Enhanced Research Capacity
Lead Research Organisation:
John Innes Centre
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Heterologous expression systems are a key resource for our ISP as a whole. In the previous ISP we developed numerous such systems for generation and study of specific metabolites, proteins and whole pathways, and for pathway engineering. Examples include the production in N. benthamiana leaves of gram quantities of the triterpene ß-amyrin as a substrate for further experiments; investigation in N. benthaminana of proteins that regulate chlorophyll degradation in pea; production of the iridoid alkaloid intermediate strictosidine in yeast and the use of Streptomyces superhosts for expressing biosynthetic gene clusters from intractable bacteria. The need for multiple, flexible systems will increase as more, and more diverse, pathways and products are discovered, characterised and engineered. The N. benthamiana transient expression system has proved of particular value for the production of virus-like particles (VPLs) because of its safety, low cost and speed. Project Leader Lomonossoff has shown that these particles, which lack endogenous nucleic acid, can be used in diagnostics and for production of human and farmed animal vaccines. However, issues including scale, product stability and problems of appropriate expression of multiple genes must be solved in order to optimise the N. benthamiana system for this and other purposes.
In this Project we will enhance and optimise our capacity to use heterologous expression systems. The advent of the Leaf Systems® facility (2017) will provide a unique opportunity to produce proteins and metabolites in N. benthamiana on a scale suitable for our research and for investigation of the translational potential of our discoveries. We anticipate that a single batch of plants in this facility will produce up to 10 g of a given protein and 1 g of a natural product. To capitalise on this opportunity we need to improve and refine methods for production of VLPs (Objective 1), and tailor N. benthamiana for specific purposes (Objective 2), for example by removing leaf enzymes that modify metabolites of interest. We also need to increase the capacity and flexibility of other heterologous expression systems, to scale up production of low-abundance proteins and metabolites (Objective 3).
In this Project we will enhance and optimise our capacity to use heterologous expression systems. The advent of the Leaf Systems® facility (2017) will provide a unique opportunity to produce proteins and metabolites in N. benthamiana on a scale suitable for our research and for investigation of the translational potential of our discoveries. We anticipate that a single batch of plants in this facility will produce up to 10 g of a given protein and 1 g of a natural product. To capitalise on this opportunity we need to improve and refine methods for production of VLPs (Objective 1), and tailor N. benthamiana for specific purposes (Objective 2), for example by removing leaf enzymes that modify metabolites of interest. We also need to increase the capacity and flexibility of other heterologous expression systems, to scale up production of low-abundance proteins and metabolites (Objective 3).
Planned Impact
unavailable
Publications
Meshcheriakova Y
(2017)
Combining high-resolution cryo-electron microscopy and mutagenesis to develop cowpea mosaic virus for bionanotechnology.
in Biochemical Society transactions
Boobier S
(2017)
Can human experts predict solubility better than computers?
in Journal of cheminformatics
Owen C
(2017)
Harnessing plant metabolic diversity.
in Current opinion in chemical biology
Hesketh EL
(2017)
The structures of a naturally empty cowpea mosaic virus particle and its genome-containing counterpart by cryo-electron microscopy.
in Scientific reports
Kautsar SA
(2017)
plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters.
in Nucleic acids research
Mazalovska M
(2017)
Detection of Serum Antibodies to Hepatitis E Virus Based on HEV Genotype 3 ORF2 Capsid Protein Expressed in Nicotiana benthamiana.
in Annals of laboratory medicine
Marsian J
(2017)
Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.
in Nature communications
Saunders K
(2017)
In Planta Synthesis of Designer-Length Tobacco Mosaic Virus-Based Nano-Rods That Can Be Used to Fabricate Nano-Wires.
in Frontiers in plant science
Osbourn A
(2017)
Painting with betalains.
in Nature plants
Huang AC
(2017)
Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution.
in Proceedings of the National Academy of Sciences of the United States of America
| Title | SAW Antibiotics - Science from the Norwich Research Park - Book published by the SAW Press (2017) - ISBN 978-0-9550180-3-9 |
| Description | A book illustrating research on the Norwich Research Park on antibiotics and antimicrobial resistance, assembled following Science, Art and Writing (SAW) projects led by NRP scientists in local schools |
| Type Of Art | Artefact (including digital) |
| Year Produced | 2017 |
| Impact | The book was appreciated by the government chief medical officer Professor Dame Sally Davies, whose comments are on the front - 'I thoroughly enjoyed this stunning book. Educating children in such an interactive way is so important. I am passionate about addressing AMR, as are the researchers, and I hope this can help inspire future generations to engage in the efforts to save modern medicine.' This project is being captured by the University of East Anglia as an example of effective impact for the next REF. |
| Description | 2017-2018 We have determined that plant-based transient expression is a highly effective method for the production of virus-like particles. These are suitable of for near atomic resolution cryo-EM analysis which is enabling hitherto unknown virus structures to be elucidated. We have also had success with the production of secondary metabolites in plants. 2018/2019/2020/2021/2022/2023 Objective 4.1: Virus-like particle production in N. benthamiana Transient expression has been used produce VLPs derived from enveloped viruses, particularly Dengue virus, serotype 1. Co-expression proteins PrM and E, which contain the antigenic determinants of the virus, resulted in the production of subviral particles. These have been assessed immunologically in collaboration with Public Health England (PHE), and the have been published (Ponndorf et al., Plant Biotech J., 2020). In addition, a conserved domain of dengue virus has been successfully presented on the surface of Hepatitis B core particles (HBcAg; Pang et al., Frontiers in Plant Science 10, 445, 2019). VLPs have also been expressed for both Nervous necrosis virus, a fish pathogen (Marsian et al., Frontiers in Plant Science 10, 880, 2019) and Hepatitis E virus (HEV; Zahmanova et al., Plants 9, 2019); a domain from HEV has also been expressed on the surface of HBcAg VLps (Zahmanova et al., Life 11(1):64, 2021). The work on dengue has led to the development of methods for the production of VLPs of other enveloped viruses, including SARS-CoV-2, in plants (Peyret et. al. Vaccines (Basel) 2021 9, 780. doi: 10.3390/vaccines9070780; Jung et al. Plant Biotech. J. .20, 1363-1372, 2022 doi: 10.1111/pbi.13813. PMID: 35325498). Members of the family Luteoviridae cause important viral diseases and are usually phloem-limited, resulting in very low virus titres within infected plants. For this reason, there is little information available regarding the structure of their capsids. Transient expression of the coat proteins of members of the family results in the formation of virus-like particles (VLPs), the structures of which have been determined to near atomic resolution by cryo-EM (in collaboration with the University of Leeds; Byrne et al. Structure 27 1-10, 2019). Such VLPs can potentially be used to develop novel diagnostic reagents and we have shown that this is possible using VLPs from the well-characterised virus, cowpea mosaic virus (CPMV; Hesketh et al., Scientific reports 9 7524, 2019). We have also used a combination of infection and transient expression to elucidate the 3-dimensional structure of a geminivirus by near atomic resolution cryo-EM and develop a model for assembly of these unique twinned particles (Hesketh EL, Saunders K, Fisher C, Potze J, Stanley J, Lomonossoff GP, Ranson NA..The 3.3 Å structure of a plant geminivirus using cryo-EM.Nat Commun. 2018 Jun 18;9(1):2369. doi: 10.1038/s41467-018-04793-6. We subsequently used the structural information to investigate the requirements for packaging the ssDNA of geminiviruses (Saunders et al. Viruses 12(11), 1235 2020). Research on CPMV has revealed that VLPs can be used to specifically encapsidate bespoke, non-viral RNA molecules (Kruse I, Peyret H, Saxena P, Lomonossoff GP. Encapsidation of Viral RNA in Picornavirales: Studies on Cowpea Mosaic Virus Demonstrate Dependence on Viral Replication. Virol. 2019 Jan 4;93(2). pii: e01520-18. doi: 10.1128/JVI.01520-18. Print 2019 Jan 15. Such encapsidated RNAs can be used for structural studies on RNA folding and can serve as in-tube diagnostic controls. Regarding the latter application, they have attracted the interest of several commercial entities. We have also used the technology developed to produce qRT-PCR positive controls for the diagnosis of Covid-19 (Peyret et al., J. Virol. Meth.doi: 10.1016/j.jviromet.2 021.114372. PMID: 34838537). These have been deployed by the Norwich Testing Initiative. The deployment of a replicating vector based on potato virus X, has enabled the production of filamentous viruses (Thuenemann et al. Viruses. 2021;13:885. doi: 10.3390/v13050885). This has enabled the structural analysis of particles of viruses that can only be isolated in low yield from infected plants. The methodology has been deployed to produced defined-length TMV nanorods which have multiple applications in bionanotechnology (Saunders et al., Front. Bioeng. Biotech.10, 877361. doi: 10.3389/fbioe.2022.877361. PMID: 35557863; Shah et al. Virology 577, 155-162. PMID: 36384077 DOI: 10.1016/j.virol.2022.10.014). It has also allowed analysis of the role of the TMV OAS sequence in particle assembly (Saunders et al. J. Molec. Biol. 434, 167873. PMID: 36328231 DOI: 10.1016/j.jmb.2022.167873 Objective 4.2: Tailoring N. benthamiana. We have used N. benthamiana as a platform for the production and engineering of triterpenoids on a gram-scale (Stephenson MJ, Reed J, Brouwer B, Osbourn A. (2018).Transient expression in Nicotiana benthamiana leaves for triterpene production at a preparative scale. Journal of Visualized Experiments issue 138: Article Number: e58169 Published: AUG 2018 10.3791/58169. ; Reed J, Osbourn A. (2018). Engineering terpenoid production through transient expression in Nicotiana benthamiana. Plant Cell Reports 37 (10): 1431-1441.; Stephenson MJ and Osbourn A (2020). Making drugs out of sunlight and 'thin air': An emerging synergy of synthetic biology and natural product chemistry. The Biochemist 42: 34-39.; Stephenson MJ, Reed J, Patron NJ, Lomonossoff GP and Osbourn A. Engineering tobacco for plant natural product production (2020). Comprehensive Natural Products III: Chemistry and Biology (eds. Begley T, Liu H-W). ISBN 978-0081026908.). We have also shown that the transient plant expression platform is very versatile, and can be used to assemble complex multi-step natural product pathways from other plant species, the exemplar being a 12-step pathway for the biosynthesis of antimicrobial triterpene glycosides from oat (Li Y, Leveau A, Zhao A.. Han B, Osbourn, A. (2021). Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals. Nat. Comms. 12(1):1-13). More recently, in a collaborative project with Syngenta, we have demonstrated the assembly of another 12-step pathway for the biosynthesis of azadirone, a structurally complex triterpene that bears the signature furan typical of limonoids. Azadirone is a precursor for the bee-friendly anti-insect compound azadirachtin, which is produced by the neem tree and its relatives (De La Pena, Hodgson, Liu et al. (2023) - Complex scaffold remodeling in plant triterpene biosynthesis | Science (New York, N.Y.), 379 (6630), pp. 361-368. N. benthamiana lines with edits to knock-out peroxidases (in collaboration with the Earlham Institute) and competing alkaloid production have been generated and are being characterized Dudley et al., Communications Biology 5: 949 (2022). Additional glycosyl transferase candidates for silencing are currently being evaluated by a combination of expression analysis and in vitro activity assay. Additional edited lines in which 2-5 of these glycosyl transferases are knocked out will be generated starting in March-April 2019. Generated plants with knocked out peroxidase gene will be assessed for their ability to support the expression of VLPs of enveloped viruses in 2020-2021. In preliminary experiments, elimination of the peroxidases did not prevent the cross-linking of plant-expressed NwV proteins. Plants edited to reduce unwanted glycosylation have been use to propagate SARS-CoV-2 VLPs. Objective 4.3: Heterologous expression systems As part of an ongoing process on enhancing expression levels in plants, two new transient expression vectors, pHRE and pHREAC, have been developed using the synthetic biology principles in their design (Peyret et al., Plant Methods 15, 108, 2019). These vectors can give very high levels of expression and their construct has defined what is necessary for this. The new vectors have been invaluable for the creation of qRT-PCR positive controls for the diagnosis of Covid-19.To compare differences between plant-based expression and other systems, we have assessed the properties of VLPs of the insect virus, nudaurelia omega capsensis virus (NwV) expressed in plants (heterologous) and insect cells (homologous). If maturation was allowed to proceed within plants, authentic mature NwV VLPs were produced which were indistinguishable from those produced in insect cells. By contrast, when procapsids were extracted from plants and matured in vitro by reducing the pH of solution, aberrant particles were formed while maturation of procapsids isolated from insect cells proceeded efficiently. This difference in behaviour is caused by the partial cross-linking of the subunits of the procapsids during extraction from plants but not insect cells (Castells-Graells & Lomonossoff Plant Biotechnol J. 2021 19:1095-1097. doi: 10.1111/pbi.13598). Near atomic resolution cryo-EM structures of procapsids and mature virus particles produced in plants have been obtained (Castells-Graells et al. Commun Biol. 2021 ;4:619. doi: 10.1038/s42003-021-02134-w) and the structures of intermediates in the maturation process are being analysed using insect cell-produced material. |
| Exploitation Route | The method is already of huge interest to structural virologists and several collaborations have already been established. Likewise the methods for the production of secondary metabolites will be of interest to the field and to numerous collaborators. In particular with technology for encapsidating specific RNA molecules in CPMV virus-like particles is being commercially exploited by Leaf Expression Systems. The ability to produce VLPs of filamentous viruses has implications both for those wishing to understand the transmission of such viruses and the deployment of such VLPs in bionanotechnology. The different properties of NwV procapsids isolated from plants and insect cells demonstrates that the correct expression system should be ascertained for protein production. The ability to observe changes in protein conformation by cryo-EM will be of great interest to those working on structural biology. Understanding the mechanism of encapsidation of RNAs into CPMV particles has led to the development of a method for the specific encapsidation of designer mRNA molecules for delivery to mammalian cells. Such an approach may lead to the next generation of RNA vaccines. |
| Sectors | Agriculture Food and Drink Chemicals Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| URL | https://www.jic.ac.uk/people/george-lomonosoff/ |
| Description | Objective 4.1 A collaboration with Plant Bioscience Ltd (PBL) and Leaf Expression Systems (LES), both situated on the Norwich Research Park (NRP) has been developed to commercially exploit plant-based expression.This collaboration has focused on the production of virus-like particles of enveloped viruses, such Dengue virus, with the aim of producing novel vaccines against emerging viral threats. The availability of such vaccines clearly has both economic and societal benefits. They have also collaborated with external commercial entities on the deployment on in-tube controls for PCR-based diagnostics. Again, this will have economic benefits, particularly in the field of agriculture. The technology developed has been used to create in-tube controls for qRT-PCR diagnosis of Covid-19.A collaboration has been developed with the University of Leeds on the determination of the structure of virus-like particles (VLPs) from viruses which are either difficult, dangerous or impossible to isolate by conventional means. The availability of such novel structures provides improved understanding of virus architecture which lead to novel ways of controlling infections. Moreover, the VLPs can be used for the production of synthetic diagnostic reagents, such as ones based on adhirons (synthetic equivalents of antibodies), for the diagnosis of disease. Objective 4.2 Nicotiana benthamiana has been developed as a platform for engineering triterpenoids, compounds with numerous agronomic, medicinal and industrial applications. . Lines of N. benthamiana with edited genomes which could be used as an alternative to wild-type plants for protein production are under development. Such lines will likely have benefits in terms of the quality and quantity of the proteins with the concomitant economic impact. Objective 4.3 Our comparison of the properties of VLPs produced in plants and insect cells will affect the choice of the optimum expression system to use. |
| First Year Of Impact | 2017 |
| Sector | Agriculture, Food and Drink,Chemicals,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal Economic Policy & public services |
| Description | Advice for Government Report on Synthetic Cell. |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or Improved professional practice |
| Description | Appointment to the scientific advisory board of the US plant-based technology company Calyxt. |
| Geographic Reach | North America |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Attendance at Department for International Trade meeting |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | Development of export opportunities |
| Description | Attended Roundtable meeting to discuss how Government might further help in the UK's engineering biology sector. |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Visit by Minister of State in the Department for Science, Innovation and Technology |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | 21EBTA Engineering specialised metabolism and new cellular architectures in plants |
| Amount | £1,517,514 (GBP) |
| Funding ID | BB/W014173/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 01/2024 |
| Description | 21EBTA: Engineering plant cell factories for the production of biomedicines and their ingredients. (Acronym; Celfacto) |
| Amount | £1,199,974 (GBP) |
| Funding ID | BB/W013932/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 01/2024 |
| Description | A world of virus structures: understanding how non-icosahedral capsids are built |
| Amount | £1,000,000 (GBP) |
| Funding ID | BB/T004703/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 02/2023 |
| Description | Bio-engineering non-sugar modifications of saponins - BBSRC CTP studentship |
| Amount | £41,000 (GBP) |
| Funding ID | BB/R505584/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 10/2021 |
| Description | Delivering stabilised mRNA to cells for antigen production |
| Amount | £49,297 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2023 |
| Description | Development of reagents to study and combat emerging SARS-CoV-2 variants |
| Amount | £14,500 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2022 |
| Description | EC H2020 |
| Amount | € 7,199,560 (EUR) |
| Funding ID | 760331 |
| Organisation | European Commission |
| Sector | Public |
| Country | Belgium |
| Start | 01/2018 |
| End | 06/2022 |
| Description | EC H2020 |
| Amount | € 8,286,008 (EUR) |
| Funding ID | 774078 |
| Organisation | European Commission |
| Sector | Public |
| Country | Belgium |
| Start | 11/2017 |
| End | 10/2021 |
| Description | Engineering Quillaja saponin biosynthesis pathways for bio-production of QS-21 |
| Amount | £1,223,712 (GBP) |
| Funding ID | BB/R005508/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 07/2020 |
| Description | Engineering saponin biosynthesis pathways for bio-production of novel vaccine adjuants |
| Amount | £646,458 (GBP) |
| Funding ID | BB/W017857/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 04/2024 |
| Description | Engineering saponin surfactants |
| Amount | £71,590 (GBP) |
| Organisation | Unilever |
| Sector | Private |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 06/2019 |
| Description | Harnessing enzymes from plants for selective functionalisation of triterpenoid scaffolds |
| Amount | £542,505 (GBP) |
| Funding ID | BB/S016023/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 06/2023 |
| Description | Scientific Outreach Grant - DNA Dave |
| Amount | £500 (GBP) |
| Organisation | Biochemical Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 12/2019 |
| Description | Towards machine learning-driven prediction of the product chemical space of oxidosqualene cyclases, key enzymes in triterpene diversification |
| Amount | £181,411 (GBP) |
| Organisation | Alan Turing Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 06/2021 |
| Title | Establishment of a reverse genetics TILLING platform for diploid oat |
| Description | We have established a TILLING platform for diploid oat (Avena strigosa accession S75) using a sodium azide-generated mutant population that we have generated. The platform has been made available to the international research community through the RevGen platform at the John Innes Centre |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | This platform will enable identification of mutants in target genes for scientific research and crop improvement. |
| URL | https://www.jic.ac.uk/research-impact/technology-platforms/genomic-services/reverse-genetics/ |
| Title | Speed breeding for crop breeding and model plant research |
| Description | To meet the challenge of feeding a growing population, breeders and scientists are continuously looking for ways to increase genetic gain in crop breeding. One way this can be achieved is through 'speed breeding' (SB), which shortens the breeding cycle and accelerates research studies through rapid generation advancement. The SB method can be carried out in a number of ways, one of which involves extending the duration of a plant's daily exposure to light (photoperiod) combined with early seed harvest in order to cycle quickly from seed to seed, thereby reducing the generation times for some long-day (LD) or day-neutral crops. We have developed glasshouse and growth chamber-based SB protocols with supporting data from experimentation with several crop species. These protocols describe the growing conditions, including soil media composition, lighting, temperature and spacing, which promote rapid growth of spring and winter bread wheat, durum wheat, barley, oat, various members of the Brassica family, chickpea, pea, grasspea, quinoa and the model grass Brachypodium distachyon. Points of flexibility within the protocols are highlighted, including how plant density can be increased to efficiently scale-up plant numbers for single seed descent (SSD) purposes. Conversely, instructions on how to perform SB on a small-scale by creating a benchtop SB growth cabinet that enables optimization of parameters at a low cost are provided. We also outline the procedure for harvesting and germinating premature wheat, barley and pea seed to reduce generation time. Finally, we provide troubleshooting suggestions to avoid potential pitfalls. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This methodology opens up opportunities to accelerate and revolutionise crop improvement programmes and the field of plant biology research more broadly. |
| URL | https://www.nature.com/articles/s41477-017-0083-8 |
| Title | Transient plant expression technology for triterpene production at preparative scale |
| Description | We have develop a method for transient heterologous expression of biosynthetic enzymes in N. benthamiana for production of high-value triterpenes. Agro-infiltration is an efficient and simple means of achieving transient expression in N. benthamiana. The process involves infiltration of plant leaves with a suspension of Agrobacterium tumefaciens carrying the expression construct(s) of interest. Co-infiltration of an additional A. tumefaciens strain carrying an expression construct encoding an enzyme that boosts precursor supply significantly increases yields. After a period of five days, the infiltrated leaf material can be harvested and processed to extract and isolate the resulting triterpene product(s). This is a process that is linearly and reliably scalable, simply by increasing the number of plants used in the experiment. We have developed a protocol for rapid preparative-scale production of triterpenes utilizing this plant-based platform. The protocol utilizes an easily replicable vacuum infiltration apparatus, which allows the simultaneous infiltration of up to four plants, enabling batch-wise infiltration of hundreds of plants in a short period of time. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Generation of gram-scale quantities of 98% pure triterpenes and demonstration that we can rapidly carry out combinatorial expression of enzymes from our triterpene toolkit to generate known and new-to-nature compounds. This had attracted considerable interest from industry and led to four new projects directly funded by different companies in the pharma, ag, food and drink and home and personal care sectors. |
| URL | https://www.jove.com/video/58169/transient-expression-nicotiana-benthamiana-leaves-for-triterpene |
| Description | A world of virus structures |
| Organisation | University of Leeds |
| Department | Astbury Centre for Structural Molecular Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This collaboration involved the plant-based production of virus-like particles (VLPs) by my group at JIC via transient expression. The future project will focus on the production of VLPs that do not have icosahedral symmetry - these will then be sent to the Astbury Centre, University of Leeds for structural characterization. |
| Collaborator Contribution | The Astury Centre has state-of-the-art Cryo electron microscope facilities that enable near-atomic resolution strcture of viruses and VLPs. The collaboration enables us to solve the structures of viruses that are difficult or impossible to propagate and purify. |
| Impact | There are numerous publications from this collaboration. These are listed under the appropriate award. |
| Start Year | 2020 |
| Description | Collaboration with Leaf expression Systems, NRP |
| Organisation | Leaf Expression Systems |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We are collaborating with Leaf expression Systems (LES) to scale-up the production of several VLPs which have previously made on a small scale at JIC. these include eVLPs from CPMV and poliovirus. The constructs originally produced at JIC have been transferred to LES. |
| Collaborator Contribution | The use of facilities and technology for the scaled-up production of VLPs with particular emphasis on process development and quality assurance. |
| Impact | The collaboration has been active for less than 1 year so there are no outcomes to report yet. |
| Start Year | 2017 |
| Description | Cryo-EM of VLP structures |
| Organisation | University of Leeds |
| Department | Astbury Centre for Structural Molecular Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Production of VLPs in plants |
| Collaborator Contribution | Cryo-EM analysis of the structure of plant-produced VLPs |
| Impact | This is a multi-disciplinary collaboration using plant-based expression (JIC) to produce VLPs. The structure of these can be determined by near -atomic resolution cryo-EM (Leeds). |
| Start Year | 2017 |
| Title | Metabolic engineering |
| Description | The invention relates generally to materials and methods for biosynthesising quillaic acid in a host by expressing heterologous nucleotide sequences in the host each of which encodes a polypeptide which in combination have said QA biosynthesis activity. Example polypeptides include (i) a Beta-amyrin synthase; (ii) an enzyme capable of oxidising Beta-amyrin or an oxidised derivative thereof at the C-28 position to a carboxylic acid; (iii) an enzyme capable of oxidising Beta-amyrin or an oxidised derivative thereof at the C-16a position to an alcohol; and (iv) an enzyme capable of oxidising Beta-amyrin or an oxidised derivative thereof at the C-23 position to an aldehyde. Preferred nucleotide sequences are obtained from, or derived from, Q. saponaria. |
| IP Reference | WO2019122259 |
| Protection | Patent application published |
| Year Protection Granted | 2019 |
| Licensed | Commercial In Confidence |
| Impact | This patent has been pivotal to the development of a large collaboration with a major pharma company. |
| Title | Scaffold modification |
| Description | he present invention relates generally to methods and materials for use in glycosylation of chemical scaffolds, such as triterpenes. |
| IP Reference | GB1808617.3 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | Commercial In Confidence |
| Impact | This patent is pivotal to the pending establishment of a spin-out company |
| Description | "Meet the Scientist" Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | During the Norwich Science Festival we organised a "meet the scientist" event where scientists who had won a space to have their images exhibited in a display were invited to come and give a 5 minute presentation next to their image about their work. This was a free ticketed event for a maximum of 50 people, all tickets went and the audience response was excellent with everyone staying behind after the presentations to chat to the scientists. |
| Year(s) Of Engagement Activity | 2019 |
| Description | "You can't judge a book from its cover". A series of 15 workshops for different ages/groups run for SAW Trust by Jenni Rant and Sami Stebbings. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The first project was on 11.05.18, for elderly people. The writing and artwork was displayed at the Norwich Science Festival in October 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | AO attended Synthetic Biology Industrial Translation Showcase @Synbio_Showcase:Synbite Showcase Programme at the Royal Academy of Engineering 17.11.22 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | The aim of the 1-Day SynbiTECH Showcase was to reflect important issues and changes in the field of synthetic biology/engineering biology. As with the previous SynbiTECH meetings, the focus was primarily be on the development of the U.K.'s industrial and commercial synthetic biology/engineering biology sector. Consequently, the programme did not only reflect industrial and company development, but, also, important associated matters including strategy and policy, finance, policy and biosecurity. |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://www.synbicite.com/news-events/2022/nov/17/synbicite-showcase-2022/ |
| Description | Activity stand at mixed arts festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We put together an activity for the science marquee at the Latitude Festival, working with colleagues from the University of East Anglia, Food and Farming Discovery Trust, CEFAS, Precious Plastics East and some local artists with the overall topic of microplastics in the environment. Some of the activity was focused on the problems microplastics cause as pollutants in the ocean and in food chains but we also had a section on plastics in our daily lives that enabled exploration of alternative plant-based materials and the potential for greener alternatives from both biological engineering for new materials and better recycling and remaking processes. We feel that by looking at a problem (microplastics in our environment) but then exploring better alternatives we conveyed a sense of agency to the families to seek out and support alternatives in their daily lives. We were particularly pleased to hear many people pledge to give up using clingfilm in favour of beeswax and paper alternatives to wrap their lunch! |
| Year(s) Of Engagement Activity | 2022 |
| Description | Agritech Sixth Former Course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | In 2016 we ran a pilot course for sixth formers to give them an insight into careers in the Agritech sector. The students spent one day at the John Innes Centre learning about academic research into crops with lots of hands-on practical work and a second day at Easton & Otley agricultural college to learn how research is applied and the innovations in precision agriculture. The course was funded by Robert Carter, Royal Norfolk Show president of 2015, who came to JIC to open the first day and also commissioned a video of the course. We presented the results to the Royal Norfolk Agricultural Association trustees and are currently fund raising to run another course this year for a larger number of students in collaboration with the University of East Anglia. |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://drive.google.com/file/d/0B2tX0hct-CoZLUVWN0gzX1REeEU/view?pref=2&pli=1 |
| Description | Anne Osbourn gave a seminar at a symposium at the Weizmann Institute of Science, Rehovot |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Anne Osbourn gave a seminar at a symposium at the Weizmann Institute of Science, Rehovot in October 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Anne Osbourn meeting with George Freeman MP during visit to Norwich Research Park |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Anne Osbourn met George Freeman MP (Minister of State in the Department for Science, Innovation and Technology) as one of the NRP Entrepreneurial Researchers. Professor Anne Osbourn, Founder of Hothouse Therapeutics, spoke about Unlocking Nature's Inaccessible Chemistry. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Anne Osbourn was on the Scientific Advisory Review Committee for the Weizmann Institute |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | President of the Weizmann Institute of Science invited the assistance of Anne Osbourn with a Scientific Academic Advisory Committee (SAAC) review of Plant and Environmental Sciences (2022) at the Weizmann Institute of Science in Israel, scheduled to take place on October 23, 2022 through October 27, 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Audio Interview BBC Radio Norfolk |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview by G.P. Lomonossoff on Matthew Gudgin show on BBC Radio Norfolk, 27th Oct 2017. This was an interview based on the "Desert Island Discs" format and last 1 hour from 18:00-19:00. |
| Year(s) Of Engagement Activity | 2017 |
| Description | BBSRC Taiwan partnering award meeting 23-24 March, 2015 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | BBSRC Taiwan partnering award meeting 23-24 March, 2015. I gave a 20 min presentation on metabolic pathway engineering in the Osbourn group. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Biodiversity Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | New SAW workshop delivered at Bignold Primary School on World Biodiversity Day to introduce year 4 children to the importance of biodiversity for people and the planet and to some of the factors that are causing species decline across the globe. The children were amazed by the wealth of species, their importance in the ecosystem and how humans utilise natural products and shocked by the driving forces to extinction, a term they believed to only apply in the past, linked to dinosaurs, and not something that was ongoing. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sawtrust.org/in-schools/world-biodiversity-day-at-bignold-primary-school/ |
| Description | Botanical workshop for children |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A botanical drawing workshop for 20 children was held at the John Innes Centre of 29 June 2015. This was led by a botanical artist from Kew Gardens who had been on many international plant hunting expeditions to document new species, who told stories about her travels. The JIC rare books collection was used to show the children historic collections and to highlight how plant natural products were discovered and documented. The children then made their own botanical drawings. They also learned about seed banks and the importance of maintaining biodiversity. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cereal engineering workshop, Dunstan Hall, Norwich UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | 20 minute talk at the cereal engineering workshop Held in the Dunston Hall near Norwich on the 27th and 28th or May 2014. |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://synthsym.org/meetings-conferences/ |
| Description | Conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "The suitability of plants for the expression of Dengue virus-like particles" at Riga, Plant based vaccines, antibodies and biologics. 10-12.06.2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation entitled "Encapsidation of viral RNA in Picornavirales: studies on cowpea mosaic virus demonstrate dependence on viral replication" at Microbiology Society Annual Meeting, Belfast, UK; 8-12th of April 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presenation entitled "The 3.3 Å structure of a begomovirus and the generation of geminivirus-like particles in infiltrated plant leaves" at Virology Africa 2020, Cape Town, South Africa |
| Year(s) Of Engagement Activity | 2020 |
| Description | Conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk entitled "Synthetic virus-like particles and how to make them in plants" at AIchE conference "Plant synthetic biology, bioengineering and biotechnology. This resulted in scientific discussions and promotion of the technology involved. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.aiche.org |
| Description | Curriculum Hacks event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented a large display on engagement activities developed and run by the SAW Trust for OpenPlant at a variety of events to share ideas with other people working in synthetic biology. |
| Year(s) Of Engagement Activity | 2018 |
| Description | DNA Dave Presentation at the Biomakers Fayre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | We were awarded Biomaker and biochemical society funding to progress ideas for creating resources and designing a workshop for schools to build their own robot and presented our prototype teaching kit at the Biomakers Fayre in Cambridge in November 2020. We will be running pilot workshop for secondary schools in 2020 to test the resources and we will follow each schools progress as they work towards building their own biology-themed robots before hosting a sharing event for students to bring their robots along to present and to discuss their experiences during the process. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.sawtrust.org/news/dna-dave-at-the-biomakers-fayre/ |
| Description | DNA workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | We delivered a Science Art and Writing workshop on the theme of DNA at a local Junior school in a deprived area who were hosting a visiting group of Chinese children. Due to the language barriers, the local children paired up with a Chinese child to work through the activities together which meant they had to first understand the required process before helping their partner to complete tasks. This gave a new depth to the learning process which was reinforced by the local children having to take on the role of the instructor in their pair. This built confidence in the children. |
| Year(s) Of Engagement Activity | 2018 |
| Description | EI Innovate: Linking datasets and bioscience |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | EI Innovate 2021: Linking datasets and bioscience Through effectively linking datasets we can accelerate bioscience and deliver the key innovations needed to improve food security, environmental management, conservation, health and wellbeing. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.earlham.ac.uk/ei-innovate-2021-linking-datasets-and-bioscience#SpeakersandOrganisers-1 |
| Description | Early Years Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Set up an exhibition stand at the Early Years conference to showcase SAW materials and in particular our Plant Growth and Development lesson plan developed for OpenPlant. We had a lot of interest from early years educators and we are now working with a local nursery school to trial some new plant-themed activities. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Emerging viruses of zoonotic and veterinary importance Meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "Can plant-based transient expression be used to combat emerging viral diseases?" G.P. Lomonossoff, Churchill College Cambridge, Emerging viruses of zoonotic and veterinary importance, 24th-26th July 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Engagement Showcase |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was an 'in-house' event where scientists were invited to put up displays of their engagement resources so that other scientists could come and get ideas, see what is available to share and to encourage more scientists to try public engagement. We took a selection of tried and tested outreach resources, including activities that help to explain genome mining, biosynthetic pathway building and biological engineering. We also took our DNA robot, 'DNA Dave' and his new companion 'RNA Ruth' that definitely seemed to encourage people to be bold and creative with their ideas for the tools they could make to help their research come to life for a general audience. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Engaging Images Competition |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | We ran an image competition for researchers across the Norwich Research Park to win a spot in an image exhibition at the Norwich Science Festival. Entrants were asked to upload high quality images of their work with accessible legends to the NRP Image Library Website. A mixed judging panel comprised of representatives from business, the media and the arts were brought together to judge the images and decide on the final 11 winning entries. The winning images were put on display in the Forum building in the centre of Norwich for 2 weeks and the images were also featured in print in a double-page spread in the Eastern Daily Press as well as on their website. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://images.norwichresearchpark.ac.uk/ |
| Description | Forest Gardens for schools project |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We are participating in a project to encourage schools to have more agency on the planting schemes in their school grounds to create better plant science learning opportunities for children. We are piloting a project with 4 schools that will ultimately lead to them creating forest gardens on their sites (an agroforestry approach to planting for food and materials) that uses the principles of forest ecology to be a less labour-intensive approach to growing food compared to exposed vegetable beds which have traditionally been more common in school gardens. We are also looking at species that may be more resilient to our changing climate, create shade and help to remove carbon from the atmosphere to give children the knowledge they will need for their future. We began working with them in July 2022 and are running regular sessions that have so far helped them to survey their existing flora and begin to create herbariums for their schools. We shall be extending this by collecting samples for DNA sequencing in collaboration with the Earlham Institute, to add genetic information about their plants to their herbariums. We are also partnering with Gressenhall Museum of Rural Life's new Eco-hub to explore the heritage and cultural past of the landscape around their schools, working with maps from 1880 right through to LIDAR created heat maps from 2020 that show plant density across the wider locality. This will enable them to explore what habitats might be close by and what species they could attract by choosing certain plants or by creating wildlife corridors. We are currently sourcing trees for planting at the schools through the Million Tree Project with Norfolk County Council. The children are excited by the concept that the maps of the future are as yet unknown and that they can make choices with their planting plans that can shape their environment. Working in this way, nurturing plants, understanding the relationship between species and working with climate change we hope this will contribute to not only children's understanding of plants and ecosystems but will also have a positive impact on their wellbeing. We plan to share our findings from the pilot project with schools across the county and are creating a project template that schools can use if they would like to create their own forest garden. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | Freethink media film 2018 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Web-based film about plant-based expression produced by Freethink media. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.facebook.com/freethinkmedia/videos/1698762333516461/ |
| Description | Gardeners Question Time Display |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The John Innes Centre hosted Gardeners Question time for BBC Radio 4 and as part of the event put up several displays for the audience to view before and after the recorded event. We put a display up about the Global Garden workshop we have been running to showcase the outputs and to raise awareness for future workshops. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Gatsby Summer School 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Invited Lecture entitled "Studying a plant virus: From fundamental research to Applications and back again", Gatsby Plant Science Summer School for 1st year undergraduates, Easingwold, UK. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Geminivirus talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "The Structural Features of a Begomovirus Particle Revealed by Cryo-Electron Microscopy" Saunders K., Hesketh E., Fisher C., Ranson N., Lomonossoff GP. The 2017 meeting of the American Society for Virology meeting at the University of Wisconsin-Madison, USA. 24th - 28h June 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Global garden |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Following on from the pilot of the Global Garden workshop in 2017 we ran a public workshop as part of the Norwich Science Festival that invited anyone to explore plant natural products and the regulations and ethics around access and benefit sharing. We then ran another session for a group of scientists which provided an interesting contrast of opinions around ethics compared to those shared by members of the public. This is an ongoing project that seeks to raise awareness of these issues as well as to get people thinking and talking about the importance of plants. In 2019 we took the Global Garden workshop to Cambridge as part of the Festival of Ideas and ran the workshop at the Cambridge Botanic Gardens. We also had garden curator Dr Sam Brockington attend and give a presentation on the importance of plant collections for research as well as for enjoyment. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | Glycosylation, Manchester 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation entitled "The mechanism of glycosylation and the consequences of glycoform on therapeutic protein functionality" by G.P.Lomonossoff. Manchester, UK,.Establishing International Partnerships in Industrial Biotechnology and Bioenergy - Improved glycoform-based biopharmaceutical production in plants. 18-20th Sept. 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Great British Bioscience Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | We were successful in a winning a BBSRC science communication award to develop a new science stand called 'Nature's Factories' to run at local events and as part of the BBSRC's Great British Bioscience Festival showcasing the best of British bioscience in its 20th anniversary year. Human evolution is tightly linked to our use of plants for food, building materials, fuel, medicines etc., and we continue to look for innovative ways to use natural resources to provide us with sustainable solutions that support our lifestyles. Scientific research is enabling us to discover and develop new plant products that improve our lifestyles by creating better medicines, healthier foods and greener technologies whilst also demonstrating the importance of protecting plant species diversity and ecosystems. The Nature's Factories stand was designed to enable the public to find out how science is exploring and exploiting the valuable variety of chemicals made by plants as well as making natural remedies to take away and pick leaves from our fact-tree. We took the stand to the Science in Norwich Day at the Forum in Norwich (1st June 2014), to the Cambridge Botanic Gardens (19th August 2014) and on the 12th November 2014 used the stand for a training workshop for EU scientists to learn how to create interactive displays for public events. On 14-16 November 2014, our exhibit headed to Museum Gardens, Bethnal Green, London to be showcased at BBSRC's Great British Bioscience Festival. The festival, delivered in partnership with London Science Festival was open to the general public and free to attend. Since then the exhibit has featured at the Bury St Edmunds family science festival (21st March 2015), the Fascination of Plants day at the John Innes Centre (14th May 2015), the Festival of Plants at Cambridge Botanic Gardens (16th May 2015) and at the Youth Stem Awards (13th January 2016). We plan to use the exhibit throughout 2016. |
| Year(s) Of Engagement Activity | 2014,2015,2016 |
| URL | http://www.bbsrc.ac.uk/engagement/exhibitions/gb-bioscience-festival/ |
| Description | HVCfP, Manchester 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk "Translating academic research - The Leaf Systems Experience" by G.P. Lomonossoff, 2017 High Value Chemicals from Plants annual meeting, Manchester, UK, 19 Oct 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Independent review of UKRI Roundtable discussion co-hosted by the Campaign for Science and Engineering & Sir David Grant |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Anne Osbourn was a member of an independent review of UKRI. Roundtable discussion. Co-hosted by the Campaign for Science and Engineering and Sir David Grant. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ukri.org/news/ukri-welcomes-independent-review-report/ |
| Description | International education visit |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Hosted a group of teachers from Shanghai and took them to visit a range of science-themed SAW workshops running in local schools to show how the academic research community can provide enrichment to the curriculum for children and opportunities for teachers to access information and new activities based on current research straight from the lab. Also organised a sharing event for teachers and representatives from the County Council to hear about how SAW is being embedded in Chinese schools and the impact it has on teaching and learning. All parties took new ideas away from the experience to try and implement in their own settings. |
| Year(s) Of Engagement Activity | 2019 |
| Description | JIC 50 Open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "Using plants as factories - from basic virology to applications" and participation in JIC 50 Alumnus Open day,17 Sep 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | JIC ASM 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "Well, we Built it - now will they come?" by GP Lomonossoff, JIC Annual Science Meeting 2017, 12 Oct 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Jeremy Vine Show |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Live interview on the Jeremy Vine Show, BBC Radio 2, concerning Covid-19 Spread. |
| Year(s) Of Engagement Activity | 2020 |
| Description | John Innes Centre 50th Anniversary Open Day. (16 September 2017) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Approximately 3000 people attended. The support of our local community, and allowing as many people as possible to find out more about what we do is important to us, so in the build-up to the event we were delighted to welcome both BBC Look East and BBC Radio Norfolk onto the site, to chat to scientists and preview the event. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.jic.ac.uk/news-and-events/blog-copy/2017/09/open-day/ |
| Description | Lecture to MBE students, University of Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | A two hour face-to-face presentation entitled: Plant-produced pharmaceuticals: myth or reality? |
| Year(s) Of Engagement Activity | 2022 |
| Description | Lecture to MBE students, University of Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Two hour lecture to MBE students at the University of Cambridge |
| Year(s) Of Engagement Activity | 2023 |
| Description | Live Radio interviews |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Live radio interviews with BBC Live Live, BBC Radio Berkshire, BBC Radio Foyle, BBC Radio Wales and BBC Radio Northampton on Covid-19. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Live TV interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Live TV interviews with BBC World News and BBC News channel about Covid-19 |
| Year(s) Of Engagement Activity | 2020 |
| Description | Live TV interview on BBC News Channel |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Live TV interview on the spread of Covid-19. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Lives in Science Workshop 2018 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Interaction with Year 11 Art students visiting JIC, 15 Jan 2018 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Meeting on Norwich Research Park |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation "Transient expressions of synthetic biology in plants" at Earlham Institute, Norwich Research Park, Meeting "Decoding and Recoding Biological Systems", 19/05/17 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Multiple TV/Radio interviews |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Multiple (approximately 100 in 2021) TV/Radio interviews on various aspects of Covid-19 pandemic |
| Year(s) Of Engagement Activity | 2021 |
| Description | NRP DTP Summer Conference 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | NRP DTP Summer Conference 2015 held in the assembly house in Norwich. 15 min talk: Pathway engineering using the GoldenGate MoClo system. Norwich Research Park Doctoral Training Partnerships |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.biodtp.norwichresearchpark.ac.uk/ |
| Description | National Institutes of Biosciences (NIB) Meeting on the 15th and 16th of June 2015. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | National Institutes of Biosciences (NIB) Meeting on the 15th and 16th of June 2015. Presented a poster. This unique multidisciplinary 2-day meeting brings together leading scientists from the 8 institutes that comprise the National Institutes of Bioscience (NIB): The Genome Analysis Centre (TGAC), The Roslin Institute, The Pirbright Institute, John Innes Centre (JIC), the Institute of Food Research (IFR), Rothamsted Research, the Babraham Institute and the Institute of Biological, Environmental and Rural Sciences (IBERS), as well as from other renowned National and International research organisations, to discuss how bioscience research is addressing global challenges affecting plant, animal and human health. There will be opportunities to find out more about the Institutes' National Capabilities and Strategic programmes, contribute to shape the UK's bioscience research priorities and establish new multidisciplinary collaborations. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Norwich Bio Makers 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Involvement by GP Lomonossoff in Norwich Bio Makers "Building Nanostructures in Plants", St. Andrews Brew House, Norwich, UK 13 Dec 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Norwich Science Festival 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Norwich Science Festival - Push Story Machine Production + Q&A with Prof George Lomonossoff. Norwich Writer's Centre Dragon Hall, King Street, Norwich. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Norwich Science Festival satellite event at Diss Corn Hall |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We took an activity stand to a science discovery day at Diss Corn Hall. This event was set up as a satellite venue for the very popular Norwich Science Festival to try and reach a broader audience. There were 3 workshop sessions throughout the day for 50 children per workshop and their families, all of which were fully booked! We took a stand that focused on the instructions held within DNA to 'make stuff' which was explained by inviting people to engage with our robot DNA Dave, pushing buttons and turning cogs to complete transcription and translation to make new products. We used examples from plants that people would be familiar with such as menthol, limonoids, vanillin and anthocyanins and then invited children to extract anthocyanins from red cabbage to use to make colour-changing paint. Many of the parents were amazed how easy the process was and were keen to build on the experiment at home with their children to make a colour palette of paints using pigments from plants and acids and bases. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral presentation at AAB Conference "Advances in Plant virology", 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lomonossoff G. P.(2018) Synthetic virus-like particles and how to make them in plants AAB meeting "Advances in Plant Virology", Jury's Inn, Birmingham 12-13th April 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at AAB Conference "Advances in Plant virology", 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Peyret H., Saxena P., Kruse I., Lomonossoff G. P.(2018) Studies on cowpea mosaic virus show that RNA encapsidation is dependent on replication: implications for the assembly of members of the order Picornavirales. AAB Conference "Advances in Plant virology", Jury's Inn, Birmingham UK 12-13th April 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at ISPMF Helsinki, 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lomonossoff G. P., Marsian J., Paley R., Hurdiss D. L., Ranson N. A.(2018) Global food security - Plant-made Virus-Like Particles as a candidate vaccine against Nervous Necrosis Virus. Oral presentation at the 3rd meeting of the International Society for Plant Molecular farming (ISPMF), 11-13th June 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at ISPMF meeting, Helsinki 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Peyret H., Lomonossoff G. P.(2018) Using a synthetic biology approach to develop a novel, easy to use, and open access transient expression system Helsinki, Finland, 3rd ISPMF conference, 11-13th June 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at Ninth International Virus Assembly Symposium, Madeira 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Castells Graells R., Johnson J. E., Lomonossoff G. P.(2018) Studying virus maturation stages with an insect virus Madeira - Portugal, Ninth International Virus Assembly Symposium, 6th-10th May 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at SEB Florence 2018 symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lomonossoff G. P.(2018) Transient expression of virus-like particles for use in biomedicine and bionanotechology SEB Florence 2018 symposium "Plant Biotechnology for health and nutrition, |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at VLPNPV, Bern 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lomonossoff G. P., Walden M., Steele J., Meshcheriakova Y., Marsian J., Saunders K., Thuenemann E., Peyret H., Hesketh E., Thompson R.(2018) Plants as a highly effective platform for VLP production VLPNPV Meeting Bern, Switzerland, 25-27th Sept. 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oral presentation at VLPNPV, Bern 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Saunders K., Hesketh E. L., Fisher C., Ranson N. A., Lomonossoff G. P.(2018) The generation of aberrant geminivirus-like particles in infiltrated plant leaves Inselspital, Universitatsspital, Bern, Switzerland. The Fifth International Conference on: Virus-Like Particle & Nano-Particle Vaccines - VLPNPV 2018 25-27th September 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | P153 - ALL ROADS LEAD TO LIMONOIDS: ANALYSIS OF A COMPLEX BIOSYNTHETIC NETWORK IN CITRUS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 4th International Conference on Natural Product Discovery & Development in the Genomic Era |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://sim.confex.com/sim/np2023/meetingapp.cgi/Session/5182 |
| Description | PBVAB Conference Presentation 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation "Combining transient expression and high resolution cryo-electron microscopy to produce novel virus-like particles" by Walden M., Meshcheriakova Y., Marsian J., Hesketh E., Ranson N., Lomonossoff G. P. PBVAB 2017, Albufeira, Portugal, ,5-7th June 2017 |
| Year(s) Of Engagement Activity | 2012,2014,2017 |
| Description | PGCE training workshops |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Delivered Science Art and Writing (SAW) workshops for the 2022 cohort of PGCE students at the University of East Anglia. The session included theory and practical activities and showcased a range of resources we have created by delivering science outreach in classrooms, including the synthetic biology for schools package and the limonoid extraction and identification practical. The trainee teachers are developing their craft and looking for teaching resources that they can try out when they progress into being NQT's going out to placement schools across the region. This is a good way to disseminate our resources widely to our target audience. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Participation in Norwich Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Manned a stand describing plant-made pharmaceuticals at the Norwich Science Festival Oct. 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Participation in a Coaching and Mentoring Workshop at John Innes Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Study participants or study members |
| Results and Impact | Initial training for Mentors, to getting them to understand coaching and mentoring, the wider pool, as well as some tools and techniques to use. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Post Doctoral Retreat |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented career pathways in science communication to a large group of Post Doctoral Researchers and led a discussion on the need and importance of engaging society with research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation at BISON workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented synthetic biology-themed science engagement approaches to a group of academics for a BISON workshop in Norwich. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://bison.ceitec.cz/ |
| Description | Presentation at a Symposium: (Metabolic Diversification in Plants) ISMPMi |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | https://www.ismpmi.org/Events/2021Congress/Pages/default.aspx December 1 - 2 Plant-microbe interactions in the environment - Navigating a complex world This symposium was held December 1-2, 2021, hosted by Cara Haney (British Columbia, Canada) and Paul Schulze-Lefert (Cologne, Germany). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ismpmi.org/Events/2021Congress/Program/Pages/December.aspx |
| Description | Presentation at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "Production of SARS-CoV-2 VLPs in plants for use as virus surrogates" at virus-like Particle & Nano-Particle Vaccines - VLPNPV 2023 27-29 June 2023. Riga, Latvia |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "Making TMV nanorods with a replicating virus vector: The need for scaffolding" at AAB meeting International Advances in Plant Virology 2022 Hybrid event hosted in Ljubljana, Slovenia 5th-7th October 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "Making VLPs of helical viruses in plants: the need for scaffolding" at First International Black Forest Symposium: "Viral Findings of Curious Scientific Friends", Freudenstadt-Lauterbad, Germany, 22-24 June 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On-line presentation "Studying viral dynamics: the trouble with plants" at 4th ISPMF Conference, on-line, 28-29 Sept. 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered talk entitled "Production of SARS-CoV-2 VLPs in plants for use as virus surrogates" at the ISPMF conference, Rome, Italy 26-28th Sept. 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled "Making geminate virus particles: interactions between geminivirus coat protein and circular single-stranded DNAs at "Viral Findings of Curious Scientific Friends" - First International Black Forest Symposium, Lauterbad, Germany, 22-24 June 2022 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation at conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation entitled "Utilizing a replicating virus vector to encapsidate designer RNA into capsids of differing morphology" Virus-like Particle & Nano-Particle Vaccines - VLPNPV 2023 27-29 June 2023. Riga, Latvia. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at conference (Brazil) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered on-line talk entitled "Pushing the envelope: expanding the range of virus-like particles produced in plants" to the XXXII Brazilian Congress of Virology |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation by D.Ponndorf, Korea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ponndorf D., Peyret H., Meshcheriakova Y., Dobon Alonso A., Lomonossoff G.(2018) Virus-like particles from plants: Versatile tools for research in vaccine development Korean Society for Plant Biotechnology: from Farming to Pharming . |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to DBT consortium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plant-expressed Proteins, The technology and its use for BTV Meeting for BBSRC/DBT India Grant Consortium, School of Veterinary Sciences, Sutton Bonnington, University of Nottingham, UK |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to the Norfolk Clinical Commissioning Group (CCG) and the Patient Participation Group at Oak Street Surgery |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | We were invited to present our work on the SAW antibiotics book to the Norfolk CCG who are interested in working with us to improve understanding on AMR in communities but also on other health-related topics. We also presented our work to the PPG at a local GP surgery who are interested in running an AMR-themed workshop for patients and potentially developing subsequent workshops on topics such as flu and norovirus to help limit the spread of infection. The work we are developing here is being fed back to Public Health England representatives from the Healthcare-Associated Infection and Antimicrobial Resistance Unit. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Henry Smith Holden Botany Lecture, University of Nottingham, 19th July 2023 "Inspired by nature: using plant virus particles in biomedicine and nanotechnology". |
| Year(s) Of Engagement Activity | 2023 |
| Description | Public art and poetry competition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Using a collection of 11 science images featuring our research on display as part of the Norwich Science Festival we invited the public to create art or poetry inspired by the images. We had a judging panel choose favourites from several catagories and the winners work was put on display at the Sainsburys Centre for Visual Arts during December. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public engagement training for undergraduate science students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Delivered a training workshop for undergraduate science students to show how a cross-disciplinary approach to science outreach can open up topics to people with varied interests and therefore widen audience participation. We used a plant-natural products example to work through a case study to give the students some practical ideas on how they could develop their own activities on a variety of science research topics. Several of the students were keen to hear about opportunities to volunteer at public engagement events to develop their confidence and science communication skills further. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Public talk, Norwich |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Delivered a public talk entitled "Grow your own - making vaccines in plants" at Earlham Library, Norwich, UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | Radio 5 live interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Live interview of Radio 5 Live regarding spread of Covid-19. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Radio Interviews Wales, Scotland |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Live radio interviews about Covid-19 on BBC Radio Wales and Scotland |
| Year(s) Of Engagement Activity | 2020 |
| Description | Radio interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Two recorded interview with BBC Radio Norfolk concerning Covid-19. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Remote lecture and Q&A session with Masters students at Wageningen University, The Netherlands |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A discussion with Masters students in the Netherlands regarding plant-based expression. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Royal Norfolk Show plant science stand |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | We designed and delivered science activities in the Discovery Zone at the Royal Norfolk Show for visiting children to learn about the properties of gluten in wheat and the use of insect predators as biocontrol for crop protection. Hundreds of children participated in our activities and most had heard of gluten as it is commonly mentioned now in terms of food allergies so we were able to give them some context around what gluten actually is, where its found and the properties it has. Many children were surprised by this! |
| Year(s) Of Engagement Activity | 2019 |
| Description | SAW Project on DNA and Cells |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Delivered a SAW project with a year 6 class at a local primary school on DNA and cells and also talked about careers in science with the children. |
| Year(s) Of Engagement Activity | 2019 |
| Description | SAW School Visit & teacher training (China) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | In December 2012 we were invited by the Tianyang Foundation and the Xuhui Education Bureau to visit Shanghai to launch the Science Art and Writing(SAW) initiative in China. This was the beginning of a very exciting partnership that enables Chinese teachers and children to develop their creativity using the SAW philosophy. We worked with a group of children and delivered a training workshop to enable teachers and volunteers to explore SAW techniques and begin experimenting with how SAW could be used in their classrooms. As the John Innes Centre strengthens its links with the Chinese Academy of Sciences, the scheme will be rolled out more widely with support from Norfolk County Council's International Schools Partnership. We returned in 2014 to give further training to new schools and found that since the launch they had used SAW with about 1000 children in 18 schools and kindergartens in the Xuhui district, training 140 teachers and involving around 50 social volunteers! In December 2015 we hosted a visit to the UK by a group of Chinese teachers who use SAW in China so they could see how it works here. During 2016 we supported collaborations between teachers locally in Norfolk and in Shanghai working on SAW Lunchbox Science projects to assist Norfolk County Council in strengthening partnerships between international schools. In April 2017, in collaboration with Norfolk County Council, we took a group of teachers from Norfolk schools who had been participating in the Lunchbox Science projects to visit the teachers in Shanghai that ad also been working on this for a series of sharing presentations, demo lessons and visits to several schools in the city. We also moved further out of the centre to deliver a SAW Plant Natural Products training workshop for 40 new Chinese teachers. Further visits are being planned for 2018. |
| Year(s) Of Engagement Activity | 2012,2014,2015,2016,2017 |
| URL | http://www.jic.ac.uk/news/2013/02/dr-jenni-rant-takes-science-and-eternal-rainbows-to-china/ |
| Description | SAW Science Inspired Poetry Workshops at the Writers Centre Norwich |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The SAW Trust have begun a new collaboration with the Writers Centre Norwich(WCN) to provide science-inspired poetry workshops for adults using current science topics as a starting point for writing. The first pilot project took place on the evening of 18th August 2015 and was delivered as a partnership with a group of undergraduate students from the University of East Anglia competing in an international synthetic biology challenge called iGEM ( http://igem.org/Main_Page ). The students wanted a novel approach to exploring the human practices component of their project so the SAW Trust helped the team link with Jonathan Morley from WCN to set up a poetry workshop. Jonathan invited Esther Morgan, a highly experienced poet and workshop provider to lead the poetry session (http://www.esthermorgan.net/). Esther came to visit the students at the Norwich Research Park prior to the session and had an afternoon of tours around the laboratories to see what the students were working on. The poetry session began with a presentation by the students on the science to give all the attending writers an insight into the aims of the research. Esther then took over providing some warm-up activities linked to the science and then got the scientists to break out into pairs with the writers to discuss the scientific language in more detail. A great selection of poetry emerged from the workshop and was presented at a jamboree for all competing teams by the Norwich iGEM team in Boston, USA, which is the final stage of the competition. The team were delighted to be awarded a gold medal for their project and be rated in the top 5 of all 280 teams for their approach to education and public engagement. We have since run an antibiotics-themed poetry workshop on 12th February 2016 and have plans for a further 3 workshops throughout the year. |
| Year(s) Of Engagement Activity | 2015 |
| Description | SAW Seminar - Sowing the seeds for science outreach |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented creative outreach projects and ways to capture impact at the department seminar to encourage scientists to be bold with their outreach plans and to demonstrate the value of documenting the process and the outcomes for reporting, reflection and to improve the method. |
| Year(s) Of Engagement Activity | 2020 |
| Description | SAW Training Workshop for PhD Students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | We provided a SAW Training workshop for PhD Students from Cambridge and Germany who are working on an EU collaborative project entitled PlaMatSu to help them think creatively about how to communicate their research topics to diverse audiences. They completed practical tasks in science, art and writing and made presentations in small groups. The students undertook this training as part of their studentships to prepare them for designing and developing an installation to be put on display at the Cambridge Botanic Garden and in a host venue in Germany. The day concluded with a brainstorming session where the students pulled together their ideas and mapped out next steps as they work to progress their designs. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.plamatsu.eu/About-Us/Events/Training-Workshop-4 |
| Description | SAW stand at the Royal Norfolk Show 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 2015 marked the 150 year anniversary of a presentation of research to the Natural Science Society in Brno by Austrian monk Gregor Mendel, who is regarded as the "father of modern genetics". In 1865, Mendel presented his work from studies done on pea plants in the gardens of the monastery in Brno that provided the first description of the Laws of Inheritance. To celebrate Mendel's work and enable children to follow his methods to understand how the Laws of Inheritance work, we ran an interactive stand in the Discovery Zone at the Royal Norfolk Show. The stand provided a mix of hands-on science led by scientists from the John Innes Centre and an art activity that invited children to contribute to the build of some giant pea pods led by environmental artist Ruth MacDougall. |
| Year(s) Of Engagement Activity | 2015 |
| Description | SAW workshop at Barford Primary School 11 March 2014 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Saw (Science, Art and Writing) project in Barford primary school together with Jenni Rant, Gemma Farré Martinez, James Reed, Chris Hann (artist) and Mike O'Driscoll (writer). We spent an entire day at school, explaining my project (Engineer wheat for "Take all" resistance) and opening a dialog about GMOs with 10 to 11 years old pupils. This project took place on the Tuesday 11th of March 2014. |
| Year(s) Of Engagement Activity | 2014 |
| Description | STEMM Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Helped to set up a STEMM conference aimed at sixth form students and provided a workshop on plant breeding, nodulation and working towards reduced toxicity in grass pea for consumption in Africa. The session was well attended (students got to choose from a range of sessions) and the pupils enjoyed the hands-on activities but also liked hearing about the research into grass peas and its potential impact. |
| Year(s) Of Engagement Activity | 2018 |
| Description | School Science Art and Writing (SAW) project |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We delivered a SAW project on the theme of plant defence at Avenues Junior School in Norwich. The children were encouraged to collect samples from the school garden of plants showing symptoms of disease and observe them using microscopes. This enabled them to look closely at plants, learn about a range of pathogens and develop confidence in using microscopes. They moved on to an experiment where they had to identify wheat and oat seedlings by grinding up roots using pestle and mortars and viewing the exudates under UV light to look for the presence of the fluorescent molecule avenacin that is present only in oat and protects it from attack by the 'take all' fungus Gaeumannomyces tritici. We then discussed how scientists are learning how plants make important molecules and reconstructing biosynthetic pathways in model systems and that wheat plants could be engineered to also produce avenacin to protect them from take all disease. The children were then asked to design a defence for a plant to protect it from 1 of 6 potential threats by turning over a 'chance card'. They were very creative and enjoyed dreaming up ideas that could be used for defence. They took the new concepts and vocabulary on to write poetry and create pieces of art that represented the modular building of pathways. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Science Art and Writing (SAW) Project in school |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Delivered a SAW project on the theme of plants at Tacolneston Primary, a very rural school in Norfolk. The school were studying Arctic and Antarctic biomes and so we worked with them to add some plant stories to the very zoocentric approach schools usually take when exploring these regions as habitats. This enabled us to explain adaptations to environments which are particularly fascinating in plants and we touched on some local work by colleagues in Cambridge who discovered alpine plants making a fine wool out of flavonoids to cover its leaves. We explored chemical diversity and its many uses in plants and then looked at chemicals in plants that are useful to humans. The children were surprised to see this dynamic side of plants. We then focused on colours, flavours and fragrances and made extractions and then altered our extracts with acids and bases to make many new versions. The children enjoyed this plant-based chemistry session and then took their new facts, vocabulary and concepts forward to write poetry and create art to explore the topic further. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Science Communication Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Delivered a science communication workshop on the Science Art and Writing (SAW) methodology for third year science undergraduates at the University of East Anglia to show how they can design accessible science activities for non-specialists and can extend into creative writing and arts to provide a rich, memorable experience for participants. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Innovation Showcase 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation "Growing vaccines in plants" and networking by G.P. Lomonossoff at Science Innovation Showcase (SIS) held at JIC 7- 8th Feb. 2018 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Science in Norwich day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Helped Jenni Rant (SAW) to hold a stand describing the scientific research ongoing at JIC, at the Science in Norwich Day at the Forum on the 1st of June 2014 . |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://soin.org.uk/2014/04/science-in-norwich-day-2014/ |
| Description | Science, Art and Poetry activity |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delegates at the Anne Osbourn Novozymes Prize Symposium held at the John Innes Centre on Sep 9th and 10th 2024 participated in plant natural product-themed art and poetry activities run by the SAW Trust, during the refreshment and poster sessions. Colour pigments, ice cubes and diffusion were used to create flower-like patterns that were added to a display that grew over the course of the event and acrostic poems using key words related to the research topics were generated by people each adding a line. These were performed during the closing remarks of the event as a collaborative piece. The activities created an opportunity for delegates to work together, create and play which fostered an atmosphere for relaxed dialogue and a chance to consider novel approaches to science communication. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://sawtrust.org/ |
| Description | Science, Art and Writing (SAW) project on plant natural products, Suffolk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A Science, Art and Writing (SAW) project on plant natural products was run for 90 students at St Benedicts Secondary School, Suffolk, UK on 3 July 2015. The students collected plant samples from the school grounds and used them in chromatography experiments to see how many different types of pigments they could extract. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Science, Art and Writing workshop at Dunston Hal, Norwich on 13 July 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A Science, Art and Writing workshop was held for delegates at the High Value Chemicals from Plants Network meeting at Dunston Hall, Norwich on 13 July 2015. The event was run over dinner. Case studies of public engagement activities that focus on plant natural products were showcased at the event and tips and tricks on ensuring good practice were shared and discussed. The participants also took part in poetry writing and portraiture over dinner, led by poet Mike O'Driscoll and artist Chris Hann. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On-line seminar for Advanced Plant Growth Centre, Hames Hutton Institute, Scotland. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Seminar at NUIG |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Synthetic virus-like particles and how to make them in plants Seminar at National University of Ireland - Galway (NUIG), Galway, Republic of Ireland. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Seminar, Glasgow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lomonossoff G. P.(2018) Plant-based transient expression of virus-like particles for use in biomedicine and bionanotechology Seminar at University of Glasgow, Glasgow, UK |
| Year(s) Of Engagement Activity | 2018 |
| Description | Seminar: "Finding drugs in the garden: Harnessing plant metabolic diversity" in the @IPS2ParisSaclay amphitheater on Tuesday 22nd November at 2 pm |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Anne Osbourn gave a seminar about "Finding drugs in the garden: Harnessing plant metabolic diversity" in the @IPS2ParisSaclay amphitheater on Tuesday 22nd November at 2 pm |
| Year(s) Of Engagement Activity | 2023 |
| Description | Series of approximately 300 national and local radio broadcasts on the subject of Covid-19 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I have given approximately 300 radio interviews on the subject of Covid-19 during the pandemic. These have included both local (e.g. BBC Radio Norfolk) and national (BBC Radio 5 live, Times Radio) as well as some international (e.g. BBC Persian service) stations. |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | Series of local radio broadcasts |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A series of 15 interviews with local radio stations across the UK over a two hour period regarding the spread of Covid-19 (24th Feb. 2020). |
| Year(s) Of Engagement Activity | 2020 |
| Description | Sixth Form/College science students visit to site |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | We have been supporting schools to run plant science experiments over the last year and ran a science communication competition for participating schools inviting students to create a poster or report about their experiments to win a tour of the John Innes Centre. We hosted a group of winners and showed them a range of things around the site including; a visit to a research lab investigating nitrogen availability, a trip to the Germplasm Resource Unit to hear about the importance of preserving genetic diversity, a tour of the glasshouse facilities and meeting with a scientist investigating new varieties of legumes for better climate resilience, agricultural approaches and nutrition, a lab session on plant chemical diversity and opportunity to infiltrate Nicotiana benthamiana plants to learn about transient expression, a demo in the metabolomics lab to see how GC and LCMS enable discovery of molecules and a tour of the sequencing facility at the Earlham Institute. The students enjoyed seeing the range of topics being investigated, how some of them fitted together and the diversity of career options within a research facility. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Synbio and bioinformatics workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A lesson plan was developed to cover how bioinformatics is used in research and how this links to synthetic biology and delivered in a secondary school to a group of science sixth form students. Synthetic biology is not well represented in the curriculum and so we worked with a teacher to create a session that enabled students to learn about the processes and to see real examples of how this is being used to create products of use to society. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sawtrust.org/news/saws-latest-intern/ |
| Description | Synthetic Biology: 4th New Phytologist Workshop, Bristol, UK June 2012 |
| Form Of Engagement Activity | Scientific meeting (conference/symposium etc.) |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research or patient groups |
| Results and Impact | Synthetic biology. Published in New Phytologist, Wiley; 0028-646X no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2012 |
| URL | http://0028-646X |
| Description | TV Broadcast |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Live TV interview on BBC Persian Service |
| Year(s) Of Engagement Activity | 2020 |
| Description | TV interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Live interview on BBC News Channel regarding coronavirus outbreak |
| Year(s) Of Engagement Activity | 2020 |
| Description | Talk at APHA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Deliver presentation entitled "A Leaf Expression platform for the production of vaccine candidate materials, mAbs and for in vitro diagnosis" at the Animal and Plant Health Agency (APHA), Weybridge, UK. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk at MfN joint workshop with Rothamsted Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Speaker at a joint MfN workshop with Rothamstead Research on Discovery and bioenginnering of plant triterpene pathways |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talking Plants Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delivered a workshop at the Talking Plants Conference at Cambridge Botanic Garden. This conference takes place at a different botanic garden nationally each year and brings together garden staff and other organisations that work with plants and the public. Our workshop showcased some of the best plant-themed outreach projects we have delivered to share ideas and activities that provide a platform to engage people with plants. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bgen.org.uk/conferences/talking-plants-2018-conference-proceedings/ |
| Description | Training Workshop - Edinburgh |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | For the third year we returned to the University of Edinburgh to deliver a Science Art and Writing training workshop for scientists, artists, writers and teachers. Following the workshop, the participants formed SAW teams and partnered with schools to deliver workshops about a variety of synthetic biology topics for children to experience with practical science, poetry and art activities. |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | Training session at the John Innes Centre |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Golden Gate training session directed by Christian Rogers in the Chris Lamb training suite at JIC. I ran a 45 min session describing the introduction of the hypertrans and 2A peptide expression system in the Golden Gate cloning system. I also co-organised an in silico practical exercise on how to build GoldenGate vectors using Vector NTI and APE. 28-05-2014 |
| Year(s) Of Engagement Activity | 2014 |
| Description | Training workshop (Edinburgh) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | OpenPlant is working with the SAW Trust to deliver some of its engagement activities, particularly with schools. The SAW team were invited by the University of Edinburgh SynthSys & UK Centre for Mammalian Synthetic Biology to deliver a training workshop for scientists, artists, writers and teachers to enable them to design and deliver SAW projects in schools around Edinburgh. This approach to engaging children in current scientific research in an accessible way provides an excellent tool for scientists who wish to use diverse methods to showcase the potential impacts of their research. Working in teams with professionals from the arts fuels creative thinking and innovation around engagement styles whilst also providing novel science themes for artistic interpretation. Working with teachers helps to inform knowledge on current research to provide new examples for use in the classroom and the whole process enables co-learning from a science starting point in a multi-disciplinary way. Several SAW projects took place in Edinburgh schools in the months following the workshop where they were greatly received. We returned in 2017 to provide training for more people and again in 2018 and so the pool of SAW-trained scientists, artists and writers has grown significantly and the popularity of SAW in schools is providing a constant network for scientists to deliver novel engagement activities with children. |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | UK Fungus Day Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | On Sunday 13th October 2013 researchers from the John Innes Centre, Institute of Food Research and University of East Anglia joined forces with volunteers from the Norfolk and Norwich University Hospital, STEM ambassadors, local businesses and community groups to host a free event for families at the John Innes Centre to celebrate the amazing kingdom of fungi. The event marked the first of a new national day set up by the British Mycological Society to raise the public's awareness of the importance of fungi to our lives. Over 30 venues across the UK hosted activities to mark the occasion and here in Norfolk we managed to impress 300 people with the many roles that fungi play. Among the activities on offer were bread making with the National Collection of Yeast Cultures, fungi-themed storytelling with Liam Carroll, beer tasting with the Craft Brewers Association, a Marmite Taste and Flavour activity, plus the chance to learn about fungal diseases of crops and humans and displays showing how fungi is used to make products that protect from disease. Fungi experts from Norfolk and Suffolk took over 100 people on fungal forays around the Norwich Research Park finding over 50 different species, including some deadly specimens and the Womens Institute cookery demonstrations provided tasty mushroom soup to warm people up. The Waveney Valley Mushroom Farmers brought a mini farm display that proved very popular and sold mushrooms to raise money for East Anglian Childrens Hospice. There were lots of fungal specimens for observing with microscopes and people were keen to learn about Ash Die Back disease using an airzooka to mimic travelling spores and were fascinated by the fungal farmers Leafcutter Ants. Science Art and Writing (SAW) Trust artists invited children to build a mycelial maze by making giant mushrooms and visitors took part in games and competitions. The feedback was overwhelmingly positive and people were genuinely surprised by all the roles that fungi play in nature and in our everyday lives. In 2014 we worked with many of the same partners to deliver an event for the general public at the Norwich School and in 2015, Dr Jenni Rant who set up the previous events travelled to RSPB Minsmere reserve in Suffolk to run activities in their visitors centre with some of the fungi experts who had previously supported the events in Norwich. |
| Year(s) Of Engagement Activity | 2013,2014,2015 |
| URL | http://www.ukfungusday.co.uk/ |
| Description | VLPNPV Singapore 2017 - 2 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk "Tackling Emerging Viruses - Plant Made Virus Like Particles As Vaccines Against Enveloped Viruses", Ponndorf D., Peyret H., Dobon Alonso A., Meshcheriakova Y., Lomonossoff G.P., Biopolis, Singapore Virus-like particle and nano-particle vaccines - VLPNV 2017, 29th November - 1st December 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | VLPNV Singapore 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk "Designer length TMV-based nano-rods for nanotechnological applications" K. Saunders G.P. Lomonossoff, Biopolis, Singapore Virus-like particle and nano-particle vaccines - VLPNV 2018 29th November - 1st December 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Vienna Meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation "Transient Expressions of Synthetic Biology in Plants" by G.P. Lomonossoff, 4th International Conference Plant Transformation & Biotechnology, Vienna, Austria 30/06/17 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Webinar in Turkmenistan |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was invited to present my work on Covid-19 to scientists in Turkmenistan |
| Year(s) Of Engagement Activity | 2020 |
| Description | Wimpy Weeds Outreach Stand at County Show |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We developed an outreach stand for the Discovery Zone area of the Royal Norfolk Show entitled 'Wimpy Weeds'. The purpose was to tackle 'plant blindness', particularly on species that people often overlook and group them into the category of being weeds and of no value. The stand celebrated a host of native species with a tremendous amount of genetic diversity. We looked at the value of these plants in terms of the environmental services they provide to ecosystems for things such as contributing to soil health, climate resilience and as nectar sources for insects. We discussed the importance of protecting biodiversity and of the many plant-derived products that are already important in our lives and the many, as yet, undiscovered products that will provide benefits in the future. Visitors were able to create a plant ident key using ink and rollers for leaf printing and make seedbombs to take away to encourage the growing and appreciation of wildflowers at home. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Workshops and conference presentation in Shanghai |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | We visited Shanghai to deliver some training workshops for teachers new to the SAW methodology and also for teachers who have been working with SAW for several years. We introduced the Plant growth and development lesson plan to teachers at our hub school and we also presented SAW at a large international education conference showcasing a plant natural products projects to describe the process, |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sawtrust.org/news/saw-returns-to-shanghai/ |
| Description | aBIOTECH Virtual Seminar by Professor Anne Osbourn. Title of talk: 'Harnessing plant metabolic diversity'. Zoom meeting. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "aBIOTECH Virtual Seminar": Zoom Presentation: Presenter: Professor Anne Osbourn (John Innes Centre) at the invitation of Professor Xiaoquan Qi (CAS Institute of Botany, Beijing, China). Title of talk: "Harnessing plant metabolic diversity" JIC organiser: Dr Jie Li. Date and time: 10:00-11:30 (UK time), 24 February 2023. Audience of approximately 1000 people. Hosted by aBIOTECH editor in chief Professor Sanwen Huang. Keywords Notes |
| Year(s) Of Engagement Activity | 2023 |
| Description | participation in Royal Society annual "Labs to Riches" event, 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lomonossoff G. P.(2018) Participation in Royal Society annual "Labs to Riches" event, Royal society, London, UK 20th March 2018 |
| Year(s) Of Engagement Activity | 2018 |