls, recovered at 1, 5, 10 and 25 days following injection with either CTX or PBS, stained with haematoxylin (H; myofibre; pink) and eosin (E; nuclei; purple) to assess the skeletal muscle architecture. Open arrows identify centrally located nuclei, an indication of muscle regeneration. Controls represent Cre-negative littermates. Scale bars: 100 µm. Representative of n = 3. (TIF 843 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| URL | https://springernature.figshare.com/articles/Additional_file_3_of_The_RNA-binding_proteins_Zfp36l1_a... |
| Title | PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS |
| Description | Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regeneration, we focused on phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol (3,4,5)-trisphosphate (PIP3). We demonstrate that adult PNS neurons utilise two catalytic subunits of PI3K for axon regeneration: p110a and p110d. However, in the CNS, axonal PIP3 decreases with development at the time when axon transport declines and regenerative competence is lost. Overexpressing p110a in CNS neurons had no effect; however, expression of p110d restored axonal PIP3 and increased regenerative axon transport. p110d expression enhanced CNS regeneration in both rat and human neurons and in transgenic mice, functioning in the same way as the hyperactivating H1047R mutation of p110a. Furthermore, viral delivery of p110d promoted robust regeneration after optic nerve injury. These findings establish a deficit of axonal PIP3 as a key reason for intrinsic regeneration failure and demonstrate that native p110d facilitates axon regeneration by functioning in a hyperactive fashion. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://axonrepair2020.figshare.com/articles/poster/PI_3-kinase_delta_enhances_axonal_PIP3_to_suppor... |
| Title | PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS |
| Description | Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regeneration, we focused on phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol (3,4,5)-trisphosphate (PIP3). We demonstrate that adult PNS neurons utilise two catalytic subunits of PI3K for axon regeneration: p110a and p110d. However, in the CNS, axonal PIP3 decreases with development at the time when axon transport declines and regenerative competence is lost. Overexpressing p110a in CNS neurons had no effect; however, expression of p110d restored axonal PIP3 and increased regenerative axon transport. p110d expression enhanced CNS regeneration in both rat and human neurons and in transgenic mice, functioning in the same way as the hyperactivating H1047R mutation of p110a. Furthermore, viral delivery of p110d promoted robust regeneration after optic nerve injury. These findings establish a deficit of axonal PIP3 as a key reason for intrinsic regeneration failure and demonstrate that native p110d facilitates axon regeneration by functioning in a hyperactive fashion. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| URL | https://axonrepair2020.figshare.com/articles/poster/PI_3-kinase_delta_enhances_axonal_PIP3_to_suppor... |
| Description | We have generated new insights into how the immune response changes with age. This has included the demonstration of diminished vaccine responses and the discovery of how to restore antibody responses using immune stimulants. Work on the lung characterised the importance of a specific signalling pathway to lung immunity. The importance of this lies in the ability to modulate this pathway to prevent lung damage. This has turned out to be very important in a group of patients with hyperactive immune systems. We have identified gene which limit immune responses. These can be modified in order to promote immune responses and boost cell based therapies. We have received new funding from a company to pursue this. |
| Exploitation Route | Boosting or inhibiting immune responses |
| Sectors | Healthcare |
| Description | The knowledge and know-how of our ISP has led to our recent involvement in a number of collaborations with Industry. The most significant of these in terms of scale is the CRT-Celgene alliance which has brought a very significant investment from Celegene into the UK science sector: as stated by Dr Iain Foulkes, Cancer Research Technology's CEO in December 2017 "This is our largest drug discovery collaboration to date and represents a major endorsement of the reputation and scale of our capacity and expertise in both drug discovery and clinical development by a leading industry partner". A further significant set of activities relates to engagement with Babraham Research Campus companies. These collaborations range from the informal sharing of expertise, reagents and equipment; the movement of people (e.g. graduated PhD students) into company staff positions; more formal collaborations and research contracts. Of note the ISPG holder is the line manager of the Flow cytometry facility manager and has empowered and supported her to develop the flow facility into a permier service provider and training resource. Geoff Butcher acts as establishment license holder and plays a key role in the management of the Biological services Unit and ethical review; and Anne Corcoran played the leading role in the renewal of the Institute Athena Swan Silver Award. The programme has been refreshed by the recruitment of significant new group leader level researchers. Anne Corcoran joined the ISPG in April 2017 and we have subsequently been joined by Sarah Ross who will bring expertise in proteomic and CD8 T cells and address questions that will enable the delivery of the Immunology ISPG projects on the regulation of gene expression; Claudia Ribeiro de Almeida who will bring expertise in molecular biology and B cells further strengthening the programme ensuring a balance between the study of B and T cells and contributing to the delivery of all of the major objectives the ISP; and Adrian Liston, an established international scientist (at ERC investigator level) recruited to the UK from Europe who will contribute to objectives addressing how T cells maintain tissue homeostasis-a fundamental problem of great relevance to healthy ageing. Our ISP has been involved in all of the major engagement activities of the Babraham Institute including Schools open day, the recent Royal Society exhibition "race against the ageing clock" and Launchpad. We believe we can use this experience to develop a new public engagement activity focused on vaccination. We believe this can showcase our research and reach-out to vaccine hesitant individual and group to explain how vaccines work and to discuss candidly the risks. To achieve this, we will partner with the British Society for Immunology which has already taken step in this direction, but needs more support from scientists. We hope that this will have been fully developed and delivered before the final year of the ISPG. |
| First Year Of Impact | 2017 |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | Wellcome science Interview committee |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://wellcome.org/grant-funding/guidance/funding-application-advisory-committees/science-intervie... |
| Description | microbiome |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | BBSRC DTP |
| Amount | £113,878 (GBP) |
| Funding ID | PAAG/048 - Task 5 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2023 |
| Description | BBSRC GCRF Data & Resources |
| Amount | £171,733 (GBP) |
| Funding ID | BBS/OS/GC/000008A |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 07/2017 |
| Description | BBSRC iCASE |
| Amount | £100,000 (AFN) |
| Funding ID | BB/L016745/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2019 |
| Description | Boosting vaccine responses in older persons |
| Amount | £118,816 (GBP) |
| Funding ID | RPGF1910\223 |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 01/2022 |
| Description | EMBO Young Investigator Award |
| Amount | € 25,000 (EUR) |
| Organisation | European Molecular Biology Organisation |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 01/2017 |
| End | 12/2020 |
| Description | ERC starting grant |
| Amount | € 1,500,000 (EUR) |
| Funding ID | LS6_637801 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 05/2015 |
| End | 05/2020 |
| Description | GCRF Networks in Vaccines Research and Development |
| Amount | £1,000,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2022 |
| Description | High-throughput automation of sequencing library generation for Wellcome Trust-funded research at the Babraham Institute |
| Amount | £244,089 (GBP) |
| Funding ID | 208380/Z/17/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 01/2019 |
| Description | Impaired selection of germinal centre B cells in ageing diminishes the quality of antibody mediated immunity upon vaccination |
| Amount | £445,214 (GBP) |
| Funding ID | BB/W001578/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2024 |
| Description | Industry collaboration |
| Amount | £168,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 02/2023 |
| End | 08/2023 |
| Description | Initial Training Networks (ITN): Horizon 2020 |
| Amount | € 6,000,000 (EUR) |
| Funding ID | ENLIGHT-TEN - AMD-675395-1 |
| Organisation | European Commission |
| Department | Horizon 2020 |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2015 |
| End | 09/2019 |
| Description | Lost-Tfh) Lost in space: How spatial dysregulation of T follicular helper cells impairs vaccine responses in ageing |
| Amount | £1,723,611 (GBP) |
| Funding ID | EP/X022382/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2022 |
| End | 08/2027 |
| Description | Molecular regulation of NK cell functional maturation by the transcription factor BACH2 |
| Amount | £658,607 (GBP) |
| Funding ID | MR/S024468/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 05/2022 |
| Description | Preventing and reversing neuroinflammatory brain damage using local expansion of regulatory T cells |
| Amount | € 150,000 (EUR) |
| Funding ID | GAP-899863 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 04/2020 |
| End | 06/2021 |
| Description | Resolving mechanisms of gene regulation within the immune system using forward genetics |
| Amount | £200,000 (GBP) |
| Organisation | Lister Institute of Preventive Medicine |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 10/2019 |
| Description | SARS COV2 vaccine ResPonse In Obesity - SCORPIO study |
| Amount | £752,294 (GBP) |
| Funding ID | MR/W020564/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2021 |
| End | 08/2023 |
| Description | Small Molecule Drug Discovery Award |
| Amount | £300,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 01/2020 |
| Description | The Evelyn Trust Medical Research Grant |
| Amount | £37,965 (GBP) |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 02/2022 |
| Description | University of Cambridge Doctoral Training Programme |
| Amount | £120,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 03/2023 |
| Title | Guidelines for the use of flow cytometry and cell sorting in immunological studies |
| Description | "Guidelines for the use of flow cytometry and cell sorting in immunological studies" represent a community effort to collect the currently accepted best methods for monitoring most of the variation of the major players of immune system (along with their organelles and functionality) and include standards for data interpretation, as well as cautions about technical issues. One aspect of the guidelines concerns data reproducibility, a topic that has recently attracted considerable attention. Therefore, the guidelines are meant to help researchers avoid potential pitfalls that could drastically alter the interpretation of their data. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | paper has been widely dowloaded, read and cited |
| URL | https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201646632 |
| Title | mouse model |
| Description | We have generated novel mouse models. The details of many of these are available in our peer-reviewed papers. A number of models are still under evaluation |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | see pubished papers |
| Title | protocol online |
| Description | Acute Streptococcus pneumoniae lung infection: Mouse model and characterisation of the immune response. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Streptococcus pneumoniae is a globally important pathogen. We describe a mouse model of S. pneumoniae respiratory tract infection through intranasal administration of bacteria which progress to bacteraemia and systemic disease. This model therefore allows assessment of different stages of infection and can be used to study local and systemic immune responses to vaccines and other treatment strategies. |
| URL | https://www.nature.com/protocolexchange/protocols/7051 |
| Title | Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice |
| Description | PTBP3 iCLIP from in vitro activated B cells (LPS 48h). Three libraries were prepared from the same iCLIP sample where the membrane containing the RNA-RBP complexes was cut at three different molecular weight ranges |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several publications in per-reviewed journals |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE168769 |
| Title | HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response |
| Description | equencing analysis of B cell transcriptome using Illumina TruSeq mRNA sample prep kit and Illumina platform. RNA was isolated from ex-vivo or LPS-activated (48h) splenic B cells from HuRflox/flox x mb1wt control or HuRflox/flox x mb1cre mice. 3-4 biological replicates per genotype and condition. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | used in several publications in peer-reviewed journals |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62129 |
| Title | HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response [Ribo-Seq] |
| Description | Sequencing analysis of ribosome protected RNA fragments in ex vivo or LPS-activated splenic B cells was performed using ARTseqâ„¢ Ribosome Profiling Kit - Mammalian (Epicentre, RPHMR12126) and Illumina platform. Splenic B cells come from HuRf/f control or HuR cKO mice. 4-5 biological replicates per genotype and condition. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Used in several publications in peer-reviewed journals |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62134 |
| Title | Identification of translated small open reading frames in lymphocytes |
| Description | Peripheral lymph nodes were isolated from 5 biological replicates of control C57BL/6 mice (Zfp36l1 floxed/floxed without Cre). Each sample was split to generate Ribosome profiling and total RNA-seq libraries. Ribosome profiling data is submitted here; the corresponding total RNA-seq datasets are available in GSE146073. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154491 |
| Title | Late pre-B cell tranLate pre-B cell transcriptomes from Zfp36l1 Zfp36l2 double knockout micescriptomes from Zfp36l1 Zfp36l2 double knockout mice |
| Description | Expression profiling by high throughput sequencing |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications. |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78249 |
| Title | Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell |
| Description | mRNA-seq (3 biological replicates), nascent, 4sU-labelled mRNA-seq (2 biological replcates, separated into labelled [nascent RNA], unlabelled [pre-existing RNA] and total fractions) and Ribo-seq (5 biological replicates) were performed in activated CD4+ T cells from control and Zfp36/Zfp36l1 double conditional knockout mice. To identify direct targets of ZFP36-family proteins, iCLIP was performed on activated CD4+ T cells from WT C57BL/6 mice (3 biological replicates), using two independent antibodies that bind to ZFP36L1. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE155087 |
| Title | NGS data |
| Description | We have submitted numerous NGS datasets including RNAseq, ribosome foot printing, iCLIP, CHIPseq |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | some data is being reused by us and others |
| Title | Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells |
| Description | Short-read Illumina mRNA-seq libraries were generated from naïve and activated CD8 T cells from control and PTBP1 conditional knockout mice, with four biological replicates per condition. The corresponding replicates for naïve and activated samples for a given genotype were from the same mouse. Long-read ONT cDNA-PCR libraries were also generated from the same RNA samples as the Illumina libraries, except that the fourth replicate for activated cells was omitted. PTBP1 iCLIP libraries were prepared from activated CD8 T cells, with four biological replicates in control cells, and two biological replicates in PTBP1 conditional knockout cells as a negative control. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE190512 |
| Title | Polypyrimidine tract binding proteins are essential for B cell development |
| Description | mRNAseq libraries were prepared from FrB pro-B cells. FrB pro-B cells were isolated from the bone marrow by flow cytometry and cell sorting of B220+, CD19+, IgD-, IgM-, CD2-, CD25-, CD43high, cKIT+, CD24+ and CD249- cells. Bone marrow cells from 4-6 mice from the same genotype and sex were pooled and depleted of unwanted cells with anti Gr-1-bio (RB6-8C5), CD11b (M1/70), IgD-bio (11-26c.2a), NK1.1-bio, CD3e (145-2C11) and Ter119 biotinylated antibodies and anti-biotin microbeads before cell sorting. Five biological replicates were carried out per genotype. iCLIP libraries were described in Monzon-Casanova, E. et al. The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. Nat. Immunol. 45, 471 (2018). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Used in several publications in peer-reviewed journals. |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE136882 |
| Title | RNA Binding Proteins As Regulators of Oxidative Stress Identified by a Targeted CRISPR-Cas9 Single Guide RNA Library |
| Description | An sgRNA library targeting human RNA binding proteins was transduced into Jurkat T cells expressing Cas9. Guide representation was assessed by NGS following 14 or 21 days culture in 0, 50 or 200µM paraquat, with 1 replicate per condition. One replicate of cells at day 0 (without paraquat) was also included. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several publications in peer-reviewed journals |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185462 |
| Title | The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition |
| Description | m6A-eCLIP libraries were generated from two biological replicates in B cells after 8 days of iGB culture. Libraries from the input RNA were also generated for each of the replicates. For CRISPR screens, an sgRNA library targeting RNA binding proteins was transduced at day 3 in iGB culture. Screens were performed to assess proliferation/survival (guide representation at day 8 compared with day 4 in bulk B cells, 1 biological replicate each), and differentiation (guide representation in CD138+ compared with CD138- cells at day 8, 2 biological replicates each). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications. |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179919 |
| Title | The RNA-binding protein HuR is required for antigen-specific germinal centre B cell selection |
| Description | Germinal centre B cells from the dark zone (DZ, CD19+ IgD- CD38- CD95+ CXCR4+ CD86- cells) and the light zone (LZ, CD19+ IgD- CD38- CD95+ CXCR4- CD86+ cells) were sorted (by FACs) from HuRfl/fl (control) or HuRfl/fl AIDCre (HuR KO) mice at day 7 after immunization with NP-KLH in alum. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications. |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145413 |
| Title | The proteome of B cell maturation identifies PDCD4 as limiting the response of marginal zone B cells |
| Description | Splenic transitional (T)1, T2, marginal zone (MZ) and follicular (FoB) B cells were FACS sorted from C57BL/6 mice (n= 4 biological replicates), based on the expression of CD19, CD93, IgM, CD23 and CD21 extracellular markers. The RNA for each sample was divided to prepare short-read Illumina mRNAseq libraries and long-read ONT RNA-seq libraries. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Dataset will be made public 2024 |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi |
| Title | The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins |
| Description | ZFP36L1 iCLIP libraries were prepared from OT-I transgenic cytotoxic T lymphocytes, with three biological replicates in control cells, and three biological replicates in Zfp36/Zfp36l1 conditional knockout cells as a negative control. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE176313 |
| Title | Transcriptome analysis of activated CD4+ T cells deficient for Zfp36 or Zfp36l1 |
| Description | mRNA sequencing libraries from Zfp36-/- and Zfp36l1-/- activated CD4+ T cells, and corresponding floxed controls. 2-3 replicate libraries were generated for each genotype. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Used in several publications in peer-reviewed journals. |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE214350 |
| Title | Transcriptome of ZFP36L1-sufficient and ZFP36L1-deficient Fo B cells |
| Description | The RNA-seq libraries were prepared using ARTseq Ribosome Profiling Kit, ten libraries were pooled and sequenced on two lanes of HiSeq 2500, after quality control both FASTQ files for each sample were concatenated and mapped as one. |
| Type Of Material | Data analysis technique |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications. |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146073 |
| Title | Transcriptomic analysis of in vitro induced germinal centre-like B cells and plasmablast differentiation |
| Description | B220high CD138- and B220low CD138+ cells were FACS sorted from splenic mouse B cells that were cultured for 8 days in iGB conditions (n= 3 biological replicates) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Used in several peer-reviewed journal publications |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179281 |
| Description | A study to determine whether Zfp36l1 plays a role in regulating CD4-mediated responses to tumours |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise, methods and research tools |
| Collaborator Contribution | Expertise, methods and research tools |
| Impact | None |
| Start Year | 2021 |
| Description | CIAA: Delivery of crystalline protein formulations to the lung and their potential utility in expanding anti-inflammatory cells |
| Organisation | Cell Guidance Systems Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise |
| Collaborator Contribution | Expertise |
| Impact | None |
| Start Year | 2022 |
| Description | CTP Exploring the role of the RNA helicase DDX1 at the crossroad of DNA repair processes during immunoglobulin gene rearrangements in B lymphocytes |
| Organisation | Artios Pharma Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PhD studentship with Artios. Data. |
| Collaborator Contribution | Expertise, facilities. |
| Impact | None. |
| Start Year | 2022 |
| Description | Delivery of samples for this research project |
| Organisation | Ifakara Health Institute |
| Country | Tanzania, United Republic of |
| Sector | Charity/Non Profit |
| PI Contribution | Scientists at the Swiss TPH have run a phase 1b clinical trial with the Ifakara Health Institute on a new malaria vaccine, they have provided samples to us from this study to enable us to deliver the content of this grant. Our contribution to this collaboration has to been to design and perform the immunological analyses to generate datasets for this study. |
| Collaborator Contribution | Scientists at the Swiss TPH have run a phase 1b clinical trial with the Ifakara Health Institute on a new malaria vaccine, they have provided samples to us from this study to enable us to deliver the content of this grant. |
| Impact | The work from this collaboration was published in 2020. https://stm.sciencemag.org/content/12/529/eaaw9522.abstract |
| Start Year | 2016 |
| Description | Delivery of samples for this research project |
| Organisation | Swiss Tropical & Public Health Institute |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Scientists at the Swiss TPH have run a phase 1b clinical trial with the Ifakara Health Institute on a new malaria vaccine, they have provided samples to us from this study to enable us to deliver the content of this grant. Our contribution to this collaboration has to been to design and perform the immunological analyses to generate datasets for this study. |
| Collaborator Contribution | Scientists at the Swiss TPH have run a phase 1b clinical trial with the Ifakara Health Institute on a new malaria vaccine, they have provided samples to us from this study to enable us to deliver the content of this grant. |
| Impact | The work from this collaboration was published in 2020. https://stm.sciencemag.org/content/12/529/eaaw9522.abstract |
| Start Year | 2016 |
| Description | Depleting regulatory T (Treg) cells in cancer |
| Organisation | Cancer Research Technology (CRT) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have generated preliminary data that has formed the basis for a drug development programme aimed at generating new immune based therapies for cancer that work by depleting immunosuppressive regulatory T cells accumulating within tumours |
| Collaborator Contribution | A discussion is currently underway to undertake an industrial collaboration with CRUK-TDL |
| Impact | Not yet delivered |
| Start Year | 2018 |
| Description | Drug discovery programme targeting the immunosuppressive transcription factor activity of BACH2 |
| Organisation | Cancer Research Technology (CRT) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have previously found that BACH2 promotes tumour immunosuppression by promoting Foxp3+ Treg cell-mediated suppression of CD8+ T cells and IFN-? within tumors (Roychoudhuri et al., J Clin Invest. 2016). This has formed the basis for an on-campus industrial collaboration with Cancer Research Technology (CRT). We aim to develop a cell-based reporter assay for the transcription factor activity of BACH2 in order to perform a high-throughput screen of small molecule inhibitors. The collaboration resulted from a meeting arranged by Martin Turner between LLSD and CRT and was supported by a Babraham Institute Knowledge Exchange and Commercialisation Committee Campus Collaboration Award (£15K). Preliminary data generated formed the basis for a successful application for a CRUK Drug Discovery Award (£300K). We are developing stable reporter cell lines using bioinformatically derived enhancer sequences that are responsive to transcriptional repression by BACH2 and amenable to high-throughput drug screening by our collaborators at CRT. |
| Collaborator Contribution | Performance of a high-throughput drug screen (>200k compounds) using cell-based reporter assays for the transcription factor activity of BACH2 generated in the laboratory. |
| Impact | This collaboration resulted in receipt of further funding - a BI Knowledge Exchange and Commercialisation Committee Campus Collaboration Award (£15K) and a CRUK Drug Discovery Award (£300K) |
| Start Year | 2017 |
| Description | Ducentis biotherapeutics |
| Organisation | Ducentis BioTherapeutics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | This work is for a small UK biotech company and is contractually confidential. |
| Collaborator Contribution | This work is for a small UK biotech company and is contractually confidential. |
| Impact | This work is for a small UK biotech company and is contractually confidential. |
| Start Year | 2018 |
| Description | GSK Immunology network |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Dr Michelle Linterman has joined the GSK Immunology Network. Made up of internationally recognised scientists, the programme bolsters connections between academic researchers and the pharmaceutical industry by embedding academics in GSK laboratories. Michelle will spend time in Stevenage at GSK's R&D hub advising on the development of immunology programmes. Dr Carolina Arancibia, GSK Immunology Network Scientific Director, said: "We are very excited to welcome Michelle to the Immunology Network in GSK. Michelle will be spending 20% of her time at our global R&D hub in Stevenage in close collaboration with our researchers. She brings invaluable expertise on how the immune system responds after immunisation or infection. We look forward to exchange ideas and to expand our knowledge this key area of immunology with the goal of developing new medicines for patients." |
| Collaborator Contribution | Collaboration opportunities. |
| Impact | Ongoing |
| Start Year | 2023 |
| Description | Human Gimap studies |
| Organisation | University of Oxford |
| Department | Weatherall Institute of Molecular Medicine (WIMM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Advice, reagents. |
| Collaborator Contribution | We have advised on ongoing studies of Gimap proteins in human immunology and mouse model systems. We have provided specific antibody reagents from our collection. |
| Impact | Progress but no outputs as yet. |
| Start Year | 2016 |
| Description | Immune development in African children a longitudinal analysis |
| Organisation | Barcelona Institute for Global Health |
| Country | Spain |
| Sector | Multiple |
| PI Contribution | My research team analysed the composition of the immune system in 170 children from Tanzania and Mozambique over a 32 month period to determine how their immune system develops. This was done in conjunction with a Phase III vaccine trial (RTS,S/AS01) to enable us to determine how the composition of the immune system influences vaccine efficacy. |
| Collaborator Contribution | The ISGlobal team provided the samples taken during the Phase III vaccine trial (RTS,S/AS01) and contributed to writing the manuscript (submitted February 2019). |
| Impact | We have written a manuscript detailing this study which was submitted for peer review in February 2019. |
| Start Year | 2017 |
| Description | Jenner Institute - ChAdOx1 nCoV19 pre-clinical work |
| Organisation | University of Oxford |
| Department | Jenner Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The University of Oxford have developed a COVID-19 vaccine ChAdOx1 nCoV19 which is currently being rolled out apace in the UK. In March 2020, we initiated a collaboration to test their vaccine in aged mice to inform the type and magnitude of the immune response stimulated in the context of ageing. |
| Collaborator Contribution | The University of Oxford have developed a COVID-19 vaccine ChAdOx1 nCoV19 which is currently being rolled out apace in the UK. In March 2020, we initiated a collaboration to test their vaccine in aged mice to inform the type and magnitude of the immune response stimulated in the context of ageing. |
| Impact | This work has been peer reviewed and published. DOI:https://doi.org/10.1016/j.medj.2020.12.006 |
| Start Year | 2020 |
| Description | Jenner UCL - CD4-Cre Zfp36l1fl/fl mice |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Professor Richard Jenner at UCL is conducting a study to determine whether Zfp36l1 plays a role in regulating CD4-mediated responses to tumours. He has requested the additional support of Dr Martin Turner to carry out research in relation to the project and wishes to collaborate with the Institute in carrying out the project. |
| Collaborator Contribution | Professor Richard Jenner at UCL is conducting a study to determine whether Zfp36l1 plays a role in regulating CD4-mediated responses to tumours. He has requested the additional support of Dr Martin Turner to carry out research in relation to the project and wishes to collaborate with the Institute in carrying out the project. |
| Impact | Ongoing. |
| Start Year | 2021 |
| Description | Katsikis 2017 onwards |
| Organisation | Erasmus MC |
| Department | Immunology (EMC-I) |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | collaborative studies of the effects of IAV on lung epithelial cells |
| Collaborator Contribution | expertise |
| Impact | manuscript in submission, another one in preparation |
| Start Year | 2017 |
| Description | Milner Project: Improving the efficacy of CAR-T cells |
| Organisation | AstraZeneca |
| Department | Astra Zeneca |
| Country | United States |
| Sector | Private |
| PI Contribution | Expertise, methods/know how and research tools |
| Collaborator Contribution | Expertise, methods/know how and research tools |
| Impact | None |
| Start Year | 2022 |
| Description | Provision of long read sequencing of RNA on the Nanopore platform and Analysis |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise, methods and research tools, facilities |
| Collaborator Contribution | Expertise, methods |
| Impact | None |
| Start Year | 2022 |
| Description | Transcriptional and epigenetic programmes of lung inflammation |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | A key commercial collaboration between Rahul Roychoudhuri (RR) and GlaxoSmithKline (GSK)/Epinova, which is now supported by two BBSRC CASE awards, aims to understand the transcriptional and epigenetic programmes that promote lung inflammation. We aim to define transcriptional and epigenetic mechanisms by which airway immune homeostasis is maintained by transcriptional and epigenetic regulators. |
| Collaborator Contribution | Support of CASE awards, co-supervision of PhD students, supply of pharmacological agents for use as tool compounds in assessment of epigenetic regulators |
| Impact | We have gained an understanding of how lung inflammation is restrained by suppression of ILC2 activation and promotion of Treg differentiation by the transcription factor BACH2 and are exploring mechanisms by which BACH2 may regulate epigenetic programmes in T cells |
| Start Year | 2016 |
| Description | Understanding the molecular and cellular basis for the function of agonist antibody-based immunotherapies |
| Organisation | F-star Therapeutics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | This collaboration with F-Star Biotechnology Limited aims to understand the molecular and cellular basis for the function of agonist antibody-based immunotherapies in cancer. The work, funded by F-Star, will take place in our laboratory and will be undertaken by a funded postdoctoral scientist. The collaboration is facilitated by the proximity of the Institute to F-Star on the Babraham Research Campus |
| Collaborator Contribution | F-Star have fully funded the research collaboration and are providing reagents for the investigations which will be conducted using pre-clinical mouse models. |
| Impact | Immunology Molecular biology Drug development Bioinformatics |
| Start Year | 2019 |
| Description | Walter and Eliza Hall Institute - Research on VIB compound |
| Organisation | Flemish Interuniversity Council |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | The parties have agreed to collaborate in research on PHP.GFAP-IL2 using TDP43(A315T) mice |
| Collaborator Contribution | The parties have agreed to collaborate in research on PHP.GFAP-IL2 using TDP43(A315T) mice |
| Impact | Ongoing. |
| Start Year | 2020 |
| Description | Walter and Eliza Hall Institute - Research on VIB compound |
| Organisation | The Walter and Eliza Hall Institute of Medical Research (WEHI) |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | The parties have agreed to collaborate in research on PHP.GFAP-IL2 using TDP43(A315T) mice |
| Collaborator Contribution | The parties have agreed to collaborate in research on PHP.GFAP-IL2 using TDP43(A315T) mice |
| Impact | Ongoing. |
| Start Year | 2020 |
| Description | Wolkers |
| Organisation | Sanquin |
| Country | Netherlands |
| Sector | Private |
| PI Contribution | We hosted a student from sanguine. we suppled essential know how and reagents to the project |
| Collaborator Contribution | they developed a model of T cell activation |
| Impact | manuscript submitted |
| Start Year | 2017 |
| Title | AutoFACS: advanced flow cytometry compensation |
| Description | Novel software tool for compensation of flow cytometry data |
| IP Reference | |
| Protection | Trade Mark |
| Year Protection Granted | 2020 |
| Licensed | Yes |
| Impact | Licensed to BD, and incorporated into their major flow cytometry analysis software program, FlowJo v10.7 (estimated by the company to reach 80,000 users, covering >95% of flow cytometry analysis by commercial software). |
| Title | METHOD OF IDENTIFYING VDJ RECOMBINATION PRODUCTS |
| Description | A high-throughput, high resolution DNA-based next generation sequencing assay to interrogate the sequences of VDJ recombined gene products resulting from antigen receptor recombination. Patent licence granted in USA and Europe in 2017. Licence application pending in Japan. Undertaking active marketing, no commercial licensee finalised as yet. |
| IP Reference | EP2820153 |
| Protection | Patent granted |
| Year Protection Granted | 2015 |
| Licensed | No |
| Impact | Collaborations with academic, clinical and commercial interests, resulting in 3 grant applications, one of which was successful |
| Title | NOVEL METHOD |
| Description | The invention relates to a method of expanding a population of regulatory T cells in a tissue or organ of a subject, wherein said method comprises administration of IL-2 and a targeting moiety specific for said tissue or organ, and wherein said tissue or organ is the central and/or peripheral nervous system. The invention further relates to populations of regulatory T cells produced according to the method and the production of said population in vivo. Also provided is a pharmaceutical composition comprising IL-2 and a targeting moiety as defined herein as well as a method of treating a disease or disorder mediated by inflammation or for the reduction of inflammation which comprises the methods defined herein or administration of a pharmaceutical composition as defined herein. |
| IP Reference | WO2021044175 |
| Protection | Patent granted |
| Year Protection Granted | 2021 |
| Licensed | Commercial In Confidence |
| Impact | Ongoing |
| Title | antibody commercialsation |
| Description | monoclonal antibody |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2018 |
| Licensed | Yes |
| Impact | Non-Exclusive Licence Agreement with Millipore Corporation until 19/05/2026 to make available Vav2 antibody reagents from the Turner lab |
| Description | |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | Commercial In Confidence |
| Impact | Agreement fully executed 040917 for the supply to Bio-Rad ABD Serotec of two hybridoma cell lines allowing the dissemination of the use of valuable antibody reagents. |
| Title | AutoSpill |
| Description | Website for automated compensation of flow cytometry data |
| Type Of Technology | Webtool/Application |
| Year Produced | 2020 |
| Open Source License? | Yes |
| Impact | 100,000-fold reduction in error in experimental analysis using this system, >1000 users |
| URL | https://autospill.vib.be/public/#/home |
| Company Name | Aila Biotech |
| Description | Aila Biotech develops gene delivery technology aimed at treating neuroinflammatory conditions. |
| Year Established | 2021 |
| Impact | Early stage spin-off, still in set-up. |
| Website | http://ailabiotech.com |
| Description | "I'm a Scientist get me out of here" - Linterman Lab |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Helping school students engaged with STEM via online panel answering questions they ask about our personal or professional life. 990 students across the UK logged in to the activity. They took part in 66 live chats and asked 384 questions, ranging from "How many estimated virus are in the whole universe?" to "What's your advice for anyone who wants to become a microbiologist?" to "What effect does COVID have on the brain?" |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://imascientist.org.uk/ |
| Description | "What's My Line?" School Careers Event - Corcoran Lab |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 180 sixth form aged students attended this event where staff discussed and answered questions about what a bioscience career is like as well as discussing research interests. Teachers reported that students had increased their knowledge of such careers and especially highlighted the breadth of different roles the event highlighted to them. |
| Year(s) Of Engagement Activity | 2021 |
| Description | 2016 Babraham Institute Schools Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The Linterman Laboratory hosted school students in the laboratory to teach them the basics of confocal microscopy. |
| Year(s) Of Engagement Activity | 2016 |
| Description | 2017 Babraham Institute Schools day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The Linterman Laboratory hosted school students in the laboratory to teach them the basics of confocal microscopy. |
| Year(s) Of Engagement Activity | 2017 |
| Description | 6th Form Conference |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Further education students present research posters which are judged by researcher staff following conversations around their work. Presentation on career journey was given to all students will a Q&A following |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/events/2022/07/sixth-form-conference-2022-healthy-ageing |
| Description | A level student work experience |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | A sixth form Year 12 student interested in studying Biology at University did one week's work experience, learning techniques, doing experiments and listening to our PhD students talking about their careers. The student had a very positive impression of undergraduate and post-graduate biology. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Annual Schools Laboratory Visit Day 2020 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | 180 GCSE/A-Level pupils attended the Institute for a school visit in which they completed a short research project in the laboratories and discussed scientific careers. |
| Year(s) Of Engagement Activity | 2020 |
| Description | BSI COVID-19 Vaccine Q&A - Anne Corcoran |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A recorded Q&A discussion video made in collaboration with the British Society for Immunology (BSI) where public questions around the COVID-19 vaccine were submitted prior to the event and then answered. To date over 500 people have watched the recording published on the BSI social media platforms with audience feedback suggesting that it has led to a change of views / understanding of the science behind vaccination. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.facebook.com/britsocimm/videos/our-expert-immunology-scientist-dr-anne-corcoran-from-the... |
| Description | Babraham Institute Annual School's Day, February 2020 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | 180 GCSE/A-Level pupils attended the Institute for a school visit in which they completed a short research project in the laboratories and discussed scientific careers. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Babraham Institute Annual Schools Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | As part of Annual Schools Day, 12 GCSE and A level students spent a day in our lab, doing a small project. Many asked questions about our research and careers in biology. Positive feedback relayed after the visit by teachers. The feedback afterwards from the students was that biological research was more interesting and scientists more normal than the students expected. |
| Year(s) Of Engagement Activity | 2010,2011,2013,2014,2015,2016,2017,2018,2019,2020 |
| Description | Babraham Institute School's day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We hosted school students in the laboratory to give them hands on experience of lab work, and to give some insight into research on the immune system. |
| Year(s) Of Engagement Activity | 2024 |
| Description | BioResource lunchtime immunology talk - Linterman Lab |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk to Bioresource team about research done in the Linterman lab and the project aims and outline for AgeVax, a clinical study where we have enlisted the help of the Bioresource team to coordinate vaccinations and venepuncture from donors. This talk allowed the nurses to have a better idea of what the samples are for, so they can explain to donors and better understand the cause they are contributing to. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Blackheath Scientific Society visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave a seminar to the Blackheath Scientific Society on the immune system. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Blog about career so far - Ntombizodwa Makuyana |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Blog titled 'From Zimbabwe to Cambridge: my global scientific journey' about Ntombizodwa Makuyana's career so far and areas of interest inside and outside the lab, published on the Institute's website and shared on social media. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/from-zimbabwe-to-cambridge |
| Description | Blog about hypoxia - Ross Lab |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Blog titled 'Oxygen: powering the immune response' published on the Institute's website and shared on social media. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/oxygen-powering-immune-response |
| Description | Blog about splicing |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Blog titled 'The splice of life' about methods for understanding differently spliced genes, published on the Institute's website and shared on social media. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/splice-of-life |
| Description | Braintree District Careers Fair - Amy Dashwood |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Discussed science careers and immunology research with year 8 students from 8 different schools in the district. Used Virus Fighter interactive to spark conversations around vaccination, as well as, pipetting activity to introduce students to lab based skills |
| Year(s) Of Engagement Activity | 2022 |
| Description | Braintree District Careers Fair - Tombi Makuyana |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Discussed science careers and immunology research with year 8 students from 8 different schools in the district. Used Virus Fighter interactive to spark conversations around vaccination, as well as, pipetting activity to introduce students to lab based skills |
| Year(s) Of Engagement Activity | 2022 |
| Description | British Science Week Careers talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | As part of British Science week in March, Dr Corcoran and two PhD students gave an online presentation about our research and our career paths to four classes of 30 year 10 Biology students at a local school in Cambridge. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Cambridge Bioresource volunteer event, CRUK, Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented our work on ageing and the response to vaccination to an adult lay audience. This included people who are interested in taking part in research studies. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cambridge-Africa lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | A lecture was given to Kenyan Masters students on our research |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge-Makerere seminars: Lecturer in Masters course in Immunology and Clinical Microbiology, Uganda. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The Cambridge-Makerere seminar series facilitates knowledge transfer from researchers based in Cambridge to Masters students and Faculty in Uganda. This is a key part of the Masters programme as it enables the students to cover topics that their local faculty does not have expertise in. My lecture covers lymphocyte responses to vaccination. Feedback is collected from the students each year, and has been very positive, with >90% of students saying the lecture is interesting and valuable, and recommending my lectures be included in the course the following year. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.cambridge-africa.cam.ac.uk/initiatives/muii-plus-cambridge/cambridge-makerere-seminar-se... |
| Description | Careers panel session for DTP Student Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Co-organised the annual DTP student symposium for Cmabridge PhD cohorts. This event had a number of sessions including: researcher talks (targetted to other PhD students likely not working in the same field of study), and a careers panel session. This careers panel featured representation from professionals working in industry, business, research, and public engagement roles. The aim of this session was to raise awareness of these career routes as well as inform the attendees around the skills needed to succeed in this jobs and routes to them developing these skills alongside their studies and research |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://bbsrcdtp.lifesci.cam.ac.uk/news/cambridge-biosciences-dtp-symposium-2023 |
| Description | Children's book on COVID19 released |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Children's book written, illustrated and released to explain COVID19 and the lockdown. Translated into French, Dutch, German and Italian |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://issuu.com/babraham.editions/docs/covid_book |
| Description | Children's book on primary immunodeficiency released |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Children's book written, illustrated and released on primary immunodeficiencies. The work was translated into Dutch, German, French, Spanish, Portuguese, Chinese, Hindi, Urdu, Czech |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.babraham.ac.uk/news/2020/03/childrens-book-battle-robots-blood-launches |
| Description | Comment contribution to national newspaper article - Michelle Linterman |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Wolf Reik, Michelle Linterman and Simon Walker spoke to Andy Martin, The Independent, about their work for a long read article "Who wants to live forever?". The article explores the biological processes that cause ageing, the effect on our immune system, and 'transient reprogramming'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.independent.co.uk/tech/anti-ageing-stay-young-science-b1859541.html |
| Description | Cornavirus science simplified social media campaign |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Development of a series of "illustrated simplified abstracts" to translate cutting-edge Coronavirus research into clear public messages. These illustrated abstracts were distributed via social media and gave early advice on: COVID-19 as an immune disease, importance of wearing facemasks, the link between smoking and severe COVID, skepticism on hydrozychloroquine as a treatment, importance of social distancing. In each case preceding the latter uptake into general public policy. http://www.liston.babraham.ac.uk/blog/2020/6/8/coronavirus-is-infectious-before-illness.html http://www.liston.babraham.ac.uk/blog/2020/4/23/sars-cov-2-is-not-a-bioweapon.html http://www.liston.babraham.ac.uk/blog/2020/4/16/smoking-and-coronavirus.html http://www.liston.babraham.ac.uk/blog/2020/4/15/should-you-wear-a-face-mask.html http://www.liston.babraham.ac.uk/blog/2020/3/29/hydroxychloroquine-azithromycin-is-not-a-treatment-for-covid.html http://www.liston.babraham.ac.uk/blog/2020/3/25/coronavirus-treatment-implicates-the-immune-system-as-killer.html |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.liston.babraham.ac.uk/blog/2020/4/15/should-you-wear-a-face-mask.html |
| Description | Development of a vaccination simulator for education about COVID-19 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Development of "VirusBreak" an online vaccination simulator. A tool-game to educate about vaccination |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | http://www.liston.babraham.ac.uk/coronavirus/ |
| Description | Discussion with Local MP about COVID vaccine strategy |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The MP for South Cambridgeshire requested a meeting with Michelle Linterman in October 2020 to discuss the progress on COVID vaccine development. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Engagement in COVID fact-checking |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Extensive work as fact-checker for international press agency DPA regarding COVID-19. Rapid response and dialogue based on new myths or popular stories on COVID. Provided expert quotes used extensively by international press agencies. |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://dpa-factchecking.com/belgium/201209-99-631695/ |
| Description | FindaPhD.com YouTube |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Made a short video for FindaPhD.com as part of a series of inspirational interviews with senior group leaders about their own PhDs. FindaPhD launched this on International Women's Day as a YouTube video, and on their website, Twitter, Facebook. Dozens of positive comments on Twitter and Facebook worldwide within 24 hours, as well as personal requests for advice about PhDs |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://youtu.be/PDu5y4s8hGQ |
| Description | Form the Future: What's My Line? |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Careers event with year 7 students where students ask questions to workout what career is represented. Following that there is a Q&A to further discuss research and career route |
| Year(s) Of Engagement Activity | 2022 |
| Description | GSK Immunology Summit presentation and participation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Participated in the GSK Immunology Summit meeting in Philadelphia. This involved giving a presentation of our work, meeting with key stakeholders in GSK, and participating in a formal discussion on scientific topics of interest to GSK. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Health Education Careers and Research Talk - Linterman Lab |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Presentation covering career route and research interests delivered to foundation year medicine students |
| Year(s) Of Engagement Activity | 2021 |
| Description | Hills Road 6th Form College University mock interviews |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Ran mock interview workshop with students from a local 6th Form College to help prepare them for university applications |
| Year(s) Of Engagement Activity | 2023 |
| Description | IUIS Day of Immunology Webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 2024 International Day of Immunology Webinar: Immunity Through the Ages: Navigating the Science of Aging and Immunology 1600 registered virtual attendees from 116 countries, watched four talks and panel discussion about the science of Aging and Immunology. There was a lively question session, and we did not have time to answer all questions posed by the audience. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://immunohub.iuis.org/iuis/2024/webinars/411459/faculty.presenters.2024.international.day.of.im... |
| Description | Interview for University magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Interview with "The Optimist", a magazine written for post-graduate students about PhD life and careers. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Interview for campus newsletter |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Interview for Babraham campus newsletter |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Speaker at GSK Immunology Summit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michelle Linterman gave a seminar at the GSK Immunology summit, an internal GSK meeting that covers all their world-wide sites. This led to a collaboration being established, for which contracting is in progress. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited Speaker at GSK Vaccines day (Virtual) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michelle Linterman gave a seminar on her team's work on Ageing and Vaccination, this led to a collaboration with the GSK vaccines team that started February 2023. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited seminar at Glaxo Smith Kline Immunology meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michelle Linterman was invited to presented the labs work on ageing and response to vaccination at an internal GSK immunology day focussed on B cells. This event included 475 participants from GSK at their USA, UK and Belgium sites. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker: Sanofi Immune Memory Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michelle Linterman was invited to present at a conference organised by Sanofi Pasteur at their headquarters in France. The presentation was followed by questions and discussion. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Launchpad schools project |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Carolyn Rogers in my group, and another student, designed, delivered and judged a new Launchpad science challenge activity for 12 year olds in 3 local schools. This involved designing a project involving understanding DNA and its regulation, delivering it to 3 local schools as a challenge to complete. They advised students on how to make a poster of their findings, and judged each contribution. The winning students from each school were invited to Babraham for a Launchpad visit, which enabled them to consolidate their experience and learn how we study gene regulation at Babraham. Specific events included Launchpad launch, Launchpad Awards, Launchpad Activity Day and Launchpad filming. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Lifelab Cambridge walking tour |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Carolyn Rogers, PhD student, organised evening walking tours of historic sites of scientific discovery in the centre or Cambridge. These were very popular, sold out in advance, and with very engaged groups of walkers |
| Year(s) Of Engagement Activity | 2018 |
| Description | Media interview, press release, press conference or other response to a media enquiry |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Coverage of a press release: 'Dissecting the immune characteristics of severe COVID-19 responses' issued by the Institute in collaboration with KU Leuven and VIB. News Medical is one example of the coverage received. Coverage also received in Belgian magazine Knack. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.news-medical.net/news/20201116/Study-sheds-light-on-the-immune-system-response-COVID-19.... |
| Description | Media interview, press release, press conference or other response to a media enquiry |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Newspaper article sharing responses by Adrian Liston as an immunologist to common questions and concerns about covid-19 vaccines. Featuring image of Adrian Liston. Headline: Covid-19 vaccines: Discussing how they work, the second dose and timing with Babraham Institute immunologist |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.cambridgeindependent.co.uk/news/covid-19-vaccination-discussing-how-they-work-the-second... |
| Description | Meet a Bioscientist - Anne Corcoran |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Virtual research and career talk with extended Q&A |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/meet-a-bioscientist-2022 |
| Description | Meet a Bioscientist - Elise French |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Virtual research and career talk with extended Q&A |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/meet-a-bioscientist-2022 |
| Description | Meet a Bioscientist - Georgia Bullen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Virtual research and career talk with extended Q&A |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/meet-a-bioscientist-2022 |
| Description | Michelle Linterman gave a talk to public group 'Polynous' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Michelle Linterman gave an invited talk on on ageing and the immune system to the Polynous group. The 45 minute seminar was followed by 45minutes of animated discussion over tea. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Milner Therapeutics Adrian Liston seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Online seminar with the Milner Institute, University of Cambridge highlighting advances in the understanding of neuroimmunological disease and therapeutic approaches. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Mosaic magazine article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Article by Tom Chivers "How Big Data is Changing Science" including interviews with me and other genomics scientists, giving our perspectives on the explosion of big data science in recent year and the opportunities and challenges this brings. The aim was to illustrate the rapidly changing skill sets needed to understand big data, which senior scientists have not learned and need to keep up with. |
| Year(s) Of Engagement Activity | 2008,2016,2018 |
| Description | News about ERC consolidator grant - Linterman Lab |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | News article about Dr Michelle Linterman's research 'Dr Michelle Linterman receives funding to understand how age affects vaccine response'. Published on the Institute's website and shared on social media. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/news/2022/03/dr-michelle-linterman-receives-funding-understand-how-age-af... |
| Description | News about Il-2 network - Liston Lab |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | News article on the Institute website 'Greater understanding of immune signalling molecule raises hope for improved clinical use'. The article was shared across the Institute's social media. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/news/2022/06/greater-understanding-immune-signalling-molecule-raises-hope... |
| Description | Newspaper article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Newspaper article reporting research led by the Linterman lab and collaborators on the immune response to the Oxford/AstraZeneca covid-19 vaccine. Main image of Michelle Linterman with quote. Headline: Babraham Institute study of Oxford University's Covid-19 vaccine underscores importance of second dose |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.cambridgeindependent.co.uk/news/babraham-institute-study-of-oxford-university-s-covid-19... |
| Description | Online article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Online article discussing a pre-print describing work by the Linterman lab on the Oxford/AstraZeneca covid-19 vaccine ChAdOx1 nCoV19 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.news-medical.net/news/20201030/Booster-dose-enhances-immunogenicity-of-ChAdOx1-SARS-CoV-... |
| Description | Online article |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interview on prospectives for a COVID-19 vaccine, discussion of potential timelines and milestones to be met. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.drugtopics.com/view/flurry-covid-19-studies-are-underway-scientists-warn-vaccine-will-ta... |
| Description | Online article - Ross Lab |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Blog post where six current PhD students shared some tips and advice for new PhD students starting. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.babraham.ac.uk/blog/advice-new-PhD-students |
| Description | Online article about scientific research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article in The Medicine Maker (a publication for scientists working in drug development) following the press release: How to boost immune response to vaccines in older people. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://themedicinemaker.com/discovery-development/back-to-immunity |
| Description | Online article about scientific research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Results in Brief article published on the EC CORDIS website in six languages |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://cordis.europa.eu/article/id/422359-germinal-efficiency-in-older-people?WT.mc_id=exp |
| Description | Online article about scientific research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Coverage of a press release: 'Charting immune system development in sub-Saharan African children' issued by the Institute. Coverage in Clinical Lab Manager, ScienceCodex and Chemical & Engineering News. https://www.clinicallabmanager.com/news/new-understanding-of-childhood-immune-systems-may-improve-vaccine-efficacy-21675 https://www.sciencecodex.com/geography-age-and-anemia-shape-childhood-vaccine-responses-sub-saharan-africa-640164 https://cen.acs.org/pharmaceuticals/vaccines/Location-age-health-status-define/98/i6 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.clinicallabmanager.com/news/new-understanding-of-childhood-immune-systems-may-improve-va... |
| Description | Online article about scientific research |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Comment in an article in New Scientist: BCG vaccine helps fight infections by boosting immune cell production |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.newscientist.com/article/2242866-bcg-vaccine-helps-fight-infections-by-boosting-immune-c... |
| Description | Online news article - Michelle Linterman |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Paul Brackley of the Cambridge Independent reports on recently published work from the Linterman lab which suggests that limiting inflammation when older adults receive the 'flu vaccine may improve vaccine efficacy. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.cambridgeindependent.co.uk/news/flu-vaccine-babraham-institute-researchers-uncover-poten... |
| Description | Presentation at GSK Vaccines, Belgium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Michelle Linterman was invited to present her lab's work on Ageing and the poor response to vaccination, and meet multiple team leaders at GSK Vaccines. The presentation was also broadcast to the GSK offices in the USA. There was an extensive Q & A session after the presentation, and discussions about the possibility of future collaboration. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at Glaxo Smith Kline, Stevenage, United Kingdom |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Presentations from Michelle Linterman and Alice Denton on the basic biology of the response to vaccination, with a specific focus on the biology of stromal cells. The presentations were followed by a discussion. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation on the use of mouse models in immunology research |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation of the reasons and uses of research using mouse models in immunology research to a large group of local parishioners visiting the Institute for the talk. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Press release about Diabetes treatment method - Liston lab |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Articles were produced covering the Liston lab's press release 'Innovative treatment prevents development of diabetes', newswire is one example outlet. The news appeared in four outlets with a combined estimated audience of 1 million readers. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.newswise.com/articles/innovative-treatment-prevents-development-of-diabetes |
| Description | Press release about stroke and MS therapeutic - Liston Lab |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Coverage of therapeutic method for harnessing the body's immune system to protect against brain damage, total news coverage had a reach of over 46 million people across 20 outlets. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.nla-eclipsweb.com/service/redirector/article/83250908.html?version=1 |
| Description | Press release and news item 'RNA binding proteins help T cells pick their weapons before battle' |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release and news article 'RNA binding proteins help T cells pick their weapons before battle' |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/news/2022/04/rna-binding-proteins-help-t-cells-pick-their-weapons-battle |
| Description | Press release on patient-relevant publication |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Press release on our article "Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes", and follow up interviews. Articles published in international press. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Press release on patient-relevant publication |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press release and subsequent media interviews/articles on Pasciuto et al, 2020 Cell. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.babraham.ac.uk/news/2020/07/new-role-white-blood-cells-developing-brain |
| Description | Press release on patient-relevant publication |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Press release on our publication "NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology." Follow-up interviews performed and articles written in the international press. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Radio New Zealand Interview: nine to noon |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interviewed by Angela Ryan on the Radio New Zealand show nine to noon, which has a nationwide audience (New Zealand), about our research on vaccination and ageing and future research plans. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.rnz.co.nz/national/programmes/ninetonoon/audio/2018871515/how-our-immune-systems-change-... |
| Description | Radio interview about COVID19 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | There are many Covid-19 vaccines in production around the world and to find out more, Zoë Larsen Cumming interviewed vaccine expert Michelle Linterman whose research at the Babraham Institute in Cambridge, U.K. focuses on the effectiveness of the Covid-19 vaccine in the elderly. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://95bfm.com/bcast/vaccinations-and-covid-19-w-michelle-linterman-november-16-2020 |
| Description | Radio interview about scientific research |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Radio interview with a Dutch radio station, BNR Nieuwsradio, on a press release: How to boost immune response to vaccines in older people |
| Year(s) Of Engagement Activity | 2020 |
| Description | Research Access Programme Student Placement with Anne Corcoran |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Higher education student carried out 8 week lab based summer placement learning a variety of techniques and data analysis methods. They reported an increase in knowledge, skills, and a broadening of their understanding of careers in science as well as how academic research functions. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/rap-2022-marzana |
| Description | Research Access Programme Student Placement with Harry White |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Higher education student carried out 8 week lab based summer placement learning a variety of techniques and data analysis methods. They reported an increase in knowledge, skills, and a broadening of their understanding of careers in science as well as how academic research functions. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/rap-2022-marzana |
| Description | Research Access Programme Student Placement with Rafael Valente Veiga |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Higher education student from disdvantaged background carried out 8 week online summer placement learning a variety of techniques and data analysis methods. They reported an increase in knowledge, skills, and a broadening of their understanding of careers in science as well as how academic research functions. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/rap-2022-khuluud |
| Description | Royal Society Summer Ageing Clock |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Carolyn Rogers, PhD student, Sam Rees, PhD student, Peter Chovanec, PhD student, helped out at the Race against the Ageing Clock exhibition at the Royal Society. Over 500 attendees, media coverage, increased understanding from public of ageing processes. |
| Year(s) Of Engagement Activity | 2018 |
| Description | School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system |
| Year(s) Of Engagement Activity | 2018 |
| Description | School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system |
| Year(s) Of Engagement Activity | 2019 |
| Description | Schools Day Laboratory visit to Turner's group |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | working with cells and DNA |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | SciSoc talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Gave at talk to the University of Cambridge Scientific Society entitled "How we make a billion antibodies: genetics and epigenetics". Audience included wide range of students and members of the public, in depth discussion about vaccination of the elderly and herd immunity. Engaged with several undergraduates at dinner afterwards and gave scientific and career advice. |
| Year(s) Of Engagement Activity | 2006,2014,2019 |
| Description | Science Storytime Book Reading (March 22) - Adrian Liston |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Recorded book reading of book made to explain the immune system to primary school aged students and parents reading the book. Book reading was released as part of the Cambridge Festival 22, advertised through social media channels and sits within the Institute's youtube channel |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=vr2Wm2_sJek |
| Description | Scientists Stories - Claudia Ribeiro de Almeida |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Recorded interview style discussion about research interests and career route. This recording was circulated around regional school teachers for use in classes and more widely through Institute social media channels. Teachers reported students being much more aware of the range of career routes when considering a role in science. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=0Kwo2Znr4vA&list=PLF5GdjNAwE_46BLAY9IkOf0ZgKptQfLmz&index=2 |
| Description | Secondary School Careers Talk - Ross Lab |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Presentation and Q&A covering education and career route, current role, and scientific research interests |
| Year(s) Of Engagement Activity | 2021 |
| Description | Sixth Form Healthy Aging Conference - Linterman Lab |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach program to sixth form students to introduce them to science biotechnology and academia as prospective career paths |
| Year(s) Of Engagement Activity | 2022 |
| Description | Sixth from student work experience |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Sam Rees, second year PhD student in the Corcoran lab, hosted a Sixth form student for a week, teaching him molecular and cell culture skills, explaining our research. The student has now applied to University to study Biological Sciences |
| Year(s) Of Engagement Activity | 2018 |
| Description | SysMod 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I organised the 2nd meeting of the ISCB Community of Special Interest SysMod. Up to 270 people attended depending on the talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | TV interview BBC look East (West) (2017) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | An interview about our research |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk on ageing to local discussion group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | This was an evening talk to a local discussion group in Great Abington, Cambridgeshire delivered by G.B and Prof Joanna Latimer (University of York) who is a Public Engagement collaborator of the Institute. Our presentation covered both the biology of ageing (illustrated by examples of relevant Babraham science) and sociological aspects of our private and public attitudes to ageing. A wide-ranging and rich discussion took place with the audience of 15-20. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk to the University of the Third age |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Michelle Linterman gave a talk on Ageing and the immune system to member of the University of the Third Age. the seminar was followed by extensive discussion with the audience. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk with Foundation Year doctors about COVID vaccines |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | To help doctors to recognise the opportunity to practice public health in aspects of their day-to-day role, and to give practical suggestions and information on COVID vaccines to support them. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Teachers' Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Our lab hosted two school teachers for a morning lab project. During this time the got to experience a research environment and visit some of the institute's research facilities. The teachers were positive about the visit and were engaged and asked questions. They also gave us insights into how science is taught in schools and ideas we could implement when running the activity for school children. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Video for Find a PhD |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Find a PhD.com sat down with some of the UK's top academics to hear their experiences and thoughts on postgraduate study. Dr Michelle Linterman is currently Group Leader in Immunology at The Babraham Institute. In this video she shares some advice for new students. As of 1/3/2019 this video has 27,890 views. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.findaphd.com/advice/blog/3180/phd-inspiration-dr-michelle-linterman-the-babraham-institu... |
| Description | Virus Fighter at Cambridge Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Virus Fighter interactive used to engage audiences with vaccination and immunology research. Resulting conversations had around viral outbreak response and immune healthcare, as well as, inspiring next generations with sceince careers. |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://www.virusfighter.org |
| Description | WT/EBI course in silico systems biology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I organised this one-week course, and gave presentations entitled: "What is Systems Biology? Where does it come from?", "The many faces of modelling in biology", "Modelling in systems biology, a few challenges", "From art to engineering: two decades of standards and tools towards digital organisms", "Modelling chemical kinetics" plus a tutorial on stochastic simulations of biological systems. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Webinar at the Midlands RNA salon |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Around 70 participants attended a webinar on the 21st May 2020 as part of the RNA Midlands salon. This event is normally organised locally by researchers from the Universities of Birmingham, Nottingham, Warwick, Leicester, Nottingham Trent and Liverpool, to promote engagement and interaction among RNA scientists from the Midlands area. Because of the Covid19 pandemic it was replaced by a virtual format, which promoted interaction between scientists across different parts of the UK, Europe and the US. One particular aspect of this webinar was that it brought together researchers from RNA biology and Immunology fields - the work presented focuses on the role of RNA structures and RNA helicases in B-cell immunity. These sparked interesting discussions at the end of the session, with some of the attendants demonstrating interest in following up with discussions on the role of RNA helicases in B-cell biology. I also believe this webinar was key for the subsequent application of two postgraduate students from Birmingham interested in RNA biology, to our PhD programme at the Babraham Institute. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.midrna.co.uk |
| Description | eLife Community Webinar - Refreshing approaches to researcher evaluation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I animated a webinar discussing various ways to bypass the traditional publication-based evaluation of researchers. |
| Year(s) Of Engagement Activity | 2017 |
| Description | ethics of animal research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Workshop on health ageing and the use of animals in research with French Sixth Form students. Carolyn Rogers, PhD student in the Corcoran group gave a talk on her use of animal models |
| Year(s) Of Engagement Activity | 2018 |
| Description | media interest |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Publication of paper in Frontiers in Immunology and press release resulted in 3 news articles - in Medindia, Labonline (Australia), Health Canal |
| Year(s) Of Engagement Activity | 2017 |
| Description | undergraduate summer project |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | A second year Zoology undergraduate from the University of Sheffield conducted a 6 week summer project in the lab. This was done online because of COVID restrictions. The student participated fully in virtual lab meetings, and one to one meetings with their PhD student supervisor and me as group leader, and produced a report and gave a talk on their work to the lab, and also participated in the programme of training ant talks provided to the Babraham Research Access Programme. |
| Year(s) Of Engagement Activity | 2020 |